Dexmedetomidine protects blood γ-aminolevulinate dehydratase from inactivation caused by hyperoxygenation in total intravenous anesthesia

Human and Experimental Toxicology

Volumn 30, Issue 4, 2011, Pages 289-295

  Rocha, João Bt ^a   Heinzmann Bulow, Neusa M ^b   Correa, Eduardo Fm ^b   Scholze, Cassiano ^a   Nogueira, Cristina W ^a   Barbosa, Nilda Bv ^a  

^a FEDERAL UNIVERSITY OF SANTA MARIA   (Brazil)

^b Centro de Ensino e Treinamento de Anestesiologia   (Brazil)

Author keywords

dexmedetomidine; hyperoxygenation; oxidative stress; remifentanil; TBARS; ALA D

Indexed keywords

DEXMEDETOMIDINE; DITHIOTHREITOL; FENTANYL; PORPHOBILINOGEN SYNTHASE; PROPOFOL; REMIFENTANIL; THIOBARBITURIC ACID REACTIVE SUBSTANCE;

ADULT; ANESTHESIA MECHANISM; ANTIOXIDANT ACTIVITY; ARTICLE; CLINICAL ARTICLE; CONTINUOUS INFUSION; CYTOTOXICITY; ENZYME ACTIVITY; ENZYME ASSAY; ERYTHROCYTE; FEMALE; HUMAN; HYPEROXIA; INTRAVENOUS ANESTHESIA; LOW DRUG DOSE; OXIDATIVE STRESS; OXYGENATION; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SINGLE DRUG DOSE;

EID: 84984569908     PISSN: 09603271     EISSN: 14770903     Source Type: Journal    
DOI: 10.1177/0960327110372399     Document Type: Article

References (33)

1. Sassa S. ALA-D porphyria. Semin Liver Dis 1998 ; 18: 95-101.
2. Jaffe EK The porphobilinogen Synthase catalyzed reaction mechanism. Bioorg Chem 2004 ; 32: 316-325. 3. Nogueira CW, Zeni G., Rocha Jbt. Organoselenium and organotellurium compounds: toxicology and pharmacology. Chem Rev 2004 ; 104: 6255-6285. (Pubitemid 39277439)
3. Farina M., Barbosa NVB, Nogueira CW, Folmer V., Andrade LH, Zeni G., et al. Reaction of diphenyl diselenide with hydrogen peroxide and inhibition of delta-aminolevulinate dehydratase from rat liver and cucumber leaves. Braz J Med Biol Res 2002 ; 35: 623-631. (Pubitemid 34716346)
4. Gonçalves TL, Benvegnu DM, Bonfanti G., Frediani AV, Rocha Jbt. Delta-Aminolevulinate dehydratase activity and oxidative stress during melphalan and cyclophosphamide-BCNU-etoposide (CBV) conditioning regimens in autologous bone marrow transplantation patients. Pharmacol Res 2009 ; 59: 279-284.
5. Paniz C., Bairros A., Valentini J., Charão M., Bulcão R., Moro A., et al. The influence of the serum vitamin C levels on oxidative stress biomarkers in elderly women. Clin Biochem 2007 ; 40: 1367-1372. (Pubitemid 350161793)
6. Valentini J., Grotto D., Paniz C., Roehrs M., Burg G., Garcia SC The influence of the hemodialysis treatment time under oxidative stress biomarkers in chronic renal failure patients. Biomed Pharmacother 2008 ; 62: 378-382. (Pubitemid 351899100)
7. Gibbs PN, Chaundhry AG, Jordan PM Purification and properties of 5-aminolevulinate deydratase from human erythrocytes. Biochem J 1985 ; 230: 25-34. (Pubitemid 16247266)
8. Monteiro HP, Abdalla Dsp, Augusto O., Bechara EJH. Free radical generation during γ-aminolevulinic acid autoxidation: induction by hemoglobin and connections with porphyrinpathies. Arch Biochem Biophys 1989 ; 271: 206-216. (Pubitemid 19119832)
9. Bechara EJH, Medeiros MHG, Monteiro HP, Hermes-Lima M., Pereira B., Demasi Costa CA, et al. A free radical hypothesis of lead poisoning and inborn porphyrias associated with 5-aminolevulinic acid overload. Quim Nova 1993 ; 16: 385-392.
10. Bechara EJH. Oxidative stress in acute intermittent porphyria and lead poisoning may be triggered by 5-aminolevulinic acid. Braz J Med Biol Res 1996 ; 29: 841-851. (Pubitemid 26245828)
11. Folmer V., Soares JCM, Rocha JBT. Oxidative stress in mice is dependent on the free glucose content of the diet. Int J Biochem Cell Biol 2002 ; 34: 1279-1285. (Pubitemid 34804362)
12. Gonçalves TL, Benvegnú DM, Bonfanti G., Frediani AV, Pereira DV, Rocha JBT. Oxidative stress and γ-ALA-D activity in different conditioning regimens in allogeneic bone marrow transplantation patients. Clin Biochem 2009 ; 42: 602-610.
13. Gonçalves TL, Benvegnú DM, Bonfanti G., Frediani AV, Rocha JBT. ALA-D activity is a reliable marker for oxidative stress in bone marrow transplantation patients. BMC Cancer 2009 ; 8: 129-138.
14. Silva AC, Rocha JBT, Morsch AL, Zanin RF, Kaizer R., Maldonado PA, et al. Oxidative stress and γ-ALA-D activity in chronic renal failure patients. Biomed Pharmacother 2007 ; 61: 180-185. (Pubitemid 46561190)
15. Bakker DJ Hyperbaric oxygen therapy: past, present and future indications. Adv Exp Med Biol 1998 ; 317: 95-105.
16. Xue Fu-shan, Liao Xu, Li Cheng-wen, Xu Ya-chao, Yag Quan-yong, Liu Yi, et al. Clinical experience of airway management and tracheal intubation under general anesthesia in patients with scar contracture of the neck. Chin Med J 2008 ; 121: 989-997.
17. Jamieson D., Chance B., Cadenas E., Boveris A. The relation of free radical production to hyperoxia. Annu Rev Physiol 1986 ; 48: 703-719. (Pubitemid 16047644)
18. Narkowicz CK, Vial JH, McCartney P. Hyperbaric oxygen therapy increase free radical levels in the blood of humans. Free Radic Res Commun 1993 ; 19: 71-80. (Pubitemid 23310629)
19. Bulow NMH, Rocha JBT, Barbosa NV Opioid consumption in total intravenous anesthesia is reduced with dexmedetomidine: a comparative study with remifentanil in gynecologic videolaparoscopic surgery. J Clin Anesth 2007 ; 19: 280-285. (Pubitemid 46901159)
20. Berlin A., Schaller KH European standardized method for determination of delta-aminolevulinic-acid dehydratase activity in blood. Z Klin Chem Klin Biochem 1974 ; 12: 389-390.
21. Cinnella G., Vendemiale G., Dambrosio M., Serviddio G., Pugliese PL, Aspromonte G., et al. Effect of propofol, sevoflurane and desflurane on systemic redox balance. Int J Immunopathol Pharmacol 2007 ; 20: 585-593. (Pubitemid 47531061)
22. Gulcin I., Dastan A. Synthesis of dimeric phenol derivatives and determination of in vitro antioxidant and radical scavenging activities. J Enzym Inhib 2007 ; 22: 685-695. (Pubitemid 350215071)
23. Ohkawa H., Ohishi N., Yagi K. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biochem 1979 ; 95: 351-358. (Pubitemid 9194347)
24. Puntel RL, Roos DH, Grotto D., Garcia SC, Nogueira CW, Rocha JTB. Antioxidant properties of Krebs cycle intermediates against malonate pro-oxidant activity in vitro: a comparative study using the colorimetric method and HPLC analysis to determine malondialdehyde in rat brain homogenates. Life Sci 2007 ; 81: 51-62. (Pubitemid 46891504)
25. Bradford MM A rapid and sensitive method for the quantification of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 1976 ; 72: 218-254.
26. Eser O., Fidan H., Sahin O., Cosar M., Yaman M., Mollaoglu H., et al. The influence of dexmedetomidine on ischemic rat hippocampus. Brain Res 2008 ; 1218: 250-256.
27. Kocoglu H., Ozturk H., Yilmaz F., Gulcu N. Effect of dexmedetomidine on ischemia-reperfusion injury in rat kidney: a histopathologic study. Ren Fail 2009 ; 31: 29-36.
28. Goyagi T., Nishikawa T., Tobe Y., Masaki Y. The combined neuroprotective effects of lidocaine and dexmedetomidine after transient forebrain ischemia in rats. Acta Anaesthesiol Scand 2009 ; 53: 1176-1183.
29. Zhang WS, Xu H., Xu B., Sun S., Deng XM, Zhang YQ Antihyperalgesic effect of systemic dexmedetomidine and gabapentin in a rat model of monoarthritis. Brain Res 2009 ; 264: 57-66.
30. Sanders RD, Xu J., Shu Y., Januszewski A., Halder S., Fidalgo A., et al. Dexmedetomidine attenuates isoflurane-induced neurocognitive impairment in neonatal rats. Anesthesiology 2009 ; 110: 1077-1085.
31. Ghiselli A., Serafini M., Maiani G., Azzini E., Ferroluzzi A. A fluorescence-based method for measuring total plasma antioxidant capability. Free Radic Biol Med 1995 ; 18: 29-36.
32. Oter S., Korkmaz A., Topal T., Ozcan O., Sadir S., Ozler M., et al. Correlation between hyperbaric oxygen exposure pressures and oxidative parameters in rat lung, brain and erythrocytes. Clin Biochem 2005 ; 38: 706-711. (Pubitemid 41019567)
33. Benedetti S., Lamorgese A., Piersantelli M., Pagliarani S., Benvenuti F., Canestrari F. Oxidative stress and antioxidant status in patients undergoing prolonged exposure to hyperbaric oxygen. Clin Biochem 2004 ; 37: 312-317. (Pubitemid 38314886)