Prevalence and significance of troponin elevations in patients without acute coronary disease

International Journal of Cardiology

Volumn 222, Issue , 2016, Pages 819-825

  Vestergaard, Kirstine Roll ^a   Jespersen, Camilla Bang ^a   Arnadottir, Asthildur ^b   Sölétormos, György ^a   Schou, Morten ^b   Steffensen, Rolf ^a   Goetze, Jens P ^c   Kjøller, Erik ^b   Iversen, Kasper K ^b  

^a HILLERØD HOSPITAL   (Denmark)

^b GENTOFTE UNIVERSITY HOSPITAL   (Denmark)

^c Rigshospitalet   (Denmark)

Author keywords

Coronary disease; Diagnosis; Myocardial infarction

Indexed keywords

C REACTIVE PROTEIN; HEMOGLOBIN; TROPONIN; TROPONIN I; TROPONIN T; BIOLOGICAL MARKER;

ACUTE CORONARY SYNDROME; ADULT; AGE; AGED; ARTICLE; CONTROLLED STUDY; DIASTOLIC BLOOD PRESSURE; FEMALE; GLOMERULUS FILTRATION RATE; HEART RATE; HOSPITAL PATIENT; HUMAN; IMMUNOASSAY; MAJOR CLINICAL STUDY; MALE; PREDICTIVE VALUE; PRIORITY JOURNAL; SENSITIVITY AND SPECIFICITY; SEX DIFFERENCE; SYSTOLIC BLOOD PRESSURE; BLOOD; FOLLOW UP; MIDDLE AGED; MYOCARDIAL INFARCTION; PREVALENCE; RETROSPECTIVE STUDY;

ACUTE CORONARY SYNDROME; AGED; BIOMARKERS; FEMALE; FOLLOW-UP STUDIES; HUMANS; MALE; MIDDLE AGED; MYOCARDIAL INFARCTION; PREVALENCE; RETROSPECTIVE STUDIES; TROPONIN I; TROPONIN T;

EID: 84982938372     PISSN: 01675273     EISSN: 18741754     Source Type: Journal    
DOI: 10.1016/j.ijcard.2016.07.166     Document Type: Article

References (48)

1. [1] Thygesen, K., Alpert, J.S., White, H.D., et al. Universal definition of myocardial infarction. Circulation 116 (2007), 2634–2653.
2. [2] Mendis, S., Thygesen, K., Kuulasmaa, K., et al. World Health Organization definition of myocardial infarction: 2008 − 09 revision. Int. J. Epidemiol. 40 (2011), 139–146.
3. [3] Alehagen, U., Dahlstrom, U., Rehfeld, J.F., Goetze, J.P., Prognostic assessment of elderly patients with symptoms of heart failure by combining high-sensitivity troponin T and N-terminal pro-B-type natriuretic peptide measurements. Clin. Chem. 56 (2010), 1718–1724.
4. [4] Tsutamoto, T., Kawahara, C., Nishiyama, K., et al. Prognostic role of highly sensitive cardiac troponin I in patients with systolic heart failure. Am. Heart J. 159 (2010), 63–67.
5. [5] Latini, R., Masson, S., Anand, I.S., et al. Prognostic value of very low plasma concentrations of troponin T in patients with stable chronic heart failure. Circulation 116 (2007), 1242–1249.
6. [6] Kawahara, C., Tsutamoto, T., Nishiyama, K., et al. Prognostic role of high-sensitivity cardiac troponin T in patients with nonischemic dilated cardiomyopathy. Circ. J. 75 (2011), 656–661.
7. [7] Kubo, T., Kitaoka, H., Yamanaka, S., et al. Significance of high-sensitivity cardiac troponin T in hypertrophic cardiomyopathy. J. Am. Coll. Cardiol. 62 (2013), 1252–1259.
8. [8] Hussein, A.A., Gottdiener, J.S., Bartz, T.M., et al. Cardiomyocyte injury assessed by a highly sensitive troponin assay and sudden cardiac death in the community: the Cardiovascular Health Study. J. Am. Coll. Cardiol. 62 (2013), 2112–2120.
9. [9] Filusch, A., Giannitsis, E., Katus, H.A., Meyer, F.J., High-sensitive troponin T: a novel biomarker for prognosis and disease severity in patients with pulmonary arterial hypertension. Clin. Sci. (Lond.) 119 (2010), 207–213.
10. [10] Lankeit, M., Friesen, D., Aschoff, J., et al. Highly sensitive troponin T assay in normotensive patients with acute pulmonary embolism. Eur. Heart J. 31 (2010), 1836–1844.
11. [11] Jensen, J.K., Kristensen, S.R., Bak, S., Atar, D., Hoilund-Carlsen, P.F., Mickley, H., Frequency and significance of troponin T elevation in acute ischemic stroke. Am. J. Cardiol. 99 (2007), 108–112.
12. [12] Rosjo, H., Varpula, M., Hagve, T.A., et al. Circulating high sensitivity troponin T in severe sepsis and septic shock: distribution, associated factors, and relation to outcome. Intensive Care Med. 37 (2011), 77–85.
13. [13] Neukamm, A.M., Hoiseth, A.D., Hagve, T.A., Soyseth, V., Omland, T., High-sensitivity cardiac troponin T levels are increased in stable COPD. Heart 99 (2013), 382–387.
14. [14] McGill, D., Talaulikar, G., Potter, J.M., Koerbin, G., Hickman, P.E., Over time, high-sensitivity TnT replaces NT-proBNP as the most powerful predictor of death in patients with dialysis-dependent chronic renal failure. Clin. Chim. Acta 411 (2010), 936–939.
15. [15] Haller, C., Zehelein, J., Remppis, A., Muller-Bardorff, M., Katus, H.A., Cardiac troponin T in patients with end-stage renal disease: absence of expression in truncal skeletal muscle. Clin. Chem. 44 (1998), 930–938.
16. [16] Ndrepepa, G., Braun, S., Mehilli, J., et al. Prognostic value of sensitive troponin T in patients with stable and unstable angina and undetectable conventional troponin. Am. Heart J. 161 (2011), 68–75.
17. [17] Reiter, M., Twerenbold, R., Reichlin, T., et al. Early diagnosis of acute myocardial infarction in patients with pre-existing coronary artery disease using more sensitive cardiac troponin assays. Eur. Heart J. 33 (2012), 988–997.
18. [18] Reynolds, T., Cecconi, M., Collinson, P., Rhodes, A., Grounds, R.M., Hamilton, M.A., Raised serum cardiac troponin I concentrations predict hospital mortality in intensive care unit patients. Br. J. Anaesth. 109 (2012), 219–224.
19. [19] Bajwa, E.K., Boyce, P.D., Januzzi, J.L., Gong, M.N., Thompson, B.T., Christiani, D.C., Biomarker evidence of myocardial cell injury is associated with mortality in acute respiratory distress syndrome. Crit. Care Med. 35 (2007), 2484–2490.
20. [20] Vasile, V.C., Chai, H.S., Khambatta, S., Afessa, B., Jaffe, A.S., Significance of elevated cardiac troponin T levels in critically ill patients with acute respiratory disease. Am. J. Med. 123 (2010), 1049–1058.
21. [21] Babuin, L., Vasile, V.C., Rio Perez, J.A., et al. Elevated cardiac troponin is an independent risk factor for short- and long-term mortality in medical intensive care unit patients. Crit. Care Med. 36 (2008), 759–765.
22. [22] Lim, W., Whitlock, R., Khera, V., et al. Etiology of troponin elevation in critically ill patients. J. Crit. Care 25 (2010), 322–328.
23. [23] Eijsvogels, T., George, K., Shave, R., et al. Effect of prolonged walking on cardiac troponin levels. Am. J. Cardiol. 105 (2010), 267–272.
24. [24] Traiperm, N., Gatterer, H., Wille, M., Burtscher, M., Cardiac troponins in young marathon runners. Am. J. Cardiol. 110 (2012), 594–598.
25. [25] de Lemos, J.A., Drazner, M.H., Omland, T., et al. Association of troponin T detected with a highly sensitive assay and cardiac structure and mortality risk in the general population. JAMA 304 (2010), 2503–2512.
26. [26] Saunders, J.T., Nambi, V., de Lemos, J.A., et al. Cardiac troponin T measured by a highly sensitive assay predicts coronary heart disease, heart failure, and mortality in the Atherosclerosis Risk in Communities Study. Circulation 123 (2011), 1367–1376.
27. [27] Zeller, T., Tunstall-Pedoe, H., Saarela, O., et al. High population prevalence of cardiac troponin I measured by a high-sensitivity assay and cardiovascular risk estimation: the MORGAM Biomarker Project Scottish Cohort. Eur. Heart J. 35 (2014), 271–281.
28. [28] McKie, P.M., Heublein, D.M., Scott, C.G., et al. Defining high-sensitivity cardiac troponin concentrations in the community. Clin. Chem. 59 (2013), 1099–1107.
29. [29] McFalls, E.O., Larsen, G., Johnson, G.R., et al. Outcomes of hospitalized patients with non-acute coronary syndrome and elevated cardiac troponin level. Am. J. Med. 124 (2011), 630–635.
30. [30] Iversen, K., Kober, L., Gotze, J.P., et al. Troponin T is a strong marker of mortality in hospitalized patients. Int. J. Cardiol. 168 (2013), 818–824.
31. [31] Omland, T., Pfeffer, M.A., Solomon, S.D., et al. Prognostic value of cardiac troponin I measured with a highly sensitive assay in patients with stable coronary artery disease. J. Am. Coll. Cardiol. 61 (2013), 1240–1249.
32. [32] de Antonio, M., Lupon, J., Galan, A., et al. Head-to-head comparison of high-sensitivity troponin T and sensitive-contemporary troponin I regarding heart failure risk stratification. Clin. Chim. Acta 426 (2013), 18–24.
33. [33] Thygesen, K., Alpert, J.S., Jaffe, A.S., et al. Third universal definition of myocardial infarction. J. Am. Coll. Cardiol. 60 (2012), 1581–1598.
34. [34] Bohula May, E.A., Bonaca, M.P., Jarolim, P., et al. Prognostic performance of a high-sensitivity cardiac troponin I assay in patients with non-ST-elevation acute coronary syndrome. Clin. Chem. 60 (2014), 158–164.
35. [35] Eken, C., Oktay, C., Bacanli, A., et al. Anxiety and depressive disorders in patients presenting with chest pain to the emergency department: a comparison between cardiac and non-cardiac origin. J. Emerg. Med. 39 (2010), 144–150.
36. [36] Mayou, R.A., Thompson, D.R., Treatment needs of patients admitted for acute chest pain. J. Psychosom. Res. 53 (2002), 1177–1183.
37. [37] Ricchiuti, V., Apple, F.S., RNA expression of cardiac troponin T isoforms in diseased human skeletal muscle. Clin. Chem. 45 (1999), 2129–2135.
38. [38] Ricchiuti, V., Voss, E.M., Ney, A., Odland, M., Anderson, P.A., Apple, F.S., Cardiac troponin T isoforms expressed in renal diseased skeletal muscle will not cause false-positive results by the second generation cardiac troponin T assay by Boehringer Mannheim. Clin. Chem. 44 (1998), 1919–1924.
39. [39] Feng, J., Schaus, B.J., Fallavollita, J.A., Lee, T.C., Canty, J.M. Jr., Preload induces troponin I degradation independently of myocardial ischemia. Circulation 103 (2001), 2035–2037.
40. [40] White, H.D., Pathobiology of troponin elevations: do elevations occur with myocardial ischemia as well as necrosis?. J. Am. Coll. Cardiol. 57 (2011), 2406–2408.
41. [41] Rivara, M.B., Bajwa, E.K., Januzzi, J.L., Gong, M.N., Thompson, B.T., Christiani, D.C., Prognostic significance of elevated cardiac troponin-T levels in acute respiratory distress syndrome patients. PLoS One, 7, 2012, e40515.
42. [42] Omland, T., de Lemos, J.A., Sabatine, M.S., et al. A sensitive cardiac troponin T assay in stable coronary artery disease. N. Engl. J. Med. 361 (2009), 2538–2547.
43. [43] Lee, G.R., Jhanji, S., Tarrant, H., James, S., Pearse, R.M., Fitzgibbon, M., Peri-operative troponin monitoring using a prototype high-sensitivity cardiac troponin I (hs-cTnI) assay: comparisons with hs-cTnT and contemporary cTnI assays. Ann. Clin. Biochem. 51 (2014), 258–268.
44. [44] Jaffe, A.S., Vasile, V.C., Milone, M., Saenger, A.K., Olson, K.N., Apple, F.S., Diseased skeletal muscle: a noncardiac source of increased circulating concentrations of cardiac troponin T. J. Am. Coll. Cardiol. 58 (2011), 1819–1824.
45. [45] Rittoo, D., Jones, A., Lecky, B., Neithercut, D., Elevation of cardiac troponin T, but not cardiac troponin I, in patients with neuromuscular diseases: implications for the diagnosis of myocardial infarction. J. Am. Coll. Cardiol. 63 (2014), 2411–2420.
46. [46] Bodor, G.S., Survant, L., Voss, E.M., Smith, S., Porterfield, D., Apple, F.S., Cardiac troponin T composition in normal and regenerating human skeletal muscle. Clin. Chem. 43 (1997), 476–484.
47. [47] Anaya, P., Moliterno, D.J., The evolving role of cardiac troponin in the evaluation of cardiac disorders. Curr. Cardiol. Rep., 15, 2013, 420.
48. [48] deFilippi, C.R., de Lemos, J.A., Christenson, R.H., et al. Association of serial measures of cardiac troponin T using a sensitive assay with incident heart failure and cardiovascular mortality in older adults. JAMA 304 (2010), 2494–2502.