The efficacy of Cognitive training in patients with VAsCular Cognitive Impairment, No dEmentia (the Cog-VACCINE study): Study protocol for a randomized controlled trial

Trials

Volumn 17, Issue 1, 2016, Pages

  Tang, Yi ^a   Zhu, Zude ^b   Liu, Qing ^a   Li, Fang ^c   Yang, Jianwei ^a   Li, Fangyu ^a   Xing, Yi ^a   Jia, Jianping ^a,d  

^a CAPITAL MEDICAL UNIVERSITY   (China)

^b JIANGSU NORMAL UNIVERSITY   (China)

^c CAPITAL MEDICAL UNIVERSITY   (China)

^d CAPITAL MEDICAL UNIVERSITY   (China)

Author keywords

Cognitive training; Magnetic resonance imaging; Neuroplasticity; No dementia; Protocol; Randomized controlled clinical trial; Vascular cognitive impairment

Indexed keywords

APOLIPOPROTEIN E;

ADULT; ARTICLE; ATTENTION; CLINICAL EFFECTIVENESS; COGNITION; COGNITIVE DEFECT; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; EXECUTIVE FUNCTION; FUNCTIONAL MAGNETIC RESONANCE IMAGING; GENOTYPING TECHNIQUE; HUMAN; LONG TERM MEMORY; MAJOR CLINICAL STUDY; MEMORY DISORDER; MENTAL PERFORMANCE; NERVE CELL PLASTICITY; NEUROPSYCHOLOGICAL TEST; PROBLEM SOLVING; RANDOMIZED CONTROLLED TRIAL; RISK FACTOR; SENSITIVITY ANALYSIS; TASK PERFORMANCE; TRAINING; VASCULAR COGNITIVE IMPAIRMENT NO DEMENTIA; WORKING MEMORY; BRAIN; CEREBROVASCULAR DISEASE; CHINA; CLINICAL PROTOCOL; CLINICAL TRIAL; COGNITIVE THERAPY; CONVALESCENCE; DIAGNOSTIC IMAGING; FEMALE; MALE; METHODOLOGY; MIDDLE AGED; MULTICENTER STUDY; NUCLEAR MAGNETIC RESONANCE IMAGING; PATHOPHYSIOLOGY; PROCEDURES; PSYCHOLOGY; TIME FACTOR; TREATMENT OUTCOME;

BRAIN; CEREBROVASCULAR DISORDERS; CHINA; CLINICAL PROTOCOLS; COGNITION; COGNITIVE DYSFUNCTION; COGNITIVE THERAPY; DOUBLE-BLIND METHOD; EXECUTIVE FUNCTION; FEMALE; HUMANS; MAGNETIC RESONANCE IMAGING; MALE; MIDDLE AGED; NEURONAL PLASTICITY; NEUROPSYCHOLOGICAL TESTS; RECOVERY OF FUNCTION; RESEARCH DESIGN; TIME FACTORS; TREATMENT OUTCOME;

EID: 84982806725     PISSN: None     EISSN: 17456215     Source Type: Journal    
DOI: 10.1186/s13063-016-1523-x     Document Type: Article

References (38)

1. Prince MJ, Wu F, Guo Y, Gutierrez Robledo LM, O'Donnell M, Sullivan R, Yusuf S. The burden of disease in older people and implications for health policy and practice. Lancet. 2015;385(9967):549-62.
2. Hachinski V, Iadecola C, Petersen RC, Breteler MM, Nyenhuis DL, Black SE, Powers WJ, DeCarli C, Merino JG, Kalaria RN, et al. National Institute of Neurological Disorders and Stroke-Canadian Stroke Network vascular cognitive impairment harmonization standards. Stroke. 2006;37(9):2220-41.
3. Sachdev P, Kalaria R, O'Brien J, Skoog I, Alladi S, Black SE, Blacker D, Blazer DG, Chen C, Chui H, et al. Diagnostic criteria for vascular cognitive disorders: a VASCOG statement. Alzheimer Dis Assoc Disord. 2014;28(3):206-18.
4. Wentzel C, Rockwood K, MacKnight C, Hachinski V, Hogan DB, Feldman H, Ostbye T, Wolfson C, Gauthier S, Verreault R, et al. Progression of impairment in patients with vascular cognitive impairment without dementia. Neurology. 2001;57(4):714-6.
5. Stephan BC, Matthews FE, Khaw KT, Dufouil C, Brayne C. Beyond mild cognitive impairment: vascular cognitive impairment, no dementia (VCIND). Alzheimers Res Ther. 2009;1(1):4.
6. Jia J, Zhou A, Wei C, Jia X, Wang F, Li F, Wu X, Mok V, Gauthier S, Tang M, et al. The prevalence of mild cognitive impairment and its etiological subtypes in elderly Chinese. Alzheimers Dement. 2014;10(4):439-47.
7. Rockwood K, Wentzel C, Hachinski V, Hogan DB, MacKnight C, McDowell I. Prevalence and outcomes of vascular cognitive impairment. Vascular Cognitive Impairment Investigators of the Canadian Study of Health and Aging. Neurology. 2000;54(2):447-51.
8. Pantoni L. Cerebral small vessel disease: from pathogenesis and clinical characteristics to therapeutic challenges. Lancet Neurol. 2010;9(7):689-701.
9. Jokinen H, Kalska H, Mantyla R, Pohjasvaara T, Ylikoski R, Hietanen M, Salonen O, Kaste M, Erkinjuntti T. Cognitive profile of subcortical ischaemic vascular disease. J Neurol Neurosurg Psychiatry. 2006;77(1):28-33.
10. Kramer JH, Reed BR, Mungas D, Weiner MW, Chui HC. Executive dysfunction in subcortical ischaemic vascular disease. J Neurol Neurosurg Psychiatry. 2002;72(2):217-20.
11. Tierney MC, Black SE, Szalai JP, Snow WG, Fisher RH, Nadon G, Chui HC. Recognition memory and verbal fluency differentiate probable Alzheimer disease from subcortical ischemic vascular dementia. Arch Neurol. 2001;58(10):1654-9.
12. Ramos-Estebanez C, Moral-Arce I, Gonzalez-Mandly A, Dhagubatti V, Gonzalez-Macias J, Munoz R, Hernadez-Hernandez JL. Vascular cognitive impairment in small vessel disease: clinical and neuropsychological features of lacunar state and Binswanger's disease. Age Ageing. 2011;40(2):175-80.
13. Toril P, Reales JM, Ballesteros S. Video game training enhances cognition of older adults: a meta-analytic study. Psychol Aging. 2014;29(3):706-16.
14. Anguera JA, Boccanfuso J, Rintoul JL, Al-Hashimi O, Faraji F, Janowich J, Kong E, Larraburo Y, Rolle C, Johnston E, et al. Video game training enhances cognitive control in older adults. Nature. 2013;501(7465):97-101.
15. Gates NJ, Sachdev P. Is cognitive training an effective treatment for preclinical and early Alzheimer's disease? J Alzheimers Dis. 2014;42 Suppl 4:S551-559.
16. Simon SS, Yokomizo JE, Bottino CM. Cognitive intervention in amnestic mild cognitive impairment: a systematic review. Neurosci Biobehav Rev. 2012;36(4):1163-78.
17. Fiatarone Singh MA, Gates N, Saigal N, Wilson GC, Meiklejohn J, Brodaty H, Wen W, Singh N, Baune BT, Suo C, et al. The Study of Mental and Resistance Training (SMART) study-resistance training and/or cognitive training in mild cognitive impairment: a randomized, double-blind, double-sham controlled trial. J Am Med Dir Assoc. 2014;15(12):873-80.
18. Barnes DE, Santos-Modesitt W, Poelke G, Kramer AF, Castro C, Middleton LE, Yaffe K. The Mental Activity and EXercise (MAX) trial: a randomized controlled trial to enhance cognitive function in older adults. JAMA Intern Med. 2013;173(9):797-804.
19. Li H, Li J, Li N, Li B, Wang P, Zhou T. Cognitive intervention for persons with mild cognitive impairment: a meta-analysis. Ageing Res Rev. 2011;10(2):285-96.
20. Herrera C, Chambon C, Michel BF, Paban V, Alescio-Lautier B. Positive effects of computer-based cognitive training in adults with mild cognitive impairment. Neuropsychologia. 2012;50(8):1871-81.
21. Buschert VC, Giegling I, Teipel SJ, Jolk S, Hampel H, Rujescu D, Buerger K. Long-term observation of a multicomponent cognitive intervention in mild cognitive impairment. J Clin Psychiatry. 2012;73(12):e1492-1498.
22. Belleville S, Clement F, Mellah S, Gilbert B, Fontaine F, Gauthier S. Training-related brain plasticity in subjects at risk of developing Alzheimer's disease. Brain. 2011;134(Pt 6):1623-34.
23. Hosseini SM, Kramer JH, Kesler SR. Neural correlates of cognitive intervention in persons at risk of developing Alzheimer's disease. Front Aging Neurosci. 2014;6:231.
24. Gutchess A. Plasticity of the aging brain: new directions in cognitive neuroscience. Science. 2014;346(6209):579-82.
25. Engvig A, Fjell AM, Westlye LT, Moberget T, Sundseth O, Larsen VA, Walhovd KB. Effects of memory training on cortical thickness in the elderly. Neuroimage. 2010;52(4):1667-76.
26. Engvig A, Fjell AM, Westlye LT, Moberget T, Sundseth O, Larsen VA, Walhovd KB. Memory training impacts short-term changes in aging white matter: a longitudinal diffusion tensor imaging study. Hum Brain Mapp. 2012;33(10):2390-406.
27. Chapman SB, Aslan S, Spence JS, Hart Jr JJ, Bartz EK, Didehbani N, Keebler MW, Gardner CM, Strain JF, DeFina LF, et al. Neural mechanisms of brain plasticity with complex cognitive training in healthy seniors. Cereb Cortex. 2015;25(2):396-405.
28. Schulz KF, Altman DG, Moher D, Group C. CONSORT 2010 statement: updated guidelines for reporting parallel group randomised trials. Int J Surg. 2011;9(8):672-7.
29. Boutron I, Moher D, Altman DG, Schulz KF, Ravaud P, Group C. Extending the CONSORT statement to randomized trials of nonpharmacologic treatment: explanation and elaboration. Ann Intern Med. 2008;148(4):295-309.
30. Winblad B, Palmer K, Kivipelto M, Jelic V, Fratiglioni L, Wahlund LO, Nordberg A, Backman L, Albert M, Almkvist O, et al. Mild cognitive impairment - beyond controversies, towards a consensus: report of the International Working Group on Mild Cognitive Impairment. J Intern Med. 2004;256(3):240-6.
31. Association AP. DSM-IV: diagnostic and statistical manual of mental disorders. 4th ed. Washington, DC: American Psychiatric Association; 1994.
32. Hughes CP, Berg L, Danziger WL, Coben LA, Martin RL. A new clinical scale for the staging of dementia. Br J Psychiatry. 1982;140:566-72.
33. Folstein MF, Folstein SE, McHugh PR. 'Mini-mental state': a practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res. 1975;12(3):189-98.
34. Zhang MY, Katzman R, Salmon D, Jin H, Cai GJ, Wang ZY, Qu GY, Grant I, Yu E, Levy P, et al. The prevalence of dementia and Alzheimer's disease in Shanghai, China: impact of age, gender, and education. Ann Neurol. 1990;27(4):428-37.
35. Fazekas F, Chawluk JB, Alavi A, Hurtig HI, Zimmerman RA. MR signal abnormalities at 1.5 T in Alzheimer's dementia and normal aging. AJR Am J Roentgenol. 1987;149(2):351-6.
36. Scheltens P, Leys D, Barkhof F, Huglo D, Weinstein HC, Vermersch P, Kuiper M, Steinling M, Wolters EC, Valk J. Atrophy of medial temporal lobes on MRI in 'probable' Alzheimer's disease and normal ageing: diagnostic value and neuropsychological correlates. J Neurol Neurosurg Psychiatry. 1992;55(10):967-72.
37. Han X, Shi D, Zhou X, Yang Y, Zhu Z. The training and transfer effect of cognitive training in old adults. Adv Psychol Sci. 2016;24(6):909-22.
38. Kueider AM, Parisi JM, Gross AL, Rebok GW. Computerized cognitive training with older adults: a systematic review. PLoS One. 2012;7(7), e40588.