Treatment with Antiangiogenic Drugs in Multiple Lines in Patients with Metastatic Colorectal Cancer: Meta-Analysis of Randomized Trials

Gastroenterology Research and Practice

Volumn 2016, Issue , 2016, Pages

  Hofheinz, R D ^a   Ronellenfitsch, U ^a   Kubicka, S ^b   Falcone, A ^c   Burkholder, I ^d   Hacker, U T ^e  

^a UNIVERSITY OF HEIDELBERG   (Germany)

^b Krebszentrum Reutlingen   (Germany)

^c UNIVERSITY OF PISA   (Italy)

^d Saarland University of Applied Sciences   (Germany)

^e UNIVERSITY HOSPITAL LEIPZIG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

AFLIBERCEPT; ANGIOGENESIS INHIBITOR; BEVACIZUMAB; REGORAFENIB; SORAFENIB;

AGE; ANTIANGIOGENIC THERAPY; CANCER GROWTH; CANCER PREVENTION; CANCER REGRESSION; CANCER THERAPY; ELECTROCORTICOGRAPHY; HUMAN; META ANALYSIS; METASTATIC COLORECTAL CANCER; OVERALL SURVIVAL; PHASE 2 CLINICAL TRIAL (TOPIC); PHASE 3 CLINICAL TRIAL (TOPIC); PROGRESSION FREE SURVIVAL; RANDOMIZED CONTROLLED TRIAL (TOPIC); REVIEW; TREATMENT RESPONSE;

EID: 84987861866     PISSN: 16876121     EISSN: 1687630X     Source Type: Journal    
DOI: 10.1155/2016/9189483     Document Type: Review

References (21)

1. D. Cunningham, I. Lang, E. Marcuello et al., "Bevacizumab plus capecitabine versus capecitabine alone in elderly patients with previously untreated metastatic colorectal cancer (AVEX): an open-label, randomised phase 3 trial," The Lancet Oncology, vol. 14, no. 11, pp. 1077-1085, 2013.
2. H. Hurwitz, L. Fehrenbacher, W. Novotny et al., "Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer," The New England Journal of Medicine, vol. 350, no. 23, pp. 2335-2342, 2004.
3. L. B. Saltz, S. Clarke, E. Diaz-Rubio et al., "Bevacizumab in combination with oxaliplatin-based chemotherapy as first-line therapy in metastatic colorectal cancer: a randomized phase III study," Journal of Clinical Oncology, vol. 26, no. 12, pp. 2013-2019, 2008.
4. N. C. Tebbutt, K. Wilson, V. J. Gebski et al., "Capecitabine, bevacizumab, and mitomycin in first-line treatment of metastatic colorectal cancer: results of the Australasian Gastrointestinal Trials Group Randomized Phase III MAX Study," Journal of Clinical Oncology, vol. 28, no. 19, pp. 3191-3198, 2010.
5. J. C. Bendell, T. S. Bekaii-Saab, A. L. Cohn et al., "Treatment patterns and clinical outcomes in patients with metastatic colorectal cancer initially treated with FOLFOX-bevacizumab or FOLFIRI-bevacizumab: results from ARIES, a bevacizumab observational cohort study," Oncologist, vol. 17, no. 12, pp. 1486-1495, 2012.
6. A. Grothey, M. M. Sugrue, D. M. Purdie et al., "Bevacizumab beyond first progression is associated with prolonged overall survival in metastatic colorectal cancer: results from a large observational cohort study (BRiTE)," Journal of Clinical Oncology, vol. 26, no. 33, pp. 5326-5334, 2008.
7. T. Boehm, J. Folkman, T. Browder, and M. S. O'Reilly, "Antiangiogenic therapy of experimental cancer does not induce acquired drug resistance," Nature, vol. 390, no. 6658, pp. 404-407, 1997.
8. G. Klement, P. Huang, B. Mayer et al., "Differences in therapeutic indexes of combination metronomic chemotherapy and an anti-VEGFR-2 antibody inmultidrug-resistant human breast cancer xenografts," Clinical Cancer Research, vol. 8, no. 1, pp. 221-232, 2002.
9. J. Bennouna, C. Borg, J.-P. Delord et al., "Bevacizumab combined with chemotherapy in the second-line treatment of metastatic colorectal cancer: results from the phase II BEVACOLOR study," Clinical Colorectal Cancer, vol. 11, no. 1, pp. 38-44, 2012.
10. G. Masi, F. Loupakis, L. Salvatore et al., "Second-line chemotherapy (CT) with or without bevacizumab (BV) in metastatic colorectal cancer (mCRC) patients (pts) who progressed to a first-line treatment containing BV: updated results of the phase III 'BEBYP' trial by the Gruppo Oncologico Nord Ovest (GONO)," Journal of Clinical Oncology, vol. 31, supplement, abstract 3615, 2013.
11. G. Masi, L. Salvatore, L. Boni et al., "Continuation or reintroduction of bevacizumab beyond progression to first-line therapy in metastatic colorectal cancer: final results of the randomized BEBYP trial," Annals of Oncology, vol. 26, no. 4, pp. 724-730, 2015.
12. E. Van Cutsem, J. Tabernero, R. Lakomy et al., "Addition of aflibercept to fluorouracil, leucovorin, and irinotecan improves survival in a phase III randomized trial in patients with metastatic colorectal cancer previously treated with an oxaliplatin-based regimen," Journal of Clinical Oncology, vol. 30, no. 28, pp. 3499-3506, 2012.
13. C. Allegra, R. Lakomy, J. Tabernero et al., "Effects of prior bevacizumab (B) use on outcomes from the VELOUR study: a phase III study of aflibercept (Afl) and FOLFIRI in patients (pts) with metastatic colorectal cancer (mCRC) after failure of an oxaliplatin regimen," Journal of Clinical Oncology, vol. 30, supplement, abstract 3505, 2012, Proceedings of the 2012 ASCO Annual Meeting.
14. A. Grothey, E. Van Cutsem, A. Sobrero et al., "Regorafenib monotherapy for previously treated metastatic colorectal cancer (CORRECT): an international, multicentre, randomised, placebo-controlled, phase 3 trial," The Lancet, vol. 381, no. 9863, pp. 303-312, 2013.
15. J. Li, S. Qin, R. Xu et al., "Regorafenib plus best supportive care versus placebo plus best supportive care in Asian patients with previously treated metastatic colorectal cancer (CONCUR): a randomised, double-blind, placebo-controlled, phase 3 trial," The Lancet Oncology, vol. 16, no. 6, pp. 619-629, 2015.
16. L. L. Siu, J. D. Shapiro, D. J. Jonker et al., "Phase III randomized, placebo-controlled study of cetuximab plus brivanib alaninate versus cetuximab plus placebo in patients with metastatic, chemotherapy-refractory, wild-type K-RAS colorectal carcinoma: the NCIC Clinical Trials Group and AGITG CO.20 Trial," Journal of Clinical Oncology, vol. 31, no. 19, pp. 2477-2484, 2013.
17. T. Hoehler, T. Decker, C. Schimanski et al., "Final results of the AIO 0307 study: a controlled, randomized, double-blind phase II study of FOLFOX6 or FOLFIRI combined with sorafenib (S) versus placebo (P) in second-line metastatic colorectal carcinoma (mCRC) treatment," Journal of Clinical Oncology, vol. 31, supplement, abstract 3586, 2013, Proceedings of the 2013 ASCO Annual Meeting.
18. J. Tabernero, T. Yoshino, A. L. Cohn et al., "Ramucirumab versus placebo in combination with second-line FOLFIRI in patients with metastatic colorectal carcinoma that progressed during or after first-line therapy with bevacizumab, oxaliplatin, and a fluoropyrimidine (RAISE): a randomised, double-blind, multicentre, phase 3 study," The Lancet Oncology, vol. 16, no. 5, pp. 499-508, 2015.
19. D. Moher, A. Liberati, J. Tetzlaff, and D. G. Altman, "Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement," Journal of Clinical Epidemiology, vol. 62, no. 10, pp. 1006-1012, 2009.
20. J. P. T. Higgins, S. G. Thompson, J. J. Deeks, and D. G. Altman, "Measuring inconsistency in meta-analyses," British Medical Journal, vol. 327, no. 7414, pp. 557-560, 2003.
21. A. Grothey, E. E. Hedrick, R. D. Mass et al., "Responseindependent survival benefit in metastatic colorectal cancer: a comparative analysis of N9741 and AVF2107," Journal of Clinical Oncology, vol. 26, no. 2, pp. 183-189, 2008.