Examining the robustness of the obesity paradox in maintenance hemodialysis patients: A marginal structural model analysis

Nephrology Dialysis Transplantation

Volumn 31, Issue 8, 2016, Pages 1310-1319

  Doshi, Megha ^a   Streja, Elani ^a   Rhee, Connie M ^a   Park, Jongha ^a,b   Ravel, Vanessa A ^a   Soohoo, Melissa ^a   Moradi, Hamid ^a,f   Lau, Wei Ling ^a   Mehrotra, Rajnish ^c   Kuttykrishnan, Sooraj ^c   Kovesdy, Csaba P ^d,e   Kalantar Zadeh, Kamyar ^a,f,g   Chen, Joline L T ^a,f  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b University of Ulsan College of Medicine   (South Korea)

^c UNIVERSITY OF WASHINGTON   (United States)

^d UNIVERSITY OF TENNESSEE HEALTH SCIENCE CENTER   (United States)

^e VETERANS AFFAIRS MEDICAL CENTER   (United States)

^f Veterans Affairs Long Beach Healthcare System   (United States)

^g UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Cardiovascular; Dialysis; Epidemiology; Nutrition; Obesity

Indexed keywords

ADULT; ARTICLE; BODY MASS; CARDIOVASCULAR MORTALITY; CHRONIC KIDNEY DISEASE; COHORT ANALYSIS; CONTROLLED STUDY; DISEASE ASSOCIATION; FEMALE; HEMODIALYSIS PATIENT; HUMAN; INFLAMMATION; MAJOR CLINICAL STUDY; MALE; MALNUTRITION; MIDDLE AGED; MORTALITY; MORTALITY RATE; MORTALITY RISK; OBESITY; PRIORITY JOURNAL; SURVIVAL RATE; ADOLESCENT; AGED; CLINICAL TRIAL; COMPLICATION; EPIDEMIOLOGY; HEMODIALYSIS; KIDNEY FAILURE, CHRONIC; MULTICENTER STUDY; PROPORTIONAL HAZARDS MODEL; TRENDS; UNITED STATES; VERY ELDERLY; YOUNG ADULT;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; BODY MASS INDEX; FEMALE; HUMANS; KIDNEY FAILURE, CHRONIC; MALE; MIDDLE AGED; OBESITY; PROPORTIONAL HAZARDS MODELS; RENAL DIALYSIS; SURVIVAL RATE; UNITED STATES; YOUNG ADULT;

EID: 84982179507     PISSN: 09310509     EISSN: 14602385     Source Type: Journal    
DOI: 10.1093/ndt/gfv379     Document Type: Article

References (52)

1. Ogden CL, Kit BK, Flegal KM. Prevalence of obesity in the United States, 2009-2010. NCHS Data Brief January 2012; (82): 1-8
2. U. S. Renal Data System. USRDS 2006 annual data report: atlas of end-stage renal disease in the United States. In: National Institutes of Health NIDDK, ed. USRDS Annual Report. Bethesda, MD: NIH/NIDDK, 2008
3. Chertow GM, Hsu CY, Johansen KL. The enlarging body of evidence: obesity and chronic kidney disease. J Am Soc Nephrol 2006; 17: 1501-1502
4. Prospective Studies Collaboration, Whitlock G, Lewington S et al. Bodymass index and cause-specific mortality in 900 000 adults: collaborative analyses of 57 prospective studies. Lancet 2009; 373: 1083-1096
5. Curtis JP, Selter JG, Wang Y et al. The obesity paradox: body mass index and outcomes in patients with heart failure. Arch Intern Med 2005; 165: 55-61
6. Gunen H, Hacievliyagil SS, Kosar F et al. Factors affecting survival of hospitalised patients with COPD. Eur Respir J 2005; 26: 234-241
7. Escalante A, Haas RW, del Rincon I. Paradoxical effect of body mass index on survival in rheumatoid arthritis: role of comorbidity and systemic inflammation. Arch Intern Med 2005; 165: 1624-1629
8. LavieCJ, Milani RV, Ventura HO. Obesity and cardiovascular disease: risk factor, paradox, and impact of weight loss. J AmColl Cardiol 2009; 53: 1925-1932
9. Lavie CJ, Milani RV, ArthamSM et al. The obesity paradox, weight loss, and coronary disease. Am J Med 2009; 122: 1106-1114
10. Kalantar-Zadeh K, Abbott KC, Salahudeen AK et al. Survival advantages of obesity in dialysis patients. Am J Clin Nutr 2005; 81: 543-554
11. Abbott KC, Glanton CW, Trespalacios FC et al. Body mass index, dialysis modality, and survival: analysis of the United States Renal Data System Dialysis Morbidity and MortalityWave II Study. Kidney Int 2004; 65: 597-605
12. Kalantar-Zadeh K, Rhee CM, Amin AN. To legitimize the contentious obesity paradox. Mayo Clin Proc 2014; 89: 1033-1035
13. Park J, Ahmadi SF, Streja E et al. Obesity paradox in end-stage kidney disease patients. Prog Cardiovasc Dis 2014; 56: 415-425
14. Bellizzi V, Cioffi MF, Cianciaruso B. Body weight is a fluctuating parameter in hemodialysis patients. Kidney Int 2000; 58: 900
15. Kalantar-Zadeh K, Ikizler TA, Block G et al. Malnutrition-inflammation complex syndrome in dialysis patients: causes and consequences. Am J Kidney Dis 2003; 42: 864-881
16. Carrero JJ, Stenvinkel P, Cuppari L et al. Etiology of the protein-energy wasting syndrome in chronic kidney disease: a consensus statement from the International Society of Renal Nutrition and Metabolism (ISRNM). J Ren Nutr 2013; 23: 77-90
17. Meuwese CL, Carrero JJ, Stenvinkel P. Recent insights in inflammation-associated wasting in patients with chronic kidney disease. Contrib Nephrol 2011; 171: 120-126
18. Banack HR, Kaufman JS. The obesity paradox explained. Epidemiology 2013; 24: 461-462
19. Robins JM, Hernan MA, Brumback B. Marginal structural models and causal inference in epidemiology. Epidemiology 2000; 11: 550-560
20. Streja E, Kovesdy CP, Molnar MZ et al. Role of nutritional status and inflammation in higher survival of African American and Hispanic hemodialysis patients. Am J Kidney Dis 2011; 57: 883-893
21. Clinical practice guidelines for nutrition in chronic renal failure. K/DOQI, National Kidney Foundation. Am J Kidney Dis 2000; 35(6 Suppl 2): S1-S140
22. Miller JE, Molnar MZ, Kovesdy CPet al. Administered paricalcitol dose and survival in hemodialysis patients: a marginal structural model analysis. Pharmacoepidemiol Drug Saf 2012; 21: 1232-1239
23. Lukowsky LR, Mehrotra R, Kheifets L et al. Comparing mortality of peritoneal and hemodialysis patients in the first 2 years of dialysis therapy: a marginal structural model analysis. Clin J Am Soc Neph 2013; 8: 619-628
24. Lertdumrongluk P, Streja E, Rhee CM et al. Dose of hemodialysis and survival: a marginal structural model analysis. Am J Nephrol 2014; 39: 383-391
25. van der Wal WM, Noordzij M, Dekker FW et al. Comparing mortality in renal patients on hemodialysis versus peritoneal dialysis using a marginal structural model. Int J Biostat 2010; 6: Article 2
26. Cole SR, Hernan MA. Constructing inverse probability weights for marginal structural models. Am J Epidemiol 2008; 168: 656-664
27. Degoulet P, Legrain M, Reach I et al. Mortality risk factors in patients treated by chronic hemodialysis. Report of the Diaphane collaborative study. Nephron 1982; 31: 103-110
28. Fleischmann E, Teal N, Dudley J et al. Influence of excess weight on mortality and hospital stay in 1346 hemodialysis patients. Kidney Int 1999; 55: 1560-1567
29. Leavey SF, McCullough K, Hecking E et al. Body mass index and mortality in 'healthier' as compared with 'sicker' haemodialysis patients: results from the Dialysis Outcomes and Practice Patterns Study (DOPPS). Nephrol Dial Transplant 2001; 16: 2386-2394
30. Johansen KL, Young B, Kaysen GA et al. Association of body size with outcomes among patients beginning dialysis. Am J Clin Nutr 2004; 80: 324-332
31. Wolfe RA, Ashby VB, Daugirdas JT et al. Body size, dose of hemodialysis, and mortality. Am J Kidney Dis 2000; 35: 80-88
32. Lu JL, Kalantar-Zadeh K, Ma JZ et al. Association of body mass index with outcomes in patients with CKD. J Am Soc Nephrol 2014; 25: 2088-2096
33. Kovesdy CP, Kalantar-Zadeh K. Why is protein-energy wasting associated with mortality in chronic kidney disease? Semin Nephrol 2009; 29: 3-14
34. Foley RN, Parfrey PS, Sarnak MJ. Clinical epidemiology of cardiovascular disease in chronic renal disease. Am J Kidney Dis 1998; 32(5 Suppl 3): S112-S119
35. Ades P, Savage P. The obesity paradox: perception vs knowledge. Mayo Clin Proc 2010; 85: 112-114
36. Sarkar SR, Kuhlmann MK, Kotanko P et al. Metabolic consequences of body size and body composition in hemodialysis patients. Kidney Int 2006; 70: 1832-1839
37. Oreopoulos A, Ezekowitz JA, McAlister FAet al. Association between direct measures of body composition and prognostic factors in chronic heart failure. Mayo Clin Proc 2010; 85: 609-617
38. De Schutter A, Lavie CJ, Kachur S et al. Body composition and mortality in a large cohort with preserved ejection fraction: untangling the obesity paradox. Mayo Clin Proc 2014; 89: 1072-1079
39. Noori N, Kopple JD, Kovesdy CP et al. Mid-arm muscle circumference and quality of life and survival in maintenance hemodialysis patients. Clin J Am Soc Nephrol 2010; 5: 2258-2268
40. Huang CX, Tighiouart H, Beddhu S et al. Both low muscle mass and low fat are associated with higher all-cause mortality in hemodialysis patients. Kidney Int 2010; 77: 624-629
41. Postorino M, Marino C, Tripepi G et al. Abdominal obesity and all-cause and cardiovascular mortality in end-stage renal disease. J Am Coll Cardiol 2009; 53: 1265-1272
42. Kovesdy CP, Czira ME, RudasAet al. Body mass index,waist circumference and mortality in kidney transplant recipients. Am J Transplant 2010; 10: 2644-2651
43. Kalantar-Zadeh K, Streja E, Molnar MZ et al. Mortality prediction by surrogates of body composition: an examination of the obesity paradox in hemodialysis patients using composite ranking score analysis. Am J Epidemiol 2012; 175: 793-803
44. Kalantar-Zadeh K, Streja E, Kovesdy CP et al. The obesity paradox and mortality associated with surrogates of body size and muscle mass in patients receiving hemodialysis. Mayo Clin Proc 2010; 85: 991-1001
45. Jahangir E, De Schutter A, Lavie CJ. Low weight and overweightness in older adults: risk and clinical management. Prog Cardiovasc Dis 2014; 57: 127-133
46. Kovesdy CP, Kalantar-Zadeh K. Observational studies versus randomized controlled trials: avenues to causal inference in nephrology. Adv Chronic Kidney Dis 2012; 19: 11-18
47. Robins JM. Correction for non-compliance in equivalence trials. Stat Med 1998; 17: 269-302; discussion 387-389
48. Barry VW, Baruth M, BeetsMWet al. Fitness vs. fatness on all-cause mortality: a meta-analysis. Prog Cardiovasc Dis 2014; 56: 382-390
49. Lavie CJ, Cahalin LP, Chase P et al. Impact of cardiorespiratory fitness on the obesity paradox in patients with heart failure. Mayo Clin Proc 2013; 88: 251-258
50. McAuley PA, Beavers KM. Contribution of cardiorespiratory fitness to the obesity paradox. Prog Cardiovasc Dis 2014; 56: 434-440
51. De Schutter A, Lavie CJ, Milani RV. The impact of obesity on risk factors and prevalence and prognosis of coronary heart disease-the obesity paradox. Prog Cardiovasc Dis 2014; 56: 401-408
52. Van BiesenW, Vanholder R, Debacquer D et al. Comparison of survival on CAPD and haemodialysis: statistical pitfalls. Nephrol Dial Transplant 2000; 15: 307-311