Restoring Study 329: Paroxetine neither effective nor safe for adolescents

Australian and New Zealand Journal of Psychiatry

Volumn 50, Issue 9, 2016, Pages 922-923

  Mulder, Roger ^a   Rucklidge, Julia J ^b   Toop, Les ^a  

^a UNIVERSITY OF OTAGO   (New Zealand)

^b UNIVERSITY OF CANTERBURY   (New Zealand)

Author keywords

[No Author keywords available]

Indexed keywords

PAROXETINE; IMIPRAMINE; SEROTONIN UPTAKE INHIBITOR; TRICYCLIC ANTIDEPRESSANT AGENT;

ADOLESCENT; CLINICAL EFFECTIVENESS; DECISION MAKING; DEPRESSION; DRUG EFFICACY; DRUG RESPONSE; DRUG SAFETY; DRUG TOLERABILITY; HUMAN; MEDICAL RESEARCH; NOTE; OUTCOME ASSESSMENT; PRESCRIPTION; SUICIDAL IDEATION; CLINICAL TRIAL; CONTROLLED STUDY; DEPRESSIVE DISORDER, MAJOR; DOUBLE BLIND PROCEDURE; FEMALE; MALE; MULTICENTER STUDY; RANDOMIZED CONTROLLED TRIAL; STATISTICS AND NUMERICAL DATA; TREATMENT FAILURE;

ADOLESCENT; ANTIDEPRESSIVE AGENTS, TRICYCLIC; DEPRESSIVE DISORDER, MAJOR; DOUBLE-BLIND METHOD; FEMALE; HUMANS; IMIPRAMINE; MALE; OUTCOME ASSESSMENT (HEALTH CARE); PAROXETINE; SEROTONIN UPTAKE INHIBITORS; TREATMENT FAILURE;

EID: 84983087251     PISSN: 00048674     EISSN: 14401614     Source Type: Journal    
DOI: 10.1177/0004867416657412     Document Type: Note

References (5)

1. De Angelis C, Drazen JM, Frizelle FA, et al. (2004) Clinical trial registration: A statement from the International Committee of Medical Journal Editors. Lancet 364: 911-912.
2. Doshi P, (2015) No correction, no retraction, no apology, no comment: Paroxetine trial reanalysis raises questions about institutional responsibility. British Medical Journal 351: h4629.
3. Keller MB, Ryan ND, Strober M, et al. (2001) Efficacy of paroxetine in the treatment of adolescent major depression: A randomized, controlled trial. Journal of the American Academy of Child and Adolescent Psychiatry 40: 762-772.
4. Le Noury J, Nardo JM, Healy D, et al. (2015) Restoring Study 329: Efficacy and harms of paroxetine and imipramine in treatment of major depression in adolescence. British Medical Journal 351: h4320.
5. Scott A, Rucklidge JJ, Mulder RT, (2015) Is mandatory prospective trial registration working to prevent publication of unregistered trials and selective outcome reporting? An observational study of five psychiatry journals that mandate prospective clinical trial registration. PLoS ONE 10: e0133718.