Nurr1 expression is modified by inflammation in microglia

NeuroReport

Volumn 27, Issue 15, 2016, Pages 1120-1127

  Lallier, Scott W ^a   Graf, Amanda E ^a,b   Waidyarante, Gavisha R ^a   Rogers, Lynette K ^a,b  

^a NATIONWIDE CHILDREN S HOSPITAL   (United States)

^b OHIO STATE UNIVERSITY   (United States)

Author keywords

BV2 cells; Inflammation; Lipopolysaccharide; Microglia; Nurr1

Indexed keywords

LIPOPOLYSACCHARIDE; NUCLEAR RECEPTOR RELATED FACTOR 1; CYTOKINE; NR4A2 PROTEIN, MOUSE; OXYGEN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN HOMOGENATE; CELL COUNT; CELL ISOLATION; CELLS BY BODY ANATOMY; CONTROLLED STUDY; HYPEROXIA; IMMORTALIZED CELL LINE; INFLAMMATION; MICROGLIA; MOUSE; NONHUMAN; OLIGODENDROGLIA; PERINATAL PERIOD; PRIORITY JOURNAL; PROTEIN EXPRESSION; ANIMAL; BRAIN; CELL CULTURE; COMPLICATION; DISEASE MODEL; DOSE RESPONSE; DRUG EFFECTS; DRUG THERAPY; FEMALE; GENE EXPRESSION REGULATION; GENETICS; MALE; MAMMALIAN EMBRYO; METABOLISM; NEWBORN; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; PREGNANCY; PRENATAL EXPOSURE;

ANIMALS; ANIMALS, NEWBORN; BRAIN; CELLS, CULTURED; CYTOKINES; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; EMBRYO, MAMMALIAN; FEMALE; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HYPEROXIA; INFLAMMATION; LIPOPOLYSACCHARIDES; MALE; MICE; MICROGLIA; NUCLEAR RECEPTOR SUBFAMILY 4, GROUP A, MEMBER 2; OXYGEN; PREGNANCY; PRENATAL EXPOSURE DELAYED EFFECTS;

EID: 84983036894     PISSN: 09594965     EISSN: 1473558X     Source Type: Journal    
DOI: 10.1097/WNR.0000000000000665     Document Type: Article

References (25)

1. Allen MC, Cristofalo EA, Kim C. Outcomes of preterm infants: morbidity replaces mortality. Clin Perinatol 2011; 38:441-454.
2. Burd I, Chai J, Gonzalez J, Ofori E, Monnerie H, Le Roux PD, Elovitz MA. Beyond white matter damage: fetal neuronal injury in a mouse model of preterm birth. Am J Obstet Gynecol 2009; 201:271.e1-271.e8.
3. Wang Z, Benoit G, Liu J, Prasad S, Aarnisalo P, Liu X, et al. Structure and function of Nurr1 identifies a class of ligand-independent nuclear receptors. Nature 2003; 423:555-560.
4. Zetterström RH, Solomin L, Jansson L, Hoffer BJ, Olson L, Perlmann T. Dopamine neuron agenesis in Nurr1-deficient mice. Science 1997; 276:248-250.
5. Garciá-Yaguë ÁJ, Rada P, Rojo AI, Lastres-Becker I, Cuadrado A. Nuclear import and export signals control the subcellular localization of Nurr1 protein in response to oxidative stress. J Biol Chem 2013; 288:5506-5517.
6. Barish GD, Downes M, AlaynickWA, Yu RT, Ocampo CB, Bookout AL, et al. A nuclear receptor Atlas: macrophage activation. Mol Endocrinol 2005; 19:2466-2477.
7. Pei L, Castrillo A, Tontonoz P. Regulation of macrophage inflammatory gene expression by the orphan nuclear receptor Nur77. Mol Endocrinol 2006; 20:786-794.
8. Saijo K, Winner B, Carson CT, Collier JG, Boyer L, Rosenfeld MG, et al. A Nurr1/CoREST pathway in microglia and astrocytes protects dopaminergic neurons from inflammation-induced death. Cell 2009; 137:47-59.
9. Graf AE, Haines KM, Pierson CR, Bolon BN, Houston RH, Velten M, et al. Perinatal inflammation results in decreased oligodendrocyte numbers in adulthood. Life Sci 2014; 94:164-171.
10. Velten M, Britt RD Jr, Heyob KM, Welty SE, Eiberger B, Tipple TE, Rogers LK. Prenatal inflammation exacerbates hyperoxia-induced functional and structural changes in adult mice. Am J Physiol Regul Integr Comp Physiol 2012; 303:R279-R290.
11. Velten M, Gorr MW, Youtz DJ, Velten C, Rogers LK, Wold LE. Adverse perinatal environment contributes to altered cardiac development and function. Am J Physiol Heart Circ Physiol 2014; 306:H1334-H1340.
12. Velten M, Heyob KM, Rogers LK, Welty SE. Deficits in lung alveolarization and function after systemic maternal inflammation and neonatal hyperoxia exposure. J Appl Physiol (1985) 2010; 108:1347-1356.
13. Velten M, Hutchinson KR, Gorr MW, Wold LE, Lucchesi PA, Rogers LK. Systemic maternal inflammation and neonatal hyperoxia induces remodeling and left ventricular dysfunction in mice. PLoS One 2011; 6:e24544.
14. Normann E, Lacaze-Masmonteil T, Eaton F, Schwendimann L, Gressens P, Thébaud B. A novel mouse model of ureaplasma-induced perinatal inflammation: effects on lung and brain injury. Pediatr Res 2009; 65:430-436.
15. Rousset CI, Kassem J, Olivier P, Chalon S, Gressens P, Saliba E. Antenatal bacterial endotoxin sensitizes the immature rat brain to postnatal excitotoxic injury. J Neuropathol Exp Neurol 2008; 67:994-1000.
16. Ramani M, van Groen T, Kadish I, Bulger A, Ambalavanan N. Neurodevelopmental impairment following neonatal hyperoxia in the mouse. Neurobiol Dis 2013; 50:69-75.
17. Yi U, Kurul SH, Kumral A, Cilaker S, Tuyan K, Genç S, Yilmaz O. Hyperoxic exposure leads to cell death in the developing brain. Brain Dev 2008; 30:556-562.
18. Zaghloul N, Nasim M, Patel H, Codipilly C, Marambaud P, Dewey S, et al. Overexpression of extracellular superoxide dismutase has a protective role against hyperoxia-induced brain injury in neonatal mice. FEBS J 2012; 279:871-881.
19. Sawicki CM, McKim DB, Wohleb ES, Jarrett BL, Reader BF, Norden DM, et al. Social defeat promotes a reactive endothelium in a brain regiondependent manner with increased expression of key adhesion molecules, selectins and chemokines associated with the recruitment of myeloid cells to the brain. Neuroscience 2015; 302:151-164.
20. Norden DM, Fenn AM, Dugan A, Godbout JP. TGF produced by IL-10 redirected astrocytes attenuates microglial activation. Glia 2014; 62:881-895.
21. Wohleb ES, Hanke ML, Corona AW, Powell ND, Stiner LM, Bailey MT, et al.-Adrenergic receptor antagonism prevents anxiety-like behavior and microglial reactivity induced by repeated social defeat. J Neurosci 2011; 31:6277-6288.
22. Wohleb ES, Powell ND, Godbout JP, Sheridan JF. Stress-induced recruitment of bone marrow-derived monocytes to the brain promotes anxiety-like behavior. J Neurosci 2013; 33:13820-13833.
23. De Miranda BR, Popichak KA, Hammond SL, Jorgensen BA, Phillips AT, Safe S, et al. The Nurr1 activator 1,1-Bis(3-Indolyl)-1-(p-Chlorophenyl) Methane blocks inflammatory gene expression in BV-2 microglial cells by inhibiting nuclear factor kappaB. Mol Pharmacol 2015; 87:1021-1034.
24. Kim CH, Han BS, Moon J, Kim DJ, Shin J, Rajan S, et al. Nuclear receptor Nurr1 agonists enhance its dual functions and improve behavioral deficits in an animal model of Parkinson's disease. Proc Natl Acad Sci USA 2015; 112:8756-8761.
25. Montarolo F, Perga S, Martire S, Bertolotto A. Nurr1 reduction influences the onset of chronic EAE in mice. Inflamm Res 2015; 64:841-844.