HMGCR antibody-associated myopathy as a paraneoplastic manifestation of esophageal carcinoma

Neurology

Volumn 87, Issue 8, 2016, Pages 841-843

  Tsujikawa, Koyo ^a   Hara, Kazuhiro ^a   Muro, Yoshinao ^a   Nakanishi, Hirotaka ^a   Niwa, Yukiko ^a   Koike, Masahiko ^a   Noda, Seiya ^a   Riku, Yuichi ^a   Sahashi, Kentaro ^a   Atsuta, Naoki ^a   Ito, Mizuki ^a   Shimoyama, Yoshie ^a   Akiyama, Masashi ^a   Katsuno, Masahisa ^a  

^a NAGOYA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

AZATHIOPRINE; CISPLATIN; FLUOROURACIL; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE; IMMUNOGLOBULIN; METHYLPREDNISOLONE; AUTOANTIBODY; HMGCR PROTEIN, HUMAN;

ADULT; AUTOIMMUNE DISEASE; CANCER CHEMOTHERAPY; CANCER COMBINATION CHEMOTHERAPY; CANCER PALLIATIVE THERAPY; CANCER PATIENT; CANCER STAGING; CANCER SURGERY; CD8+ T LYMPHOCYTE; CLINICAL ARTICLE; COMPUTER ASSISTED TOMOGRAPHY; DISEASE COURSE; ELECTROMYOGRAM; ESOPHAGUS CARCINOMA; ESOPHAGUS RESECTION; GASTROINTESTINAL ENDOSCOPY; GENETIC RISK; HMGCR ANTIBODY ASSOCIATED MYOPATHY; HOSPITAL ADMISSION; HOSPITALIZATION; HUMAN; HUMAN TISSUE; JAPANESE (PEOPLE); LABORATORY TEST; LYMPH NODE DISSECTION; LYMPH NODE METASTASIS; MAJOR HISTOCOMPATIBILITY COMPLEX; MALE; MEDICAL HISTORY; MIDDLE AGED; MUSCLE BIOPSY; MUSCLE WEAKNESS; MYOPATHY; NEUROLOGIC EXAMINATION; NOTE; PARANEOPLASTIC SYNDROME; PRIORITY JOURNAL; SURGICAL PATIENT; TUMOR RECURRENCE; BLOOD; CASE REPORT; COMPLICATION; ESOPHAGUS TUMOR; IMMUNOLOGY; MUSCLE DISEASE;

AUTOANTIBODIES; ESOPHAGEAL NEOPLASMS; HUMANS; HYDROXYMETHYLGLUTARYL COA REDUCTASES; MALE; MIDDLE AGED; MUSCULAR DISEASES; PARANEOPLASTIC SYNDROMES;

EID: 84983542741     PISSN: 00283878     EISSN: 1526632X     Source Type: Journal    
DOI: 10.1212/WNL.0000000000003006     Document Type: Note

References (7)

1. Mammen AL, Chung T, Christopher-Stine L, et al. Autoantibodies against 3-hydroxy-3-methylglutaryl-coenzyme A reductase in patients with statin-Associated autoimmune myopathy. Arthritis Rheum 2011; 63: 713-721.
2. Zhong C, Fan L, Yao F, Shi J, Fang W, Zhao H. HMGCR is necessary for the tumorigenecity of esophageal squamous cell carcinoma and is regulated by Myc. Tumour Biol 2014; 35: 4123-4129.
3. Alshehri A, Choksi R, Bucelli R, Pestronk A. Myopathy with anti-HMGCR antibodies: Perimysium and myofiber pathology. Neurol Neuroimmunol Neuroinflamm 2015; 2: e124.
4. Limaye V, Bundell C, Hollingsworth P, et al. Clinical and genetic associations of autoantibodies to 3-hydroxy-3-methyl-glutaryl-coenzyme a reductase in patients with immune-mediated myositis and necrotizing myopathy. Muscle Nerve 2015; 52: 196-203.
5. Muro Y, Sugiura K, Akiyama M. A new ELISA for dermatomyositis autoantibodies: rapid introduction of autoantigen cDNA to recombinant assays for autoantibody measurement. Clin Dev Immunol 2013; 2013: 856815.
6. Chung T, Christopher-Stine L, Paik JJ, Corse A, Mammen AL. The composition of cellular infiltrates in anti-HMG-CoA reductase-Associated myopathy. Muscle Nerve 2015; 52: 189-195.
7. Casciola-Rosen L, Nagaraju K, Plotz P, et al. Enhanced autoantigen expression in regenerating muscle cells in idiopathic inflammatory myopathy. J Exp Med 2005; 201: 591-601.