Dysregulation of the glutamatergic receptors after antidepressant treatment in human neural progenitor cells

Molecular Psychiatry

Volumn 22, Issue 9, 2017, Pages 1228-1229

  Cruceanu, C ^a   Lopez, J P ^a   Tsai, W T ^a   Turecki, G ^a  

^a MCGILL UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CITALOPRAM; GLUTAMATE RECEPTOR; IMIPRAMINE; ANTIDEPRESSANT AGENT;

GENE EXPRESSION REGULATION; HUMAN; LETTER; NEURAL STEM CELL; NEUROTRANSMISSION; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

ANTIDEPRESSIVE AGENTS; HUMANS; NEURAL STEM CELLS;

EID: 84983077429     PISSN: 13594184     EISSN: 14765578     Source Type: Journal    
DOI: 10.1038/mp.2016.138     Document Type: Letter

References (8)

1. Orrego F, Villanueva S. The chemical nature of the main central excitatory transmitter: a critical appraisal based upon release studies and synaptic vesicle localization. Neuroscience 1993; 56: 539-555.
2. Gray AL, Hyde TM, Deep-Soboslay A, Kleinman JE, Sodhi MS. Sex differences in glutamate receptor gene expression in major depression and suicide. Mol Psychiatry 2015; 20: 1057-1068.
3. Sanacora G, Treccani G, Popoli M. Towards a glutamate hypothesis of depression: an emerging frontier of neuropsychopharmacology for mood disorders. Neuropharmacology 2012; 62: 63-77.
4. Lodge D. The history of the pharmacology and cloning of ionotropic glutamate receptors and the development of idiosyncratic nomenclature. Neuropharmacology 2009; 56: 6-21.
5. Lopez JP, Lim R, Cruceanu C, Crapper L, Fasano C, Labonte B et al. miR-1202 is a primate-specific and brain-enriched microRNA involved in major depression and antidepressant treatment. Nat Med 2014; 20: 764-768.
6. Lambe EK, Aghajanian GK. Hallucinogen-induced UP states in the brain slice of rat prefrontal cortex: role of glutamate spillover and NR2B-NMDA receptors. Neuropsychopharmacology 2006; 31: 1682-1689.
7. Sanacora G, Zarate CA, Krystal JH, Manji HK. Targeting the glutamatergic system to develop novel, improved therapeutics for mood disorders. Nat Rev Drug Discov 2008; 7: 426-437.
8. Swanson CJ, Bures M, Johnson MP, Linden AM, Monn JA, Schoepp DD. Metabotropic glutamate receptors as novel targets for anxiety and stress disorders. Nat Rev Drug Discov 2005; 4: 131-144.