A randomized trial of focused ultrasound thalamotomy for essential tremor

New England Journal of Medicine

Volumn 375, Issue 8, 2016, Pages 730-739

  Elias, W Jeffrey ^a   Lipsman, Nir ^b   Ondo, William G ^d   Ghanouni, Pejman ^e   Kim, Young G ^f   Lee, Wonhee ^f   Schwartz, Michael ^c   Hynynen, Kullervo ^c   Lozano, Andres M ^b   Shah, Binit B ^a   Huss, Diane ^a   Dallapiazza, Robert F ^a   Gwinn, Ryder ^g   Witt, Jennifer ^g   Ro, Susie ^g   Eisenberg, Howard M ^h   Fishman, Paul S ^h   Gandhi, Dheeraj ^h   Halpern, Casey H ^e   Chuang, Rosalind ^g   Pauly, Kim Butts ^e   Tierney, Travis S ⁱ   Hayes, Michael T ^j   Cosgrove, G Rees ^j   Yamaguchi, Toshio ^k   Abe, Keiichi ^l   Taira, Takaomi ^l   Chang, Jin W ^f   more..

^a UNIVERSITY OF VIRGINIA HEALTH SYSTEM   (United States)

^b TORONTO WESTERN HOSPITAL   (Canada)

^c SUNNYBROOK RESEARCH INSTITUTE   (Canada)

^d HOUSTON METHODIST RESEARCH INSTITUTE   (United States)

^e STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^f Yonsei University College of Medicine   (South Korea)

^g SWEDISH MEDICAL CENTER   (United States)

^h UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

ⁱ UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

^j BRIGHAM AND WOMEN S HOSPITAL   (United States)

^k Endoscopic Center   (Japan)

^l TOKYO WOMEN'S MEDICAL UNIVERSITY   (Japan)

more..

Author keywords

[No Author keywords available]

Indexed keywords

AGE DISTRIBUTION; AGED; ARTICLE; BALANCE DISORDER; CLINICAL EFFECTIVENESS; CONTROLLED STUDY; CROSSOVER PROCEDURE; DAILY LIFE ACTIVITY; DISEASE DURATION; DISEASE SEVERITY; DOUBLE BLIND PROCEDURE; DYSARTHRIA; DYSMETRIA; DYSPHAGIA; ESSENTIAL TREMOR; FEMALE; FUNCTIONAL ASSESSMENT; GAIT DISORDER; HAND TREMOR; HEADACHE; HIGH INTENSITY FOCUSED ULTRASOUND; HUMAN; INTENTION TO TREAT ANALYSIS; MAJOR CLINICAL STUDY; MALE; NUCLEAR MAGNETIC RESONANCE IMAGING; OUTCOME ASSESSMENT; PARESTHESIA; POSTOPERATIVE COMPLICATION; PRIORITY JOURNAL; PROSPECTIVE STUDY; QUALITY OF LIFE; RANDOMIZED CONTROLLED TRIAL; SEX DIFFERENCE; THALAMOTOMY; TINNITUS; TREATMENT FAILURE; TREATMENT OUTCOME; TREATMENT RESPONSE; WEAKNESS; ADVERSE EFFECTS; CLINICAL TRIAL; INTERVENTIONAL ULTRASONOGRAPHY; MIDDLE AGED; MULTICENTER STUDY; PROCEDURES; SURGERY; THALAMUS; ULTRASOUND THERAPY;

ACTIVITIES OF DAILY LIVING; AGED; DOUBLE-BLIND METHOD; ESSENTIAL TREMOR; FEMALE; HUMANS; MAGNETIC RESONANCE IMAGING; MALE; MIDDLE AGED; POSTOPERATIVE COMPLICATIONS; QUALITY OF LIFE; THALAMUS; ULTRASONIC THERAPY; ULTRASONOGRAPHY, INTERVENTIONAL;

EID: 84984694311     PISSN: 00284793     EISSN: 15334406     Source Type: Journal    
DOI: 10.1056/NEJMoa1600159     Document Type: Article

References (34)

1. Louis ED, Ferreira JJ. How common is the most common adult movement disorder? Update on the worldwide prevalence of essential tremor. Mov Disord 2010;25:534-41.
2. Ho AL, Erickson-Direnzo E, Pendharkar AV, Sung CK, Halpern CH. Deep brain stimulation for vocal tremor: a comprehensive, multidisciplinary methodology. Neurosurg Focus 2015;38(6):E6.
3. Elias WJ, Shah BB. Tremor. JAMA 2014;311:948-54.
4. Lorenz D, Schwieger D, Moises H, Deuschl G. Quality of life and personality in essential tremor patients. Mov Disord 2006;21:1114-8.
5. Louis ED, Machado DG. Tremor-related quality of life: a comparison of essential tremor vs. Parkinson's disease patients. Parkinsonism Relat Disord 2015;21:729-35.
6. Schneier FR, Barnes LF, Albert SM, Louis ED. Characteristics of social phobia among persons with essential tremor. J Clin Psychiatry 2001;62:367-72.
7. Deuschl G, Bain P, Brin M; Ad Hoc Scientific Committee. Consensus statement of the Movement Disorder Society on Tremor. Mov Disord 1998;13:Suppl 3:2-23.
8. Deuschl G, Raethjen J, Hellriegel H, Elble R. Treatment of patients with essential tremor. Lancet Neurol 2011;10:148-61.
9. Findley LJ, Calzetti S. Double-blind controlled study of primidone in essential tremor: preliminary results. Br Med J (Clin Res Ed) 1982;285:608.
10. Winkler GF, Young RR. Efficacy of chronic propranolol therapy in action tremors of the familial, senile or essential varieties. N Engl J Med 1974;290:984-8.
11. Zesiewicz TA, Elble R, Louis ED, et al. Practice parameter: therapies for essential tremor: report of the Quality Standards Subcommittee of the American Academy of Neurology. Neurology 2005; 64:2008-20.
12. Benabid AL, Pollak P, Seigneuret E, Hoffmann D, Gay E, Perret J. Chronic VIM thalamic stimulation in Parkinson's disease, essential tremor and extra-pyramidal dyskinesias. Acta Neurochir Suppl (Wien) 1993;58:39-44.
13. Goldman MS, Kelly PJ. Stereotactic thalamotomy for medically intractable essential tremor. Stereotact Funct Neurosurg 1992;58:22-5.
14. Koller W, Pahwa R, Busenbark K, et al. High-frequency unilateral thalamic stimulation in the treatment of essential and parkinsonian tremor. Ann Neurol 1997;42:292-9.
15. Kumar K, Kelly M, Toth C. Deep brain stimulation of the ventral intermediate nucleus of the thalamus for control of tremors in Parkinson's disease and essential tremor. Stereotact Funct Neurosurg 1999;72:47-61.
16. Zirh A, Reich SG, Dougherty PM, Lenz FA. Stereotactic thalamotomy in the treatment of essential tremor of the upper extremity: reassessment including a blinded measure of outcome. J Neurol Neurosurg Psychiatry 1999;66:772-5.
17. Fry WJ, Mosberg WH Jr, Barnard JW, Fry FJ. Production of focal destructive lesions in the central nervous system with ultrasound. J Neurosurg 1954;11:471-8.
18. Meyers R, Fry WJ, Fry FJ, Dreyer LL, Schultz DF, Noyes RF. Early experiences with ultrasonic irradiation of the pallidofugal and nigral complexes in hyperkinetic and hypertonic disorders. J Neurosurg 1959;16:32-54.
19. Nelson E, Lindstrom PA, Haymaker W. Pathological effects of ultrasound on the human brain: a study of 25 cases in which ultrasonic irradiation was used as a lobotomy procedure. J Neuropathol Exp Neurol 1959;18:489-508.
20. Clement GT, White J, Hynynen K. Investigation of a large-area phased array for focused ultrasound surgery through the skull. Phys Med Biol 2000;45:1071-83.
21. Hynynen K, Vykhodtseva NI, Chung AH, Sorrentino V, Colucci V, Jolesz FA. Thermal effects of focused ultrasound on the brain: determination with MR imaging. Radiology 1997;204:247-53.
22. McDannold N, Moss M, Killiany R, et al. MRI-guided focused ultrasound surgery in the brain: tests in a primate model. Magn Reson Med 2003;49:1188-91.
23. Chang WS, Jung HH, Kweon EJ, Zadicario E, Rachmilevitch I, Chang JW. Unilateral magnetic resonance guided focused ultrasound thalamotomy for essential tremor: practices and clinicoradiological outcomes. J Neurol Neurosurg Psychiatry 2015;86:257-64.
24. Elias WJ, Huss D, Voss T, et al. A pilot study of focused ultrasound thalamotomy for essential tremor. N Engl J Med 2013;369:640-8.
25. Lipsman N, Schwartz ML, Huang Y, et al. MR-guided focused ultrasound thalamotomy for essential tremor: a proof-of-concept study. Lancet Neurol 2013;12:462-8.
26. Stacy MA, Elble RJ, Ondo WG, Wu SC, Hulihan J. Assessment of interrater and intrarater reliability of the Fahn-Tolosa-Marin Tremor Rating Scale in essential tremor. Mov Disord 2007;22:833-8.
27. Tröster AI, Pahwa R, Fields JA, Tanner CM, Lyons KE. Quality of life in Essential Tremor Questionnaire (QUEST): development and initial validation. Parkinsonism Relat Disord 2005;11:367-73.
28. Wintermark M, Druzgal J, Huss DS, et al. Imaging findings in MR imagingguided focused ultrasound treatment for patients with essential tremor. AJNR Am J Neuroradiol 2014;35:891-6.
29. Anderson VC, Burchiel KJ, Hart MJ, Berk C, Lou JS. A randomized comparison of thalamic stimulation and lesion on self-paced finger movement in essential tremor. Neurosci Lett 2009;462:166-70.
30. Schuurman PR, Bosch DA, Bossuyt PMM, et al. A comparison of continuous thalamic stimulation and thalamotomy for suppression of severe tremor. N Engl J Med 2000;342:461-8.
31. Tasker RR. Deep brain stimulation is preferable to thalamotomy for tremor suppression. Surg Neurol 1998;49:145-53.
32. Witjas T, Carron R, Krack P, et al. A prospective single-blind study of Gamma Knife thalamotomy for tremor. Neurology 2015;85:1562-8.
33. Elias WJ, Khaled M, Hilliard JD, et al. A magnetic resonance imaging, histological, and dose modeling comparison of focused ultrasound, radiofrequency, and Gamma Knife radiosurgery lesions in swine thalamus. J Neurosurg 2013;119:307-17.
34. Lee MSD, ter Haar G, Sela B, et al. Thermal dose and radiation dose comparison based on cell survival. J Ther Ultrasound 2015;3:Suppl 1:26.10.1186/2050-5736-3-S1-P26