Acetaminophen versus Ibuprofen in young children with Mild Persistent Asthma

New England Journal of Medicine

Volumn 375, Issue 7, 2016, Pages 619-630

  Sheehan, W J ^a   Mauger, D T ^d   Paul, I M ^e   Moy, J N ^h   Boehmer, S J ^d   Szefler, S J ^k,l   Fitzpatrick, A M ^p   Jackson, D J ^q   Bacharier, L B ^s   Cabana, M D ^t   Covar, R ⁿ   Holguin, F ^f   Lemanske, R F ^q   Martinez, F D ^y   Pongracic, J A ⁱ   Beigelman, A ^s   Baxi, S N ^a   Benson, M ^w   Blake, K ^z   Chmiel, J F ^ab   Daines, C L ^y   Daines, M O ^y   Gaffin, J M ^b   Gentile, D A ^g   Gower, W A ^ac   Israel, E ^c   Kumar, H V ^j   Lang, J E ^aa   Lazarus, S C ^u   Lima, J J ^z   Ly, N ^v   Marbin, J ^w   Morgan, W J ^y   Myers, R E ^ab   Olin, J T ⁿ   Peters, S P ^ac   Raissy, H H ^ad   Robison, R G ⁱ   Ross, K ^ab   Sorkness, C A ^r   Thyne, S M ^x   Wechsler, M E ^m,o   Phipatanakul, W ^a   more..

^a Division of Rheumatology Immunology and Allergy   (United States)

^b Division of Infectious Diseases Laboratory   (United States)

^c BOSTON CHILDREN S HOSPITAL   (United States)

^d Departments of Public Health Sciences   (United States)

^e Departments of Pediatrics   (United States)

^f UNIVERSITY OF PITTSBURGH MEDICAL CENTER   (United States)

^g ALLEGHENY GENERAL HOSPITAL   (United States)

^h City of Pittsburgh Department of Public Safety   (United States)

ⁱ RUSH UNIVERSITY MEDICAL CENTER   (United States)

^j Ann and Robert H Lurie Children's Hospital   (United States)

^k UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

^l Children's Hospital Colorado   (United States)

^m Departments of Pediatrics   (United States)

ⁿ Departments of Medicine   (United States)

^o University of Colorado Denver and Children s Hospital Colorado   (United States)

^p Critical Care and Sleep Medicine   (United States)

^q DEPARTMENT OF MEDICINE   (United States)

^r EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^s UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

^t UNIVERSITY OF WISCONSIN MADISON   (United States)

^u ST LOUIS CHILDREN S HOSPITAL   (United States)

^v Airway Clinical Research Center   (United States)

^w CHILDREN S HOSPITAL OAKLAND   (United States)

^x OLIVE VIEW UCLA MEDICAL CENTER   (United States)

^y UNIVERSITY OF ARIZONA   (United States)

^z NEMOURS CHILDREN S CLINIC   (United States)

^aa UNIVERSITY OF CENTRAL FLORIDA COLLEGE OF MEDICINE   (United States)

^ab CASE WESTERN RESERVE UNIVERSITY   (United States)

^ac WAKE FOREST SCHOOL OF MEDICINE   (United States)

^ad UNIVERSITY OF NEW MEXICO SCHOOL OF MEDICINE   (United States)

more..

Author keywords

[No Author keywords available]

Indexed keywords

FLUTICASONE PROPIONATE; IBUPROFEN; MONTELUKAST; PARACETAMOL; SALBUTAMOL;

ARTICLE; BEDTIME DOSAGE; CHILD; CONTROLLED STUDY; DISEASE CONTROL; DISEASE EXACERBATION; DISEASE SEVERITY; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; DRUG SAFETY; FEMALE; FEVER; HEALTH CARE UTILIZATION; HUMAN; MAJOR CLINICAL STUDY; MALE; MEDICATION COMPLIANCE; MILD PERSISTENT ASTHMA; MULTICENTER STUDY; PAIN; PATIENT COMPLIANCE; PRIORITY JOURNAL; PROSPECTIVE STUDY; RANDOMIZED CONTROLLED TRIAL; TREATMENT OUTCOME; UNSPECIFIED SIDE EFFECT; ASTHMA; CHEMICALLY INDUCED; CLINICAL TRIAL; COMPARATIVE STUDY; INCIDENCE; INFANT; KAPLAN MEIER METHOD; PRESCHOOL CHILD;

ACETAMINOPHEN; ASTHMA; CHILD, PRESCHOOL; DOUBLE-BLIND METHOD; FEMALE; FEVER; HUMANS; IBUPROFEN; INCIDENCE; INFANT; KAPLAN-MEIER ESTIMATE; MALE; PAIN; PROSPECTIVE STUDIES;

EID: 84982082512     PISSN: 00284793     EISSN: 15334406     Source Type: Journal    
DOI: 10.1056/NEJMoa1515990     Document Type: Article

References (17)

1. Vernacchio L, Kelly JP, Kaufman DW, Mitchell AA. Medication use among children <12 years of age in the United States: Results from the Slone Survey. Pediatrics 2009; 124: 446-54.
2. Beasley R, Clayton T, Crane J, et al. Association between paracetamol use in infancy and childhood, and risk of asthma, rhinoconjunctivitis, and eczema in children aged 6-7 years: Analysis from Phase Three of the ISAAC programme. Lancet 2008; 372: 1039-48.
3. Beasley RW, Clayton TO, Crane J, et al. Acetaminophen use and risk of asthma, rhinoconjunctivitis, and eczema in adolescents: International Study of Asthma and Allergies in Childhood Phase Three. Am J Respir Crit Care Med 2011; 183: 171- 8.
4. Davey G, Berhane Y, Duncan P, Aref-Adib G, Britton J, Venn A. Use of acetaminophen and the risk of self-reported allergic symptoms and skin sensitization in Butajira, Ethiopia. J Allergy Clin Immunol 2005; 116: 863-8.
5. Wickens K, Beasley R, Town I, et al. The effects of early and late paracetamol exposure on asthma and atopy: A birth cohort. Clin Exp Allergy 2011; 41: 399-406.
6. McKeever TM, Lewis SA, Smit HA, Burney P, Britton JR, Cassano PA. The association of acetaminophen, aspirin, and ibuprofen with respiratory disease and lung function. Am J Respir Crit Care Med 2005; 171: 966-71.
7. Lesko SM, Louik C, Vezina RM, Mitchell AA. Asthma morbidity after the short- Term use of ibuprofen in children. Pediatrics 2002; 109(2): E20.
8. McBride JT. The association of acetaminophen and asthma prevalence and severity. Pediatrics 2011; 128: 1181-5.
9. Sordillo JE, Scirica CV, Rifas-Shiman SL, et al. Prenatal and infant exposure to acetaminophen and ibuprofen and the risk for wheeze and asthma in children. J Allergy Clin Immunol 2015; 135: 441-8.
10. National Asthma Education and Pre-vention Program. Expert Panel Report 3 (EPR-3): Guidelines for the Diagnosis and Management of Asthma - summary report 2007. J Allergy Clin Immunol 2007; 120(Suppl): S94-S138.
11. Sullivan JE, Farrar HC, Section on Clinical Pharmacology and Therapeutics, Committee on Drugs. Fever and antipyretic use in children. Pediatrics 2011; 127: 580-7.
12. Hilbe J. Negative binomial regression. 2nd ed. New York: Cambridge University Press, 2007.
13. Schnabel E, Heinrich J. Respiratory tract infections and not paracetamol medication during infancy are associated with asthma development in childhood. J Allergy Clin Immunol 2010; 126: 1071-3.
14. Ioannides SJ, Williams M, Jefferies S, et al. Randomised placebo-controlled study of the effect of paracetamol on asthma severity in adults. BMJ Open 2014; 4(2): E004324.
15. Soferman R, Tsivion A, Farber M, Sivan Y. The effect of a single dose of acetaminophen on airways response in children with asthma. Clin Pediatr (Phila) 2013; 52: 42-8.
16. Shaheen SO, Newson RB, Henderson AJ, et al. Prenatal paracetamol exposure and risk of asthma and elevated immunoglobulin E in childhood. Clin Exp Allergy 2005; 35: 18-25.
17. Perzanowski MS, Miller RL, Tang D, et al. Prenatal acetaminophen exposure and risk of wheeze at age 5 years in an urban low-income cohort. Thorax 2010; 65: 118-23.