Immunohistochemical evidence of tissue hypoxia and astrogliosis in the rostral ventrolateral medulla of spontaneously hypertensive rats

Brain Research

Volumn 1650, Issue , 2016, Pages 178-183

  Turlejski, Tymoteusz ^a   Humoud, Ibrahim ^a   Desai, Roshni ^b   Smith, Kenneth J ^b   Marina, Nephtali ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

Arterial hypertension; Astrogliosis; Hypoxia; Sympathetic nervous system

Indexed keywords

GLIAL FIBRILLARY ACIDIC PROTEIN; HYPOXIA INDUCIBLE FACTOR 1ALPHA; PIMONIDAZOLE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ASTROCYTE; ASTROCYTOSIS; BRAIN STEM TISSUE; CONTROLLED STUDY; GLIA CELL; HYPOXEMIA; IMMUNOFLUORESCENCE; IMMUNOHISTOCHEMISTRY; MALE; NERVE CELL NETWORK; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; ROSTRAL VENTROLATERAL MEDULLA; SPONTANEOUSLY HYPERTENSIVE RAT; ADRENERGIC SYSTEM; ANIMAL; BLOOD PRESSURE; BRAIN STEM; GLIOSIS; HEART RATE; HYPERTENSION; HYPOXIA; MEDULLA OBLONGATA; METABOLISM; NERVE CELL; PATHOPHYSIOLOGY; PHYSIOLOGY; WISTAR RAT;

ANIMALS; ASTROCYTES; BLOOD PRESSURE; BRAIN STEM; GLIOSIS; HEART RATE; HYPERTENSION; HYPOXIA; MALE; MEDULLA OBLONGATA; NEURONS; RATS; RATS, INBRED SHR; RATS, WISTAR; SYMPATHETIC NERVOUS SYSTEM;

EID: 84988028204     PISSN: 00068993     EISSN: 18726240     Source Type: Journal    
DOI: 10.1016/j.brainres.2016.09.012     Document Type: Article

References (24)

1. Angelova, P.R., et al. Functional oxygen sensitivity of astrocytes. J. Neurosci. 35 (2015), 10460–10473.
2. Arteel, G.E., Thurman, R.G., Raleigh, J.A., Reductive metabolism of the hypoxia marker pimonidazole is regulated by oxygen tension independent of the pyridine nucleotide redox state. Eur. J. Biochem. 253 (1998), 743–750.
3. Calcinaghi, N., et al. Multimodal imaging in rats reveals impaired neurovascular coupling in sustained hypertension. Stroke 44 (2013), 1957–1964.
4. Cates, M.J., et al. Neurogenic hypertension and elevated vertebrobasilar arterial resistance: is there a causative link?. Curr. Hypertens. Rep. 14 (2012), 261–269.
5. Cates, M.J., et al. Hypertension before and after posterior circulation infarction: analysis of data from the South London Stroke Register. J. Stroke Cerebrovasc. Dis. 21 (2012), 612–618.
6. Cates, M.J., et al. Elevated vertebrobasilar artery resistance in neonatal spontaneously hypertensive rats. J. Appl. Physiol. (1985) 111, 2011, 149–156.
7. Dampney, R.A., Moon, E.A., Role of ventrolateral medulla in vasomotor response to cerebral ischemia. Am. J. Physiol. 239 (1980), H349–H358.
8. Davies, A.L., et al. Neurological deficits caused by tissue hypoxia in neuroinflammatory disease. Ann. Neurol. 74 (2013), 815–825.
9. Dickinson, C.J., Thomson, A.D., A post mortem study of the main cerebral arteries with special reference to their possible role in blood pressure regulation. Clin. Sci. 19 (1960), 513–538.
10. Eng, L.F., Ghirnikar, R.S., GFAP and astrogliosis. Brain Pathol. 4 (1994), 229–237.
11. Esler, M., The 2009 Carl Ludwig Lecture: pathophysiology of the human sympathetic nervous system in cardiovascular diseases: the transition from mechanisms to medical management. J. Appl. Physiol. (1985) 108 (2010), 227–237.
12. Esler, M., et al. Assessment of human sympathetic nervous system activity from measurements of norepinephrine turnover. Hypertension 11 (1988), 3–20.
13. Esler, M., Lambert, G., Jennings, G., Regional norepinephrine turnover in human hypertension. Clin. Exp. Hypertens. A 11 (1989), 75–89.
14. Esler, M., et al. Sympathetic nerve biology in essential hypertension. Clin. Exp. Pharmacol. Physiol. 28 (2001), 986–989.
15. Iddings, J.A., et al. Enhanced parenchymal arteriole tone and astrocyte signaling protect neurovascular coupling mediated parenchymal arteriole vasodilation in the spontaneously hypertensive rat. J. Cereb. Blood Flow Metab. 35 (2001), 1127–1136.
16. Jennings, J.R., et al. Reduced cerebral blood flow response and compensation among patients with untreated hypertension. Neurology 64 (2005), 1358–1365.
17. Karagiannis, A., et al. Hemichannel-mediated release of lactate. J. Cereb. Blood Flow Metab. 36 (2016), 1202–1211.
18. Marina, N., et al. Suckling-induced activation of neural c-fos expression at lower thoracic rat spinal cord segments. Brain Res. 954 (2002), 100–114.
19. Marina, N., et al. Purinergic signalling in the rostral ventro-lateral medulla controls sympathetic drive and contributes to the progression of heart failure following myocardial infarction in rats. Basic Res. Cardiol., 108, 2013, 317.
20. Marina, N., et al. Brainstem hypoxia contributes to the development of hypertension in the spontaneously hypertensive rat. Hypertension 65 (2015), 775–783.
21. Marina, N., et al. Glia, sympathetic activity and cardiovascular disease. Exp. Physiol. 101 (2016), 565–576.
22. Paton, J.F., Dickinson, C.J., Mitchell, G., Harvey Cushing and the regulation of blood pressure in giraffe, rat and man: introducing ‘Cushing's mechanism’. Exp. Physiol. 94 (2009), 11–17.
23. Rodbard, S., Stone, W., Pressor mechanisms induced by intracranial compression. Circulation 12 (1955), 883–890.
24. Sun, M.K., Reis, D.J., Hypoxia selectively excites vasomotor neurons of rostral ventrolateral medulla in rats. Am. J. Physiol. 266 (1994), R245–R256.