Ethnic minority under-representation in clinical trials:Whose responsibility is it anyway?

Journal of Health Organization and Management

Volumn 17, Issue 2, 2003, Pages 138-143

  Hussain Gambles, Mahvash ^a  

^a UNIVERSITY OF LEEDS   (United Kingdom)

Author keywords

Clinical effectiveness; Clinical guidelines; Ethnic groups; Health care

Indexed keywords

EID: 84986145204     PISSN: 14777266     EISSN: None     Source Type: Journal    
DOI: 10.1108/14777260310476177     Document Type: Article

References (17)

1. Bartlett, C., Davey, P., Dieppe, P., Doyal, L., Ebrahim, S. and Egger, M. (2003), “Women, older persons and ethnic minorities: factors associated with their inclusion in randomised trials of statins 1990 to 2001”, Heart, Vol. 89, pp. 327–8
2. Davis, S., Wright, P.W., Schulman, S.F., Hill, L.D., Pinkham, R.D. and Johnson, L.P. (1985), ”Participants in prospective, randomised clinical trials for resected non-small cell lung cancer have improved survival compared with nonparticipants in such trials”, Cancer, Vol. 56, pp. 1710–8
3. Department of Health (2000), NHS Plan: A Plan for Investment, a Plan for Reform, HMSO, London
4. Edwards, S.J.L., Lilford, R., Braunholtz, D.A., Jackson, J.C., Hewison, J. and Thornton, J. (1998), “Ethical issues in the design and conduct of randomised controlled trials”, Health Technology Assessment, Vol. 2 No. 15
5. Gottlieb, S. (2002), “Genetic link explains greater prevalence of heart failure among black Americans”, British Medical Journal No. 325, p. 855
6. Hall, W.D. (1999), “Representation of blacks, women, and the very elderly (aged > or=80) in 28 major randomized clinical trials”, Ethnicity and Disease, Vol. 9, pp. 333–40
7. Heiat, A., Gross, C. and Krumholz, H. (2002), “Representation of the elderly, women, and minorities in heart failure clinical trials”, Archives of Internal Medicine, Vol. 162, pp. 1682–8
8. Hohmann, A.A. and Parron, D.L. (1996), “How the new NIH Guidelines on inclusion of women and minorities apply: efficacy trials, effectiveness trials, and validity”, Journal of Consulting and Clinical Psychology, Vol. 64, pp. 851–5
9. Kahn, J.P., Mastroianni, A.C. and Sugarman, J. (1998), Beyond Consent: Seeking Justice in Research, Oxford University Press, New York, NY
10. Karjalainen, S. and Palva, I. (1989), “Do treatment protocols improve end results? A study of survival of patients with multiple myeloma in Finland”, British Medical Journal No. 299, pp. 1069–72
11. Krecic-Shepard, M.E., Park, K., Barnas, C., Slimko, J., Kerwin, D.R. and Schwartz, J.B. (2000), “Race and sex influence clearance of nifedipine: results of a population study”, Clinical Pharmacology and Therapeutics, Vol. 68, pp. 130–42
12. McCann, J. (2000), “Gender differences in cancer that don't make sense – or do they?”, Journal of the National Cancer Institute, Vol. 92, pp. 1560–2
13. Magee, M.H., Blum, R.A., Lates, C.D. and Jusko, W.J. (2001), “Prednisolone parmacokinetics and pharmacodynamics in relation to sex and race”, Journal of Clinical Pharmacology, Vol. 41, pp. 1180–94
14. Mason, S.A., Hussain, M., Leese, B., Atkin, K. and Brown, J. (2002), “Lack of participation in randomised clinical trials by South Asian People”, British Medical Journal
15. Meinert, C.L. (1999), “Redesign of trials under different enrolement mixes”, Statistics in Medicine, Vol. 18, pp. 241–51
16. Nazroo, J.Y. (1997), The Health of Britain's Ethnic Minorities: Findings from a National Survey, Policy Studies Institute, London
17. Swanson, G.M. and Ward, A.J. (1995), “Recruiting minorities into clinical trials: toward a participant-friendly system”, Journal of the National Cancer Institute, Vol. 87, pp. 1747–59