Characterizing microscopic and submicroscopic malaria parasitaemia at three sites with varied transmission intensity in Uganda

Malaria Journal

Volumn 15, Issue 1, 2016, Pages

  Rek, John ^a   Katrak, Shereen ^b   Obasi, Hannah ^b   Nayebare, Patience ^a   Katureebe, Agaba ^a   Kakande, Elijah ^a   Arinaitwe, Emmanuel ^a   Nankabirwa, Joaniter I ^a,c   Jagannathan, Prasanna ^b   Drakeley, Chris ^d   Staedke, Sarah G ^d   Smith, David L ^e   Bousema, Teun ^f   Kamya, Moses ^a,c   Rosenthal, Philip J ^b   Dorsey, Grant ^b   Greenhouse, Bryan ^b  

^a INFECTIOUS DISEASES RESEARCH COLLABORATION   (Uganda)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c MAKERERE UNIVERSITY   (Uganda)

^d LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE   (United Kingdom)

^e UNIVERSITY OF WASHINGTON   (United States)

^f RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

LAMP; Malaria; Parasitaemia; Sub microscopic infection

Indexed keywords

ANTIMALARIAL AGENT; HEMOGLOBIN;

ADULT; AGE; ARTICLE; CHILD; COHORT ANALYSIS; CONTROLLED STUDY; FEMALE; HEMOGLOBIN BLOOD LEVEL; HUMAN; INFANT; LOOP MEDIATED ISOTHERMAL AMPLIFICATION; MAJOR CLINICAL STUDY; MALARIA; MALE; MICROSCOPY; PARASITE PREVALENCE; PARASITE TRANSMISSION; PARASITEMIA; UGANDA; DISEASE TRANSMISSION; MIDDLE AGED; MOLECULAR DIAGNOSIS; PARASITOLOGY; PRESCHOOL CHILD; PREVALENCE; TRANSMISSION;

ADULT; CHILD; CHILD, PRESCHOOL; COHORT STUDIES; DISEASE TRANSMISSION, INFECTIOUS; FEMALE; HUMANS; INFANT; MALARIA; MALE; MICROSCOPY; MIDDLE AGED; MOLECULAR DIAGNOSTIC TECHNIQUES; PARASITEMIA; PREVALENCE; UGANDA;

EID: 84987899336     PISSN: None     EISSN: 14752875     Source Type: Journal    
DOI: 10.1186/s12936-016-1519-8     Document Type: Article

References (34)

1. Bhatt S, Weiss DJ, Cameron E, Bisanzio D, Mappin B, Dalrymple U, et al. The effect of malaria control on Plasmodium falciparum in Africa between 2000 and 2015. Nature. 2015;526:207-11.
2. Okell LC, Ghani AC, Lyons E, Drakeley CJ. Submicroscopic infection in Plasmodium falciparum-endemic populations: a systematic review and meta-analysis. J Infect Dis. 2009;200:1509-17.
3. Wu L, van den Hoogen LL, Slater H, Walker PGT, Ghani AC, Drakeley CJ, et al. Comparison of diagnostics for the detection of asymptomatic Plasmodium falciparum infections to inform control and elimination strategies. Nature. 2015;528:S86-93.
4. Oriero EC, Jacobs J, Van Geertruyden JP, Nwakanma D, D'Alessandro U. Molecular-based isothermal tests for field diagnosis of malaria and their potential contribution to malaria elimination. J Antimicrob Chemother. 2014;70:2-13.
5. Aydin-Schmidt B, Xu W, González IJ, Polley SD, Bell D, Shakely D, et al. Loop mediated isothermal amplification (LAMP) accurately detects malaria DNA from filter paper blood samples of low density parasitaemias. PLoS One. 2014;9:e103905-9.
6. Cook J, Aydin-Schmidt B, González IJ, Bell D, Edlund E, Nassor MH, et al. Loop-mediated isothermal amplification (LAMP) for point-of-care detection of asymptomatic low-density malaria parasite carriers in Zanzibar. Malar J. 2015;14:43.
7. Hopkins H, Gonzalez IJ, Polley SD, Angutoko P, Ategeka J, Asiimwe C, et al. Highly sensitive detection of malaria parasitemia in a malaria-endemic setting: performance of a new loop-mediated isothermal amplification kit in a remote clinic in Uganda. J Infect Dis. 2013;208:645-52.
8. Gaye A, Bousema T, Libasse G, Ndiath MO, Konaté L, Jawara M, et al. Infectiousness of the human population to Anopheles arabiensis by direct skin feeding in an area hypoendemic for malaria in Senegal. Am J Trop Med Hyg. 2015;92:648-52.
9. Ouédraogo AL, Gonçalves BP, Gnémé A, Wenger EA, Guelbeogo MW, Ouédraogo A, et al. Dynamics of the human infectious reservoir for malaria determined by mosquito feeding assays and ultrasensitive malaria diagnosis in Burkina Faso. J Infect Dis. 2015;213:90-9.
10. Kamya MR, Arinaitwe E, Wanzira H, Katureebe A, Barusya C, Kigozi SP, et al. Malaria transmission, infection, and disease at three sites with varied transmission intensity in Uganda: implications for malaria control. Am J Trop Med Hyg. 2015;92:903-12.
11. Yeka A, Nankabirwa J, Mpimbaza A, Kigozi R, Arinaitwe E, Drakeley C, et al. Factors associated with malaria parasitemia, anemia and serological responses in a spectrum of epidemiological settings in Uganda. PLoS One. 2015;10:e0118901.
12. Eiken Chemical Co., Ltd. Manual of Standard Operating Procedures for malaria LAMP. 2012:1-30. http://www.finddx.org/wp-content/uploads/2016/04/SOP-LAMP-Malaria-Aug2012.pdf. Accessed Sept 2015.
13. Nankabirwa JI, Yeka A, Arinaitwe E, Kigozi R, Drakeley C, Kamya MR, et al. Estimating malaria parasite prevalence from community surveys in Uganda: a comparison of microscopy, rapid diagnostic tests and polymerase chain reaction. Malar J. 2015;14:528.
14. Okell LC, Bousema T, Griffin JT, Ouédraogo AL, Ghani AC, Drakeley CJ. Factors determining the occurrence of submicroscopic malaria infections and their relevance for control. Nat Commun. 2012;3:1237.
15. Smith DL, Guerra CA, Snow RW, Hay SI. Standardizing estimates of the I parasite rate. Malar J. 2007;6:131.
16. Katrak S, Day N, Ssemmondo E, Kwarisiima D, Midekisa A, Greenhouse B, et al. Community-wide prevalence of malaria parasitemia in hiv-infected and uninfected populations in a high-transmission setting in Uganda. J Infect Dis. 2016;213:1971-8.
17. Runsewe-Abiodun IT, Ogunfowora OB, Fetuga BM. Neonatal malaria in Nigeria -a 2 year review. BMC Pediatr. 2006;6:19.
18. Uganda Malaria Control Programme, Ministry of Health. Uganda Malaria Indicator Survey 2014-15 - Key Indicators Report. 2015:1-33. http://dhsprogram.com/pubs/pdf/PR64/PR64.pdf. Accessed 9/2015.
19. Dechavanne C, Cottrell G, Garcia A, Migot-Nabias F. Placental malaria: decreased transfer of maternal antibodies directed to Plasmodium falciparum and impact on the incidence of febrile infections in infants. PLoS One. 2015;10:e0145464.
20. Dobbs KR, Dent AE. Plasmodium malaria and antimalarial antibodies in the first year of life. Parasitology. 2016;143:129-38.
21. Smith T, Maire N, Dietz K, Killeen GF, Vounatsou P, Molineaux L, et al. Relationship between the entomologic inoculation rate and the force of infection for Plasmodium falciparum malaria. Am J Trop Med Hyg. 2006;75(2 Suppl):11-8.
22. Walldorf JA, Cohee LM, Coalson JE, Bauleni A, Nkanaunena K, Kapito-Tembo A, et al. School-age children are a reservoir of malaria infection in Malawi. PLoS One. 2015;10:e0134061.
23. Doolan DL, Dobaño C, Baird JK. Acquired immunity to malaria. Clin Microbiol Rev. 2009;22:13-36.
24. Langhorne J, Ndungu FM, Sponaas A-M, Marsh K. Immunity to malaria: more questions than answers. Nat Immunol. 2008;9:725-32.
25. Beshir KB, Sutherland CJ, Sawa P, Drakeley CJ, Okell L, Mweresa CK, et al. Residual Plasmodium falciparum parasitemia in Kenyan children after artemisinin-combination therapy is associated with increased transmission to mosquitoes and parasite recurrence. J Infect Dis. 2013;208:2017-24.
26. Djimde AA, Maiga AW, Ouologuem D, Fofana B, Sagara I, Dembele D, et al. Gametocyte clearance dynamics following oral artesunate treatment of uncomplicated falciparum malaria in Malian children. Parasite. 2016;23:3.
27. Phillips RE, Pasvol G. Anaemia of Plasmodium falciparum malaria. Baillières Clin Haematol. 1992;5:315-30.
28. Price RN, Simpson JA, Nosten F, Luxemburger C, Hkirjaroen L, ter Kuile F, et al. Factors contributing to anemia after uncomplicated falciparum malaria. Am J Trop Med Hyg. 2001;65:614-22.
29. de Mast Q, Brouwers J, Syafruddin D, Bousema T, Baidjoe AY, de Groot PG, et al. Is asymptomatic malaria really asymptomatic? Hematological, vascular and inflammatory effects of asymptomatic malaria parasitemia. J Infect. 2015;71:587-96.
30. Gudo ES, Prista A, Jani IV. Impact of asymptomatic Plasmodium falciparum parasitemia on the immunohematological indices among school children and adolescents in a rural area highly endemic for malaria in southern Mozambique. BMC Infect Dis. 2013;13:244.
31. Chen I, Clarke SE, Gosling R, Hamainza B, Killeen G, Magill A, et al. "Asymptomatic" malaria: a chronic and debilitating infection that should be treated. PLoS Med. 2016;13:e1001942.
32. Cottrell G, Moussiliou A, Luty AJF, Cot M, Fievet N, Massougbodji A, et al. Submicroscopic Plasmodium falciparum infections are associated with maternal anemia, premature births, and low birth weight. Clin Infect Dis. 2015;60:1481-8.
33. Ashley EA, White NJ. The duration of Plasmodium falciparum infections. Malar J. 2014;13:500.
34. Waltmann A, Darcy AW, Harris I, Koepfli C, Lodo J, Vahi V, et al. High rates of asymptomatic, sub-microscopic Plasmodium vivax infection and disappearing Plasmodium falciparum malaria in an area of low transmission in Solomon Islands. PLoS Negl Trop Dis. 2015;9:e0003758.