-
1
-
-
77956537218
-
Primary myelofibrosis
-
Swerdlow S.H., Campo E., Harris N.L., (eds), Lyon: IARC
-
J.Thiele, H.M.Kvasnicka, A.Tefferi, et al. Primary myelofibrosis. In:S.H.Swerdlow, E.Campo, N.L.Harris, et al., editors. WHO classification of tumours of haematopoietic and lymphoid tissues. Lyon:IARC; 2008. p. 44–47.
-
(2008)
WHO classification of tumours of haematopoietic and lymphoid tissues
, pp. 44-47
-
-
Thiele, J.1
Kvasnicka, H.M.2
Tefferi, A.3
-
2
-
-
84908243201
-
How I treat myelofibrosis
-
F.Cervantes How I treat myelofibrosis. Blood. 2014;124:2635–2642.
-
(2014)
Blood
, vol.124
, pp. 2635-2642
-
-
Cervantes, F.1
-
3
-
-
84864300766
-
British committee for standards in haematology, guideline for the diagnosis and management of myelofibrosis
-
J.T.Reilly, M.F.McMullin, P.A.Beer, et al. British committee for standards in haematology, guideline for the diagnosis and management of myelofibrosis. Br J Haematol. 2012;158:453–471.
-
(2012)
Br J Haematol
, vol.158
, pp. 453-471
-
-
Reilly, J.T.1
McMullin, M.F.2
Beer, P.A.3
-
4
-
-
0032916213
-
Population-based incidence and survival figures in essential thrombocythemia and agnogenic myeloid metaplasia: an Olmsted County study, 1976–1995
-
R.A.Mesa, M.N.Silverstein, S.J.Jacobsen, et al. Population-based incidence and survival figures in essential thrombocythemia and agnogenic myeloid metaplasia:an Olmsted County study, 1976–1995. Am J Hematol. 1999;61:10–15.
-
(1999)
Am J Hematol
, vol.61
, pp. 10-15
-
-
Mesa, R.A.1
Silverstein, M.N.2
Jacobsen, S.J.3
-
5
-
-
17844383458
-
A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia vera
-
C.James, V.Ugo, J.P.Le Couedic, et al. A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia vera. Nature. 2005;434:1144–1148.
-
(2005)
Nature
, vol.434
, pp. 1144-1148
-
-
James, C.1
Ugo, V.2
Le Couedic, J.P.3
-
6
-
-
84904042955
-
CALR vs JAK2 vs MPL-mutated or triple-negative myelofibrosis: clinical, cytogenetic and molecular comparisons
-
A.Tefferi, T.L.Lasho, C.M.Finke, et al. CALR vs JAK2 vs MPL-mutated or triple-negative myelofibrosis:clinical, cytogenetic and molecular comparisons. Leukemia. 2014;28:1472–1477.
-
(2014)
Leukemia
, vol.28
, pp. 1472-1477
-
-
Tefferi, A.1
Lasho, T.L.2
Finke, C.M.3
-
7
-
-
84890328032
-
Somatic CALR mutations in myeloproliferative neoplasms with nonmutated JAK2
-
J.Nangalia, C.E.Massie, E.J.Baxter, et al. Somatic CALR mutations in myeloproliferative neoplasms with nonmutated JAK2. N Engl J Med. 2013;369:2391–2405.
-
(2013)
N Engl J Med
, vol.369
, pp. 2391-2405
-
-
Nangalia, J.1
Massie, C.E.2
Baxter, E.J.3
-
8
-
-
84890372480
-
Somatic mutations of calreticulin in myeloproliferative neoplasms
-
T.Klampfl, H.Gisslinger, A.S.Harutyunyan, et al. Somatic mutations of calreticulin in myeloproliferative neoplasms. N Engl J Med. 2013;369:2379–2390.
-
(2013)
N Engl J Med
, vol.369
, pp. 2379-2390
-
-
Klampfl, T.1
Gisslinger, H.2
Harutyunyan, A.S.3
-
9
-
-
84908065771
-
The prognostic advantage of calreticulin mutations in myelofibrosis might be confined to type 1 or type 1-like CALR variants
-
A.Tefferi, T.L.Lasho, A.Tischer, et al. The prognostic advantage of calreticulin mutations in myelofibrosis might be confined to type 1 or type 1-like CALR variants. Blood. 2014;124:2465–2466.
-
(2014)
Blood
, vol.124
, pp. 2465-2466
-
-
Tefferi, A.1
Lasho, T.L.2
Tischer, A.3
-
10
-
-
84901714382
-
Integrated genomic analysis illustrates the central role of JAK-STAT pathway activation in myeloproliferative neoplasm pathogenesis
-
R.Rampal, F.Al-Shahrour, O.Abdel-Wahab, et al. Integrated genomic analysis illustrates the central role of JAK-STAT pathway activation in myeloproliferative neoplasm pathogenesis. Blood. 2014;123:123–133.
-
(2014)
Blood
, vol.123
, pp. 123-133
-
-
Rampal, R.1
Al-Shahrour, F.2
Abdel-Wahab, O.3
-
11
-
-
84960851640
-
Thrombopoietin receptor activation by myeloproliferative neoplasm associated calreticulin mutants
-
I.Chachoua, C.Pecquet, M.El-Khoury, et al. Thrombopoietin receptor activation by myeloproliferative neoplasm associated calreticulin mutants. Blood. 2016;127:1325–1335.
-
(2016)
Blood
, vol.127
, pp. 1325-1335
-
-
Chachoua, I.1
Pecquet, C.2
El-Khoury, M.3
-
12
-
-
63849328927
-
New prognostic scoring system for primary myelofibrosis based on a study of the International Working Group for Myelofibrosis Research and Treatment
-
F.Cervantes, B.Dupriez, A.Pereira, et al. New prognostic scoring system for primary myelofibrosis based on a study of the International Working Group for Myelofibrosis Research and Treatment. Blood. 2009;113:2895–2901.
-
(2009)
Blood
, vol.113
, pp. 2895-2901
-
-
Cervantes, F.1
Dupriez, B.2
Pereira, A.3
-
13
-
-
77950352432
-
A dynamic prognostic model to predict survival in primary myelofibrosis: a study by the IWG-MRT (International Working Group for Myeloproliferative Neoplasms Research and Treatment)
-
F.Passamonti, F.Cervantes, A.M.Vannucchi, et al. A dynamic prognostic model to predict survival in primary myelofibrosis:a study by the IWG-MRT (International Working Group for Myeloproliferative Neoplasms Research and Treatment). Blood. 2010;115:1703–1708.
-
(2010)
Blood
, vol.115
, pp. 1703-1708
-
-
Passamonti, F.1
Cervantes, F.2
Vannucchi, A.M.3
-
14
-
-
79952087335
-
DIPSS plus: a refined Dynamic International Prognostic Scoring System for primary myelofibrosis that incorporates prognostic information from karyotype, platelet count, and transfusion status
-
N.Gangat, D.Caramazza, R.Vaidya, et al. DIPSS plus:a refined Dynamic International Prognostic Scoring System for primary myelofibrosis that incorporates prognostic information from karyotype, platelet count, and transfusion status. J Clin Oncol. 2011;29:392–397.
-
(2011)
J Clin Oncol
, vol.29
, pp. 392-397
-
-
Gangat, N.1
Caramazza, D.2
Vaidya, R.3
-
15
-
-
80055075486
-
Predictors of greater than 80% 2-year mortality in primary myelofibrosis: a Mayo Clinic study of 884 karyotypically annotated patients
-
A.Tefferi, T.Jimma, N.Gangat, et al. Predictors of greater than 80% 2-year mortality in primary myelofibrosis:a Mayo Clinic study of 884 karyotypically annotated patients. Blood. 2011;118:4595–459.
-
(2011)
Blood
, vol.118
, pp. 4459-4595
-
-
Tefferi, A.1
Jimma, T.2
Gangat, N.3
-
16
-
-
84904056081
-
CALR and ASXL1 mutations-based molecular prognostication in primary myelofibrosis: an international study of 570 patients
-
A.Tefferi, P.Guglielmelli, T.L.Lasho, et al. CALR and ASXL1 mutations-based molecular prognostication in primary myelofibrosis:an international study of 570 patients. Leukemia. 2014;28:1494–1500.
-
(2014)
Leukemia
, vol.28
, pp. 1494-1500
-
-
Tefferi, A.1
Guglielmelli, P.2
Lasho, T.L.3
-
17
-
-
84930006828
-
Impact of allogeneic stem cell transplantation on survival of patients less than 65 years of age with primary myelofibrosis
-
N.Kröger, T.Giorgino, B.L.Scott, et al. Impact of allogeneic stem cell transplantation on survival of patients less than 65 years of age with primary myelofibrosis. Blood. 2015;125:3347–3350.
-
(2015)
Blood
, vol.125
, pp. 3347-3350
-
-
Kröger, N.1
Giorgino, T.2
Scott, B.L.3
-
18
-
-
84946496578
-
Indication and management of allogeneic stem cell transplantation in primary myelofibrosis: a consensus process by an EBMT/ELN international working group
-
N.Kröger, J.H.Deeg, E.Olavarria, et al. Indication and management of allogeneic stem cell transplantation in primary myelofibrosis:a consensus process by an EBMT/ELN international working group. Leukaemia. 2015;29:2126–2133.
-
(2015)
Leukaemia
, vol.29
, pp. 2126-2133
-
-
Kröger, N.1
Deeg, J.H.2
Olavarria, E.3
-
19
-
-
84912000790
-
Use of JAK inhibitors in the management of myelofibrosis: a revision of the British Committee for Standards in Haematology Guidelines for Investigation and Management of Myelofibrosis 2012
-
J.T.Reilly, M.F.McMullin, P.A.Beer, et al. Use of JAK inhibitors in the management of myelofibrosis:a revision of the British Committee for Standards in Haematology Guidelines for Investigation and Management of Myelofibrosis 2012. Br J Haematol. 2014;167:418–420.•• Updated guideline recommending ruxolitinib as first-line treatment for myelofibrosis.
-
(2014)
Br J Haematol
, vol.167
, pp. 418-420
-
-
Reilly, J.T.1
McMullin, M.F.2
Beer, P.A.3
-
20
-
-
84921891315
-
Ruxolitinib versus standard therapy for the treatment of polycythemia vera
-
A.M.Vannucchi, J.J.Kiladjian, M.Griesshammer, et al. Ruxolitinib versus standard therapy for the treatment of polycythemia vera. N Engl J Med. 2015;372:426–435.
-
(2015)
N Engl J Med
, vol.372
, pp. 426-435
-
-
Vannucchi, A.M.1
Kiladjian, J.J.2
Griesshammer, M.3
-
21
-
-
84863393110
-
A double-blind, placebo-controlled trial of ruxolitinib for myelofibrosis
-
S.Verstovsek, R.A.Mesa, J.Gotlib, et al. A double-blind, placebo-controlled trial of ruxolitinib for myelofibrosis. N Engl J Med. 2012;366:799–807.•• COMFORT-I Trial.
-
(2012)
N Engl J Med
, vol.366
, pp. 799-807
-
-
Verstovsek, S.1
Mesa, R.A.2
Gotlib, J.3
-
22
-
-
84984635819
-
-
[cited 2012 Aug]. Available from
-
European Medicines Agency Summary of Product Characteristics on ruxolotinib. Jakavi [Internet]. Novartis Pharmaceuticals UK Ltd. [cited 2012 Aug]. Available from:http://www.ema.europa.eu/docs/en_GB/document_library/EPAR_-_Product_Information/human/002464/WC500133223.pdf
-
Jakavi [Internet]. Novartis Pharmaceuticals UK Ltd
-
-
-
23
-
-
84857837774
-
JAK inhibition with ruxolitinib versus best available therapy for myelofibrosis
-
C.Harrison, J.J.Kiladjian, H.K.Al-Ali, et al. JAK inhibition with ruxolitinib versus best available therapy for myelofibrosis. N Engl J Med. 2012;366:787–798.•• COMFORT-II Trial.
-
(2012)
N Engl J Med
, vol.366
, pp. 787-798
-
-
Harrison, C.1
Kiladjian, J.J.2
Al-Ali, H.K.3
-
24
-
-
84926337489
-
Efficacy, safety, and survival with ruxolitinib in patients with myelofibrosis: results of a median 3-year follow-up of COMFORT-I
-
S.Verstovsek, R.A.Mesa, J.Gotlib, et al. Efficacy, safety, and survival with ruxolitinib in patients with myelofibrosis:results of a median 3-year follow-up of COMFORT-I. Haematologica. 2015;100:479–488.
-
(2015)
Haematologica
, vol.100
, pp. 479-488
-
-
Verstovsek, S.1
Mesa, R.A.2
Gotlib, J.3
-
25
-
-
84891303523
-
Three-year efficacy, safety, and survival findings from COMFORT-II, a phase 3 study comparing ruxolitinib with best available therapy for myelofibrosis
-
F.Cervantes, A.M.Vannucchi, J.J.Kiladjian, et al. Three-year efficacy, safety, and survival findings from COMFORT-II, a phase 3 study comparing ruxolitinib with best available therapy for myelofibrosis. Blood. 2013;122:4047–4053.
-
(2013)
Blood
, vol.122
, pp. 4047-4053
-
-
Cervantes, F.1
Vannucchi, A.M.2
Kiladjian, J.J.3
-
26
-
-
77956696835
-
Safety and efficacy of INCB018424, a JAK1 and JAK2 inhibitor, in myelofibrosis
-
S.Verstovsek, H.Kantarjian, R.A.Mesa, et al. Safety and efficacy of INCB018424, a JAK1 and JAK2 inhibitor, in myelofibrosis. N Engl J Med. 2010;363:1117–1127.
-
(2010)
N Engl J Med
, vol.363
, pp. 1117-1127
-
-
Verstovsek, S.1
Kantarjian, H.2
Mesa, R.A.3
-
27
-
-
84940912122
-
A pooled analysis of overall survival in COMFORT-I and COMFORT-II, 2 randomized phase III trials of ruxolitinib for the treatment of myelofibrosis
-
A.M.Vannucchi, H.M.Kantarjian, J.J.Kiladjian, et al. A pooled analysis of overall survival in COMFORT-I and COMFORT-II, 2 randomized phase III trials of ruxolitinib for the treatment of myelofibrosis. Haematologica. 2015;100:1139–1145.• Pooled analysis of COMFORT Trials.
-
(2015)
Haematologica
, vol.100
, pp. 1139-1145
-
-
Vannucchi, A.M.1
Kantarjian, H.M.2
Kiladjian, J.J.3
-
28
-
-
84899056972
-
Associazione Italiana per la Ricerca sul Cancro Gruppo Italiano Malattie Mieloproliferative (AGIMM) Investigators. Impact of mutational status on outcomes in myelofibrosis patients treated with ruxolitinib in the COMFORT-II study
-
P.Guglielmelli, F.Biamonte, G.Rotunno, et al.; COMFORT-II Investigators. Associazione Italiana per la Ricerca sul Cancro Gruppo Italiano Malattie Mieloproliferative (AGIMM) Investigators. Impact of mutational status on outcomes in myelofibrosis patients treated with ruxolitinib in the COMFORT-II study. Blood. 2014;123:2157–2160.
-
(2014)
Blood
, vol.123
, pp. 2157-2160
-
-
Guglielmelli, P.1
Biamonte, F.2
Rotunno, G.3
-
29
-
-
84978024581
-
The use of erythropoiesis-stimulating agents with ruxolitinib in patients with myelofibrosis in COMFORT-II: an open-label, phase 3 study assessing efficacy and safety of ruxolitinib versus best available therapy in the treatment of myelofibrosis
-
M.F.McMullin, C.N.Harrison, D.Niederwieser, et al. The use of erythropoiesis-stimulating agents with ruxolitinib in patients with myelofibrosis in COMFORT-II:an open-label, phase 3 study assessing efficacy and safety of ruxolitinib versus best available therapy in the treatment of myelofibrosis. Exp Hematol Oncol. 2015;4:26.
-
(2015)
Exp Hematol Oncol
, vol.4
, pp. 26
-
-
McMullin, M.F.1
Harrison, C.N.2
Niederwieser, D.3
-
30
-
-
84892882122
-
Ruxolinitinib is a potent immunosuppressive compound: is it time for anti-infective prophylaxis?
-
A.Heine, P.Brossart, D.Wolf. Ruxolinitinib is a potent immunosuppressive compound:is it time for anti-infective prophylaxis? Blood. 2013;122:3843–3844.•• Immunosuppressive effects of ruxolitinib.
-
(2013)
Blood
, vol.122
-
-
Heine, A.1
Brossart, P.2
Wolf, D.3
-
31
-
-
84891853911
-
Reactivation of hepatitis B virus infection following ruxolitinib treatment in a patient with myelofibrosis
-
G.Caocci, F.Murgia, L.Podda, et al. Reactivation of hepatitis B virus infection following ruxolitinib treatment in a patient with myelofibrosis. Leukemia. 2014;28:225–227.
-
(2014)
Leukemia
, vol.28
, pp. 225-227
-
-
Caocci, G.1
Murgia, F.2
Podda, L.3
-
32
-
-
84880323178
-
Progressive multifocal leukoencephalopathy associated with ruxolitinib
-
R.Wathes, S.Moule, D.Milojkovic. Progressive multifocal leukoencephalopathy associated with ruxolitinib. N Engl J Med. 2013;369:197–198.
-
(2013)
N Engl J Med
, vol.369
, pp. 197-198
-
-
Wathes, R.1
Moule, S.2
Milojkovic, D.3
-
33
-
-
84941736772
-
JAK inhibition induces silencing of T helper cytokine secretion and a profound reduction in T regulatory cells
-
C.Keohane, S.Kordasti, T.Seidl, et al. JAK inhibition induces silencing of T helper cytokine secretion and a profound reduction in T regulatory cells. Br J Haematol. 2015;171:60–73.
-
(2015)
Br J Haematol
, vol.171
, pp. 60-73
-
-
Keohane, C.1
Kordasti, S.2
Seidl, T.3
-
34
-
-
84902657461
-
The JAK1/JAK2 inhibitor ruxolitinib substantially affects NK cell biology
-
K.Schonberg, J.Rudolph, I.Cornez, et al. The JAK1/JAK2 inhibitor ruxolitinib substantially affects NK cell biology. Blood. 2013;122:16.
-
(2013)
Blood
, vol.122
, pp. 16
-
-
Schonberg, K.1
Rudolph, J.2
Cornez, I.3
-
35
-
-
84887193830
-
The JAK-inhibitor ruxolitinib impairs dendritic cell function in vitro and in vivo
-
A.Heine, S.A.Held, S.N.Daecke, et al. The JAK-inhibitor ruxolitinib impairs dendritic cell function in vitro and in vivo. Blood. 2013;122:1192–1202.
-
(2013)
Blood
, vol.122
, pp. 1192-1202
-
-
Heine, A.1
Held, S.A.2
Daecke, S.N.3
-
36
-
-
83155182714
-
Serious adverse events during ruxolitinib treatment discontinuation in patients with myelofibrosis
-
A.Tefferi, A.Pardanani. Serious adverse events during ruxolitinib treatment discontinuation in patients with myelofibrosis. Mayo Clin Proc. 2011;86:1188–1191.
-
(2011)
Mayo Clin Proc
, vol.86
, pp. 1188-1191
-
-
Tefferi, A.1
Pardanani, A.2
-
37
-
-
84865192181
-
Long-term outcomes of 107 patients with myelofibrosis receiving JAK1/JAK2 inhibitor ruxolitinib: survival advantage in comparison to matched historical controls
-
S.Verstovsek, H.M.Kantarjian, Z.Estrov, et al. Long-term outcomes of 107 patients with myelofibrosis receiving JAK1/JAK2 inhibitor ruxolitinib:survival advantage in comparison to matched historical controls. Blood. 2012;120:1202–1209.
-
(2012)
Blood
, vol.120
, pp. 1202-1209
-
-
Verstovsek, S.1
Kantarjian, H.M.2
Estrov, Z.3
-
38
-
-
84908887878
-
Development of extramedullary sites of leukaemia during ruxolitinib therapy for myelofibrosis
-
M.Kremyanskaya, J.Mascarenhas, R.Rampal, et al. Development of extramedullary sites of leukaemia during ruxolitinib therapy for myelofibrosis. Br J Haematol. 2014;167:144–146.
-
(2014)
Br J Haematol
, vol.167
, pp. 144-146
-
-
Kremyanskaya, M.1
Mascarenhas, J.2
Rampal, R.3
-
39
-
-
84924784206
-
Response to ruxolitinib in patients with intermediate-1, intermediate-2 and high-risk myelofibrosis: results of the UK Robust trial
-
A.Mead, R.Clark, J.Chacko, et al. Response to ruxolitinib in patients with intermediate-1, intermediate-2 and high-risk myelofibrosis:results of the UK Robust trial. Br J Haematol. 2015;170:29–39.
-
(2015)
Br J Haematol
, vol.170
, pp. 29-39
-
-
Mead, A.1
Clark, R.2
Chacko, J.3
-
40
-
-
84984662415
-
Safety and efficacy of ruxolitinib retreatment after treatment interruption in patients enrolled in an open-label, multicenter, expanded-access study in myelofibrosis
-
V.Gupta, R.S.Tavares, M.Griesshammer, et al. Safety and efficacy of ruxolitinib retreatment after treatment interruption in patients enrolled in an open-label, multicenter, expanded-access study in myelofibrosis. Blood. 2014;124:5567.
-
(2014)
Blood
, vol.124
, pp. 5567
-
-
Gupta, V.1
Tavares, R.S.2
Griesshammer, M.3
-
41
-
-
84896984163
-
Update on the long-term efficacy and safety of momelotinib, a JAK1 and JAK2 inhibitor, for the treatment of myelofibrosis
-
J.Gotlib, V.Gupta, A.W.Roberts, et al. Update on the long-term efficacy and safety of momelotinib, a JAK1 and JAK2 inhibitor, for the treatment of myelofibrosis. Blood. 2013;122:108.• Phase 1/2 study of momelotinib for treatment of myelofibrosis.
-
(2013)
Blood
, vol.122
, pp. 108
-
-
Gotlib, J.1
Gupta, V.2
Roberts, A.W.3
-
42
-
-
84924965031
-
Momelotinib treatment-emergent neuropathy: prevalence, risk factors and outcome in 100 patients with myelofibrosis
-
R.A.Abdelrahman, K.H.Begna, A.Al-Kali, et al. Momelotinib treatment-emergent neuropathy:prevalence, risk factors and outcome in 100 patients with myelofibrosis. Br J Haematol. 2015;169:77–80.
-
(2015)
Br J Haematol
, vol.169
, pp. 77-80
-
-
Abdelrahman, R.A.1
Begna, K.H.2
Al-Kali, A.3
-
43
-
-
84928901823
-
Results of a phase 2 study of pacritinib (SB1518), a JAK2/JAK2(V617F) inhibitor, in patients with myelofibrosis
-
R.S.Komrokji, J.F.Seymour, A.W.Roberts, et al. Results of a phase 2 study of pacritinib (SB1518), a JAK2/JAK2(V617F) inhibitor, in patients with myelofibrosis. Blood. 2015;125:2649–2655.
-
(2015)
Blood
, vol.125
, pp. 2649-2655
-
-
Komrokji, R.S.1
Seymour, J.F.2
Roberts, A.W.3
-
44
-
-
84942120079
-
Results of the PERSIST-1 phase III study of pacritinib (PAC) versus best available therapy (BAT) in primary myelofibrosis (PMF), post-polycythemia vera myelofibrosis (PPV-MF), or post-essential thrombocythemia-myelofibrosis (PET-MF)
-
R.Mesa, E.Miklos, A.Szoke, et al. Results of the PERSIST-1 phase III study of pacritinib (PAC) versus best available therapy (BAT) in primary myelofibrosis (PMF), post-polycythemia vera myelofibrosis (PPV-MF), or post-essential thrombocythemia-myelofibrosis (PET-MF). J Clin Oncol. 2015;33(suppl; abstr LBA7006).
-
(2015)
J Clin Oncol
, vol.33
-
-
Mesa, R.1
Miklos, E.2
Szoke, A.3
-
45
-
-
84984648882
-
-
Available from
-
CTI BioPharma Provides Update On Investigational Agent Pacritinb [Internet]. [cited 2016 Feb]. Available from:http://www.prnewswire.com/news-releases/cti-biopharma-provides-update-on-investigational-agent-pacritinib-300216412.html.•• Recent clinical hold put on pacritinib due to deaths in pacritinib-treated cohort.
-
-
-
-
46
-
-
84964694744
-
Safety and efficacy of fedratinib in patients with primary or secondary myelofibrosis: a randomized clinical trial
-
A.Pardanani, C.Harrison, J.E.Cortes, et al. Safety and efficacy of fedratinib in patients with primary or secondary myelofibrosis:a randomized clinical trial. JAMA Oncol. 2015;1:643–651.
-
(2015)
JAMA Oncol
, vol.1
, pp. 643-651
-
-
Pardanani, A.1
Harrison, C.2
Cortes, J.E.3
-
47
-
-
84907912086
-
The Janus kinase 2 inhibitor fedratinib inhibits thiamine uptake: a putative mechanism for the onset of Wernicke’s encephalopathy
-
Q.Zhang, Y.Zhang, S.Diamond, et al. The Janus kinase 2 inhibitor fedratinib inhibits thiamine uptake:a putative mechanism for the onset of Wernicke’s encephalopathy. Drug Metab Dispos. 2014;42(10):1656–1662.
-
(2014)
Drug Metab Dispos
, vol.42
, Issue.10
, pp. 1656-1662
-
-
Zhang, Q.1
Zhang, Y.2
Diamond, S.3
-
49
-
-
0024212665
-
Management of polcythaemia vera, essential thrombocythaemia, and myelofibrosis with hydroxyurea
-
E.Lofvenberg, A.Wahlin. Management of polcythaemia vera, essential thrombocythaemia, and myelofibrosis with hydroxyurea. Eur J Haematol. 1988;41:375–381.
-
(1988)
Eur J Haematol
, vol.41
, pp. 375-381
-
-
Lofvenberg, E.1
Wahlin, A.2
-
50
-
-
78549245112
-
Efficacy and tolerability of hydroxyurea in the treatment of the hyperproliferative manifestations of myelofibrosis: results in 40 patients
-
A.Martínez-Trillos, A.Gaya, M.Maffioli, et al. Efficacy and tolerability of hydroxyurea in the treatment of the hyperproliferative manifestations of myelofibrosis:results in 40 patients. Ann Hematol. 2010;89:1233–1237.
-
(2010)
Ann Hematol
, vol.89
, pp. 1233-1237
-
-
Martínez-Trillos, A.1
Gaya, A.2
Maffioli, M.3
-
51
-
-
33748205495
-
International Working Group consensus criteria for treatment response in myelofibrosis with myeloid metaplasia: on behalf of the IWG for myelofibrosis research and treatment (IWG-MRT)
-
A.Tefferi, G.Barosi, R.A.Mesa, et al. International Working Group consensus criteria for treatment response in myelofibrosis with myeloid metaplasia:on behalf of the IWG for myelofibrosis research and treatment (IWG-MRT). Blood. 2006;108:1497–1503.
-
(2006)
Blood
, vol.108
, pp. 1497-1503
-
-
Tefferi, A.1
Barosi, G.2
Mesa, R.A.3
-
52
-
-
20244370678
-
Melphalan treatment in patients with myelofibrosis with myeloid metaplasia
-
M.C.Petti, R.Latagliata, T.Spadea, et al. Melphalan treatment in patients with myelofibrosis with myeloid metaplasia. Br J Haematol. 2002;116:576–581.
-
(2002)
Br J Haematol
, vol.116
, pp. 576-581
-
-
Petti, M.C.1
Latagliata, R.2
Spadea, T.3
-
53
-
-
54049141336
-
Pegylated interferon-alfa-2a induces complete hematologic and molecular responses with low toxicity in polycythemia vera
-
J.J.Kiladjian, B.Cassinat, S.Chevret, et al. Pegylated interferon-alfa-2a induces complete hematologic and molecular responses with low toxicity in polycythemia vera. Blood. 2008;112:3065–3072.
-
(2008)
Blood
, vol.112
, pp. 3065-3072
-
-
Kiladjian, J.J.1
Cassinat, B.2
Chevret, S.3
-
54
-
-
56249104095
-
Inerferon-alpha therapy in bcr-abl-negative myeloproliferative neoplasms
-
J.J.Kiladjian, C.Chomienne, P.Fenaux. Inerferon-alpha therapy in bcr-abl-negative myeloproliferative neoplasms. Leukaemia. 2008;22:1990–1998.
-
(2008)
Leukaemia
, vol.22
, pp. 1990-1998
-
-
Kiladjian, J.J.1
Chomienne, C.2
Fenaux, P.3
-
55
-
-
23844552419
-
Guidelines for the diagnosis, investigation and management of polycythaemia/erythrocytosis
-
M.F.McMullin, D.Bareford, P.Campbell, et al. Guidelines for the diagnosis, investigation and management of polycythaemia/erythrocytosis. Br J Haematol. 2005;130:174–195.
-
(2005)
Br J Haematol
, vol.130
, pp. 174-195
-
-
McMullin, M.F.1
Bareford, D.2
Campbell, P.3
-
56
-
-
77950809860
-
Guideline for investigation and management of adults and children presenting with a thrombocytosis
-
C.N.Harrison, D.Bareford, N.Butt, et al. Guideline for investigation and management of adults and children presenting with a thrombocytosis. Br J Haematol. 2010;149:352–375.
-
(2010)
Br J Haematol
, vol.149
, pp. 352-375
-
-
Harrison, C.N.1
Bareford, D.2
Butt, N.3
-
57
-
-
0037040869
-
Activation of the p38 mitogen-activated protein kinase mediates the suppressive effects of type 1 interferons and transforming growth factor-beta on normal haematopoiesis
-
A.Verma, D.K.Deb, A.Sassano, et al. Activation of the p38 mitogen-activated protein kinase mediates the suppressive effects of type 1 interferons and transforming growth factor-beta on normal haematopoiesis. J Biol Chem. 2002;277:7726–7735.
-
(2002)
J Biol Chem
, vol.277
, pp. 7726-7735
-
-
Verma, A.1
Deb, D.K.2
Sassano, A.3
-
58
-
-
79955947379
-
The renaissance of interferon therapy for the treatment of myeloid malignancies
-
J.J.Kiladjian, R.A.Mesa, R.Hoffman. The renaissance of interferon therapy for the treatment of myeloid malignancies. Blood. 2011;117:4706–4715.
-
(2011)
Blood
, vol.117
, pp. 4706-4715
-
-
Kiladjian, J.J.1
Mesa, R.A.2
Hoffman, R.3
-
59
-
-
79959232873
-
Recombinant interferon-alpha may retard progression of early primary myelofibrosis: a preliminary report
-
R.T.Silver, K.Vandris, J.J.Goldman. Recombinant interferon-alpha may retard progression of early primary myelofibrosis:a preliminary report. Blood. 2011;117:6669–6672.
-
(2011)
Blood
, vol.117
, pp. 6669-6672
-
-
Silver, R.T.1
Vandris, K.2
Goldman, J.J.3
-
60
-
-
84883282867
-
Efficacy and safety of pegylated-interferon a-2a in myelofibrosis: a study by the FIM and GEM French cooperative groups
-
J.C.Ianotto, F.Boyer-Perrard. Efficacy and safety of pegylated-interferon a-2a in myelofibrosis:a study by the FIM and GEM French cooperative groups. Br J Haematol. 2013;162:783–791.• Outcomes of interferon use in myelofibrosis.
-
(2013)
Br J Haematol
, vol.162
, pp. 783-791
-
-
Ianotto, J.C.1
Boyer-Perrard, F.2
-
61
-
-
0035134688
-
Interferon in oncological practice: review of interferon biology, clinical applications, and toxicities
-
E.Jonasch, F.Haluska. Interferon in oncological practice:review of interferon biology, clinical applications, and toxicities. Oncologist. 2001;6(1):34–55.
-
(2001)
Oncologist
, vol.6
, Issue.1
, pp. 34-55
-
-
Jonasch, E.1
Haluska, F.2
-
62
-
-
84988816713
-
Safety and efficacy of combination therapy of interferon-alpha2 + JAK1-2 inhibitor in the Philadelphia-negative chronic myeloproliferative neoplasms. Preliminary results from the Danish combi-trial – an open label, single arm, non-randomized multicenter phase II study
-
[abstract]
-
S.Mikkelsen, L.Kjaer, V.Skov, et al. Safety and efficacy of combination therapy of interferon-alpha2 + JAK1-2 inhibitor in the Philadelphia-negative chronic myeloproliferative neoplasms. Preliminary results from the Danish combi-trial – an open label, single arm, non-randomized multicenter phase II study [abstract]. Blood. 2015;126:824.
-
(2015)
Blood
, vol.126
-
-
Mikkelsen, S.1
Kjaer, L.2
Skov, V.3
-
63
-
-
0031171663
-
Effects of thalidomide and related metabolites in a mouse corneal model of neovascularization
-
B.M.Kenton, F.Browne, R.J.D’Amato. Effects of thalidomide and related metabolites in a mouse corneal model of neovascularization. Exp Eye Res. 1997;64:971–978.
-
(1997)
Exp Eye Res
, vol.64
, pp. 971-978
-
-
Kenton, B.M.1
Browne, F.2
D’Amato, R.J.3
-
64
-
-
0012889254
-
A phase 2 trial of combination low-dose thalidomide and prednisone for the treatment of myelofibrosis with myeloid metaplasia
-
R.A.Mesa, D.P.Steensma, A.Pardanani, et al. A phase 2 trial of combination low-dose thalidomide and prednisone for the treatment of myelofibrosis with myeloid metaplasia. Blood. 2003;101:2534–2541.
-
(2003)
Blood
, vol.101
, pp. 2534-2541
-
-
Mesa, R.A.1
Steensma, D.P.2
Pardanani, A.3
-
65
-
-
78650355146
-
International working group for myelofibrosis research and treatment response assessment and long-term follow-up of 50 myelofibrosis patients treated with thalidomide-prednisone based regimens
-
P.Thapaliya, A.Tefferi, A.Pardanani, et al. International working group for myelofibrosis research and treatment response assessment and long-term follow-up of 50 myelofibrosis patients treated with thalidomide-prednisone based regimens. Am J Hematol. 2011;86:96–98.
-
(2011)
Am J Hematol
, vol.86
, pp. 96-98
-
-
Thapaliya, P.1
Tefferi, A.2
Pardanani, A.3
-
66
-
-
33747167338
-
Lenalidomide therapy in myelofibrosis with myeloid metaplasia
-
A.Tefferi, J.Cortes, S.Verstovsek, et al. Lenalidomide therapy in myelofibrosis with myeloid metaplasia. Blood. 2006;108:1158–1164.
-
(2006)
Blood
, vol.108
, pp. 1158-1164
-
-
Tefferi, A.1
Cortes, J.2
Verstovsek, S.3
-
67
-
-
78649475876
-
Lenalidomide and prednisolone for myelofibrosis: Eastern Cooperative Oncology Group (ECOG) phase 2 trial E4903
-
R.Mesa, X.Yao, L.D.Cripe, et al. Lenalidomide and prednisolone for myelofibrosis:Eastern Cooperative Oncology Group (ECOG) phase 2 trial E4903. Blood. 2010;116:4436–4438.
-
(2010)
Blood
, vol.116
, pp. 4436-4438
-
-
Mesa, R.1
Yao, X.2
Cripe, L.D.3
-
68
-
-
71949121402
-
Pomalidomide is active in the treatment of anaemia associated with myelofibrosis
-
A.Tefferi, S.Verstovsek, G.Barosi, et al. Pomalidomide is active in the treatment of anaemia associated with myelofibrosis. J Clin Oncol. 2009;27:4563–4569.
-
(2009)
J Clin Oncol
, vol.27
, pp. 4563-4569
-
-
Tefferi, A.1
Verstovsek, S.2
Barosi, G.3
-
69
-
-
84896968737
-
Phase 3 study of pomalidomide in myeloproliferative neoplasm (MPN)-associated myelofibrosis with RBC-transfusion-dependence
-
[abstract]
-
A.Tefferi, F.Passamonti, T.Barbui, et al. Phase 3 study of pomalidomide in myeloproliferative neoplasm (MPN)-associated myelofibrosis with RBC-transfusion-dependence [abstract]. Blood. 2013;122:394.
-
(2013)
Blood
, vol.122
-
-
Tefferi, A.1
Passamonti, F.2
Barbui, T.3
-
70
-
-
0029906904
-
Treatment of agnogenic myeloid metaplasia with danazol: a report of four cases
-
V.Levy, A.Bourgarit, A.Delmer, et al. Treatment of agnogenic myeloid metaplasia with danazol:a report of four cases. Am J Hematol. 1996;53:239–241.
-
(1996)
Am J Hematol
, vol.53
, pp. 239-241
-
-
Levy, V.1
Bourgarit, A.2
Delmer, A.3
-
71
-
-
21344468831
-
Efficacy and tolerability of danazol as a treatment for the anaemia of myelofibrosis with myeloid metaplasia: long-term results in 30 patients
-
F.Cervantes, A.Alvarez-Larran, A.Domingo, et al. Efficacy and tolerability of danazol as a treatment for the anaemia of myelofibrosis with myeloid metaplasia:long-term results in 30 patients. Br J Haematol. 2005;129:771–775.
-
(2005)
Br J Haematol
, vol.129
, pp. 771-775
-
-
Cervantes, F.1
Alvarez-Larran, A.2
Domingo, A.3
-
72
-
-
18844467494
-
Danazol treatment of idiopathic myelofibrosis with severe anaemia
-
F.Cervantes, J.C.Hernandez-Boluda, A.Alvarez, et al. Danazol treatment of idiopathic myelofibrosis with severe anaemia. Haematologica. 2000;85:595–599.
-
(2000)
Haematologica
, vol.85
, pp. 595-599
-
-
Cervantes, F.1
Hernandez-Boluda, J.C.2
Alvarez, A.3
-
73
-
-
33947691295
-
Recombinant human erythropoietin for the treatment of anaemia in patients with chronic idiopathic myelofibrosis
-
S.N.Tsiara, A.Chaidos, L.K.Bourantas, et al. Recombinant human erythropoietin for the treatment of anaemia in patients with chronic idiopathic myelofibrosis. Acta Haematol. 2007;117:156–161.
-
(2007)
Acta Haematol
, vol.117
, pp. 156-161
-
-
Tsiara, S.N.1
Chaidos, A.2
Bourantas, L.K.3
-
74
-
-
33745149293
-
Darbepoetin-alpha for the anaemia of myelofibrosis with myeloid metaplasia
-
F.Cervantes, A.Alvarez-Larrán, J.C.Hernández-Boluda, et al. Darbepoetin-alpha for the anaemia of myelofibrosis with myeloid metaplasia. Br J Haematol. 2006;134:184–186.
-
(2006)
Br J Haematol
, vol.134
, pp. 184-186
-
-
Cervantes, F.1
Alvarez-Larrán, A.2
Hernández-Boluda, J.C.3
-
75
-
-
84936939904
-
Improvement of bone marrow fibrosis with ruxolitinib: will this finding change our perception of the drug?
-
M.Breccia, M.Molica, G.Colafigli, et al. Improvement of bone marrow fibrosis with ruxolitinib:will this finding change our perception of the drug? Expert Rev Hematol. 2015;8(4):387–389.
-
(2015)
Expert Rev Hematol
, vol.8
, Issue.4
, pp. 387-389
-
-
Breccia, M.1
Molica, M.2
Colafigli, G.3
-
76
-
-
84905990634
-
Clinical effect of driver mutations of JAK2, CALR, or MPL in primary myelofibrosis
-
E.Rumi, D.Pietra, C.Pascutto, et al. Clinical effect of driver mutations of JAK2, CALR, or MPL in primary myelofibrosis. Blood. 2014;124:1062–1069.• Effect of key mutations on survival in myelofibrosis.
-
(2014)
Blood
, vol.124
, pp. 1062-1069
-
-
Rumi, E.1
Pietra, D.2
Pascutto, C.3
-
77
-
-
84924585836
-
Genetic determinants of response and survival in momelotinib-treated patients with myelofibrosis
-
A.Pardanani, R.A.Abdelrahman, C.Finke, et al. Genetic determinants of response and survival in momelotinib-treated patients with myelofibrosis. Leukemia. 2015;29:741–744.
-
(2015)
Leukemia
, vol.29
, pp. 741-744
-
-
Pardanani, A.1
Abdelrahman, R.A.2
Finke, C.3
-
78
-
-
84940099833
-
Correlation of mutation profile and response in patients with myelofibrosis treated with ruxolitinib
-
K.P.Patel, K.J.Newberry, R.Luthra, et al. Correlation of mutation profile and response in patients with myelofibrosis treated with ruxolitinib. Blood. 2015;126:790–797.
-
(2015)
Blood
, vol.126
, pp. 790-797
-
-
Patel, K.P.1
Newberry, K.J.2
Luthra, R.3
-
80
-
-
84865735256
-
Heterodimeric JAK-STAT activation as a mechanism of persistence to JAK2 inhibitor therapy
-
P.Koppikar, N.Bhagwat, O.Kipivaara, et al. Heterodimeric JAK-STAT activation as a mechanism of persistence to JAK2 inhibitor therapy. Nature. 2012;489:155–159.
-
(2012)
Nature
, vol.489
, pp. 155-159
-
-
Koppikar, P.1
Bhagwat, N.2
Kipivaara, O.3
-
81
-
-
84893812843
-
Allogeneic hematopoietic cell transplantation for myelofibrosis in patients pretreated with the JAK1 and JAK2 inhibitor ruxolitinib
-
N.Jaekel, G.Behre, A.Behning, et al. Allogeneic hematopoietic cell transplantation for myelofibrosis in patients pretreated with the JAK1 and JAK2 inhibitor ruxolitinib. Bone Marrow Transplant. 2014;49:179–184.•• Ruxolitinib use prior to allogeneic bone marrow transplantation.
-
(2014)
Bone Marrow Transplant
, vol.49
, pp. 179-184
-
-
Jaekel, N.1
Behre, G.2
Behning, A.3
-
82
-
-
84902652715
-
Ruxolitinib before allogeneic hematopoietic stem cell transplantation (HSCT) in patients with myelofibrosis: a preliminary descriptive report of the JAK ALLO study, a phase II trial sponsored by Goelams-FIM in collaboration with the Sfgmtc
-
M.Robin, S.Francois, A.Huynh, et al. Ruxolitinib before allogeneic hematopoietic stem cell transplantation (HSCT) in patients with myelofibrosis:a preliminary descriptive report of the JAK ALLO study, a phase II trial sponsored by Goelams-FIM in collaboration with the Sfgmtc. Blood. 2013;122:306.
-
(2013)
Blood
, vol.122
, pp. 306
-
-
Robin, M.1
Francois, S.2
Huynh, A.3
-
83
-
-
84943582032
-
Ruxolitinib in corticosteroid-refractory graft-versus-host disease after allogeneic stem cell transplantation: a multicenter survey
-
R.Zeiser, A.Burchert, C.Lengerke, et al. Ruxolitinib in corticosteroid-refractory graft-versus-host disease after allogeneic stem cell transplantation:a multicenter survey. Leukaemia. 2015;29:2062–2068.•• Ruxolitinib as a potential treatment for graft versus host disease.
-
(2015)
Leukaemia
, vol.29
, pp. 2062-2068
-
-
Zeiser, R.1
Burchert, A.2
Lengerke, C.3
|