Diagnostic test accuracy of a 2-transcript host RNA signature for discriminating bacterial vs viral infection in febrile children

JAMA - Journal of the American Medical Association

Volumn 316, Issue 8, 2016, Pages 835-845

  Herberg, Jethro A ^a   Kaforou, Myrsini ^a   Wright, Victoria J ^a   Shailes, Hannah ^a   Eleftherohorinou, Hariklia ^a   Hoggart, Clive J ^a   Cebey López, Miriam ^b,c   Carter, Michael J ^a   Janes, Victoria A ^a   Gormley, Stuart ^a   Shimizu, Chisato ^d,e   Tremoulet, Adriana H ^d,e   Barendregt, Anouk M ^f   Salas, Antonio ^b,c,g   Kanegaye, John ^d,e   Pollard, Andrew J ^h,i   Faust, Saul N ^j,k   Patel, Sanjay ^k   Kuijpers, Taco ^f   Martinón Torres, Federico ^b,c   Burns, Jane C ^d,e   Coin, Lachlan J M ^l   Levin, Michael ^a   more..

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

^b Pediatric Nutrition Research Group Health Research Institute of Santiago de Compostela   (Spain)

^c UNIVERSITY OF SANTIAGO DE COMPOSTELA   (Spain)

^d UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^e RADY CHILDREN'S HOSPITAL   (United States)

^f UNIVERSITY OF AMSTERDAM   (Netherlands)

^g Instituto de Ciencias Forenses   (Spain)

^h UNIVERSITY OF OXFORD   (United Kingdom)

ⁱ Queen Mary University of London and Barts NIHR BRC NHS Trust National Institute for Health and Care Research   (United Kingdom)

^j UNIVERSITY OF SOUTHAMPTON   (United Kingdom)

^k UNIVERSITY HOSPITAL SOUTHAMPTON NHS FOUNDATION TRUST   (United Kingdom)

^l UNIVERSITY OF QUEENSLAND   (Australia)

more..

Author keywords

[No Author keywords available]

Indexed keywords

RNA; ANTIGEN; ANTIINFECTIVE AGENT; BIOLOGICAL MARKER; CYTOSKELETON PROTEIN; GENETIC MARKER; IFI44 PROTEIN, HUMAN;

ARTICLE; BACTERIAL INFECTION; CHILD; CLINICAL FEATURE; CLINICAL PRACTICE; CONTROLLED STUDY; DIAGNOSTIC ACCURACY; DIAGNOSTIC TEST ACCURACY STUDY; FEMALE; FEVER; HUMAN; INFORMED CONSENT; LYMPHOCYTE COUNT; MAJOR CLINICAL STUDY; MALE; MOLECULAR DIAGNOSIS; MONOCYTE; NETHERLANDS; NEUTROPHIL COUNT; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROSPECTIVE STUDY; RECEIVER OPERATING CHARACTERISTIC; RNA ANALYSIS; RNA TRANSCRIPTION; SENSITIVITY AND SPECIFICITY; SPAIN; UNITED KINGDOM; UNITED STATES; VALIDATION STUDY; VIRUS INFECTION; AREA UNDER THE CURVE; BACTERIAL INFECTIONS; BLOOD; CLINICAL TRIAL; COINFECTION; COMPLICATION; DIFFERENTIAL DIAGNOSIS; GENE EXPRESSION PROFILING; GENETIC MARKER; GENETICS; INFANT; MICROBIOLOGY; MULTICENTER STUDY; PRESCHOOL CHILD; RISK; SEVERITY OF ILLNESS INDEX; STATISTICAL MODEL; VIROLOGY; VIRUS DISEASES;

ANTI-BACTERIAL AGENTS; ANTIGENS; AREA UNDER CURVE; BACTERIAL INFECTIONS; BIOMARKERS; CHILD, PRESCHOOL; COINFECTION; CYTOSKELETAL PROTEINS; DIAGNOSIS, DIFFERENTIAL; FEMALE; FEVER; GENE EXPRESSION PROFILING; GENETIC MARKERS; HUMANS; INFANT; LOGISTIC MODELS; MALE; PROSPECTIVE STUDIES; RISK; RNA; SENSITIVITY AND SPECIFICITY; SEVERITY OF ILLNESS INDEX; VIRUS DISEASES;

EID: 84985860512     PISSN: 00987484     EISSN: 15383598     Source Type: Journal    
DOI: 10.1001/jama.2016.11236     Document Type: Article

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