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Volumn 15, Issue 9, 2016, Pages 1185-1192

Safety considerations when treating myelofibrosis

Author keywords

JAK inhibitors; myelofibrosis; ruxolitinib; safety

Indexed keywords

ALKYLATING AGENT; ALPHA INTERFERON; ANDROGEN; BUSULFAN; DANAZOL; FEDRATINIB; HYDROXYUREA; IMMUNOMODULATING AGENT; INTERFERON; IRON CHELATING AGENT; JANUS KINASE INHIBITOR; LENALIDOMIDE; MELPHALAN; MOMELOTINIB; PACRITINIB; PEGINTERFERON; POMALIDOMIDE; RECOMBINANT ALPHA2B INTERFERON; RECOMBINANT ERYTHROPOIETIN; RUXOLITINIB; THALIDOMIDE; 11-(2-PYRROLIDIN-1-YLETHOXY)-14,19-DIOXA-5,7,26-TRIAZATETRACYCLO(19.3.1.1(2,6).1(8,12))HEPTACOSA-1(25),2(26),3,5,8,10,12(27),16,21,23-DECAENE; BENZAMIDE DERIVATIVE; BRIDGED COMPOUND; JANUS KINASE; N-(CYANOMETHYL)-4-(2-((4-(4-MORPHOLINYL)PHENYL)AMINO)-4-PYRIMIDINYL)BENZAMIDE; PROTEIN KINASE INHIBITOR; PYRAZOLE DERIVATIVE; PYRIMIDINE DERIVATIVE;

EID: 84984638433     PISSN: 14740338     EISSN: 1744764X     Source Type: Journal    
DOI: 10.1080/14740338.2016.1185414     Document Type: Review
Times cited : (8)

References (83)
  • 2
    • 84908243201 scopus 로고    scopus 로고
    • How I treat myelofibrosis
    • F.Cervantes How I treat myelofibrosis. Blood. 2014;124:2635–2642.
    • (2014) Blood , vol.124 , pp. 2635-2642
    • Cervantes, F.1
  • 3
    • 84864300766 scopus 로고    scopus 로고
    • British committee for standards in haematology, guideline for the diagnosis and management of myelofibrosis
    • J.T.Reilly, M.F.McMullin, P.A.Beer, et al. British committee for standards in haematology, guideline for the diagnosis and management of myelofibrosis. Br J Haematol. 2012;158:453–471.
    • (2012) Br J Haematol , vol.158 , pp. 453-471
    • Reilly, J.T.1    McMullin, M.F.2    Beer, P.A.3
  • 4
    • 0032916213 scopus 로고    scopus 로고
    • Population-based incidence and survival figures in essential thrombocythemia and agnogenic myeloid metaplasia: an Olmsted County study, 1976–1995
    • R.A.Mesa, M.N.Silverstein, S.J.Jacobsen, et al. Population-based incidence and survival figures in essential thrombocythemia and agnogenic myeloid metaplasia:an Olmsted County study, 1976–1995. Am J Hematol. 1999;61:10–15.
    • (1999) Am J Hematol , vol.61 , pp. 10-15
    • Mesa, R.A.1    Silverstein, M.N.2    Jacobsen, S.J.3
  • 5
    • 17844383458 scopus 로고    scopus 로고
    • A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia vera
    • C.James, V.Ugo, J.P.Le Couedic, et al. A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia vera. Nature. 2005;434:1144–1148.
    • (2005) Nature , vol.434 , pp. 1144-1148
    • James, C.1    Ugo, V.2    Le Couedic, J.P.3
  • 6
    • 84904042955 scopus 로고    scopus 로고
    • CALR vs JAK2 vs MPL-mutated or triple-negative myelofibrosis: clinical, cytogenetic and molecular comparisons
    • A.Tefferi, T.L.Lasho, C.M.Finke, et al. CALR vs JAK2 vs MPL-mutated or triple-negative myelofibrosis:clinical, cytogenetic and molecular comparisons. Leukemia. 2014;28:1472–1477.
    • (2014) Leukemia , vol.28 , pp. 1472-1477
    • Tefferi, A.1    Lasho, T.L.2    Finke, C.M.3
  • 7
    • 84890328032 scopus 로고    scopus 로고
    • Somatic CALR mutations in myeloproliferative neoplasms with nonmutated JAK2
    • J.Nangalia, C.E.Massie, E.J.Baxter, et al. Somatic CALR mutations in myeloproliferative neoplasms with nonmutated JAK2. N Engl J Med. 2013;369:2391–2405.
    • (2013) N Engl J Med , vol.369 , pp. 2391-2405
    • Nangalia, J.1    Massie, C.E.2    Baxter, E.J.3
  • 8
    • 84890372480 scopus 로고    scopus 로고
    • Somatic mutations of calreticulin in myeloproliferative neoplasms
    • T.Klampfl, H.Gisslinger, A.S.Harutyunyan, et al. Somatic mutations of calreticulin in myeloproliferative neoplasms. N Engl J Med. 2013;369:2379–2390.
    • (2013) N Engl J Med , vol.369 , pp. 2379-2390
    • Klampfl, T.1    Gisslinger, H.2    Harutyunyan, A.S.3
  • 9
    • 84908065771 scopus 로고    scopus 로고
    • The prognostic advantage of calreticulin mutations in myelofibrosis might be confined to type 1 or type 1-like CALR variants
    • A.Tefferi, T.L.Lasho, A.Tischer, et al. The prognostic advantage of calreticulin mutations in myelofibrosis might be confined to type 1 or type 1-like CALR variants. Blood. 2014;124:2465–2466.
    • (2014) Blood , vol.124 , pp. 2465-2466
    • Tefferi, A.1    Lasho, T.L.2    Tischer, A.3
  • 10
    • 84901714382 scopus 로고    scopus 로고
    • Integrated genomic analysis illustrates the central role of JAK-STAT pathway activation in myeloproliferative neoplasm pathogenesis
    • R.Rampal, F.Al-Shahrour, O.Abdel-Wahab, et al. Integrated genomic analysis illustrates the central role of JAK-STAT pathway activation in myeloproliferative neoplasm pathogenesis. Blood. 2014;123:123–133.
    • (2014) Blood , vol.123 , pp. 123-133
    • Rampal, R.1    Al-Shahrour, F.2    Abdel-Wahab, O.3
  • 11
    • 84960851640 scopus 로고    scopus 로고
    • Thrombopoietin receptor activation by myeloproliferative neoplasm associated calreticulin mutants
    • I.Chachoua, C.Pecquet, M.El-Khoury, et al. Thrombopoietin receptor activation by myeloproliferative neoplasm associated calreticulin mutants. Blood. 2016;127:1325–1335.
    • (2016) Blood , vol.127 , pp. 1325-1335
    • Chachoua, I.1    Pecquet, C.2    El-Khoury, M.3
  • 12
    • 63849328927 scopus 로고    scopus 로고
    • New prognostic scoring system for primary myelofibrosis based on a study of the International Working Group for Myelofibrosis Research and Treatment
    • F.Cervantes, B.Dupriez, A.Pereira, et al. New prognostic scoring system for primary myelofibrosis based on a study of the International Working Group for Myelofibrosis Research and Treatment. Blood. 2009;113:2895–2901.
    • (2009) Blood , vol.113 , pp. 2895-2901
    • Cervantes, F.1    Dupriez, B.2    Pereira, A.3
  • 13
    • 77950352432 scopus 로고    scopus 로고
    • A dynamic prognostic model to predict survival in primary myelofibrosis: a study by the IWG-MRT (International Working Group for Myeloproliferative Neoplasms Research and Treatment)
    • F.Passamonti, F.Cervantes, A.M.Vannucchi, et al. A dynamic prognostic model to predict survival in primary myelofibrosis:a study by the IWG-MRT (International Working Group for Myeloproliferative Neoplasms Research and Treatment). Blood. 2010;115:1703–1708.
    • (2010) Blood , vol.115 , pp. 1703-1708
    • Passamonti, F.1    Cervantes, F.2    Vannucchi, A.M.3
  • 14
    • 79952087335 scopus 로고    scopus 로고
    • DIPSS plus: a refined Dynamic International Prognostic Scoring System for primary myelofibrosis that incorporates prognostic information from karyotype, platelet count, and transfusion status
    • N.Gangat, D.Caramazza, R.Vaidya, et al. DIPSS plus:a refined Dynamic International Prognostic Scoring System for primary myelofibrosis that incorporates prognostic information from karyotype, platelet count, and transfusion status. J Clin Oncol. 2011;29:392–397.
    • (2011) J Clin Oncol , vol.29 , pp. 392-397
    • Gangat, N.1    Caramazza, D.2    Vaidya, R.3
  • 15
    • 80055075486 scopus 로고    scopus 로고
    • Predictors of greater than 80% 2-year mortality in primary myelofibrosis: a Mayo Clinic study of 884 karyotypically annotated patients
    • A.Tefferi, T.Jimma, N.Gangat, et al. Predictors of greater than 80% 2-year mortality in primary myelofibrosis:a Mayo Clinic study of 884 karyotypically annotated patients. Blood. 2011;118:4595–459.
    • (2011) Blood , vol.118 , pp. 4459-4595
    • Tefferi, A.1    Jimma, T.2    Gangat, N.3
  • 16
    • 84904056081 scopus 로고    scopus 로고
    • CALR and ASXL1 mutations-based molecular prognostication in primary myelofibrosis: an international study of 570 patients
    • A.Tefferi, P.Guglielmelli, T.L.Lasho, et al. CALR and ASXL1 mutations-based molecular prognostication in primary myelofibrosis:an international study of 570 patients. Leukemia. 2014;28:1494–1500.
    • (2014) Leukemia , vol.28 , pp. 1494-1500
    • Tefferi, A.1    Guglielmelli, P.2    Lasho, T.L.3
  • 17
    • 84930006828 scopus 로고    scopus 로고
    • Impact of allogeneic stem cell transplantation on survival of patients less than 65 years of age with primary myelofibrosis
    • N.Kröger, T.Giorgino, B.L.Scott, et al. Impact of allogeneic stem cell transplantation on survival of patients less than 65 years of age with primary myelofibrosis. Blood. 2015;125:3347–3350.
    • (2015) Blood , vol.125 , pp. 3347-3350
    • Kröger, N.1    Giorgino, T.2    Scott, B.L.3
  • 18
    • 84946496578 scopus 로고    scopus 로고
    • Indication and management of allogeneic stem cell transplantation in primary myelofibrosis: a consensus process by an EBMT/ELN international working group
    • N.Kröger, J.H.Deeg, E.Olavarria, et al. Indication and management of allogeneic stem cell transplantation in primary myelofibrosis:a consensus process by an EBMT/ELN international working group. Leukaemia. 2015;29:2126–2133.
    • (2015) Leukaemia , vol.29 , pp. 2126-2133
    • Kröger, N.1    Deeg, J.H.2    Olavarria, E.3
  • 19
    • 84912000790 scopus 로고    scopus 로고
    • Use of JAK inhibitors in the management of myelofibrosis: a revision of the British Committee for Standards in Haematology Guidelines for Investigation and Management of Myelofibrosis 2012
    • J.T.Reilly, M.F.McMullin, P.A.Beer, et al. Use of JAK inhibitors in the management of myelofibrosis:a revision of the British Committee for Standards in Haematology Guidelines for Investigation and Management of Myelofibrosis 2012. Br J Haematol. 2014;167:418–420.•• Updated guideline recommending ruxolitinib as first-line treatment for myelofibrosis.
    • (2014) Br J Haematol , vol.167 , pp. 418-420
    • Reilly, J.T.1    McMullin, M.F.2    Beer, P.A.3
  • 20
    • 84921891315 scopus 로고    scopus 로고
    • Ruxolitinib versus standard therapy for the treatment of polycythemia vera
    • A.M.Vannucchi, J.J.Kiladjian, M.Griesshammer, et al. Ruxolitinib versus standard therapy for the treatment of polycythemia vera. N Engl J Med. 2015;372:426–435.
    • (2015) N Engl J Med , vol.372 , pp. 426-435
    • Vannucchi, A.M.1    Kiladjian, J.J.2    Griesshammer, M.3
  • 21
    • 84863393110 scopus 로고    scopus 로고
    • A double-blind, placebo-controlled trial of ruxolitinib for myelofibrosis
    • S.Verstovsek, R.A.Mesa, J.Gotlib, et al. A double-blind, placebo-controlled trial of ruxolitinib for myelofibrosis. N Engl J Med. 2012;366:799–807.•• COMFORT-I Trial.
    • (2012) N Engl J Med , vol.366 , pp. 799-807
    • Verstovsek, S.1    Mesa, R.A.2    Gotlib, J.3
  • 22
    • 84984635819 scopus 로고    scopus 로고
    • [cited 2012 Aug]. Available from
    • European Medicines Agency Summary of Product Characteristics on ruxolotinib. Jakavi [Internet]. Novartis Pharmaceuticals UK Ltd. [cited 2012 Aug]. Available from:http://www.ema.europa.eu/docs/en_GB/document_library/EPAR_-_Product_Information/human/002464/WC500133223.pdf
    • Jakavi [Internet]. Novartis Pharmaceuticals UK Ltd
  • 23
    • 84857837774 scopus 로고    scopus 로고
    • JAK inhibition with ruxolitinib versus best available therapy for myelofibrosis
    • C.Harrison, J.J.Kiladjian, H.K.Al-Ali, et al. JAK inhibition with ruxolitinib versus best available therapy for myelofibrosis. N Engl J Med. 2012;366:787–798.•• COMFORT-II Trial.
    • (2012) N Engl J Med , vol.366 , pp. 787-798
    • Harrison, C.1    Kiladjian, J.J.2    Al-Ali, H.K.3
  • 24
    • 84926337489 scopus 로고    scopus 로고
    • Efficacy, safety, and survival with ruxolitinib in patients with myelofibrosis: results of a median 3-year follow-up of COMFORT-I
    • S.Verstovsek, R.A.Mesa, J.Gotlib, et al. Efficacy, safety, and survival with ruxolitinib in patients with myelofibrosis:results of a median 3-year follow-up of COMFORT-I. Haematologica. 2015;100:479–488.
    • (2015) Haematologica , vol.100 , pp. 479-488
    • Verstovsek, S.1    Mesa, R.A.2    Gotlib, J.3
  • 25
    • 84891303523 scopus 로고    scopus 로고
    • Three-year efficacy, safety, and survival findings from COMFORT-II, a phase 3 study comparing ruxolitinib with best available therapy for myelofibrosis
    • F.Cervantes, A.M.Vannucchi, J.J.Kiladjian, et al. Three-year efficacy, safety, and survival findings from COMFORT-II, a phase 3 study comparing ruxolitinib with best available therapy for myelofibrosis. Blood. 2013;122:4047–4053.
    • (2013) Blood , vol.122 , pp. 4047-4053
    • Cervantes, F.1    Vannucchi, A.M.2    Kiladjian, J.J.3
  • 26
    • 77956696835 scopus 로고    scopus 로고
    • Safety and efficacy of INCB018424, a JAK1 and JAK2 inhibitor, in myelofibrosis
    • S.Verstovsek, H.Kantarjian, R.A.Mesa, et al. Safety and efficacy of INCB018424, a JAK1 and JAK2 inhibitor, in myelofibrosis. N Engl J Med. 2010;363:1117–1127.
    • (2010) N Engl J Med , vol.363 , pp. 1117-1127
    • Verstovsek, S.1    Kantarjian, H.2    Mesa, R.A.3
  • 27
    • 84940912122 scopus 로고    scopus 로고
    • A pooled analysis of overall survival in COMFORT-I and COMFORT-II, 2 randomized phase III trials of ruxolitinib for the treatment of myelofibrosis
    • A.M.Vannucchi, H.M.Kantarjian, J.J.Kiladjian, et al. A pooled analysis of overall survival in COMFORT-I and COMFORT-II, 2 randomized phase III trials of ruxolitinib for the treatment of myelofibrosis. Haematologica. 2015;100:1139–1145.• Pooled analysis of COMFORT Trials.
    • (2015) Haematologica , vol.100 , pp. 1139-1145
    • Vannucchi, A.M.1    Kantarjian, H.M.2    Kiladjian, J.J.3
  • 28
    • 84899056972 scopus 로고    scopus 로고
    • Associazione Italiana per la Ricerca sul Cancro Gruppo Italiano Malattie Mieloproliferative (AGIMM) Investigators. Impact of mutational status on outcomes in myelofibrosis patients treated with ruxolitinib in the COMFORT-II study
    • P.Guglielmelli, F.Biamonte, G.Rotunno, et al.; COMFORT-II Investigators. Associazione Italiana per la Ricerca sul Cancro Gruppo Italiano Malattie Mieloproliferative (AGIMM) Investigators. Impact of mutational status on outcomes in myelofibrosis patients treated with ruxolitinib in the COMFORT-II study. Blood. 2014;123:2157–2160.
    • (2014) Blood , vol.123 , pp. 2157-2160
    • Guglielmelli, P.1    Biamonte, F.2    Rotunno, G.3
  • 29
    • 84978024581 scopus 로고    scopus 로고
    • The use of erythropoiesis-stimulating agents with ruxolitinib in patients with myelofibrosis in COMFORT-II: an open-label, phase 3 study assessing efficacy and safety of ruxolitinib versus best available therapy in the treatment of myelofibrosis
    • M.F.McMullin, C.N.Harrison, D.Niederwieser, et al. The use of erythropoiesis-stimulating agents with ruxolitinib in patients with myelofibrosis in COMFORT-II:an open-label, phase 3 study assessing efficacy and safety of ruxolitinib versus best available therapy in the treatment of myelofibrosis. Exp Hematol Oncol. 2015;4:26.
    • (2015) Exp Hematol Oncol , vol.4 , pp. 26
    • McMullin, M.F.1    Harrison, C.N.2    Niederwieser, D.3
  • 30
    • 84892882122 scopus 로고    scopus 로고
    • Ruxolinitinib is a potent immunosuppressive compound: is it time for anti-infective prophylaxis?
    • A.Heine, P.Brossart, D.Wolf. Ruxolinitinib is a potent immunosuppressive compound:is it time for anti-infective prophylaxis? Blood. 2013;122:3843–3844.•• Immunosuppressive effects of ruxolitinib.
    • (2013) Blood , vol.122
    • Heine, A.1    Brossart, P.2    Wolf, D.3
  • 31
    • 84891853911 scopus 로고    scopus 로고
    • Reactivation of hepatitis B virus infection following ruxolitinib treatment in a patient with myelofibrosis
    • G.Caocci, F.Murgia, L.Podda, et al. Reactivation of hepatitis B virus infection following ruxolitinib treatment in a patient with myelofibrosis. Leukemia. 2014;28:225–227.
    • (2014) Leukemia , vol.28 , pp. 225-227
    • Caocci, G.1    Murgia, F.2    Podda, L.3
  • 32
    • 84880323178 scopus 로고    scopus 로고
    • Progressive multifocal leukoencephalopathy associated with ruxolitinib
    • R.Wathes, S.Moule, D.Milojkovic. Progressive multifocal leukoencephalopathy associated with ruxolitinib. N Engl J Med. 2013;369:197–198.
    • (2013) N Engl J Med , vol.369 , pp. 197-198
    • Wathes, R.1    Moule, S.2    Milojkovic, D.3
  • 33
    • 84941736772 scopus 로고    scopus 로고
    • JAK inhibition induces silencing of T helper cytokine secretion and a profound reduction in T regulatory cells
    • C.Keohane, S.Kordasti, T.Seidl, et al. JAK inhibition induces silencing of T helper cytokine secretion and a profound reduction in T regulatory cells. Br J Haematol. 2015;171:60–73.
    • (2015) Br J Haematol , vol.171 , pp. 60-73
    • Keohane, C.1    Kordasti, S.2    Seidl, T.3
  • 34
    • 84902657461 scopus 로고    scopus 로고
    • The JAK1/JAK2 inhibitor ruxolitinib substantially affects NK cell biology
    • K.Schonberg, J.Rudolph, I.Cornez, et al. The JAK1/JAK2 inhibitor ruxolitinib substantially affects NK cell biology. Blood. 2013;122:16.
    • (2013) Blood , vol.122 , pp. 16
    • Schonberg, K.1    Rudolph, J.2    Cornez, I.3
  • 35
    • 84887193830 scopus 로고    scopus 로고
    • The JAK-inhibitor ruxolitinib impairs dendritic cell function in vitro and in vivo
    • A.Heine, S.A.Held, S.N.Daecke, et al. The JAK-inhibitor ruxolitinib impairs dendritic cell function in vitro and in vivo. Blood. 2013;122:1192–1202.
    • (2013) Blood , vol.122 , pp. 1192-1202
    • Heine, A.1    Held, S.A.2    Daecke, S.N.3
  • 36
    • 83155182714 scopus 로고    scopus 로고
    • Serious adverse events during ruxolitinib treatment discontinuation in patients with myelofibrosis
    • A.Tefferi, A.Pardanani. Serious adverse events during ruxolitinib treatment discontinuation in patients with myelofibrosis. Mayo Clin Proc. 2011;86:1188–1191.
    • (2011) Mayo Clin Proc , vol.86 , pp. 1188-1191
    • Tefferi, A.1    Pardanani, A.2
  • 37
    • 84865192181 scopus 로고    scopus 로고
    • Long-term outcomes of 107 patients with myelofibrosis receiving JAK1/JAK2 inhibitor ruxolitinib: survival advantage in comparison to matched historical controls
    • S.Verstovsek, H.M.Kantarjian, Z.Estrov, et al. Long-term outcomes of 107 patients with myelofibrosis receiving JAK1/JAK2 inhibitor ruxolitinib:survival advantage in comparison to matched historical controls. Blood. 2012;120:1202–1209.
    • (2012) Blood , vol.120 , pp. 1202-1209
    • Verstovsek, S.1    Kantarjian, H.M.2    Estrov, Z.3
  • 38
    • 84908887878 scopus 로고    scopus 로고
    • Development of extramedullary sites of leukaemia during ruxolitinib therapy for myelofibrosis
    • M.Kremyanskaya, J.Mascarenhas, R.Rampal, et al. Development of extramedullary sites of leukaemia during ruxolitinib therapy for myelofibrosis. Br J Haematol. 2014;167:144–146.
    • (2014) Br J Haematol , vol.167 , pp. 144-146
    • Kremyanskaya, M.1    Mascarenhas, J.2    Rampal, R.3
  • 39
    • 84924784206 scopus 로고    scopus 로고
    • Response to ruxolitinib in patients with intermediate-1, intermediate-2 and high-risk myelofibrosis: results of the UK Robust trial
    • A.Mead, R.Clark, J.Chacko, et al. Response to ruxolitinib in patients with intermediate-1, intermediate-2 and high-risk myelofibrosis:results of the UK Robust trial. Br J Haematol. 2015;170:29–39.
    • (2015) Br J Haematol , vol.170 , pp. 29-39
    • Mead, A.1    Clark, R.2    Chacko, J.3
  • 40
    • 84984662415 scopus 로고    scopus 로고
    • Safety and efficacy of ruxolitinib retreatment after treatment interruption in patients enrolled in an open-label, multicenter, expanded-access study in myelofibrosis
    • V.Gupta, R.S.Tavares, M.Griesshammer, et al. Safety and efficacy of ruxolitinib retreatment after treatment interruption in patients enrolled in an open-label, multicenter, expanded-access study in myelofibrosis. Blood. 2014;124:5567.
    • (2014) Blood , vol.124 , pp. 5567
    • Gupta, V.1    Tavares, R.S.2    Griesshammer, M.3
  • 41
    • 84896984163 scopus 로고    scopus 로고
    • Update on the long-term efficacy and safety of momelotinib, a JAK1 and JAK2 inhibitor, for the treatment of myelofibrosis
    • J.Gotlib, V.Gupta, A.W.Roberts, et al. Update on the long-term efficacy and safety of momelotinib, a JAK1 and JAK2 inhibitor, for the treatment of myelofibrosis. Blood. 2013;122:108.• Phase 1/2 study of momelotinib for treatment of myelofibrosis.
    • (2013) Blood , vol.122 , pp. 108
    • Gotlib, J.1    Gupta, V.2    Roberts, A.W.3
  • 42
    • 84924965031 scopus 로고    scopus 로고
    • Momelotinib treatment-emergent neuropathy: prevalence, risk factors and outcome in 100 patients with myelofibrosis
    • R.A.Abdelrahman, K.H.Begna, A.Al-Kali, et al. Momelotinib treatment-emergent neuropathy:prevalence, risk factors and outcome in 100 patients with myelofibrosis. Br J Haematol. 2015;169:77–80.
    • (2015) Br J Haematol , vol.169 , pp. 77-80
    • Abdelrahman, R.A.1    Begna, K.H.2    Al-Kali, A.3
  • 43
    • 84928901823 scopus 로고    scopus 로고
    • Results of a phase 2 study of pacritinib (SB1518), a JAK2/JAK2(V617F) inhibitor, in patients with myelofibrosis
    • R.S.Komrokji, J.F.Seymour, A.W.Roberts, et al. Results of a phase 2 study of pacritinib (SB1518), a JAK2/JAK2(V617F) inhibitor, in patients with myelofibrosis. Blood. 2015;125:2649–2655.
    • (2015) Blood , vol.125 , pp. 2649-2655
    • Komrokji, R.S.1    Seymour, J.F.2    Roberts, A.W.3
  • 44
    • 84942120079 scopus 로고    scopus 로고
    • Results of the PERSIST-1 phase III study of pacritinib (PAC) versus best available therapy (BAT) in primary myelofibrosis (PMF), post-polycythemia vera myelofibrosis (PPV-MF), or post-essential thrombocythemia-myelofibrosis (PET-MF)
    • R.Mesa, E.Miklos, A.Szoke, et al. Results of the PERSIST-1 phase III study of pacritinib (PAC) versus best available therapy (BAT) in primary myelofibrosis (PMF), post-polycythemia vera myelofibrosis (PPV-MF), or post-essential thrombocythemia-myelofibrosis (PET-MF). J Clin Oncol. 2015;33(suppl; abstr LBA7006).
    • (2015) J Clin Oncol , vol.33
    • Mesa, R.1    Miklos, E.2    Szoke, A.3
  • 45
    • 84984648882 scopus 로고    scopus 로고
    • Available from
    • CTI BioPharma Provides Update On Investigational Agent Pacritinb [Internet]. [cited 2016 Feb]. Available from:http://www.prnewswire.com/news-releases/cti-biopharma-provides-update-on-investigational-agent-pacritinib-300216412.html.•• Recent clinical hold put on pacritinib due to deaths in pacritinib-treated cohort.
  • 46
    • 84964694744 scopus 로고    scopus 로고
    • Safety and efficacy of fedratinib in patients with primary or secondary myelofibrosis: a randomized clinical trial
    • A.Pardanani, C.Harrison, J.E.Cortes, et al. Safety and efficacy of fedratinib in patients with primary or secondary myelofibrosis:a randomized clinical trial. JAMA Oncol. 2015;1:643–651.
    • (2015) JAMA Oncol , vol.1 , pp. 643-651
    • Pardanani, A.1    Harrison, C.2    Cortes, J.E.3
  • 47
    • 84907912086 scopus 로고    scopus 로고
    • The Janus kinase 2 inhibitor fedratinib inhibits thiamine uptake: a putative mechanism for the onset of Wernicke’s encephalopathy
    • Q.Zhang, Y.Zhang, S.Diamond, et al. The Janus kinase 2 inhibitor fedratinib inhibits thiamine uptake:a putative mechanism for the onset of Wernicke’s encephalopathy. Drug Metab Dispos. 2014;42(10):1656–1662.
    • (2014) Drug Metab Dispos , vol.42 , Issue.10 , pp. 1656-1662
    • Zhang, Q.1    Zhang, Y.2    Diamond, S.3
  • 49
    • 0024212665 scopus 로고
    • Management of polcythaemia vera, essential thrombocythaemia, and myelofibrosis with hydroxyurea
    • E.Lofvenberg, A.Wahlin. Management of polcythaemia vera, essential thrombocythaemia, and myelofibrosis with hydroxyurea. Eur J Haematol. 1988;41:375–381.
    • (1988) Eur J Haematol , vol.41 , pp. 375-381
    • Lofvenberg, E.1    Wahlin, A.2
  • 50
    • 78549245112 scopus 로고    scopus 로고
    • Efficacy and tolerability of hydroxyurea in the treatment of the hyperproliferative manifestations of myelofibrosis: results in 40 patients
    • A.Martínez-Trillos, A.Gaya, M.Maffioli, et al. Efficacy and tolerability of hydroxyurea in the treatment of the hyperproliferative manifestations of myelofibrosis:results in 40 patients. Ann Hematol. 2010;89:1233–1237.
    • (2010) Ann Hematol , vol.89 , pp. 1233-1237
    • Martínez-Trillos, A.1    Gaya, A.2    Maffioli, M.3
  • 51
    • 33748205495 scopus 로고    scopus 로고
    • International Working Group consensus criteria for treatment response in myelofibrosis with myeloid metaplasia: on behalf of the IWG for myelofibrosis research and treatment (IWG-MRT)
    • A.Tefferi, G.Barosi, R.A.Mesa, et al. International Working Group consensus criteria for treatment response in myelofibrosis with myeloid metaplasia:on behalf of the IWG for myelofibrosis research and treatment (IWG-MRT). Blood. 2006;108:1497–1503.
    • (2006) Blood , vol.108 , pp. 1497-1503
    • Tefferi, A.1    Barosi, G.2    Mesa, R.A.3
  • 52
    • 20244370678 scopus 로고    scopus 로고
    • Melphalan treatment in patients with myelofibrosis with myeloid metaplasia
    • M.C.Petti, R.Latagliata, T.Spadea, et al. Melphalan treatment in patients with myelofibrosis with myeloid metaplasia. Br J Haematol. 2002;116:576–581.
    • (2002) Br J Haematol , vol.116 , pp. 576-581
    • Petti, M.C.1    Latagliata, R.2    Spadea, T.3
  • 53
    • 54049141336 scopus 로고    scopus 로고
    • Pegylated interferon-alfa-2a induces complete hematologic and molecular responses with low toxicity in polycythemia vera
    • J.J.Kiladjian, B.Cassinat, S.Chevret, et al. Pegylated interferon-alfa-2a induces complete hematologic and molecular responses with low toxicity in polycythemia vera. Blood. 2008;112:3065–3072.
    • (2008) Blood , vol.112 , pp. 3065-3072
    • Kiladjian, J.J.1    Cassinat, B.2    Chevret, S.3
  • 54
    • 56249104095 scopus 로고    scopus 로고
    • Inerferon-alpha therapy in bcr-abl-negative myeloproliferative neoplasms
    • J.J.Kiladjian, C.Chomienne, P.Fenaux. Inerferon-alpha therapy in bcr-abl-negative myeloproliferative neoplasms. Leukaemia. 2008;22:1990–1998.
    • (2008) Leukaemia , vol.22 , pp. 1990-1998
    • Kiladjian, J.J.1    Chomienne, C.2    Fenaux, P.3
  • 55
    • 23844552419 scopus 로고    scopus 로고
    • Guidelines for the diagnosis, investigation and management of polycythaemia/erythrocytosis
    • M.F.McMullin, D.Bareford, P.Campbell, et al. Guidelines for the diagnosis, investigation and management of polycythaemia/erythrocytosis. Br J Haematol. 2005;130:174–195.
    • (2005) Br J Haematol , vol.130 , pp. 174-195
    • McMullin, M.F.1    Bareford, D.2    Campbell, P.3
  • 56
    • 77950809860 scopus 로고    scopus 로고
    • Guideline for investigation and management of adults and children presenting with a thrombocytosis
    • C.N.Harrison, D.Bareford, N.Butt, et al. Guideline for investigation and management of adults and children presenting with a thrombocytosis. Br J Haematol. 2010;149:352–375.
    • (2010) Br J Haematol , vol.149 , pp. 352-375
    • Harrison, C.N.1    Bareford, D.2    Butt, N.3
  • 57
    • 0037040869 scopus 로고    scopus 로고
    • Activation of the p38 mitogen-activated protein kinase mediates the suppressive effects of type 1 interferons and transforming growth factor-beta on normal haematopoiesis
    • A.Verma, D.K.Deb, A.Sassano, et al. Activation of the p38 mitogen-activated protein kinase mediates the suppressive effects of type 1 interferons and transforming growth factor-beta on normal haematopoiesis. J Biol Chem. 2002;277:7726–7735.
    • (2002) J Biol Chem , vol.277 , pp. 7726-7735
    • Verma, A.1    Deb, D.K.2    Sassano, A.3
  • 58
    • 79955947379 scopus 로고    scopus 로고
    • The renaissance of interferon therapy for the treatment of myeloid malignancies
    • J.J.Kiladjian, R.A.Mesa, R.Hoffman. The renaissance of interferon therapy for the treatment of myeloid malignancies. Blood. 2011;117:4706–4715.
    • (2011) Blood , vol.117 , pp. 4706-4715
    • Kiladjian, J.J.1    Mesa, R.A.2    Hoffman, R.3
  • 59
    • 79959232873 scopus 로고    scopus 로고
    • Recombinant interferon-alpha may retard progression of early primary myelofibrosis: a preliminary report
    • R.T.Silver, K.Vandris, J.J.Goldman. Recombinant interferon-alpha may retard progression of early primary myelofibrosis:a preliminary report. Blood. 2011;117:6669–6672.
    • (2011) Blood , vol.117 , pp. 6669-6672
    • Silver, R.T.1    Vandris, K.2    Goldman, J.J.3
  • 60
    • 84883282867 scopus 로고    scopus 로고
    • Efficacy and safety of pegylated-interferon a-2a in myelofibrosis: a study by the FIM and GEM French cooperative groups
    • J.C.Ianotto, F.Boyer-Perrard. Efficacy and safety of pegylated-interferon a-2a in myelofibrosis:a study by the FIM and GEM French cooperative groups. Br J Haematol. 2013;162:783–791.• Outcomes of interferon use in myelofibrosis.
    • (2013) Br J Haematol , vol.162 , pp. 783-791
    • Ianotto, J.C.1    Boyer-Perrard, F.2
  • 61
    • 0035134688 scopus 로고    scopus 로고
    • Interferon in oncological practice: review of interferon biology, clinical applications, and toxicities
    • E.Jonasch, F.Haluska. Interferon in oncological practice:review of interferon biology, clinical applications, and toxicities. Oncologist. 2001;6(1):34–55.
    • (2001) Oncologist , vol.6 , Issue.1 , pp. 34-55
    • Jonasch, E.1    Haluska, F.2
  • 62
    • 84988816713 scopus 로고    scopus 로고
    • Safety and efficacy of combination therapy of interferon-alpha2 + JAK1-2 inhibitor in the Philadelphia-negative chronic myeloproliferative neoplasms. Preliminary results from the Danish combi-trial – an open label, single arm, non-randomized multicenter phase II study
    • [abstract]
    • S.Mikkelsen, L.Kjaer, V.Skov, et al. Safety and efficacy of combination therapy of interferon-alpha2 + JAK1-2 inhibitor in the Philadelphia-negative chronic myeloproliferative neoplasms. Preliminary results from the Danish combi-trial – an open label, single arm, non-randomized multicenter phase II study [abstract]. Blood. 2015;126:824.
    • (2015) Blood , vol.126
    • Mikkelsen, S.1    Kjaer, L.2    Skov, V.3
  • 63
    • 0031171663 scopus 로고    scopus 로고
    • Effects of thalidomide and related metabolites in a mouse corneal model of neovascularization
    • B.M.Kenton, F.Browne, R.J.D’Amato. Effects of thalidomide and related metabolites in a mouse corneal model of neovascularization. Exp Eye Res. 1997;64:971–978.
    • (1997) Exp Eye Res , vol.64 , pp. 971-978
    • Kenton, B.M.1    Browne, F.2    D’Amato, R.J.3
  • 64
    • 0012889254 scopus 로고    scopus 로고
    • A phase 2 trial of combination low-dose thalidomide and prednisone for the treatment of myelofibrosis with myeloid metaplasia
    • R.A.Mesa, D.P.Steensma, A.Pardanani, et al. A phase 2 trial of combination low-dose thalidomide and prednisone for the treatment of myelofibrosis with myeloid metaplasia. Blood. 2003;101:2534–2541.
    • (2003) Blood , vol.101 , pp. 2534-2541
    • Mesa, R.A.1    Steensma, D.P.2    Pardanani, A.3
  • 65
    • 78650355146 scopus 로고    scopus 로고
    • International working group for myelofibrosis research and treatment response assessment and long-term follow-up of 50 myelofibrosis patients treated with thalidomide-prednisone based regimens
    • P.Thapaliya, A.Tefferi, A.Pardanani, et al. International working group for myelofibrosis research and treatment response assessment and long-term follow-up of 50 myelofibrosis patients treated with thalidomide-prednisone based regimens. Am J Hematol. 2011;86:96–98.
    • (2011) Am J Hematol , vol.86 , pp. 96-98
    • Thapaliya, P.1    Tefferi, A.2    Pardanani, A.3
  • 66
    • 33747167338 scopus 로고    scopus 로고
    • Lenalidomide therapy in myelofibrosis with myeloid metaplasia
    • A.Tefferi, J.Cortes, S.Verstovsek, et al. Lenalidomide therapy in myelofibrosis with myeloid metaplasia. Blood. 2006;108:1158–1164.
    • (2006) Blood , vol.108 , pp. 1158-1164
    • Tefferi, A.1    Cortes, J.2    Verstovsek, S.3
  • 67
    • 78649475876 scopus 로고    scopus 로고
    • Lenalidomide and prednisolone for myelofibrosis: Eastern Cooperative Oncology Group (ECOG) phase 2 trial E4903
    • R.Mesa, X.Yao, L.D.Cripe, et al. Lenalidomide and prednisolone for myelofibrosis:Eastern Cooperative Oncology Group (ECOG) phase 2 trial E4903. Blood. 2010;116:4436–4438.
    • (2010) Blood , vol.116 , pp. 4436-4438
    • Mesa, R.1    Yao, X.2    Cripe, L.D.3
  • 68
    • 71949121402 scopus 로고    scopus 로고
    • Pomalidomide is active in the treatment of anaemia associated with myelofibrosis
    • A.Tefferi, S.Verstovsek, G.Barosi, et al. Pomalidomide is active in the treatment of anaemia associated with myelofibrosis. J Clin Oncol. 2009;27:4563–4569.
    • (2009) J Clin Oncol , vol.27 , pp. 4563-4569
    • Tefferi, A.1    Verstovsek, S.2    Barosi, G.3
  • 69
    • 84896968737 scopus 로고    scopus 로고
    • Phase 3 study of pomalidomide in myeloproliferative neoplasm (MPN)-associated myelofibrosis with RBC-transfusion-dependence
    • [abstract]
    • A.Tefferi, F.Passamonti, T.Barbui, et al. Phase 3 study of pomalidomide in myeloproliferative neoplasm (MPN)-associated myelofibrosis with RBC-transfusion-dependence [abstract]. Blood. 2013;122:394.
    • (2013) Blood , vol.122
    • Tefferi, A.1    Passamonti, F.2    Barbui, T.3
  • 70
    • 0029906904 scopus 로고    scopus 로고
    • Treatment of agnogenic myeloid metaplasia with danazol: a report of four cases
    • V.Levy, A.Bourgarit, A.Delmer, et al. Treatment of agnogenic myeloid metaplasia with danazol:a report of four cases. Am J Hematol. 1996;53:239–241.
    • (1996) Am J Hematol , vol.53 , pp. 239-241
    • Levy, V.1    Bourgarit, A.2    Delmer, A.3
  • 71
    • 21344468831 scopus 로고    scopus 로고
    • Efficacy and tolerability of danazol as a treatment for the anaemia of myelofibrosis with myeloid metaplasia: long-term results in 30 patients
    • F.Cervantes, A.Alvarez-Larran, A.Domingo, et al. Efficacy and tolerability of danazol as a treatment for the anaemia of myelofibrosis with myeloid metaplasia:long-term results in 30 patients. Br J Haematol. 2005;129:771–775.
    • (2005) Br J Haematol , vol.129 , pp. 771-775
    • Cervantes, F.1    Alvarez-Larran, A.2    Domingo, A.3
  • 72
    • 18844467494 scopus 로고    scopus 로고
    • Danazol treatment of idiopathic myelofibrosis with severe anaemia
    • F.Cervantes, J.C.Hernandez-Boluda, A.Alvarez, et al. Danazol treatment of idiopathic myelofibrosis with severe anaemia. Haematologica. 2000;85:595–599.
    • (2000) Haematologica , vol.85 , pp. 595-599
    • Cervantes, F.1    Hernandez-Boluda, J.C.2    Alvarez, A.3
  • 73
    • 33947691295 scopus 로고    scopus 로고
    • Recombinant human erythropoietin for the treatment of anaemia in patients with chronic idiopathic myelofibrosis
    • S.N.Tsiara, A.Chaidos, L.K.Bourantas, et al. Recombinant human erythropoietin for the treatment of anaemia in patients with chronic idiopathic myelofibrosis. Acta Haematol. 2007;117:156–161.
    • (2007) Acta Haematol , vol.117 , pp. 156-161
    • Tsiara, S.N.1    Chaidos, A.2    Bourantas, L.K.3
  • 74
    • 33745149293 scopus 로고    scopus 로고
    • Darbepoetin-alpha for the anaemia of myelofibrosis with myeloid metaplasia
    • F.Cervantes, A.Alvarez-Larrán, J.C.Hernández-Boluda, et al. Darbepoetin-alpha for the anaemia of myelofibrosis with myeloid metaplasia. Br J Haematol. 2006;134:184–186.
    • (2006) Br J Haematol , vol.134 , pp. 184-186
    • Cervantes, F.1    Alvarez-Larrán, A.2    Hernández-Boluda, J.C.3
  • 75
    • 84936939904 scopus 로고    scopus 로고
    • Improvement of bone marrow fibrosis with ruxolitinib: will this finding change our perception of the drug?
    • M.Breccia, M.Molica, G.Colafigli, et al. Improvement of bone marrow fibrosis with ruxolitinib:will this finding change our perception of the drug? Expert Rev Hematol. 2015;8(4):387–389.
    • (2015) Expert Rev Hematol , vol.8 , Issue.4 , pp. 387-389
    • Breccia, M.1    Molica, M.2    Colafigli, G.3
  • 76
    • 84905990634 scopus 로고    scopus 로고
    • Clinical effect of driver mutations of JAK2, CALR, or MPL in primary myelofibrosis
    • E.Rumi, D.Pietra, C.Pascutto, et al. Clinical effect of driver mutations of JAK2, CALR, or MPL in primary myelofibrosis. Blood. 2014;124:1062–1069.• Effect of key mutations on survival in myelofibrosis.
    • (2014) Blood , vol.124 , pp. 1062-1069
    • Rumi, E.1    Pietra, D.2    Pascutto, C.3
  • 77
    • 84924585836 scopus 로고    scopus 로고
    • Genetic determinants of response and survival in momelotinib-treated patients with myelofibrosis
    • A.Pardanani, R.A.Abdelrahman, C.Finke, et al. Genetic determinants of response and survival in momelotinib-treated patients with myelofibrosis. Leukemia. 2015;29:741–744.
    • (2015) Leukemia , vol.29 , pp. 741-744
    • Pardanani, A.1    Abdelrahman, R.A.2    Finke, C.3
  • 78
    • 84940099833 scopus 로고    scopus 로고
    • Correlation of mutation profile and response in patients with myelofibrosis treated with ruxolitinib
    • K.P.Patel, K.J.Newberry, R.Luthra, et al. Correlation of mutation profile and response in patients with myelofibrosis treated with ruxolitinib. Blood. 2015;126:790–797.
    • (2015) Blood , vol.126 , pp. 790-797
    • Patel, K.P.1    Newberry, K.J.2    Luthra, R.3
  • 80
    • 84865735256 scopus 로고    scopus 로고
    • Heterodimeric JAK-STAT activation as a mechanism of persistence to JAK2 inhibitor therapy
    • P.Koppikar, N.Bhagwat, O.Kipivaara, et al. Heterodimeric JAK-STAT activation as a mechanism of persistence to JAK2 inhibitor therapy. Nature. 2012;489:155–159.
    • (2012) Nature , vol.489 , pp. 155-159
    • Koppikar, P.1    Bhagwat, N.2    Kipivaara, O.3
  • 81
    • 84893812843 scopus 로고    scopus 로고
    • Allogeneic hematopoietic cell transplantation for myelofibrosis in patients pretreated with the JAK1 and JAK2 inhibitor ruxolitinib
    • N.Jaekel, G.Behre, A.Behning, et al. Allogeneic hematopoietic cell transplantation for myelofibrosis in patients pretreated with the JAK1 and JAK2 inhibitor ruxolitinib. Bone Marrow Transplant. 2014;49:179–184.•• Ruxolitinib use prior to allogeneic bone marrow transplantation.
    • (2014) Bone Marrow Transplant , vol.49 , pp. 179-184
    • Jaekel, N.1    Behre, G.2    Behning, A.3
  • 82
    • 84902652715 scopus 로고    scopus 로고
    • Ruxolitinib before allogeneic hematopoietic stem cell transplantation (HSCT) in patients with myelofibrosis: a preliminary descriptive report of the JAK ALLO study, a phase II trial sponsored by Goelams-FIM in collaboration with the Sfgmtc
    • M.Robin, S.Francois, A.Huynh, et al. Ruxolitinib before allogeneic hematopoietic stem cell transplantation (HSCT) in patients with myelofibrosis:a preliminary descriptive report of the JAK ALLO study, a phase II trial sponsored by Goelams-FIM in collaboration with the Sfgmtc. Blood. 2013;122:306.
    • (2013) Blood , vol.122 , pp. 306
    • Robin, M.1    Francois, S.2    Huynh, A.3
  • 83
    • 84943582032 scopus 로고    scopus 로고
    • Ruxolitinib in corticosteroid-refractory graft-versus-host disease after allogeneic stem cell transplantation: a multicenter survey
    • R.Zeiser, A.Burchert, C.Lengerke, et al. Ruxolitinib in corticosteroid-refractory graft-versus-host disease after allogeneic stem cell transplantation:a multicenter survey. Leukaemia. 2015;29:2062–2068.•• Ruxolitinib as a potential treatment for graft versus host disease.
    • (2015) Leukaemia , vol.29 , pp. 2062-2068
    • Zeiser, R.1    Burchert, A.2    Lengerke, C.3


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