메뉴 건너뛰기




Volumn 15, Issue 5, 2016, Pages 673-681

NASH: A glance at the landscape of pharmacological treatment

Author keywords

Bile acids; Fatty liver; Gliflozins; GLP 1 agonists; PPARs

Indexed keywords

ALANINE AMINOTRANSFERASE; ARAMCHOL; CANAGLIFLOZIN; CENICRIVIROC; DAPAGLIFLOZIN; ELAFIBRANOR; GALECTIN; GRMD 02; HEMOGLOBIN A1C; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; INT 767; INT 777; LIRAGLUTIDE; LIVER PROTECTIVE AGENT; LOW DENSITY LIPOPROTEIN CHOLESTEROL; OBETICHOLIC ACID; SIMTUZUMAB; TRIACYLGLYCEROL; UNCLASSIFIED DRUG; NEW DRUG;

EID: 84982931638     PISSN: 16652681     EISSN: None     Source Type: Journal    
DOI: 10.5604/16652681.1212318     Document Type: Review
Times cited : (29)

References (69)
  • 1
    • 84962661546 scopus 로고    scopus 로고
    • European Association for the Study of Diabetes, European Association for the Study of Obesity. EASL-EASD-EASO Clinical Practice Guidelines for the management of non-alcoholic fatty liver disease
    • European Association for the Study of the Liver
    • European Association for the Study of the Liver, European Association for the Study of Diabetes, European Association for the Study of Obesity. EASL-EASD-EASO Clinical Practice Guidelines for the management of non-alcoholic fatty liver disease. J Hepatol 2016; 64: 1388-402.
    • (2016) J Hepatol , vol.64 , pp. 1388-1402
  • 3
    • 84928209634 scopus 로고    scopus 로고
    • Fibrosis stage is the strongest predictor for disease-specific mortality in NAFLD after up to 33 years of follow-up
    • Ekstedt M, Hagstrom H, Nasr P, Fredrikson M, Stal P, Kechagias S, Hultcrantz R. Fibrosis stage is the strongest predictor for disease-specific mortality in NAFLD after up to 33 years of follow-up. Hepatology 2015; 61: 1547-54.
    • (2015) Hepatology , vol.61 , pp. 1547-1554
    • Ekstedt, M.1    Hagstrom, H.2    Nasr, P.3    Fredrikson, M.4    Stal, P.5    Kechagias, S.6    Hultcrantz, R.7
  • 4
    • 84991081650 scopus 로고    scopus 로고
    • NAFLD-associated hepatocellular carcinoma: A threat to patients with metabolic disorders
    • Sasdelli AS, Brodosi L, Marchesini G. NAFLD-associated hepatocellular carcinoma: a threat to patients with metabolic disorders. Curr Hepatology Rep 2016; 15: 103-12.
    • (2016) Curr Hepatology Rep , vol.15 , pp. 103-112
    • Sasdelli, A.S.1    Brodosi, L.2    Marchesini, G.3
  • 5
    • 84923893879 scopus 로고    scopus 로고
    • Nonalcoholic steatohepatitis is the second leading etiology of liver disease among adults awaiting liver transplantation in the United States
    • Wong RJ, Aguilar M, Cheung R, Perumpail RB, Harrison SA, Younossi ZM, Ahmed A. Nonalcoholic steatohepatitis is the second leading etiology of liver disease among adults awaiting liver transplantation in the United States. Gastroenterology 2015; 148: 547-55.
    • (2015) Gastroenterology , vol.148 , pp. 547-555
    • Wong, R.J.1    Aguilar, M.2    Cheung, R.3    Perumpail, R.B.4    Harrison, S.A.5    Younossi, Z.M.6    Ahmed, A.7
  • 7
  • 8
    • 77957375969 scopus 로고    scopus 로고
    • Risk of cardiovascular disease in patients with nonalcoholic fatty liver disease
    • Targher G, Day CP, Bonora E. Risk of cardiovascular disease in patients with nonalcoholic fatty liver disease. N Engl J Med 2010; 363: 1341-50.
    • (2010) N Engl J Med , vol.363 , pp. 1341-1350
    • Targher, G.1    Day, C.P.2    Bonora, E.3
  • 9
    • 84902672359 scopus 로고    scopus 로고
    • Non-alcoholic fatty liver disease as a cause and a consequence of metabolic syndrome
    • Yki-Jarvinen H. Non-alcoholic fatty liver disease as a cause and a consequence of metabolic syndrome. Lancet Diabetes Endocrinol 2014; 2: 901-10.
    • (2014) Lancet Diabetes Endocrinol , vol.2 , pp. 901-910
    • Yki-Jarvinen, H.1
  • 10
  • 11
    • 84930654328 scopus 로고    scopus 로고
    • Current efforts and trends in the treatment of NASH
    • Ratziu V, Goodman Z, Sanyal A. Current efforts and trends in the treatment of NASH. J Hepatol 2015; 62: S65-S75.
    • (2015) J Hepatol , vol.62 , pp. S65-S75
    • Ratziu, V.1    Goodman, Z.2    Sanyal, A.3
  • 12
    • 84925374835 scopus 로고    scopus 로고
    • American Association for the Study of Liver Diseases, United States Food & Drug Administration. Challenges and opportunities in drug and biomarker development for nonalcoholic steatohepatitis: Findings and recommendations from an American Association for the Study of Liver Diseases-U.S. Food and Drug Administration Joint Workshop
    • Sanyal A.J., Friedman S.L., McCullough A.J., Dimick-Santos L., American Association for the Study of Liver Diseases, United States Food & Drug Administration. Challenges and opportunities in drug and biomarker development for nonalcoholic steatohepatitis: findings and recommendations from an American Association for the Study of Liver Diseases-U.S. Food and Drug Administration Joint Workshop. Hepatology 2015; 61: 1392-405.
    • (2015) Hepatology , vol.61 , pp. 1392-1405
    • Sanyal, A.J.1    Friedman, S.L.2    McCullough, A.J.3    Dimick-Santos, L.4
  • 14
    • 34248223285 scopus 로고    scopus 로고
    • Biology of incretins: GLP-1 and GIP
    • Baggio LL, Drucker DJ. Biology of incretins: GLP-1 and GIP. Gastroenterology 2007; 132: 2131-57.
    • (2007) Gastroenterology , vol.132 , pp. 2131-2157
    • Baggio, L.L.1
  • 15
    • 84855829644 scopus 로고    scopus 로고
    • Efficacy of antihyperglycemic therapies and the influence of baseline hemoglobin A(1C): A meta-analysis of the liraglutide development program
    • Henry RR, Buse JB, Sesti G, Davies MJ, Jensen KH, Brett J, Pratley RE. Efficacy of antihyperglycemic therapies and the influence of baseline hemoglobin A(1C): a meta-analysis of the liraglutide development program. Endocr Pract 2011; 17: 906-13.
    • (2011) Endocr Pract , vol.17 , pp. 906-913
    • Henry, R.R.1    Buse, J.B.2    Sesti, G.3    Davies, M.J.4    Jensen, K.H.5    Brett, J.6    Pratley, R.E.7
  • 16
    • 33644803761 scopus 로고    scopus 로고
    • Exendin-4, a glucagon-like protein-1 (GLP-1) receptor agonist, reverses hepatic steatosis in ob/ob mice
    • Ding X, Saxena NK, Lin S, Gupta NA, Anania FA. Exendin-4, a glucagon-like protein-1 (GLP-1) receptor agonist, reverses hepatic steatosis in ob/ob mice. Hepatology 2006; 43: 173-81.
    • (2006) Hepatology , vol.43 , pp. 173-181
    • Ding, X.1    Saxena, N.K.2    Lin, S.3    Gupta, N.A.4    Anania, F.A.5
  • 19
    • 79956114434 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 reduces hepatic lipogenesis via activation of AMP-activated protein kinase
    • Ben-Shlomo S, Zvibel I, Shnell M, Shlomai A, Chepurko E, Halpern Z, Barzilai N, et al. Glucagon-like peptide-1 reduces hepatic lipogenesis via activation of AMP-activated protein kinase. J Hepatol 2011; 54: 1214-23.
    • (2011) J Hepatol , vol.54 , pp. 1214-1223
    • Ben-Shlomo, S.1    Zvibel, I.2    Shnell, M.3    Shlomai, A.4    Chepurko, E.5    Halpern, Z.6    Barzilai, N.7
  • 20
    • 77951436599 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 receptor is present on human hepatocytes and has a direct role in decreasing hepatic steatosis in vitro by modulating elements of the insulin signaling pathway
    • Gupta NA, Mells J, Dunham RM, Grakoui A, Handy J, Saxena NK, Anania FA. Glucagon-like peptide-1 receptor is present on human hepatocytes and has a direct role in decreasing hepatic steatosis in vitro by modulating elements of the insulin signaling pathway. Hepatology 2010; 51: 1584-92.
    • (2010) Hepatology , vol.51 , pp. 1584-1592
    • Gupta, N.A.1    Mells, J.2    Dunham, R.M.3    Grakoui, A.4    Handy, J.5    Saxena, N.K.6    Anania, F.A.7
  • 21
    • 84957840942 scopus 로고    scopus 로고
    • Liraglutide safety and efficacy in patients with non-alcoholic steatohepatitis (LEAN): A multicentre, double-blind, randomised, placebo-controlled phase 2 study
    • Armstrong MJ, Gaunt P, Aithal GP, Barton D, Hull D, Parker R, Hazlehurst JM, et al. Liraglutide safety and efficacy in patients with non-alcoholic steatohepatitis (LEAN): a multicentre, double-blind, randomised, placebo-controlled phase 2 study. Lancet 2016; 387: 679-90.
    • (2016) Lancet , vol.387 , pp. 679-690
    • Armstrong, M.J.1    Gaunt, P.2    Aithal, G.P.3    Barton, D.4    Hull, D.5    Parker, R.6    Hazlehurst, J.M.7
  • 25
    • 7644244675 scopus 로고    scopus 로고
    • The nuclear receptor SHP mediates inhibition of hepatic stellate cells by FXR and protects against liver fibrosis
    • Fiorucci S, Antonelli E, Rizzo G, Renga B, Mencarelli A, Riccardi L, Orlandi S, et al. The nuclear receptor SHP mediates inhibition of hepatic stellate cells by FXR and protects against liver fibrosis. Gastroenterology 2004; 127: 1497-512.
    • (2004) Gastroenterology , vol.127 , pp. 1497-1512
    • Fiorucci, S.1    Antonelli, E.2    Rizzo, G.3    Renga, B.4    Mencarelli, A.5    Riccardi, L.6    Orlandi, S.7
  • 26
    • 84865499656 scopus 로고    scopus 로고
    • Farnesoid X receptor targeting to treat nonalcoholic steatohepatitis
    • Adorini L, Pruzanski M, Shapiro D. Farnesoid X receptor targeting to treat nonalcoholic steatohepatitis. Drug Discov Today 2012; 17: 988-97.
    • (2012) Drug Discov Today , vol.17 , pp. 988-997
    • Adorini, L.1    Pruzanski, M.2    Shapiro, D.3
  • 27
    • 0037414757 scopus 로고    scopus 로고
    • Natural structural variants of the nuclear receptor farnesoid X receptor affect transcriptional activation
    • Zhang Y, Kast-Woelbern HR, Edwards PA. Natural structural variants of the nuclear receptor farnesoid X receptor affect transcriptional activation. J Biol Chem 2003; 278: 104-10.
    • (2003) J Biol Chem , vol.278 , pp. 104-110
    • Zhang, Y.1    Kast-Woelbern, H.R.2    Edwards, P.A.3
  • 28
    • 84880664792 scopus 로고    scopus 로고
    • Efficacy and safety of the farnesoid X receptor agonist obeticholic acid in patients with type 2 diabetes and nonalcoholic fatty liver disease
    • Mudaliar S, Henry RR, Sanyal AJ, Morrow L, Marschall HU, Kipnes M, Adorini L, et al. Efficacy and safety of the farnesoid X receptor agonist obeticholic acid in patients with type 2 diabetes and nonalcoholic fatty liver disease. Gastroenterology 2013; 145: 574-82 e1.
    • (2013) Gastroenterology , vol.145 , pp. 574-582
    • Mudaliar, S.1    Henry, R.R.2    Sanyal, A.J.3    Morrow, L.4    Marschall, H.U.5    Kipnes, M.6    Adorini, L.7
  • 29
    • 32244447570 scopus 로고    scopus 로고
    • Activation of the nuclear receptor FXR improves hyperglycemia and hyperlipidemia in diabetic mice
    • Zhang Y, Lee FY, Barrera G, Lee H, Vales C, Gonzalez FJ, Willson TM, et al. Activation of the nuclear receptor FXR improves hyperglycemia and hyperlipidemia in diabetic mice. Proc Natl Acad Sci U S A 2006; 103: 1006-11.
    • (2006) Proc Natl Acad Sci , vol.103 , pp. 1006-1011
    • Zhang, Y.1    Lee, F.Y.2    Barrera, G.3    Lee, H.4    Vales, C.5    Gonzalez, F.J.6    Willson, T.M.7
  • 30
    • 37349010675 scopus 로고    scopus 로고
    • FXR signaling in metabolic disease
    • Zhang Y, Edwards PA. FXR signaling in metabolic disease. FEBS Lett 2008; 582: 10-8.
    • (2008) FEBS Lett , vol.582 , pp. 10-18
    • Zhang, Y.1
  • 32
    • 11844269279 scopus 로고    scopus 로고
    • Ligand-dependent coactivation of the human bile acid receptor FXR by the peroxisome proliferator-activated receptor gamma coactivator-1alpha
    • Savkur RS, Thomas JS, Bramlett KS, Gao Y, Michael LF, Burris TP. Ligand-dependent coactivation of the human bile acid receptor FXR by the peroxisome proliferator-activated receptor gamma coactivator-1alpha. J Pharmacol Exp Ther 2005; 312: 170-8.
    • (2005) J Pharmacol Exp Ther , vol.312 , pp. 170-178
    • Savkur, R.S.1    Thomas, J.S.2    Bramlett, K.S.3    Gao, Y.4    Michael, L.F.5    Burris, T.P.6
  • 33
    • 56149085041 scopus 로고    scopus 로고
    • Farnesoid X receptor antagonizes nuclear factor kappaB in hepatic inflammatory response
    • Wang YD, Chen WD, Wang M, Yu D, Forman BM, Huang W. Farnesoid X receptor antagonizes nuclear factor kappaB in hepatic inflammatory response. Hepatology 2008; 48: 1632-43.
    • (2008) Hepatology , vol.48 , pp. 1632-1643
    • Wang, Y.D.1    Chen, W.D.2    Wang, M.3    Yu, D.4    Forman, B.M.5    Huang, W.6
  • 35
    • 84929266699 scopus 로고    scopus 로고
    • Farnesoid X nuclear receptor ligand obeticholic acid for non-cirrhotic, non-alcoholic steatohepatitis (FLINT): A multicentre, randomised, placebo-controlled trial
    • Neuschwander-Tetri BA, Loomba R, Sanyal AJ, Lavine JE, Van Natta ML, Abdelmalek MF, Chalasani N, et al. Farnesoid X nuclear receptor ligand obeticholic acid for non-cirrhotic, non-alcoholic steatohepatitis (FLINT): a multicentre, randomised, placebo-controlled trial. Lancet 2015; 385: 956-65.
    • (2015) Lancet , vol.385 , pp. 956-965
    • Neuschwander-Tetri, B.A.1    Loomba, R.2    Sanyal, A.J.3    Lavine, J.E.4    Van Natta, M.L.5    Abdelmalek, M.F.6    Chalasani, N.7
  • 36
    • 84923067081 scopus 로고    scopus 로고
    • Molecular mechanism of PPARalpha action and its impact on lipid metabolism, inflammation and fibrosis in non-alcoholic fatty liver disease
    • Pawlak M, Lefebvre P, Staels B. Molecular mechanism of PPARalpha action and its impact on lipid metabolism, inflammation and fibrosis in non-alcoholic fatty liver disease. J Hepatol 2015; 62: 720-33.
    • (2015) J Hepatol , vol.62 , pp. 720-733
    • Pawlak, M.1    Lefebvre, P.2    Staels, B.3
  • 37
    • 84875190733 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor delta: A multifaceted metabolic player
    • Bojic LA, Huff MW. Peroxisome proliferator-activated receptor delta: a multifaceted metabolic player. Curr Opin Lipidol 2013; 24: 171-7.
    • (2013) Curr Opin Lipidol , vol.24 , pp. 171-177
    • Bojic, L.A.1    Huff, M.W.2
  • 38
    • 84888285959 scopus 로고    scopus 로고
    • Hepatoprotective effects of the dual peroxisome proliferator-activated receptor alpha/delta agonist, GFT505, in rodent models of nonalcoholic fatty liver disease/ nonalcoholic steatohepatitis
    • Staels B, Rubenstrunk A, Noel B, Rigou G, Delataille P, Millatt LJ, Baron M, et al. Hepatoprotective effects of the dual peroxisome proliferator-activated receptor alpha/delta agonist, GFT505, in rodent models of nonalcoholic fatty liver disease/ nonalcoholic steatohepatitis. Hepatology 2013; 58: 1941-52.
    • (2013) Hepatology , vol.58 , pp. 1941-1952
    • Staels, B.1    Rubenstrunk, A.2    Noel, B.3    Rigou, G.4    Delataille, P.5    Millatt, L.J.6    Baron, M.7
  • 39
    • 84885405205 scopus 로고    scopus 로고
    • Dual peroxisome proliferator-activated receptor alpha/delta agonist GFT505 improves hepatic and peripheral insulin sensitivity in abdominally obese subjects
    • Cariou B, Hanf R, Lambert-Porcheron S, Zair Y, Sauvinet V, Noel B, Flet L, et al. Dual peroxisome proliferator-activated receptor alpha/delta agonist GFT505 improves hepatic and peripheral insulin sensitivity in abdominally obese subjects. Diabetes Care 2013; 36: 2923-30.
    • (2013) Diabetes Care , vol.36 , pp. 2923-2930
    • Cariou, B.1    Hanf, R.2    Lambert-Porcheron, S.3    Zair, Y.4    Sauvinet, V.5    Noel, B.6    Flet, L.7
  • 40
    • 84907056944 scopus 로고    scopus 로고
    • GFT505 for the treatment of nonalcoholic steatohepatitis and type 2 diabetes
    • Cariou B, Staels B. GFT505 for the treatment of nonalcoholic steatohepatitis and type 2 diabetes. Expert Opin Investig Drugs 2014; 23: 1441-8.
    • (2014) Expert Opin Investig Drugs , vol.23 , pp. 1441-1448
    • Cariou, B.1    Staels, B.2
  • 41
    • 79960988152 scopus 로고    scopus 로고
    • Effects of the new dual PPAR alpha/delta agonist GFT505 on lipid and glucose homeostasis in abdominally obese patients with combined dyslipidemia or impaired glucose metabolism
    • Cariou B, Zair Y, Staels B, Bruckert E. Effects of the new dual PPAR alpha/delta agonist GFT505 on lipid and glucose homeostasis in abdominally obese patients with combined dyslipidemia or impaired glucose metabolism. Diabetes Care 2011; 34: 2008-14.
    • (2011) Diabetes Care , vol.34 , pp. 2008-2014
    • Cariou, B.1    Zair, Y.2    Staels, B.3    Bruckert, E.4
  • 42
    • 84960140218 scopus 로고    scopus 로고
    • Elafibranor, an agonist of the peroxisome proliferator-activated receptor-alpha and -delta, induces resolution of nonalcoholic steatohepatitis without fibrosis worsening
    • Ratziu V, Harrison SA, Francque S, Bedossa P, Lehert P, Serfaty L, Romero-Gomez M, et al. Elafibranor, an agonist of the peroxisome proliferator-activated receptor-alpha and -delta, induces resolution of nonalcoholic steatohepatitis without fibrosis worsening. Gastroenterology 2016; 150: 1147-59 e5.
    • (2016) Gastroenterology , vol.150 , Issue.5 , pp. 1147-1159
    • Ratziu, V.1    Harrison, S.A.2    Francque, S.3    Bedossa, P.4    Lehert, P.5    Serfaty, L.6
  • 43
    • 84957709696 scopus 로고    scopus 로고
    • Sodium-glucose cotransporter inhibitors: Effects on renal and intestinal glucose transport: From bench to bedside
    • Mudaliar S, Polidori D, Zambrowicz B, Henry RR. Sodium-glucose cotransporter inhibitors: effects on renal and intestinal glucose transport: from bench to bedside. Diabetes Care 2015; 38: 2344-53.
    • (2015) Diabetes Care , vol.38 , pp. 2344-2353
    • Mudaliar, S.1    Polidori, D.2    Zambrowicz, B.3    Henry, R.R.4
  • 46
    • 84893682957 scopus 로고    scopus 로고
    • SGLT2 selective inhibitor ipragliflozin reduces body fat mass by increasing fatty acid oxidation in high-fat diet-induced obese rats
    • Yokono M, Takasu T, Hayashizaki Y, Mitsuoka K, Kihara R, Muramatsu Y, Miyoshi S, et al. SGLT2 selective inhibitor ipragliflozin reduces body fat mass by increasing fatty acid oxidation in high-fat diet-induced obese rats. Eur J Pharmacol 2014; 727: 66-74.
    • (2014) Eur J Pharmacol , vol.727 , pp. 66-74
    • Yokono, M.1    Takasu, T.2    Hayashizaki, Y.3    Mitsuoka, K.4    Kihara, R.5    Muramatsu, Y.6    Miyoshi, S.7
  • 47
    • 84923902007 scopus 로고    scopus 로고
    • Ipragliflozin, an SGLT2 inhibitor, exhibits a prophylactic effect on hepatic steatosis and fibrosis induced by choline-deficient l-amino acid-defined diet in rats
    • Hayashizaki-Someya Y, Kurosaki E, Takasu T, Mitori H, Yamazaki S, Koide K, Takakura S. Ipragliflozin, an SGLT2 inhibitor, exhibits a prophylactic effect on hepatic steatosis and fibrosis induced by choline-deficient l-amino acid-defined diet in rats. Eur J Pharmacol 2015; 754: 19-24.
    • (2015) Eur J Pharmacol , vol.754 , pp. 19-24
    • Hayashizaki-Someya, Y.1    Kurosaki, E.2    Takasu, T.3    Mitori, H.4    Yamazaki, S.5    Koide, K.6    Takakura, S.7
  • 48
    • 84887997289 scopus 로고    scopus 로고
    • Efficacy and safety of canagliflozin compared with placebo and sitagliptin in patients with type 2 diabetes on background metformin monotherapy: A randomised trial
    • Lavalle-Gonzalez FJ, Januszewicz A, Davidson J, Tong C, Qiu R, Canovatchel W, Meininger G. Efficacy and safety of canagliflozin compared with placebo and sitagliptin in patients with type 2 diabetes on background metformin monotherapy: a randomised trial. Diabetologia 2013; 56: 2582-92.
    • (2013) Diabetologia , vol.56 , pp. 2582-2592
    • Lavalle-Gonzalez, F.J.1    Januszewicz, A.2    Davidson, J.3    Tong, C.4    Qiu, R.5    Canovatchel, W.6    Meininger, G.7
  • 49
    • 77953857048 scopus 로고    scopus 로고
    • Effect of dapagliflozin in patients with type 2 diabetes who have inadequate glycaemic control with metformin: A randomised, double-blind, placebo-controlled trial
    • Bailey CJ, Gross JL, Pieters A, Bastien A, List JF. Effect of dapagliflozin in patients with type 2 diabetes who have inadequate glycaemic control with metformin: a randomised, double-blind, placebo-controlled trial. Lancet 2010; 375: 2223-33.
    • (2010) Lancet , vol.375 , pp. 2223-2233
    • Bailey, C.J.1    Gross, J.L.2    Pieters, A.3    Bastien, A.4    List, J.F.5
  • 51
    • 84979487099 scopus 로고    scopus 로고
    • Remogliflozin etabonate reduces insulin resistance and liver function enzymes: Role for treatment of NASH
    • Wilkinson W, Cheatham B, Walker S. Remogliflozin etabonate reduces insulin resistance and liver function enzymes: role for treatment of NASH. J Hepatol 2015; 62: S211.
    • (2015) J Hepatol , vol.62 , pp. 211
    • Wilkinson, W.1    Cheatham, B.2    Walker, S.3
  • 52
  • 53
    • 84906558405 scopus 로고    scopus 로고
    • Significant anti-fibrootic activity of cenicriviroc, a dual CCR2/CCR5 antagonist, in a rat model of thioacetamide-induced liver fibrosis and cirrhosis
    • Hong F, Chou H, Friedman SL. Significant anti-fibrootic activity of cenicriviroc, a dual CCR2/CCR5 antagonist, in a rat model of thioacetamide-induced liver fibrosis and cirrhosis. Hepatology 2013; 58: 1381A-2A.
    • (2013) Hepatology , vol.58 , pp. 1381-1382
    • Hong, F.1    Chou, H.2    Friedman, S.L.3
  • 54
    • 84977139510 scopus 로고    scopus 로고
    • Antifibrotic effects of the dual CCR2/ CCR5 antagonist cenicriviroc in animal models of liver and kidney fibrosis
    • Lefebvre E, Moyle G, Reshef R, Richman LP, Thompson M, Hong F, Chou HL, et al. Antifibrotic effects of the dual CCR2/ CCR5 antagonist cenicriviroc in animal models of liver and kidney fibrosis. PLoS One 2016; 11: e0158156.
    • (2016) Plos One , vol.11
    • Lefebvre, E.1    Moyle, G.2    Reshef, R.3    Richman, L.P.4    Thompson, M.5    Hong, F.6    Chou, H.L.7
  • 55
    • 84960425749 scopus 로고    scopus 로고
    • A 48-week randomized phase 2b study evaluating cenicriviroc versus efavirenz in treatment-naive HIV-infected adults with C-C chemokine receptor type 5-tropic virus
    • Thompson M, Saag M, DeJesus E, Gathe J, Lalezari J, Landay AL, Cade J, et al. A 48-week randomized phase 2b study evaluating cenicriviroc versus efavirenz in treatment-naive HIV-infected adults with C-C chemokine receptor type 5-tropic virus. AIDS 2016; 30: 869-78.
    • (2016) AIDS , vol.30 , pp. 869-878
    • Thompson, M.1    Saag, M.2    Dejesus, E.3    Gathe, J.4    Lalezari, J.5    Landay, A.L.6    Cade, J.7
  • 56
    • 85027920092 scopus 로고    scopus 로고
    • Pharmacokinetics, safety, and CCR2/CCR5 antagonist activity of cenicriviroc in participants with mild or moderate hepatic impairment
    • Lefebvre E, Gottwald M, Lasseter K, Chang W, Willett M, Smith PF, Somasunderam A, et al. Pharmacokinetics, safety, and CCR2/CCR5 antagonist activity of cenicriviroc in participants with mild or moderate hepatic impairment. Clin Transl Sci 2016; 9: 139-48.
    • (2016) Clin Transl Sci , vol.9 , pp. 139-148
    • Lefebvre, E.1    Gottwald, M.2    Lasseter, K.3    Chang, W.4    Willett, M.5    Smith, P.F.6    Somasunderam, A.7
  • 57
    • 20044394029 scopus 로고    scopus 로고
    • Effects of fatty acid bile acid conjugates (FABACs) on biliary lithogenesis: Potential consequences for non-surgical treatment of gallstones
    • Konikoff FM, Gilat T. Effects of fatty acid bile acid conjugates (FABACs) on biliary lithogenesis: potential consequences for non-surgical treatment of gallstones. Curr Drug Targets Immune Endocr Metabol Disord 2005; 5: 171-5.
    • (2005) Curr Drug Targets Immune Endocr Metabol Disord , vol.5 , pp. 171-175
    • Konikoff, F.M.1    Gilat, T.2
  • 58
    • 13844250258 scopus 로고    scopus 로고
    • Stearoyl-CoA desaturase-1 deficiency reduces ceramide synthesis by downregulating serine palmitoyltransferase and increasing beta-oxidation in skeletal muscle
    • Dobrzyn A, Dobrzyn P, Lee SH, Miyazaki M, Cohen P, Asilmaz E, Hardie DG, et al. Stearoyl-CoA desaturase-1 deficiency reduces ceramide synthesis by downregulating serine palmitoyltransferase and increasing beta-oxidation in skeletal muscle. Am J Physiol Endocrinol Metab 2005; 288: E599-E607.
    • (2005) Am J Physiol Endocrinol Metab , vol.288 , pp. E599-E607
    • Dobrzyn, A.1    Dobrzyn, P.2    Lee, S.H.3    Miyazaki, M.4    Cohen, P.5    Asilmaz, E.6    Hardie, D.G.7
  • 60
    • 84903553831 scopus 로고    scopus 로고
    • Opportunities and challenges in developing stearoyl-coenzyme A desaturase-1 inhibitors as novel therapeutics for human disease
    • Zhang Z, Dales NA, Winther MD. Opportunities and challenges in developing stearoyl-coenzyme A desaturase-1 inhibitors as novel therapeutics for human disease. J Med Chem 2014; 57: 5039-56.
    • (2014) J Med Chem , vol.57 , pp. 5039-5056
    • Zhang, Z.1    Dales, N.A.2    Winther, M.D.3
  • 61
    • 84918843434 scopus 로고    scopus 로고
    • The fatty acid-bile acid conjugate Aramchol reduces liver fat content in patients with nonalcoholic fatty liver disease
    • Safadi R, Konikoff FM, Mahamid M, Zelber-Sagi S, Halpern M, Gilat T, Oren R., et al. The fatty acid-bile acid conjugate Aramchol reduces liver fat content in patients with nonalcoholic fatty liver disease. Clin Gastroenterol Hepatol 2014; 12: 2085-91 e1.
    • (2014) Clin Gastroenterol Hepatol , vol.12 , Issue.1 , pp. 2085-2091
    • Safadi, R.1    Konikoff, F.M.2    Mahamid, M.3    Zelber-Sagi, S.4    Halpern, M.5    Gilat, T.6    Oren, R.7
  • 64
    • 84876896348 scopus 로고    scopus 로고
    • Bile acid receptor activation modulates hepatic monocyte activity and improves nonalcoholic fatty liver disease
    • McMahan RH, Wang XX, Cheng LL, Krisko T, Smith M, El Kasmi K, Pruzanski M, et al. Bile acid receptor activation modulates hepatic monocyte activity and improves nonalcoholic fatty liver disease. J Biol Chem 2013; 288: 11761-70.
    • (2013) J Biol Chem , vol.288 , pp. 11761-11770
    • McMahan, R.H.1    Wang, X.X.2    Cheng, L.L.3    Krisko, T.4    Smith, M.5    El Kasmi, K.6    Pruzanski, M.7
  • 65
    • 84978245141 scopus 로고    scopus 로고
    • Pathophysiology, evidence, and practice
    • Marchesini G, Petta S, Dalle Grave R. Diet, weight loss, and liver health in nonalcoholic fatty liver disease: Pathophysiology, evidence, and practice. Hepatology 2016; 63: 2032-43.
    • (2016) Hepatology , vol.63 , pp. 2032-2043
    • Marchesini, G.1    Petta, S.2    Diet, D.G.R.3
  • 67
    • 84964724191 scopus 로고    scopus 로고
    • Very-low-calorie diet and 6 months of weight stability in type 2 diabetes: Pathophysiologic changes in responders and nonresponders
    • Steven S, Hollingsworth KG, Al-Mrabeh A, Avery L, Aribisala B, Caslake M, Taylor R. Very-low-calorie diet and 6 months of weight stability in type 2 diabetes: pathophysiologic changes in responders and nonresponders. Diabetes Care 2016; 39: 808-15.
    • (2016) Diabetes Care , vol.39 , pp. 808-815
    • Steven, S.1    Hollingsworth, K.G.2    Al-Mrabeh, A.3    Avery, L.4    Aribisala, B.5    Caslake, M.6    Taylor, R.7
  • 69
    • 0242268980 scopus 로고    scopus 로고
    • Type 2 diabetes and the Naaman syndrome
    • Marchesini G, Trovati M. Type 2 diabetes and the Naaman syndrome. Diabetes Care 2003; 26: 3195.
    • (2003) Diabetes Care , vol.26 , pp. 3195
    • Marchesini, G.1    Trovati, M.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.