Novel unbiased assay for circulating podocyte-toxic factors associated with recurrent focal segmental glomerulosclerosis

American Journal of Physiology - Renal Physiology

Volumn 310, Issue 10, 2016, Pages F1148-F1156

  Kachurina, Nadezda ^a   Chung, Chen Fang ^a   Benderoff, Erin ^a   Babayeva, Sima ^a   Bitzan, Martin ^b   Goodyer, Paul ^b,c   Kitzler, Thomas ^c   Matar, Dany ^d   Cybulsky, Andrey V ^a   Alachkar, Nada ^e   Torban, Elena ^a  

^a MCGILL UNIVERSITY   (Canada)

^b MONTREAL CHILDREN S HOSPITAL   (Canada)

^c MCGILL UNIVERSITY   (Canada)

^d MCKINSEY AND COMPANY   (United States)

^e JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Idiopathic focal segmental glomerulosclerosis; Renal allograft

Indexed keywords

DOXORUBICIN; TUMOR NECROSIS FACTOR; VINCULIN; TOXIN;

ACTIN FILAMENT; ADOLESCENT; ADULT; ARTICLE; CLINICAL ARTICLE; CLINICAL EVALUATION; CONGENITAL NEPHROTIC SYNDROME; CONTROLLED STUDY; END STAGE RENAL DISEASE; FEMALE; FOCAL ADHESION; FOCAL GLOMERULOSCLEROSIS; GLOMERULUS BASEMENT MEMBRANE; GLOMERULUS FILTRATION; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE; IMMUNOFLUORESCENCE MICROSCOPY; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; KIDNEY ALLOGRAFT; KIDNEY TRANSPLANTATION; MALE; MIDDLE AGED; MULTICENTER STUDY; NONHUMAN; PLASMAPHERESIS; PODOCYTE; PRIORITY JOURNAL; PROTEINURIA; RECURRENT DISEASE; YOUNG ADULT; BLOOD; CELL CULTURE; CHILD; CLINICAL TRIAL; DRUG EFFECTS; EVALUATION STUDY; METABOLISM; PRESCHOOL CHILD; REPRODUCIBILITY; RISK ASSESSMENT;

ADOLESCENT; ADULT; CELLS, CULTURED; CHILD; CHILD, PRESCHOOL; DOXORUBICIN; FEMALE; FOCAL ADHESIONS; GLOMERULOSCLEROSIS, FOCAL SEGMENTAL; HUMANS; MALE; MIDDLE AGED; PODOCYTES; RECURRENCE; REPRODUCIBILITY OF RESULTS; RISK ASSESSMENT; TOXINS, BIOLOGICAL; TUMOR NECROSIS FACTOR-ALPHA; YOUNG ADULT;

EID: 84984621741     PISSN: 1931857X     EISSN: 15221466     Source Type: Journal    
DOI: 10.1152/ajprenal.00349.2015     Document Type: Article

References (31)

1. Babayeva S, Miller M, Zilber Y, El Kares R, Bernard C, Bitzan M, Goodyer P, Torban E. Plasma from a case of recurrent idiopathic FSGS perturbs non-muscle myosin IIA (MYH9 protein) in human podocytes. Pediatr Nephrol 26: 1071-1081, 2011.
2. Bao H, Ge Y, Peng A, Gong R. Fine-tuning of NFkappaB by glycogen synthase kinase 3beta directs the fate of glomerular podocytes upon injury. Kidney Int 87: 1176-1190, 2015.
3. Bitzan M, Babayeva S, Vasudevan A, Goodyer P, Torban E. TNFalpha pathway blockade ameliorates toxic effects of FSGS plasma on podocyte cytoskeleton and beta3 integrin activation. Pediatr Nephrol 27: 2217-2226, 2012.
4. Cattran D, Neogi T, Sharma R, McCarthy ET, Savin VJ. Serial estimates of serum permeability activity and clinical correlates in patients with native kidney focal segmental glomerulosclerosis. J Am Soc Nephrol 14: 448-453, 2003.
5. Coward RJ, Foster RR, Patton D, Ni L, Lennon R, Bates DO, Harper SJ, Mathieson PW, Saleem MA. Nephrotic plasma alters slit diaphragm-dependent signaling and translocates nephrin, Podocin, and CD2 associated protein in cultured human podocytes. J Am Soc Nephrol 16: 629-637, 2005.
6. D’Agati VD. The spectrum of focal segmental glomerulosclerosis: new insights. Curr Opin Nephrol Hypertens 17: 271-281, 2008
7. D’Agati VD, Kaskel FJ, Falk RJ. Focal segmental glomerulosclerosis. N Engl J Med 365: 2398-2411, 2011.
8. Ding WY, Koziell A, McCarthy HJ, Bierzynska A, Bhagavatula MK, Dudley JA, Inward CD, Coward RJ, Tizard J, Reid C, Antignac C, Boyer O, Saleem MA. Initial steroid sensitivity in children with steroid-resistant nephrotic syndrome predicts post-transplant recurrence. J Am Soc Nephrol 25: 1342-1348, 2014.
9. Faul C, Asanuma K, Yanagida-Asanuma E, Kim K, Mundel P. Actin up: regulation of podocyte structure and function by components of the actin cytoskeleton. Trends Cell Biol 17: 428-437, 2007.
10. Genovese G, Friedman DJ, Ross MD, Lecordier L, Uzureau P, Freed-man BI, Bowden DW, Langefeld CD, Oleksyk TK, Uscinski Knob AL, Bernhardy AJ, Hicks PJ, Nelson GW, Vanhollebeke B, Winkler CA, Kopp JB, Pays E, Pollak MR. Association of trypanolytic ApoL1 variants with kidney disease in African Americans. Science 329: 841-845, 2010.
11. Harris JJ, McCarthy HJ, Ni L, Wherlock M, Kang H, Wetzels JF, Welsh GI, Saleem MA. Active proteases in nephrotic plasma lead to a podocin-dependent phosphorylation of VASP in podocytes via protease activated receptor-1. J Pathol 229: 660-671, 2013.
12. Joy MS, Gipson DS, Powell L, MacHardy J, Jennette JC, Vento S, Pan C, Savin V, Eddy A, Fogo AB, Kopp JB, Cattran D, Trachtman H. Phase 1 trial of adalimumab in focal segmental glomerulosclerosis (FSGS). II. Report of the FONT (Novel Therapies for Resistant FSGS) study group. Am J Kidney Dis 55: 50-60, 2010.
13. Lee HW, Khan SQ, Faridi MH, Wei C, Tardi NJ, Altintas MM, Elshabrawy HA, Mangos S, Quick KL, Sever S, Reiser J, Gupta V. A podocyte-based automated screening assay identifies protective small molecules. J Am Soc Nephrol 26: 2741-2752, 2015.
14. Lee VW, Harris DC. Adriamycin nephropathy: a model of focal segmental glomerulosclerosis. Nephrology (Carlton) 16: 30-38, 2011.
15. McCarthy ET, Sharma M, Savin VJ. Circulating permeability factors in idiopathic nephrotic syndrome and focal segmental glomerulosclerosis. Clin J Am Soc Nephrol 5: 2115-2121, 2010.
16. McCarthy ET, Sharma R, Sharma M, Li JZ, Ge XL, Dileepan KN, Savin VJ. TNF-alpha increases albumin permeability of isolated rat glomeruli through the generation of superoxide. J Am Soc Nephrol 9: 433-438, 1998.
17. McCarthy HJ, Bierzynska A, Wherlock M, Ognjanovic M, Kerecuk L, Hegde S, Feather S, Gilbert RD, Krischock L, Jones C, Sinha MD, Webb NJ, Christian M, Williams MM, Marks S, Koziell A, Welsh GI, Saleem MA. Simultaneous sequencing of 24 genes associated with ste-roid-resistant nephrotic syndrome. Clin J Am Soc Nephrol 8: 637-648, 2013.
18. Mundel P, Reiser J, Zuniga Mejia Borja A, Pavenstadt H, Davidson GR, Kriz W, Zeller R. Rearrangements of the cytoskeleton and cell contacts induce process formation during differentiation of conditionally immortalized mouse podocyte cell lines. Exp Cell Res 236: 248-258, 1997.
19. Reiser J, Kriz W, Kretzler M, Mundel P. The glomerular slit diaphragm is a modified adherens junction. J Am Soc Nephrol 11: 1-8, 2000.
20. Reiser J, von Gersdorff G, Loos M, Oh J, Asanuma K, Giardino L, Rastaldi MP, Calvaresi N, Watanabe H, Schwarz K, Faul C, Kretzler M, Davidson A, Sugimoto H, Kalluri R, Sharpe AH, Kreidberg JA, Mundel P. Induction of B7-1 in podocytes is associated with nephrotic syndrome. J Clin Invest 113: 1390-1397, 2004.
21. Rood IM, Deegens JK, Wetzels JF. Genetic causes of focal segmental glomerulosclerosis: implications for clinical practice. Nephrol Dial Transplant 27: 882-890, 2012.
22. Saleem MA. The phenomenon of focal segmental glomerulosclerosis post-transplantation-a one-hit wonder? Pediatr Nephrol 27: 2163-2166, 2012.
23. Saleem MA, O’Hare MJ, Reiser J, Coward RJ, Inward CD, Farren T, Xing CY, Ni L, Mathieson PW, Mundel P. A conditionally immortalized human podocyte cell line demonstrating nephrin and podocin expression. J Am Soc Nephrol 13: 630-638, 2002.
24. Savin VJ, McCarthy ET, Sharma R, Charba D, Sharma M. Galactose binds to focal segmental glomerulosclerosis permeability factor and inhibits its activity. Transl Res 151: 288-292, 2008.
25. Savin VJ, Sharma R, Sharma M, McCarthy ET, Swan SK, Ellis E, Lovell H, Warady B, Gunwar S, Chonko AM, Artero M, Vincenti F. Circulating factor associated with increased glomerular permeability to albumin in recurrent focal segmental glomerulosclerosis. N Engl J Med 334: 878-883, 1996.
26. Sharma R, Sharma M, McCarthy ET, Ge XL, Savin VJ. Components of normal serum block the focal segmental glomerulosclerosis factor activity in vitro. Kidney Int 58: 1973-1979, 2000.
27. Srivastava T, Sharma M, Yew KH, Sharma R, Duncan RS, Saleem MA, McCarthy ET, Kats A, Cudmore PA, Alon US, Harrison CJ. LPS and PAN-induced podocyte injury in an in vitro model of minimal change disease: changes in TLR profile. J Cell Commun Signal 7: 49-60, 2013.
28. Torban E, Bitzan M, Goodyer P. Recurrent focal segmental glomerulosclerosis: a discrete clinical entity. Int J Nephrol 2012: 246128, 2012.
29. Wapstra FH, van Goor H, de Jong PE, Navis G, de Zeeuw D. Dose of doxorubicin determines severity of renal damage and responsiveness to ACE-inhibition in experimental nephrosis. J Pharmacol Toxicol Methods 41: 69-73, 1999.
30. Winograd-Katz SE, Fassler R, Geiger B, Legate KR. The integrin adhesome: from genes and proteins to human disease. Nat Rev Mol Cell Biol 15: 273-288, 2014.
31. Zaidel-Bar R, Itzkovitz S, Ma’ayan A, Iyengar R, Geiger B. Functional atlas of the integrin adhesome. Nat Cell Biol 9: 858-867, 2007.