Synthesis of some new fluorinated hexahydroquinoline and acridinedione derivatives in trifluoroethanol

Applied Sciences (Switzerland)

Volumn 2, Issue 2, 2012, Pages 368-374

  Okoro, Cosmas O ^a   Ogunwale, Mumiye A ^a   Siddiquee, Tasneem ^a  

^a TENNESSEE STATE UNIVERSITY   (United States)

Author keywords

Acridinedione; Dihydropyridine; Hexahydroquinoline; Trifluoroethanol; Trifluoromethyl; Unsymmetric Hantzsch reaction

Indexed keywords

EID: 84983199355     PISSN: None     EISSN: 20763417     Source Type: Journal    
DOI: 10.3390/app2020368     Document Type: Article

References (14)

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14. X-ray diffraction studies were performed at room temperature on a pale yellow crystal of 4d of approximate 0.57 × 0.52 × 0.36 mm dimensions. All measurements were made on a Rigaku Mercury375R/M CCD (XtaLAB mini) diffractometer using graphite monochromated Mo-Ka radiation. Cell constants and an orientation matrix for data collection corresponded to a primitive monoclinic cell (space group P21/n) with dimensions: a = 11.8544(10) Å, b = 13.9622(12) Å, c = 12.5692(11) Å and ß = 110.300(8)°. Data reduction: of the 20341 reflections that were collected, 4477 were unique (Rint = 0.0212). Data were collected and processed using CrystalClear a (Rigaku). The linear absorption coefficient, μ, for Mo-Ka radiation is 2.435 cm-1. An empirical absorption correction was applied which resulted in transmission factors ranging from 0.796 to 0.916. The data were corrected for Lorentz and polarization effects. Structure Solution and Refinement: The structure was solved by direct methods b and expanded using Fourier techniques. The non-hydrogen atoms were refined anisotropically. Hydrogen atoms were refined using the riding model. The final cycle of full-matrix least-squares refinement on F2 was based on 4477 observed reflections and 269 variable parameters and converged (largest parameter shift was 0.12 times its esd) with unweighted and weighted agreement factors of: R1 = 0.0490 and wR2 = 0.1938. This was conducted using the program suiteWINGX c. (a) CrystalClear: Rigaku Corporation, 1999. CrystalClear Software User's Guide, Molecular Structure Corporation, ©2000. Pflugrath, J.W. Acta Cryst. 1999, D55, 1718-1725. (b) Sheldrick, G.M. SHELX-97, Program for the Solution and Refinement of Crystal Structures; University of Göttingen: Göttingen, Germany, 1997. (c) Farrugia, L.J. WinGX suite for small-molecule single-crystal crystallography. J. Appl. Cryst. 1999, 32, 837-838