Experimental Validation of Antidiabetic and Antioxidant Potential of Cassia tora (L.): An Indigenous Medicinal Plant

Indian Journal of Clinical Biochemistry

Volumn 32, Issue 3, 2017, Pages 323-328

  Kumar, Vishnu ^a   Singh, Ranjana ^b   Mahdi, Farzana ^a   Mahdi, Abbas Ali ^b   Singh, Raj Kumar ^c  

^a Era's Lucknow Medical College and Hospital   (India)

^b KING GEORGE'S MEDICAL UNIVERSITY   (India)

^c T S Misra Medical College and Hospital   (India)

Author keywords

Anti dyslipidemic agent; Cassia tora seeds extract; Plant antioxidant; Post heparin lipolytic activity; Streptozotocin induced diabetes

Indexed keywords

2,3 DIHYDROXYBENZOIC ACID; ANTIDIABETIC AGENT; ANTIOXIDANT; CHOLESTEROL; FATTY ACID; GLIBENCLAMIDE; GLUCOSE; GUM ARABIC; HYDROXYL RADICAL; LIPID PEROXIDE; PHOSPHOLIPID; PLANT EXTRACT; SENNA TORA EXTRACT; STREPTOZOCIN; SUPEROXIDE; TRIACYLGLYCEROL; UNCLASSIFIED DRUG; URIC ACID; XANTHINE OXIDASE;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIDIABETIC ACTIVITY; ANTIOXIDANT ACTIVITY; AQUEOUS SOLUTION; ARTICLE; CHARLES FOSTER RAT; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; DIABETES CONTROL; DRUG INHIBITION; DRUG POTENCY; FATTY ACID BLOOD LEVEL; GLUCOSE BLOOD LEVEL; IN VITRO STUDY; IN VIVO STUDY; MALE; NONHUMAN; PHOSPHOLIPID BLOOD LEVEL; PLANT SEED; RAT; SENNA TORA; STREPTOZOTOCIN-INDUCED DIABETES MELLITUS; SUSPENSION; TRIACYLGLYCEROL BLOOD LEVEL; URIC ACID BLOOD LEVEL;

EID: 84984797192     PISSN: 09701915     EISSN: 09740422     Source Type: Journal    
DOI: 10.1007/s12291-016-0608-3     Document Type: Article

References (28)

1. Fonseca VA. Clinical diabetes: translating research into practice. Philadelphia: Saunders Elsevier; 2006. p. 2–3.
2. Ashok K, Lakshman K, Nandeesh R, Arun K, Manoj K, Kumar V. In vitro alpha amylase inhibition and in vivo antioxidant potential of Amaranthus spinosus in alloxan induced oxidative stress in diabetic rats. Saudi J Biol Sci. 2011;18:1–5.
3. Hiremath MB, Jali MV. Diabetes. Ind J Sci Technol. 2010;3:1106–8.
4. Olubomehin OO, Abo KA, Ajaiyeoba EO. Alpha amylase inhibitory activity of two Anthocleista species and in vivo rat model antidiabetic activities of Anthocleista djalonensis extracts and fractions. J Ethnopharmacol. 2013;146:811–4.
5. Hosakatte NM, Vijayalaxmi SD, Eun JL, Kee YP. Efficacy of ginseng adventitious root extract on hyperglycemia in streptozotocin induced diabetic rats. J Ethnopharmacol. 2014;153:917–21.
6. Sujatha S, Anand S, Sangeetha KN, Shilpa K, Lakshmi J, Balakrishnan A, et al. Biological evaluation of (3β)-Stigmast-5-en-3-ol as potent antidiabetic agent in regulating glucose transport using in vitro model. Int J Diabetes Mellit. 2010;2:101–9.
7. Chattopadhyaya R, Pathak D, Jindal DP. Antihyperlipidemic agents: a review. Indian Drugs. 1996;33:85–97.
8. Warrier PK, Nambiar VPK, Ramankutty C. A text book of Indian medicinal plants, a compendium of 500 species, vol. 2. Chennai: Orient Longman Private Limited; 2001. p. 26.
9. Pawar HA, D’mello PM. Cassia tora Linn: an overview. Int J Pharm Sci Res. 2011;2:2286–91.
10. Chaurasia B, Dhakad RS, Dhakar VK, Jain PK. Preliminary Phytochemical and pharmacological (Antidiabetic) screening of Cassia tora Linn. Int J Pharm Life Sci. 2011;2:759–66.
11. Kee CH. The pharmacology of Chinese herbs. BocaRaton: CRC Press; 2001. p. 103.
12. Banskota AH, Nguyen NT, Tezuka Y, Nobukawa TKS. Hypoglycemic effects of the wood of Taxus yunnanensis on streptozotocin induced diabetic rats and its active components. Phytomedicine. 2006;13:109–14.
13. Trinder P. Determination of glucose in blood using glucose oxidase with an alternative oxygen acceptor. Ann Clin Biochem. 1969;6:24–30.
14. Deeg R, Ziegenborn J. Kinetic enzymatic method for automated determination of total cholesterol in serum. Clin Chem. 1983;29:1798–803.
15. Zilversmith DB, Davis DK. Micro determination of plasma phospholipids by trichloroacetic acid precipitation. J Lab Clin Med. 1950;35:155–60.
16. Buccolo G, David H. Quantitative determination of serum triglyceride by the use of enzymes. Clin Chem. 1973;19:476–80.
17. Mosinger F. Photometric adaptation of Dole’s microdetermination of free fatty acids. J Lipid Res. 1965;6:157–9.
18. Wing DR, Robinson DS. Clearing factor lipase in adipose tissue. Biochem J. 1968;29:1798–803.
19. Okhawa H, Qohishi N. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biochem. 1978;95:351–8.
20. Bindoli A, Valante M, Cavallin L. Inhibition of Xanthine oxidase and xanthine dehydrogenase activity. Pharmacol Res Commun. 1985;17:831–9.
21. McCord JM, Fridovich IJ. Superoxide dismutase; an enzymic function for erythrocuprein (hemocuprein). J Biol Chem. 1969;244:6049–55.
22. Richmond R, Halliwell R, Chauhan J, Darbre A. Suproxide dependent formation of hydroxyl radical by hydroxylation of aromatic compounds. Anal Biochem. 1981;118:320–35.
23. Halliwell B, Gutteridge JMC, Aroma OI. The deoxyribose method: a simple test tube assay for determination of rate constants for reaction OH-radicals. Anal Biochem. 1987;165:215–9.
24. Woodson RF. Statistical methods for the analysis of biochemical data. Chichester: Wiley; 1957. p. 315.
25. Goud BJ, Dwarkanath B, Chikka swamy BK. Streptozotocin—a diabetogenic agent in animal models. Int J Pharm Pharm Res Hum. 2015;3:253–69.
26. Awasthi VK, Mahdi F, Chander R, Khanna AK, Saxena JK, Singh R, et al. Hypolipidemic activity of Cassia tora seed in hyperlipidemic rats. Ind J Clin Biochem. 2015;30:78–83.
27. Kumar V, Mahdi F, Chander R, Khanna AK, Singh R, Saxena JK, et al. Cassia tora regulates lipid metabolism in alloxan induced diabetic rats. Int J Pharm Sci Res. 2015;6:3484–9.
28. Saklani A, Kutty SK. Plant derived compounds in clinical trials. Drug Discov Today. 2008;13:161–71.