Fresh versus frozen embryos for infertility in the polycystic ovary syndrome

New England Journal of Medicine

Volumn 375, Issue 6, 2016, Pages 523-533

  Chen, Z J ^a,b,c   Shi, Y ^a   Sun, Y ^b,c   Zhang, B ^d   Liang, X ^e   Cao, Y ^f   Yang, J ^g   Liu, J ^h   Wei, D ^a   Weng, N ⁱ   Tian, L ^j   Hao, C ^k   Yang, D ^e   Zhou, F ^l   Shi, J ^m   Xu, Y ⁿ   Li, J ^a   Yan, J ^a   Qin, Y ^a   Zhao, H ^a   Zhang, H ^o   Legro, R S ^p   more..

^a SHANDONG UNIVERSITY   (China)

^b SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

^c Shanghai Key Laboratory for Assisted Reproduction and Reproductive Genetics   (China)

^d Maternal and Child Health Hospital in Guangxi   (China)

^e SUN YAT SEN UNIVERSITY   (China)

^f ANHUI MEDICAL UNIVERSITY   (China)

^g WUHAN UNIVERSITY   (China)

^h NANJING MEDICAL UNIVERSITY   (China)

ⁱ Jinghua Hospital Shenyang Dongfang Medical Group   (China)

^j Child Health Hospital   (China)

^k YANTAI YUHUANGDING HOSPITAL   (China)

^l ZHEJIANG UNIVERSITY   (China)

^m Maternal and Child Health Care Hospital of Shanxi Province   (China)

ⁿ SUZHOU MUNICIPAL HOSPITAL   (China)

^o YALE UNIVERSITY   (United States)

^p PENN STATE COLLEGE OF MEDICINE   (United States)

more..

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; ARTICLE; BIRTH WEIGHT; CONGENITAL MALFORMATION; CONTROLLED STUDY; CRYOPRESERVATION; DISEASE SEVERITY; ECTOPIC PREGNANCY; EMBRYO; EMBRYO CRYOPRESERVATION; EMBRYO TRANSFER; FEMALE; FEMALE INFERTILITY; FRESH EMBRYO TRANSFER; FROZEN EMBRYO TRANSFER; HUMAN; INTERMETHOD COMPARISON; LIVE BIRTH; MAJOR CLINICAL STUDY; MATERNAL HYPERTENSION; MULTICENTER STUDY; NEWBORN; NEWBORN DEATH; OUTCOME ASSESSMENT; OVARY HYPERSTIMULATION; OVARY POLYCYSTIC DISEASE; PREECLAMPSIA; PREGNANCY COMPLICATION; PREGNANCY LOSS; PREMATURE LABOR; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; STILLBIRTH; ADVERSE EFFECTS; CLINICAL TRIAL; COMPARATIVE STUDY; COMPLICATION; EMBRYO CULTURE; INFERTILITY, FEMALE; MAMMALIAN EMBRYO; OVARIAN HYPERSTIMULATION SYNDROME; OVULATION INDUCTION; PRE-ECLAMPSIA; PREGNANCY; PREGNANCY RATE;

FOLLITROPIN;

ADULT; CRYOPRESERVATION; EMBRYO CULTURE TECHNIQUES; EMBRYO TRANSFER; EMBRYO, MAMMALIAN; FEMALE; FOLLICLE STIMULATING HORMONE; HUMANS; INFERTILITY, FEMALE; LIVE BIRTH; OVARIAN HYPERSTIMULATION SYNDROME; OVULATION INDUCTION; POLYCYSTIC OVARY SYNDROME; PRE-ECLAMPSIA; PREGNANCY; PREGNANCY RATE;

EID: 84981723025     PISSN: 00284793     EISSN: 15334406     Source Type: Journal    
DOI: 10.1056/NEJMoa1513873     Document Type: Article

References (38)

1. Kissin DM, Jamieson DJ, Barfield WD. Monitoring health outcomes of assisted reproductive technology. N Engl J Med 2014;371:91-3.
2. Kawwass JF, Kissin DM, Kulkarni AD, et al. Safety of assisted reproductive technology in the United States, 2000-2011. JAMA 2015;313:88-90.
3. Delvigne A, Rozenberg S. Epidemiology and prevention of ovarian hyperstimulation syndrome (OHSS): a review. Hum Reprod Update 2002;8:559-77.
4. Hansen M, Kurinczuk JJ, Bower C, Webb S. The risk of major birth defects after intracytoplasmic sperm injection and in vitro fertilization. N Engl J Med 2002;346:725-30.
5. Helmerhorst FM, Perquin DA, Donker D, Keirse MJ. Perinatal outcome of singletons and twins after assisted conception: a systematic review of controlled studies. BMJ 2004;328:261.
6. Jackson RA, Gibson KA, Wu YW, Croughan MS. Perinatal outcomes in singletons following in vitro fertilization: a meta-analysis. Obstet Gynecol 2004;103:551-63.
7. Pandey S, Shetty A, Hamilton M, Bhattacharya S, Maheshwari A. Obstetric and perinatal outcomes in singleton pregnancies resulting from IVF/ICSI: a systematic review and meta-analysis. Hum Reprod Update 2012;18:485-503.
8. Tang T, Glanville J, Hayden CJ, White D, Barth JH, Balen AH. Combined life-style modification and metformin in obese patients with polycystic ovary syndrome: a randomized, placebo-controlled, double-blind multicentre study. Hum Reprod 2006;21:80-9.
9. Devroey P, Bourgain C, Macklon NS, Fauser BC. Reproductive biology and IVF: ovarian stimulation and endometrial receptivity. Trends Endocrinol Metab 2004;15:84-90.
10. Bourgain CDP, Devroey P. The endometrium in stimulated cycles for IVF. Hum Reprod Update 2003;9:515-22.
11. Horcajadas JA, Riesewijk A, Polman J, et al. Effect of controlled ovarian hyperstimulation in IVF on endometrial gene expression profiles. Mol Hum Reprod 2005;11:195-205.
12. Choux C, Carmignac V, Bruno C, Sagot P, Vaiman D, Fauque P. The placenta: phenotypic and epigenetic modifications induced by assisted reproductive technologies throughout pregnancy. Clin Epigenetics 2015;7:87.
13. Kansal Kalra S, Ratcliffe SJ, Milman L, Gracia CR, Coutifaris C, Barnhart KT. Perinatal morbidity after in vitro fertilization is lower with frozen embryo transfer. Fertil Steril 2011;95:548-53.
14. Maheshwari A, Pandey S, Shetty A, Hamilton M, Bhattacharya S. Obstetric and perinatal outcomes in singleton pregnancies resulting from the transfer of frozen thawed versus fresh embryos generated through in vitro fertilization treatment: a systematic review and meta-analysis. Fertil Steril 2012;98:368-77.
15. Shapiro BS, Daneshmand ST, Garner FC, Aguirre M, Hudson C, Thomas S. Evidence of impaired endometrial receptivity after ovarian stimulation for in vitro fertilization: a prospective randomized trial comparing fresh and frozen-thawed embryo transfer in normal responders. Fertil Steril 2011;96:344-8.
16. Shi Y, Wei D, Liang X, et al. Live birth after fresh embryo transfer vs elective embryo cryopreservation/frozen embryo transfer in women with polycystic ovary syndrome undergoing IVF (FreFro-PCOS): study protocol for a multicenter, prospective, randomized controlled clinical trial. Trials 2014;15:154.
17. Rotterdam ESHRE/ASRM-Sponsored PCOS Consensus Workshop Group. Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome. Fertil Steril 2004;81:19-25.
18. Legro RS, Brzyski RG, Diamond MP, et al. Letrozole versus clomiphene for infertility in the polycystic ovary syndrome. N Engl J Med 2014;371:119-29.
19. Chen ZJ, Zhang YW, Liu JY, et al. China diagnosis criteria of polycystic ovarian syndrome diagnosis. Zhonghua Fu Chan Ke Za Zhi 2012;47:74-5.
20. Hatch R, Rosenfield RL, Kim MH, Tredway D. Hirsutism: implications, etiology, and management. Am J Obstet Gynecol 1981;140:815-30.
21. Legro RS, Barnhart HX, Schlaff WD, et al. Clomiphene, metformin, or both for infertility in the polycystic ovary syndrome. N Engl J Med 2007;356:551-66.
22. Balen AH, Laven JS, Tan SL, Dewailly D. Ultrasound assessment of the polycystic ovary: international consensus definitions. Hum Reprod Update 2003;9:505-14.
23. Practice Committee of American Society for Reproductive Medicine; Practice Committee of Society for Assisted Reproductive Technology. Criteria for number of embryos to transfer: a committee opinion. Fertil Steril 2013;99:44-6.
24. Puissant F, Van Rysselberge M, Barlow P, Deweze J, Leroy F. Embryo scoring as a prognostic tool in IVF treatment. Hum Reprod 1987;2:705-8.
25. Golan A, Ron-el R, Herman A, Soffer Y, Weinraub Z, Caspi E. Ovarian hyperstimulation syndrome: an update review. Obstet Gynecol Surv 1989;44:430-40.
26. Harbin Consensus Conference Workshop Group. Improving the reporting of clinical trials of infertility treatments (IMPRINT): modifying the CONSORT statement. Hum Reprod 2014;29:2075-82.
27. Shapiro BS, Daneshmand ST, Garner FC, Aguirre M, Hudson C, Thomas S. Evidence of impaired endometrial receptivity after ovarian stimulation for in vitro fertilization: a prospective randomized trial comparing fresh and frozen-thawed embryo transfers in high responders. Fertil Steril 2011;96:516-8.
28. Sazonova A, Källen K, Thurin-Kjellberg A, Wennerholm UB, Bergh C. Obstetric outcome in singletons after in vitro fertilization with cryopreserved/thawed embryos. Hum Reprod 2012;27:1343-50.
29. Opdahl S, Henningsen AA, Tiitinen A, et al. Risk of hypertensive disorders in pregnancies following assisted reproductive technology: a cohort study from the CoNARTaS group. Hum Reprod 2015;30:1724-31.
30. Ishihara O, Araki R, Kuwahara A, Itakura A, Saito H, Adamson GD. Impact of frozen-thawed single-blastocyst transfer on maternal and neonatal outcome: an analysis of 277,042 single-embryo transfer cycles from 2008 to 2010 in Japan. Fertil Steril 2014;101:128-33.
31. Davies MJ, Moore VM, Willson KJ, et al. Reproductive technologies and the risk of birth defects. N Engl J Med 2012;366:1803-13.
32. Wennerholm UB, Henningsen AK, Romundstad LB, et al. Perinatal outcomes of children born after frozen-thawed embryo transfer: a Nordic cohort study from the CoNARTaS group. Hum Reprod 2013;28:2545-53.
33. Pinborg A, Loft A, Aaris Henningsen AK, Rasmussen S, Andersen AN. Infant outcome of 957 singletons born after frozen embryo replacement: the Danish National Cohort Study 1995-2006. Fertil Steril 2010;94:1320-7.
34. Wennerholm UB, Söderström-Anttila V, Bergh C, et al. Children born after cryopreservation of embryos or oocytes: a systematic review of outcome data. Hum Reprod 2009;24:2158-72.
35. Haning RV Jr, Austin CW, Carlson IH, Kuzma DL, Shapiro SS, Zweibel WJ. Plasma estradiol is superior to ultrasound and urinary estriol glucuronide as a predictor of ovarian hyperstimulation during induction of ovulation with menotropins. Fertil Steril 1983;40:31-6.
36. Wang JX, Norman RJ, Wilcox AJ. Incidence of spontaneous abortion among pregnancies produced by assisted reproductive technology. Hum Reprod 2004;19:272-7.
37. Abdalla HI, Bhattacharya S, Khalaf Y. Is meaningful reporting of national IVF outcome data possible? Hum Reprod 2010;25:9-13.
38. Maheshwari A, Bhattacharya S. Elective frozen replacement cycles for all: ready for prime time? Hum Reprod 2013;28:6-9.