A Biocatalytic Route to the Novel Antiepileptic Drug Brivaracetam

Organic Process Research and Development

Volumn 20, Issue 9, 2016, Pages 1566-1575

  Schülé, Arnaud ^a   Merschaert, Alain ^a   Szczepaniak, Christophe ^a   Maréchal, Christophe ^a   Carly, Nicolas ^a   O'Rourke, John ^a   Ates, Célal ^a  

^a UCB PHARMA   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

ENZYMES; ESTERS; STEREOCHEMISTRY; STEREOSELECTIVITY;

ANTIEPILEPTIC DRUGS; ASYMMETRIC SYNTHESIS; CHIRAL INTERMEDIATES; COMMERCIAL QUALITIES; PH CONTROL; SCALE-UP; SOLVENT MEDIA;

QUALITY CONTROL;

EID: 84987918412     PISSN: 10836160     EISSN: 1520586X     Source Type: Journal    
DOI: 10.1021/acs.oprd.6b00094     Document Type: Article

References (8)

1. Kenda, B. M.; Matagne, A. C.; Talaga, P. E.; Pasau, P. M.; Differding, E.; Lallemand, B. I.; Frycia, A. M.; Moureau, F. G.; Klitgaard, H. V.; Gillard, M. R.; Fuks, B.; Michel, P. J. J. Med. Chem. 2004, 47 (3) 530-549 10.1021/jm030913e
2. Bialer, M.; Johannessen, S. I.; Levy, R. H.; Perucca, E.; Tomson, T.; White, H. S. Epilepsy Res. 2013, 103 (1) 2-30 10.1016/j.eplepsyres.2012.10.001
3. Klein, P.; Schiemann, J.; Sperling, M. R.; Whitesides, J.; Liang, W.; Stalvey, T.; Brandt, C.; Kwan, P. Epilepsia 2015, 56, 1890-1898 10.1111/epi.13212
4. Yates, S. L.; Fakhoury, T.; Liang, W.; Eckhardt, K.; Borghs, S.; D'Souza, J. Epilepsy & Behavior 2015, 52, 165-168 10.1016/j.yebeh.2015.09.005
5. Beaulieu, P. L.; Gillard, J.; Bailey, M.; Beaulieu, C.; Duceppe, J.-S.; Lavallée, P.; Wernic, D. J. Org. Chem. 1999, 64, 6622-6634 10.1021/jo990321x
6. Bailey, M. D.; Halmos, T.; Adamson, D.; Bordeleau, J.; Grand-Maître, C. Tetrahedron: Asymmetry 1999, 10, 3285-3295 10.1016/S0957-4166(99)00330-4
7. Davis, R. E.; Gottbrath, J. A. J. Am. Chem. Soc. 1962, 84, 895-898 10.1021/ja00865a003
8. Snider, B.; Lu, Q. J. Org. Chem. 1996, 61, 2839-2844 10.1021/jo952053i