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Journal of Heterocyclic Chemistry

Volumn 25, Issue 3, 1988, Pages 911-914

The synthesis of XTT: A new tetrazolium reagent that is bioreducible to a water‐soluble formazan

(13) Paull, Kenneth D a Shoemaker, Robert H a Boyd, Michael R a Parsons, Jack L b Risbood, Prabhakar A b Barbera, William A b Sharma, Mahenda N b Baker, David C c Hand, Elli c Scudiero, Dominic A d Monks, Anne d Alley, Michael C d Grote, Manfred e

a NATIONAL CANCER INSTITUTE (United States)

b Starks Associates Inc (United States)

c UNIVERSITY OF ALABAMA (United States)

d NATIONAL CANCER INSTITUTE (United States)

e UNIVERSITY OF PADERBORN (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 84986452945 PISSN: 0022152X EISSN: 19435193 Source Type: Journal
DOI: 10.1002/jhet.5570250340 Document Type: Article

Times cited : (120)

References (18)

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- The unprecedented scale of the in vitro program conceived of and directed by M. B. led R. S. to focus on tetrazolium assay technology and to define the need for a water‐soluble formazan. A general design stragety was developed by K. P. The initial small sample of formazan 2 was selected from the NCI repository by K. P. The authors thank M. G. for this sample. The first small‐scale synthesis of 1 from 2 was achieved by authors D. B. and E. H. whose work was funded by NCI contract NO1‐CM‐27571. The authors thank Dr. Roger Haugwitz, Project Officer of that contract for his cooperation in this project. The large‐scale synthesis was achieved by authors J. L. P., P. A. R., W. A. B. and M. N. S. whose work was funded by NCI contract NO1‐CM‐67926. The authors thank Dr. Karl Flora, the Project Officer for that contract, for his cooperation. The biological evaluation of XTT was performed by D. S., M. A. and A. M. whose work was supported by NCI contract NO1‐CO‐23910.

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