High prevalence of primary drug resistance in children with intrathoracic tuberculosis in India

Paediatrics and International Child Health

Volumn 36, Issue 3, 2016, Pages 214-218

  Prajapati, Suneel ^a   Upadhyay, Kriti ^a   Mukherjee, Aparna ^b   Kabra, S K ^b   Lodha, Rakesh ^b   Singh, Varinder ^c   Grewal, Harleen M S ^d   Singh, Sarman ^a  

^a Department of Laboratory Medicine ^*  (India)

^b ALL INDIA INSTITUTE OF MEDICAL SCIENCES   (India)

^c KALAWATI SARAN CHILDREN'S HOSPITAL   (India)

^d UNIVERSITY OF BERGEN   (Norway)

Author keywords

Gastric lavage; India; Induced sputum; Multi drug resistant TB; Rifampicin; Tuberculosis

Indexed keywords

ETHAMBUTOL; ISONIAZID; RIFAMPICIN; STREPTOMYCIN; TUBERCULOSTATIC AGENT;

ADOLESCENT; ANTIBIOTIC RESISTANCE; ARTICLE; ATYPICAL MYCOBACTERIUM; BACTERIUM CONTAMINATION; BACTERIUM CULTURE; BACTERIUM DETECTION; BACTERIUM ISOLATE; CHILD; COHORT ANALYSIS; COMBINATION DRUG THERAPY; CONTROLLED STUDY; DRUG RESISTANT TUBERCULOSIS; FEMALE; GASTRIC SUCTION; HUMAN; IN VITRO STUDY; INDIA; INFANT; INTRATHORACIC TUBERCULOSIS; MAJOR CLINICAL STUDY; MALE; MONOTHERAPY; MULTIDRUG RESISTANT TUBERCULOSIS; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PREVALENCE; PROSPECTIVE STUDY; SPUTUM CULTURE; TUBERCULOSIS; DRUG EFFECTS; ISOLATION AND PURIFICATION; MICROBIAL SENSITIVITY TEST; MICROBIOLOGY; PRESCHOOL CHILD; TUBERCULOSIS, PULMONARY;

ADOLESCENT; ANTITUBERCULAR AGENTS; CHILD; CHILD, PRESCHOOL; DRUG RESISTANCE, BACTERIAL; FEMALE; HUMANS; INDIA; INFANT; MALE; MICROBIAL SENSITIVITY TESTS; MYCOBACTERIUM TUBERCULOSIS; PREVALENCE; PROSPECTIVE STUDIES; TUBERCULOSIS, PULMONARY;

EID: 84985994819     PISSN: 20469047     EISSN: 20469055     Source Type: Journal    
DOI: 10.1179/2046905515Y.0000000041     Document Type: Article

References (19)

1. World Health Organization. Epidemiology of Childhood TB Global Tuberculosis Report, 2014. Geneva:WHO; 2014. Available at:http://www.who.int/tb/challenges/ChildhhoodTB_section1.pdf?ua=1. Accessed on 31 March 2015.
2. A.Kumar, D.Gupta, S.B.Nagaraja, V.Singh, G.R.Sethi, J.Prasad. Updated National Guidelines for Pediatric Tuberculosis in India. Indian Pediatr. 2013;50:301–6.
3. H.E.Jenkins, A.W.Tolman, C.M.Yuen, J.B.Parr, S.Keshavjee, C.M.Pérez-Vélez, et al. Incidence of multidrug-resistant tuberculosis disease in children:systematic review and global estimates. Lancet. 2014;383:1572–9.
4. D.Parashar, S.K.Kabra, R.Lodha, V.Singh, A.Mukherjee, T.Arya, et al. Does neutralization of gastric aspirates from children with probable intrathoracic tuberculosis affect mycobacterial yields on MGIT culture? J Clin Microbiol. 2013;51:1753–6.
5. A.Mukherjee, S.Singh, R.Lodha, V.Singh, A.C.Hesseling, H.M.Grewal, et al. Ambulatory gastric lavages provide better yields of Mycobacterium tuberculosis than induced sputum in children with intra-thoracic tuberculosis. Pediatr Infec Dis J. 2013;32:1313–7.
6. TB India. Annual Status Report. Central TB Division Directorate General of Health Services, Ministry of Health and Family Welfare, Nirman Bhavan, New Delhi, India 2014.
7. I.Shah, S.Chilkar. Clinical profile of drug resistant tuberculosis in children. Indian Pediatr. 2012;49:741–4.
8. K.L.Therese, R.Gayathri, S.Balasubramanian, S.Natrajan, H.N.Madhavan. Phenotypic and genotypic characteristics of drug resistance in Mycobacterium tuberculosis isolates from pediatric population of Chennai, India. Indian J Med Microbiol. 2012;30:411–7.
9. Working group on Tuberculosis, Indian Academy of Pediatrics (IAP). Consensus statement on childhood tuberculosis. Indian Pediatr. 2010;47:41–55.
10. M.Y.C.Barez, M.T.Mendoza, R.S.Celada, H.R.Santos. Accuracy of AFB in relation to TB culture in detection of pulmonary tuberculosis. Phil J Microbiol Infect Dis. 1995;24:33–6.
11. TM 960 Mycobacterium Detection System. Available at:< http://catalog.bd.com/bdCat/viewProduct.doCustomer?productnumber=445870>.
12. K.Gopinath, S.Singh. Multiplex PCR assay for simultaneous detection and differentiation of Mycobacterium tuberculosis, Mycobacterium avium complexes and other Mycobacterial species directly from clinical specimens. J Appl Microbiol. 2009;107:425–35.
13. S.Swaminathan, B.Rekha. Pediatric tuberculosis:global overview and challenges. Clin Infect Dis. 2010;50(Suppl 3):S184–94.
14. H.S.Schaaf, B.J.Marais, A.C.Hesseling, W.Brittle, P.R.Donald. Surveillance of anti-tuberculosis drug resistance among children from the Western Cape Province of South Africa – an upward trend. Am J Public Health. 2009;99:1486–90.
15. B.Rekha, S.Swaminathan. Childhood tuberculosis – global epidemiology and the impact of HIV. Paediatr Respir Rev. 2007;8:99–106.
16. World Health Organization. Guidance for National Tuberculosis Programmes on the Management of Tuberculosis in Children. Geneva:WHO; 2014. Available at:http://apps.who.int/medicinedocs/documents/s21535en/s21535en.pdf. Accessed on 31 March 2015.
17. J.S.Mukherjee, M.L.Rich, A.R.Socci, J.K.Joseph, F.A.Viru, S.S.Shin, et al. Programmes and principles in treatment of multidrug-resistant tuberculosis. Lancet. 2004;363:474–81.
18. S.Rüsch-Gerdes, G.E.Pfyffer, M.Casal, M.Chadwick, S.Siddiqi. Multicenter evaluation of the mycobacteria growth indicator tube for testing susceptibility of Mycobacterium tuberculosis to first-line drugs. J Clin Microbiol. 1999;37:45–8.
19. P.Bemer, F.Palicova, S.Rüsch-Gerdes, H.B.Drugeon, G.E.Pfyffer. Multicenter evaluation of fully automated BACTEC mycobacteria growth indicator tube 960 system for susceptibility testing of Mycobacterium tuberculosis. J Clin Microbiol. 2002;40:150–4.