Inflammation modifies the paradoxical association between body mass index and mortality in hemodialysis patients

Journal of the American Society of Nephrology

Volumn 27, Issue 5, 2016, Pages 1479-1486

  Stenvinkel, Peter ^a   Gillespie, Iain A ^b   Tunks, Jamie ^b   Addison, Janet ^b   Kronenberg, Florian ^c   Drueke, Tilman B ^d   Marcelli, Daniele ^e   Schernthaner, Guntram ^f   Eckardt, Kai Uwe ^g   Floege, Jürgen ^h   Froissart, Marc ⁱ   Anker, Stefan D ^j  

^a KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^b AMGEN LTD   (United Kingdom)

^c INNSBRUCK MEDICAL UNIVERSITY   (Austria)

^d HÔPITAL PAUL BROUSSE   (France)

^e FRESENIUS MEDICAL CARE   (Germany)

^f KRANKENANSTALT RUDOLFSTIFTUNG   (Austria)

^g UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

^h RWTH AACHEN UNIVERSITY   (Germany)

ⁱ AMGEN INC   (United States)

^j UNIVERSITY MEDICAL CENTER GÖTTINGEN   (Germany)

more..

Author keywords

[No Author keywords available]

Indexed keywords

ALBUMIN; C REACTIVE PROTEIN; CALCIUM PHOSPHATE; CREATININE; FERRITIN; HEMOGLOBIN; LIPID; PARATHYROID HORMONE; SERUM ALBUMIN;

ADULT; ALBUMIN BLOOD LEVEL; ARTICLE; BODY MASS; CARDIOVASCULAR MORTALITY; CAUSE OF DEATH; COHORT ANALYSIS; COMPARATIVE STUDY; CONTROLLED STUDY; CREATININE BLOOD LEVEL; FERRITIN BLOOD LEVEL; FOLLOW UP; HEMODIALYSIS PATIENT; HEMOGLOBIN BLOOD LEVEL; HUMAN; INFLAMMATION; LIPID BLOOD LEVEL; MAJOR CLINICAL STUDY; MORTALITY; MORTALITY RISK; PARATHYROID HORMONE BLOOD LEVEL; PATIENT HISTORY OF KIDNEY TRANSPLANTATION; PERITONEAL DIALYSIS; PRIORITY JOURNAL; PROSPECTIVE STUDY; PROTEIN BLOOD LEVEL; SURVIVAL; CLINICAL TRIAL; COMPLICATION; HEMODIALYSIS; KIDNEY FAILURE, CHRONIC; MULTICENTER STUDY; OBESITY; RISK;

BODY MASS INDEX; CAUSE OF DEATH; COHORT STUDIES; HUMANS; INFLAMMATION; KIDNEY FAILURE, CHRONIC; OBESITY; RENAL DIALYSIS; RISK;

EID: 84985995731     PISSN: 10466673     EISSN: 15333450     Source Type: Journal    
DOI: 10.1681/ASN.2015030252     Document Type: Article

References (54)

1. Fleischmann E, Teal N, Dudley J, May W, Bower JD, Salahudeen AK: Influence of excess weight on mortality and hospital stay in 1346 hemodialysis patients. Kidney Int 55: 1560-1567, 1999
2. Kalantar-Zadeh K, Kopple JD, Kilpatrick RD, McAllister CJ, Shinaberger CS, Gjertson DW, Greenland S: Association of morbid obesity and weight change over time with cardiovascular survival in hemodialysis population. AmJ Kidney Dis 46: 489-500, 2005
3. Lu JL, Kalantar-Zadeh K,Ma JZ,Quarles LD, KovesdyCP: Association of body mass index with outcomes in patients with CKD. J Am Soc Nephrol 25: 2088-2096, 2014
4. Gruberg L, Weissman NJ, Waksman R, Fuchs S, Deible R, Pinnow EE, Ahmed LM, Kent KM, Pichard AD, SuddathWO, Satler LF, Lindsay J Jr: The impact of obesity on the short-term and long-term outcomes after percutaneous coronary intervention: the obesity paradox? J Am Coll Cardiol 39: 578-584, 2002
5. Olsen TS, Dehlendorff C, Petersen HG, Andersen KK: Body mass index and poststroke mortality. Neuroepidemiology 30: 93-100, 2008
6. Wolfe F, Michaud K: Effect of body mass index on mortality and clinical status in rheumatoid arthritis. Arthritis Care Res (Hoboken) 64: 1471-1479, 2012
7. Carnethon MR, De Chavez PJ, Biggs ML, Lewis CE, Pankow JS, Bertoni AG, Golden SH, Liu K, Mukamal KJ, Campbell-Jenkins B, Dyer AR: Association of weight status with mortality in adults with incident diabetes. JAMA 308: 581-590, 2012
8. Choi Y, Park B, Jeong BC, Seo SI, Jeon SS, Choi HY, Adami HO, Lee JE, Lee HM: Body mass index and survival in patients with renal cell carcinoma: a clinical-based cohort and meta-analysis. Int J Cancer 132: 625-634, 2013
9. García-Ptacek S, Kareholt I, Farahmand B, Cuadrado ML, Religa D, Eriksdotter M: Body-mass index and mortality in incident dementia: a cohort study on 11,398 patients fromSveDem, the SwedishDementia Registry. J AmMed Dir Assoc 15: 447.e1-447.e7, 2014
10. Oreopoulos A, Padwal R, Kalantar-Zadeh K, Fonarow GC, Norris CM, McAlister FA: Body mass index and mortality in heart failure: a metaanalysis. Am Heart J 156: 13-22, 2008
11. Dixon JB, Egger GJ, Finkelstein EA, Kral JG, Lambert GW: 'Obesity paradox' misunderstands the biology of optimal weight throughout the life cycle. Int J Obes 39: 82-84, 2015
12. Dehlendorff C, Andersen KK, Olsen TS: Body mass index and death by stroke: no obesity paradox. JAMA Neurol 71: 978-984, 2014
13. Shah RV, Abbasi SA, Yamal JM,Davis BR, Barzilay J, Einhorn PT,Goldfine AB;ALLHAT Collaborative Research Group: Impaired fasting glucose and body mass index as determinants of mortality in ALLHAT: is the obesity paradox real? J Clin Hypertens (Greenwich) 16: 451-458, 2014
14. de Mutsert R, Snijder MB, van der Sman-de Beer F, Seidell JC, Boeschoten EW, Krediet RT, Dekker JM, Vandenbroucke JP, Dekker FW: Association between bodymass index andmortality is similar in the hemodialysis population and the general population at high age and equal duration of follow-up. J Am Soc Nephrol 18: 967-974, 2007
15. Johansen KL, Kutner NG, Young B, Chertow GM: Association of body size with health status in patients beginning dialysis. AmJ Clin Nutr 83: 543-549, 2006
16. Park J, Jin DC, Molnar MZ, Dukkipati R, Kim YL, Jing J, Levin NW, Nissenson AR, Lee JS, Kalantar-Zadeh K: Mortality predictability of body size and muscle mass surrogates in Asian vs white and African American hemodialysis patients. Mayo Clin Proc 88: 479-486, 2013
17. Chazot C, Gassia JP, Di Benedetto A, Cesare S, Ponce P, Marcelli D: Is there any survival advantage of obesity in Southern European haemodialysis patients? Nephrol Dial Transplant 24: 2871-2876, 2009
18. Vashistha T,Mehrotra R, Park J, Streja E, Dukkipati R,Nissenson AR,Ma JZ, Kovesdy CP, Kalantar-Zadeh K: Effect of age and dialysis vintage on obesity paradox in long-term hemodialysis patients. Am J Kidney Dis 63: 612-622, 2014
19. Carrero JJ, Stenvinkel P: Inflammation in end-stage renal disease-what have we learned in 10 years? Semin Dial 23: 498-509, 2010
20. Koo JR, Yoon JW, Kim SG, Lee YK, Oh KH, Kim GH, Kim HJ, Chae DW, Noh JW, Lee SK, Son BK: Association of depression with malnutrition in chronic hemodialysis patients. Am J Kidney Dis 41: 1037-1042, 2003
21. Honda H, Qureshi AR, Axelsson J, Heimburger O, Suliman ME, Barany P, Stenvinkel P, Lindholm B: Obese sarcopenia in patients with endstage renal disease is associated with inflammation and increased mortality. Am J Clin Nutr 86: 633-638, 2007
22. Stenvinkel P, Zoccali C, Ikizler TA: Obesity in CKD-what should nephrologists know? J Am Soc Nephrol 24: 1727-1736, 2013
23. Carrero JJ, Qureshi AR, Axelsson J, Avesani CM, Suliman ME, Kato S, Bárány P, Snaedal-Jonsdottir S,AlvestrandA,HeimbürgerO, LindholmB, Stenvinkel P: Comparison of nutritional and inflammatory markers in dialysis patients with reduced appetite. Am J Clin Nutr 85: 695-701, 2007
24. Kalantar-Zadeh K, Block G, McAllister CJ, Humphreys MH, Kopple JD: Appetite and inflammation, nutrition, anemia, and clinical outcome in hemodialysis patients. Am J Clin Nutr 80: 299-307, 2004
25. Sarkar SR, Kuhlmann MK, Kotanko P, Zhu F, Heymsfield SB, Wang J, Meisels IS, Gotch FA, Kaysen GA, Levin NW: Metabolic consequences of body size and body composition in hemodialysis patients. Kidney Int 70: 1832-1839, 2006
26. Bellows CF, Zhang Y, Simmons PJ, Khalsa AS, KoloninMG: Influence of BMI on level of circulating progenitor cells. Obesity (Silver Spring) 19: 1722-1726, 2011
27. Graziani F, Leone AM, Basile E, Cialdella P, TritarelliA, Bona RD, Liuzzo G, Nanni G, Iaconelli A, Iaconelli A, Mingrone G, Biasucci LM, Crea F: Endothelial progenitor cells in morbid obesity. Circ J 78: 977-985, 2014
28. Ramirez R, Carracedo J, Merino A, Nogueras S, Alvarez-Lara MA, Rodríguez M, Martin-Malo A, Tetta C, Aljama P: Microinflammation induces endothelial damage in hemodialysis patients: the role of convective transport. Kidney Int 72: 108-113, 2007
29. Verma S, Kuliszewski MA, Li SH, Szmitko PE, Zucco L, Wang CH, BadiwalaMV,Mickle DA,Weisel RD, Fedak PW, Stewart DJ, KutrykMJ: C-reactive protein attenuates endothelial progenitor cell survival, differentiation, and function: further evidence of a mechanistic link between C-reactive protein and cardiovascular disease. Circulation 109: 2058-2067, 2004
30. Horwich TB, Leifer ES, Brawner CA, Fitz-Gerald MB, Fonarow GC; HF-ACTION Investigators: The relationship between body mass index and cardiopulmonary exercise testing in chronic systolic heart failure. Am Heart J 158[Suppl]: S31-S36, 2009
31. Lavebratt C, Wahlqvist S, Nordfors L, Hoffstedt J, Arner P: AHSG gene variant is associated with leanness among Swedish men. Hum Genet 117: 54-60, 2005
32. Weber MA, Neutel JM, Smith DH: Contrasting clinical properties and exercise responses in obese and lean hypertensive patients. J AmColl Cardiol 37: 169-174, 2001
33. Niebauer J, Volk HD, Kemp M, Dominguez M, Schumann RR, Rauchhaus M, Poole-Wilson PA, Coats AJ, Anker SD: Endotoxin and immune activation in chronic heart failure: a prospective cohort study. Lancet 353: 1838-1842, 1999
34. Keith DS, Nichols GA, Gullion CM, Brown JB, Smith DH: Longitudinal follow-up and outcomes among a population with chronic kidney disease in a large managed care organization. Arch Intern Med 164: 659-663, 2004
35. Johnson RJ, Stenvinkel P, Martin SL, Jani A, Sánchez-Lozada LG, Hill JO, Lanaspa MA: Redefining metabolic syndrome as a fat storage condition based on studies of comparative physiology. Obesity (Silver Spring) 21: 659-664, 2013
36. Beddhu S, Pappas LM, Ramkumar N, Samore M: Effects of body size and body composition on survival in hemodialysis patients. J Am Soc Nephrol 14: 2366-2372, 2003
37. Kalantar-Zadeh K, Streja E, Kovesdy CP,Oreopoulos A,NooriN, Jing J, Nissenson AR, Krishnan M, Kopple JD, Mehrotra R, Anker SD: The obesity paradox and mortality associated with surrogates of body size andmusclemass in patients receiving hemodialysis.Mayo Clin Proc 85: 991-1001, 2010
38. Noori N, Kopple JD, Kovesdy CP, Feroze U, Sim JJ, Murali SB, Luna A, Gomez M, Luna C, Bross R, Nissenson AR, Kalantar-Zadeh K: Mid-arm muscle circumference and quality of life and survival in maintenance hemodialysis patients. Clin J Am Soc Nephrol 5: 2258-2268, 2010
39. Kakiya R, Shoji T, Tsujimoto Y, Tatsumi N, Hatsuda S, Shinohara K, Kimoto E, Tahara H, Koyama H, Emoto M, Ishimura E, Miki T, Tabata T, Nishizawa Y: Body fat mass and lean mass as predictors of survival in hemodialysis patients. Kidney Int 70: 549-556, 2006
40. Batsis JA, Mackenzie TA, Barre LK, Lopez-Jimenez F, Bartels SJ: Sarcopenia, sarcopenic obesity and mortality in older adults: results from theNationalHealth and Nutrition Examination Survey III. Eur JClinNutr 68: 1001-1007, 2014
41. Fouque D, Kalantar-Zadeh K, Kopple J, Cano N, Chauveau P, Cuppari L, Franch H,GuarnieriG, IkizlerTA,KaysenG, LindholmB,Massy Z, MitchW, Pineda E, Stenvinkel P, Treviño-Becerra A, Wanner C: A proposed nomenclature and diagnostic criteria for protein-energy wasting in acute and chronic kidney disease. Kidney Int 73: 391-398, 2008
42. Manson JE, Stampfer MJ, Hennekens CH,WillettWC: Body weight and longevity. A reassessment. JAMA 257: 353-358, 1987
43. Stenvinkel P, HeimbürgerO, Paultre F, Diczfalusy U,Wang T, Berglund L, Jogestrand T: Strong association between malnutrition, inflammation, and atherosclerosis in chronic renal failure. Kidney Int 55: 1899-1911, 1999
44. Deger SM, Ellis CD, Bian A, Shintani A, Ikizler TA, Hung AM: Obesity, diabetes and survival in maintenance hemodialysis patients. Ren Fail 36: 546-551, 2014
45. Liu Y, Coresh J, Eustace JA, Longenecker JC, Jaar B, Fink NE, Tracy RP, Powe NR, KlagMJ: Association between cholesterol level andmortality in dialysis patients: role of inflammation and malnutrition. JAMA 291: 451-459, 2004
46. Carrero JJ, Stenvinkel P: Persistent inflammation as a catalyst for other risk factors in chronic kidney disease: a hypothesis proposal. Clin J Am Soc Nephrol 4[Suppl 1]: S49-S55, 2009
47. Snaedal S, Heimbürger O, Qureshi AR, Danielsson A, Wikström B, Fellström B, Fehrman-Ekholm I, Carrero JJ, Alvestrand A, Stenvinkel P, Bárány P: Comorbidity and acute clinical events as determinants of C-reactive protein variation in hemodialysis patients: implications for patient survival. AmJ Kidney Dis 53: 1024-1033, 2009
48. Friedman AN, Fadem SZ: Reassessment of albumin as a nutritional marker in kidney disease. J Am Soc Nephrol 21: 223-230, 2010
49. Gama-Axelsson T, Heimbürger O, Stenvinkel P, Bárány P, Lindholm B, Qureshi AR: Serum albumin as predictor of nutritional status in patients with ESRD. Clin J Am Soc Nephrol 7: 1446-1453, 2012
50. de Mutsert R, Grootendorst DC, Indemans F, Boeschoten EW, Krediet RT, Dekker FW; Netherlands Cooperative Study on the Adequacy of Dialysis-II Study Group: Association between serum albumin and mortality in dialysis patients is partly explained by inflammation, and not by malnutrition. J Ren Nutr 19: 127-135, 2009
51. de Francisco AL, Kim J, Anker SD, Belozeroff V, Canaud B, Chazot C, Drüeke TB, Eckardt KU, Floege J, Kronenberg F, Macdougall IC, Marcelli D, Molemans B, Passlick-Deetjen J, Schernthaner G, Stenvinkel P, Wheeler DC, Fouqueray B, Aljama P: An epidemiological study of hemodialysis patients based on the European Fresenius Medical Care hemodialysis network: results of the ARO study. Nephron Clin Pract 118: c143-c154, 2011
52. Floege J, Gillespie IA, Kronenberg F, Anker SD, Gioni I, Richards S, Pisoni RL, Robinson BM, Marcelli D, Froissart M, Eckardt KU: Development and validation of a predictive mortality risk score from a European hemodialysis cohort. Kidney Int 87: 996-1008, 2015
53. Steil H, Amato C, Carioni C, Kirchgessner J, Marcelli D, Mitteregger A, Moscardo V, Orlandini G, Gatti E: EuCliD-A medical registry. Methods Inf Med 43: 83-88, 2004
54. Schoenfeld D: Partial residuals for the proportional hazards regression model. Biometrika (1982) 69: 239-241, 1982