Gradual cerebral hypoperfusion in spontaneously hypertensive rats induces slowly evolving white matter abnormalities and impairs working memory

Journal of Cerebral Blood Flow and Metabolism

Volumn 36, Issue 9, 2016, Pages 1592-1602

  Kitamura, Akihiro ^a   Saito, Satoshi ^a,b   Maki, Takakuni ^a   Oishi, Naoya ^a   Ayaki, Takashi ^a   Hattori, Yorito ^b   Yamamoto, Yumi ^b   Urushitani, Makoto ^a   Kalaria, Raj N ^c   Fukuyama, Hidenao ^a   Horsburgh, Karen ^d   Takahashi, Ryosuke ^a   Ihara, Masafumi ^b  

^a KYOTO UNIVERSITY   (Japan)

^b NATIONAL CEREBRAL AND CARDIOVASCULAR CENTER   (Japan)

^c NEWCASTLE UNIVERSITY   (United Kingdom)

^d UNIVERSITY OF EDINBURGH   (United Kingdom)

Author keywords

ameroid constrictor; chronic cerebral hypoperfusion; spontaneously hypertensive rat; Vascular dementia; white matter change

Indexed keywords

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN BLOOD FLOW; BRAIN PERFUSION; CAROTID ARTERY OBSTRUCTION; COMMON CAROTID ARTERY; CONTROLLED STUDY; MALE; MORTALITY RATE; MULTIINFARCT DEMENTIA; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; RAT; RISK FACTOR; SHAM PROCEDURE; SPONTANEOUSLY HYPERTENSIVE RAT; SUBCORTICAL ISCHEMIC VASCULAR DEMENTIA; WHITE MATTER; WISTAR KYOTO RAT; WORKING MEMORY; ANIMAL; BRAIN CIRCULATION; MORTALITY; SHORT TERM MEMORY;

ANIMALS; CAROTID ARTERY, COMMON; CEREBROVASCULAR CIRCULATION; DEMENTIA, VASCULAR; MEMORY, SHORT-TERM; MORTALITY; RATS, INBRED SHR; RATS, INBRED WKY; WHITE MATTER;

EID: 84984971073     PISSN: 0271678X     EISSN: 15597016     Source Type: Journal    
DOI: 10.1177/0271678X15606717     Document Type: Article

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