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Volumn 10, Issue , 2016, Pages 31-39

Tumor-infiltrating lymphocytes in triple negative breast cancer: The future of immune targeting

Author keywords

Breast cancer (BC); Prognosis; Programmed cell death ligand 1 (PD L1); Triple negative (TN); Tumor infiltrating lymphocytes (TILs)

Indexed keywords

ANTHRACYCLINE DERIVATIVE; ATEZOLIZUMAB; BEVACIZUMAB; CARBOPLATIN; CD8 ANTIGEN; CYCLOPHOSPHAMIDE; EPIDERMAL GROWTH FACTOR RECEPTOR 2; ESTROGEN RECEPTOR; FLUOROURACIL; IMMUNOMODULATING AGENT; METHOTREXATE; NAVELBINE; PACLITAXEL; PEMBROLIZUMAB; PROGESTERONE RECEPTOR; PROGRAMMED DEATH 1 LIGAND 1; PROGRAMMED DEATH 1 RECEPTOR; TAXANE DERIVATIVE; TICILIMUMAB; TRANSCRIPTION FACTOR FOXP3;

EID: 84988378157     PISSN: None     EISSN: 11795549     Source Type: Journal    
DOI: 10.4137/CMO.S34540     Document Type: Review
Times cited : (153)

References (53)
  • 1
    • 45749134564 scopus 로고    scopus 로고
    • Etal. The anticancer immune response: Indispensable for therapeutics success
    • Zitvogel L, Apetoh L, Ghiringhelli F, etal. The anticancer immune response: indispensable for therapeutics success? J Clin Investig. 2008;118:1991–2001, doi:10.1172/JCI35180.
    • (2008) J Clin Investig , vol.118 , pp. 1991-2001
    • Zitvogel, L.1    Apetoh, L.2    Ghiringhelli, F.3
  • 2
    • 0036852241 scopus 로고    scopus 로고
    • Cancer immunoediting: From immunosurveillance to tumor escape
    • Dunn G, Bruce AT, Ikeda H, et al. Cancer immunoediting: from immunosurveillance to tumor escape. Nat Immunol. 2002;3:991–8.
    • (2002) Nat Immunol , vol.3 , pp. 991-998
    • Dunn, G.1    Bruce, A.T.2    Ikeda, H.3
  • 4
    • 0034796870 scopus 로고    scopus 로고
    • Development of tumor-infiltrating lymphocytes in breast cancer after neoadjuvant paclitaxel chemotherapy
    • Demaria S, Volm MD, Shapiro RL, et al. Development of tumor-infiltrating lymphocytes in breast cancer after neoadjuvant paclitaxel chemotherapy. Clinical Cancer Res. 2001;7:3025–30
    • (2001) Clinical Cancer Res , vol.7 , pp. 3025-3030
    • Demaria, S.1    Volm, M.D.2    Shapiro, R.L.3
  • 5
    • 73949092850 scopus 로고    scopus 로고
    • Tumor-associated lymphocytes as an independent predictor of response to neoadjuvant chemotherapy in breast cancer
    • Denkert C, Loibl S, Noske A, et al. Tumor-associated lymphocytes as an independent predictor of response to neoadjuvant chemotherapy in breast cancer. J Clin Oncol. 2010;28:105–3.
    • (2010) J Clin Oncol , vol.28 , pp. 105-113
    • Denkert, C.1    Loibl, S.2    Noske, A.3
  • 6
    • 84875722651 scopus 로고    scopus 로고
    • Prognostic and predictive value of tumor-infiltrating lymphocytes in a phase III randomized adjuvant breast cancer trial in node-positive breast cancer comparing the addition of docetaxel to doxorubicin with doxorubicin-based chemotherapy: BIG 02-98
    • Loi S, Sirtaine N, Piette F, et al. Prognostic and predictive value of tumor-infiltrating lymphocytes in a phase III randomized adjuvant breast cancer trial in node-positive breast cancer comparing the addition of docetaxel to doxorubicin with doxorubicin-based chemotherapy: BIG 02-98. J Clin Oncol. 2013;31(3):860–67.
    • (2013) J Clin Oncol , vol.31 , Issue.3 , pp. 860-867
    • Loi, S.1    Sirtaine, N.2    Piette, F.3
  • 7
    • 84905178989 scopus 로고    scopus 로고
    • Tumor infiltrating lymphocytes are prognostic in triple negative breast cancer and predictive for trastuzumab benefit in early breast cancer: The FinHER trial
    • Loi S, Michiels S, Salgado R, et al. Tumor infiltrating lymphocytes are prognostic in triple negative breast cancer and predictive for trastuzumab benefit in early breast cancer: the FinHER trial. Ann Oncol. 2014;25:1544–50.
    • (2014) Ann Oncol , vol.25 , pp. 1544-1550
    • Loi, S.1    Michiels, S.2    Salgado, R.3
  • 8
    • 84907198355 scopus 로고    scopus 로고
    • Prognostic value of tumor-infiltrating lymphocites in triple negative breast cancers from two phase III randomized adjuvant breast cancer trials: ECOG 2197 and ECOG 1199
    • Adams S, Gray RJ, Demaria S, et al. Prognostic value of tumor-infiltrating lymphocites in triple negative breast cancers from two phase III randomized adjuvant breast cancer trials: ECOG 2197 and ECOG 1199. J Clin Oncol. 2014;32:2959–67.
    • (2014) J Clin Oncol , vol.32 , pp. 2959-2967
    • Adams, S.1    Gray, R.J.2    Demaria, S.3
  • 9
    • 84858766182 scopus 로고    scopus 로고
    • The blockade of immune checkpoints in cancer immunotherapy
    • Pardoll DM. The blockade of immune checkpoints in cancer immunotherapy. Nat Rev Cancer. 2012;12:252–64.
    • (2012) Nat Rev Cancer , vol.12 , pp. 252-264
    • Pardoll, D.M.1
  • 10
    • 84983370835 scopus 로고    scopus 로고
    • PD-L1 expression correlation with tumor-infiltrating lymphocytes and response to neoadjuvant chemotherapy in breast cancer
    • Wimberly H, Brown JR, Schalper KA, et al. PD-L1 expression correlation with tumor-infiltrating lymphocytes and response to neoadjuvant chemotherapy in breast cancer. Cancer Immunol Res. 2015;3(4):326–32.
    • (2015) Cancer Immunol Res , vol.3 , Issue.4 , pp. 326-332
    • Wimberly, H.1    Brown, J.R.2    Schalper, K.A.3
  • 12
    • 0034680102 scopus 로고    scopus 로고
    • Molecular portraits of human breast tumours
    • Perou CM, Sorlie T, Eisen MB, et al. Molecular portraits of human breast tumours. Nature. 2000;406(6797):747–52.
    • (2000) Nature , vol.406 , Issue.6797 , pp. 747-752
    • Perou, C.M.1    Sorlie, T.2    Eisen, M.B.3
  • 13
    • 78951482208 scopus 로고    scopus 로고
    • Deconstructing the molecular portraits of breast cancer
    • Prat A, Perou CM. Deconstructing the molecular portraits of breast cancer. Mol Oncol. 2011;5:5–23.
    • (2011) Mol Oncol , vol.5 , pp. 5-23
    • Prat, A.1    Perou, C.M.2
  • 14
    • 84948709397 scopus 로고    scopus 로고
    • Clinical implications of the intrinsic molecular subtypes of breast cancer
    • Prat A, Pineda E, Adamo B, et al. Clinical implications of the intrinsic molecular subtypes of breast cancer. The Breast. 2015, http://dx.doi.org/10.1016/j.breast.2015.07.008.
    • (2015) The Breast
    • Prat, A.1    Pineda, E.2    Adamo, B.3
  • 15
    • 79960015997 scopus 로고    scopus 로고
    • Identification of human triple-negative breast cancer subtypes and preclinical models for selection of targeted therapies
    • Lehman BD, Bauer JA, Chen X, et al. Identification of human triple-negative breast cancer subtypes and preclinical models for selection of targeted therapies. Clin Invest. 2011;121(7):2750–67. doi:10.1172/JCI45014.
    • (2011) Clin Invest , vol.121 , Issue.7 , pp. 2750-2767
    • Lehman, B.D.1    Bauer, J.A.2    Chen, X.3
  • 16
    • 84927621560 scopus 로고    scopus 로고
    • Comprehensive genomic analysis identifies novel subtypes and targets of triple-negative breast cancer
    • Bunstein MD, Tsimelzon A, Poage GM, et al. Comprehensive genomic analysis identifies novel subtypes and targets of triple-negative breast cancer. Clinical Cancer Res. 2015; 21:1688–98.
    • (2015) Clinical Cancer Res , vol.21 , pp. 1688-1698
    • Bunstein, M.D.1    Tsimelzon, A.2    Poage, G.M.3
  • 17
    • 78649663247 scopus 로고    scopus 로고
    • Triple negative cancer: Disease entity or title convenience
    • Carey L, Winer E, Viale G, et al. Triple negative cancer: disease entity or title convenience? Nat Rev Clin Oncol. 2010;7:683–92.
    • (2010) Nat Rev Clin Oncol , vol.7 , pp. 683-692
    • Carey, L.1    Winer, E.2    Viale, G.3
  • 18
    • 84949844816 scopus 로고    scopus 로고
    • Clinical relevance of host immunity in breast cancer: From TILs to the clinic
    • published on line 15 Dec
    • Savas P, Salgado R, Denkert C, et al. Clinical relevance of host immunity in breast cancer: from TILs to the clinic. Nature Rev in Clin Oncol. published on line 15 Dec 2015. Doi: 10.1038/nrclinonc.2015.215.
    • (2015) Nature Rev in Clin Oncol
    • Savas, P.1    Salgado, R.2    Denkert, C.3
  • 19
    • 84924076132 scopus 로고    scopus 로고
    • The evaluation of tumor-infiltrating lymphocytes (TILs) in breast cancer: Recommendations by an international TILs Working Group 2014
    • Salgado R, Denkert C, Demaria S, et al. The evaluation of tumor-infiltrating lymphocytes (TILs) in breast cancer: recommendations by an international TILs Working Group 2014. Ann Oncol. 2015;26:259–71.
    • (2015) Ann Oncol , vol.26 , pp. 259-271
    • Salgado, R.1    Denkert, C.2    Demaria, S.3
  • 20
    • 84927138902 scopus 로고    scopus 로고
    • Tumor-infiltrating lymphocytes and response to neoadjuvant chemotherapy with or without carboplatin in human epidermal growth factor receptor 2-positive and triple negative primary breast cancers
    • Denkert C, Minckwitz G, Brasen JA, et al. Tumor-infiltrating lymphocytes and response to neoadjuvant chemotherapy with or without carboplatin in human epidermal growth factor receptor 2-positive and triple negative primary breast cancers. J Clin Oncol. 2015;33:983–1.
    • (2015) J Clin Oncol , vol.33 , pp. 983-991
    • Denkert, C.1    Minckwitz, G.2    Brasen, J.A.3
  • 21
    • 84988314049 scopus 로고    scopus 로고
    • Clinical validity of tumor-infiltrating lymphocytes analysis in patients with triple negative breast cancer
    • published November 23
    • Pruneri G, Vingiani A, Bagnardi V, et al. Clinical validity of tumor-infiltrating lymphocytes analysis in patients with triple negative breast cancer. Ann Oncol Advance Access published November 23, 2015.
    • (2015) Ann Oncol Advance Access
    • Pruneri, G.1    Vingiani, A.2    Bagnardi, V.3
  • 23
    • 36549004041 scopus 로고    scopus 로고
    • Gene expression profiling and histopathological characterization of triple negative/basal-like breast carcinomas
    • Kreike B, van Kouwenhove M, Horlings H, et al. Gene expression profiling and histopathological characterization of triple negative/basal-like breast carcinomas. Breast Cancer Res. 2007;9:R65.
    • (2007) Breast Cancer Res , vol.9
    • Kreike, B.1    Van Kouwenhove, M.2    Horlings, H.3
  • 24
    • 84862784272 scopus 로고    scopus 로고
    • CD8+ lymphocyte infiltration is an independent favorable prognostic indicator in basal-like breast cancer
    • Liu S, Lachapelle J, Leung S, et al. CD8+ lymphocyte infiltration is an independent favorable prognostic indicator in basal-like breast cancer. Breast Cancer Res. 2012;14:R48. http://breast-cancer-research.com/content/14/2/R48
    • (2012) Breast Cancer Res , vol.14
    • Liu, S.1    Lachapelle, J.2    Leung, S.3
  • 25
    • 84872608638 scopus 로고    scopus 로고
    • Tumour-infiltrating FOXP3(+) lymphocytes are associated with cytotoxic immune responses and good clinical outcome in oestrogen receptor-negative breast cancer
    • West NR, Kost SE, Martin SD, et al. Tumour-infiltrating FOXP3(+) lymphocytes are associated with cytotoxic immune responses and good clinical outcome in oestrogen receptor-negative breast cancer. Br J Cancer. 2013;108, 155–62 | doi: 10.1038/bjc.2012.524
    • (2013) Br J Cancer , vol.108 , pp. 155-162
    • West, N.R.1    Kost, S.E.2    Martin, S.D.3
  • 26
    • 84905186948 scopus 로고    scopus 로고
    • Association between CD8+ T-cell infiltration and breast cancer survival in 12,439 patients
    • Ali HR, Provenzano E, Dawson E, et al. Association between CD8+ T-cell infiltration and breast cancer survival in 12,439 patients. Ann Oncol. 2014;25:1536–43.
    • (2014) Ann Oncol , vol.25 , pp. 1536-1543
    • Ali, H.R.1    Provenzano, E.2    Dawson, E.3
  • 27
    • 84899685321 scopus 로고    scopus 로고
    • Intratumoral CD8(+) cytotoxic lymphocyte is a favourable prognostic marker in node-negative breast cancer
    • Chen Z, Chen X, Zhou E, et al. Intratumoral CD8(+) cytotoxic lymphocyte is a favourable prognostic marker in node-negative breast cancer. PLoS One. 2014; 9(4):e95475. doi: 10.1371/journal.pone.0095475.
    • (2014) Plos One , vol.9 , Issue.4 , pp. e95475
    • Chen, Z.1    Chen, X.2    Zhou, E.3
  • 28
    • 84865191854 scopus 로고    scopus 로고
    • Tumor-infiltrating lymphocytes are correlated with response to neoadjuvant chemotherapy in triple-negative breast cancer
    • Ono M, Tsuda H, Shimizu C, et al. Tumor-infiltrating lymphocytes are correlated with response to neoadjuvant chemotherapy in triple-negative breast cancer. Breast Cancer Res Treat. 2012;132:793–805.
    • (2012) Breast Cancer Res Treat , vol.132 , pp. 793-805
    • Ono, M.1    Tsuda, H.2    Shimizu, C.3
  • 29
    • 84918537575 scopus 로고    scopus 로고
    • The value of tumor-infiltrating lymphocytes (TILs) for predicting response to neoadjuvant chemotherapy in breast cancer: A systematic review and meta-analysis
    • Mao Y, Zhang Y, et al. The value of tumor-infiltrating lymphocytes (TILs) for predicting response to neoadjuvant chemotherapy in breast cancer: a systematic review and meta-analysis. PLoS One. 2014;9:e115103.
    • (2014) Plos One , vol.9
    • Mao, Y.1    Zhang, Y.2
  • 30
    • 84927142845 scopus 로고    scopus 로고
    • Tumor-infiltrating lymphocytes and response to platinum in Triple-Negative Breast Cancer
    • Tung NM, Winer E. Tumor-infiltrating lymphocytes and response to platinum in Triple-Negative Breast Cancer. J Clin Oncol. 2015;33:969–71.
    • (2015) J Clin Oncol , vol.33 , pp. 969-971
    • Tung, N.M.1    Winer, E.2
  • 31
    • 85043539132 scopus 로고    scopus 로고
    • Effects of conventional therapeutic interventions on the number and function of regulatory T cells
    • Roselli m, Cereda V, di Bari MG, et al. Effects of conventional therapeutic interventions on the number and function of regulatory T cells. Oncoimmunology. 2013; 2:e26440; 10.4161/onci.26440.
    • (2013) Oncoimmunology , vol.2
    • Rosellim, C.V.1    Di Bari, M.G.2
  • 32
    • 0034852872 scopus 로고    scopus 로고
    • Immune responses to tumour antigens implications for antigen specific immunotherapy of cancer
    • Jäger D, Jäger E, Knuth A. Immune responses to tumour antigens implications for antigen specific immunotherapy of cancer. J Clin Pathol. 2001;54:669–74.
    • (2001) J Clin Pathol , vol.54 , pp. 669-674
    • Jäger, D.1    Jäger, E.2    Knuth, A.3
  • 33
    • 79953151458 scopus 로고    scopus 로고
    • Cancer immunoediting: Integrat ing immunity’s roles in cancer suppression and promotion
    • Schreiber RD, Old LJ, Smyth MJ. Cancer immunoediting: Integrat ing immunity’s roles in cancer suppression and promotion. Science. 2011;331:1565–70.
    • (2011) Science , vol.331 , pp. 1565-1570
    • Schreiber, R.D.1    Old, L.J.2    Smyth, M.J.3
  • 34
    • 84904188903 scopus 로고    scopus 로고
    • Pathological complete response and long-term clinical benefit in breast cancer: The CTNeoBC pooled analysis
    • Cortázar P, Zhang L, Untch M, et al. Pathological complete response and long-term clinical benefit in breast cancer: the CTNeoBC pooled analysis. Lancet. 2015;384;164–72.
    • (2015) Lancet , vol.384 , pp. 164-172
    • Cortázar, P.1    Zhang, L.2    Untch, M.3
  • 35
    • 84896872171 scopus 로고    scopus 로고
    • Prognostic value of tumor-infiltrating lymphocytes on residual disease after primary chemotherapy for triple-negative breast cancer: A retrospective multicenter study
    • Dieci MV, Criscitiello C, Goubar A, et al. Prognostic value of tumor-infiltrating lymphocytes on residual disease after primary chemotherapy for triple-negative breast cancer: a retrospective multicenter study. Ann Oncol. 2014;25:611–18.
    • (2014) Ann Oncol , vol.25 , pp. 611-618
    • Dieci, M.V.1    Criscitiello, C.2    Goubar, A.3
  • 36
    • 84964696930 scopus 로고    scopus 로고
    • Tumor-infiltrating immune cell profiles and their change after neoadjuvant chemotherapy predict response and prognosis of breast cancer
    • García-Martínez E, Luengo G, Chaves A, et al. Tumor-infiltrating immune cell profiles and their change after neoadjuvant chemotherapy predict response and prognosis of breast cancer. Breast Cancer Res, 2014;16;488.
    • (2014) Breast Cancer Res , vol.16 , pp. 488
    • García-Martínez, E.1    Luengo, G.2    Chaves, A.3
  • 37
    • 84940735047 scopus 로고    scopus 로고
    • Prognostic significance of tumor-infiltrating CD8+ and FOXP3+ lymphocytes in residual tumors and alterations in these parameters after neoadjuvant chemotherapy in triple-negative breast cancer: A retrospective multicenter study
    • Miyashita M, Sasano H, Tamaki K, et al. Prognostic significance of tumor-infiltrating CD8+ and FOXP3+ lymphocytes in residual tumors and alterations in these parameters after neoadjuvant chemotherapy in triple-negative breast cancer: a retrospective multicenter study. Breast Cancer Research. 2015;17:124.
    • (2015) Breast Cancer Research , vol.17 , pp. 124
    • Miyashita, M.1    Sasano, H.2    Tamaki, K.3
  • 38
    • 84890980389 scopus 로고    scopus 로고
    • Breathing new life into immunotherapy: Review of melanoma, lung and kidney cancer
    • Drake CG, Lipson EJ and Brahmer JR. Breathing new life into immunotherapy: review of melanoma, lung and kidney cancer. Nat Rev Clin Oncol. 2014;11:24–37. Doi:10.1038/ncrlinonc.2013.208.
    • (2014) Nat Rev Clin Oncol , vol.11 , pp. 24-37
    • Drake, C.G.1    Lipson, E.J.2    Brahmer, J.R.3
  • 39
    • 84995785011 scopus 로고    scopus 로고
    • Immunotherapy for advanced gastric and esophageal cancer: Preclinical rationale and ongoing clinical investigations
    • Raufi AG and Kemplern SJ. Immunotherapy for advanced gastric and esophageal cancer: preclinical rationale and ongoing clinical investigations. J Gastrointest Oncol. 2015;6:561–69.
    • (2015) J Gastrointest Oncol , vol.6 , pp. 561-569
    • Raufi, A.G.1    Kemplern, S.J.2
  • 40
    • 84937961692 scopus 로고    scopus 로고
    • A phase Ib study of pembrolizumab (MK-3475) in patients with advanced triple-negative breast cancer [abstract]
    • 2014 Dec 9–13; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res, Abstract nr S1–09
    • Nanda R, Chow LQ, Dees EC, et al. A phase Ib study of pembrolizumab (MK-3475) in patients with advanced triple-negative breast cancer [abstract]. In: Proceedings of the Thirty-Seventh Annual CTRC-AACR San Antonio Breast Cancer Symposium: 2014 Dec 9–13; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res. 2015;75(9 Suppl):Abstract nr S1–09.
    • (2015) Proceedings of the Thirty-Seventh Annual CTRC-AACR San Antonio Breast Cancer Symposium , vol.75 , Issue.9
    • Nanda, R.1    Chow, L.Q.2    Dees, E.C.3
  • 41
    • 84944041240 scopus 로고    scopus 로고
    • Inhibition of PD-L1 by MPDL3280A leads to clinical activity in with metastatic triple-negative breast cancer (TNBC). [abstract]
    • 2015Apr 18–22; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Res, Abstract nr 2859
    • Emens LA, Braiteh FS, Cassier P, et al. Inhibition of PD-L1 by MPDL3280A leads to clinical activity in with metastatic triple-negative breast cancer (TNBC). [abstract]. In: Proceedings of the 106th Annual Meeting of the American Association for Cancer Research; 2015Apr 18–22; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Res. 2015;75(15 Suppl):Abstract nr 2859. doi:10.1158/1538-7445.AM2015-859.
    • (2015) Proceedings of the 106Th Annual Meeting of the American Association for Cancer Research , vol.75 , Issue.15
    • Emens, L.A.1    Braiteh, F.S.2    Cassier, P.3
  • 42
    • 85019342419 scopus 로고    scopus 로고
    • Safety and clinical activity of atezolizumab (Anti-PDL1) in combination with nab-paclitaxel in patients with metastatic triple-negative breast cancer. “[abstract]
    • 2015 Dec 8-12; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res, Abstract nr OT1-01-06
    • Adams S, Diamond J, Hamilton E, Pohlmann, et al. Safety and clinical activity of atezolizumab (anti-PDL1) in combination with nab-paclitaxel in patients with metastatic triple-negative breast cancer. “[abstract]. In: Proceedings of the Thirty-Eighth Annual CTRC-AACR San Antonio Breast Cancer Symposium: 2015 Dec 8-12; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res. 2016;76(4 Suppl):Abstract nr OT1-01-06.
    • (2016) Proceedings of the Thirty-Eighth Annual CTRC-AACR San Antonio Breast Cancer Symposium , vol.76 , Issue.4
    • Adams, S.1    Diamond, J.2    Hamilton, E.3
  • 43
    • 84901044976 scopus 로고    scopus 로고
    • In situ tumorPD-L1mRNA expression is associated with increased TILs and better outcome in breast carcinomas
    • Schalper KA, Velcheti V, Carbajal D, et al. In situ tumorPD-L1mRNA expression is associated with increased TILs and better outcome in breast carcinomas. Clin Cancer Res. 2014;20:2773–8.
    • (2014) Clin Cancer Res , vol.20 , pp. 2773-2778
    • Schalper, K.A.1    Velcheti, V.2    Carbajal, D.3
  • 44
    • 84891534246 scopus 로고    scopus 로고
    • Programmed death ligand-1 expression in non-small cell lung cancer
    • Velcheti V, Schalper KA, Carvajal DE, et al. Programmed death ligand-1 expression in non-small cell lung cancer. Lab Invest. 2014;94:107–6.
    • (2014) Lab Invest , vol.94 , pp. 107-116
    • Velcheti, V.1    Schalper, K.A.2    Carvajal, D.E.3
  • 45
    • 84862859820 scopus 로고    scopus 로고
    • Safety, activity, and immune correlates of anti-PD-1 antibody in cancer
    • Topalian SL, Hodi FS, Brahmer JR, et al. Safety, activity, and immune correlates of anti-PD-1 antibody in cancer. N Engl J Med. 2012;366:2443–54.
    • (2012) N Engl J Med , vol.366 , pp. 2443-2454
    • Topalian, S.L.1    Hodi, F.S.2    Brahmer, J.R.3
  • 46
    • 33646367200 scopus 로고    scopus 로고
    • The B7-H1 T lymphocyte-inhibitory molecule is expressed in breast cancer patients with infiltrating ductal carcinoma: Correlation with important high-risk prognostic factors
    • Ghebeh H, Mohammed S, Al Omair A, et al. The B7-H1 T lymphocyte-inhibitory molecule is expressed in breast cancer patients with infiltrating ductal carcinoma: correlation with important high-risk prognostic factors. Neoplasia. 2006;8:190–98.
    • (2006) Neoplasia , vol.8 , pp. 190-198
    • Ghebeh, H.1    Mohammed, S.2    Al Omair, A.3
  • 47
    • 84879795618 scopus 로고    scopus 로고
    • The presence of programmed cell death (PD-1)-positive tumor-infiltrating lymphocytes is associated with poor prognosis in human breast cancer
    • Muenst S, Soysal SD, Gao F, et al. The presence of programmed cell death (PD-1)-positive tumor-infiltrating lymphocytes is associated with poor prognosis in human breast cancer. Breast Cancer Res Treat. 2013;139. doi:10.1007/s10549-013-2581-3.
    • (2013) Breast Cancer Res Treat
    • Muenst, S.1    Soysal, S.D.2    Gao, F.3
  • 48
    • 84902582266 scopus 로고    scopus 로고
    • PD-L1 expression in triple-negative breast cancer
    • Mittendorf EA, Philips AV, Meric-Bemstam F, et al. PD-L1 expression in triple-negative breast cancer. Cancer Immunol Res. 2014;2:361–70. doi: 10.1158/2326-6066.CIR-13-0127.
    • (2014) Cancer Immunol Res , vol.2 , pp. 361-370
    • Mittendorf, E.A.1    Philips, A.V.2    Meric-Bemstam, F.3
  • 49
    • 84925002847 scopus 로고    scopus 로고
    • Prognostic and predictive value of PDL1 expression in breast cancer
    • Sabatier R, Finetti P, Mamessier E, et al. Prognostic and predictive value of PDL1 expression in breast cancer. Oncotarget. 2014;6:5449–64.
    • (2014) Oncotarget , vol.6 , pp. 5449-5464
    • Sabatier, R.1    Finetti, P.2    Mamessier, E.3
  • 50
    • 84974717586 scopus 로고    scopus 로고
    • Accepted Article
    • Beckers RK, Selinger CI, Vilain R, et al. PDL1 expression in triple-negative breast cancer is associated with tumour-infiltrating lymphocytes and improved outcome. Accepted Article, doi 10.1111/his.12904.
    • Beckers, R.K.1    Selinger, C.I.2    Vilain, R.3
  • 51
    • 84928774156 scopus 로고    scopus 로고
    • The future of immune checkpoint therapy
    • Sharma P, Allison JP. The future of immune checkpoint therapy. Science. 2015;348:56–61.
    • (2015) Science , vol.348 , pp. 56-61
    • Sharma, P.1    Allison, J.P.2
  • 52
    • 84920956732 scopus 로고    scopus 로고
    • PD-1 blockade induces responses by inhibiting adaptive immune resistance
    • Tumeh PC, Harview CL, Yearley JH, et al. PD-1 blockade induces responses by inhibiting adaptive immune resistance. Nature. 2014;515:568–71. doi:10.1038/nature13954.
    • (2014) Nature , vol.515 , pp. 568-571
    • Tumeh, P.C.1    Harview, C.L.2    Yearley, J.H.3
  • 53
    • 84904024273 scopus 로고    scopus 로고
    • Association of PD-1, PD-1 ligands, and other features of the tumor immune microenvironment with response to anti-PD-1 therapy
    • Taube JM, Klein A, Brahmenr JR, et al. Association of PD-1, PD-1 ligands, and other features of the tumor immune microenvironment with response to anti-PD-1 therapy. Clin Cancer Res. 2014;20:5064–74. doi:10.1158/1078–0432.CCR-13–3271.
    • (2014) Clin Cancer Res , vol.20 , pp. 5064-5074
    • Taube, J.M.1    Klein, A.2    Brahmenr, J.R.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.