Correlation of body muscle/fat ratio with insulin sensitivity using hyperinsulinemic-euglycemic clamp in treatment-naïve type 2 diabetes mellitus

Diabetes Research and Clinical Practice

Volumn 120, Issue , 2016, Pages 65-72

  Kurinami, Noboru ^a   Sugiyama, Seigo ^a   Yoshida, Akira ^a   Hieshima, Kunio ^a   Miyamoto, Fumio ^a   Kajiwara, Keizo ^a   Jinnouchi, Tomio ^a   Jinnouchi, Hideaki ^a  

^a Jinnouchi Hospital   (Japan)

Author keywords

Body fat; Body muscle; Diabetes mellitus; Insulin resistance; Obesity

Indexed keywords

GLUCOSE; INSULIN;

ANALYTICAL PARAMETERS; AREA UNDER THE CURVE; ARTICLE; ASSESSMENT OF HUMANS; BIOELECTRICAL IMPEDANCE ANALYSIS; BODY FAT; BODY MASS; BODY MUSCLE FAT RATIO; CHEMICAL COMPOSITION; CONTROLLED STUDY; DISEASE ASSOCIATION; GLUCOSE BLOOD LEVEL; HOMEOSTASIS MODEL ASSESSMENT INSULIN RESISTANCE; HUMAN; HYPERINSULINEMIC-EUGLYCEMIC CLAMP TECHNIQUE; IMPEDANCE; INSULIN BLOOD LEVEL; INSULIN RESISTANCE; INSULIN SENSITIVITY; LIPID COMPOSITION; MAJOR CLINICAL STUDY; MUSCLE COMPOSITION; NON INSULIN DEPENDENT DIABETES MELLITUS; PREDICTIVE VALUE; QUANTITATIVE INSULIN SENSITIVITY CHECK INDEX; RECEIVER OPERATING CHARACTERISTIC; REFERENCE VALUE; SENSITIVITY AND SPECIFICITY; WAIST CIRCUMFERENCE; ADIPOSE TISSUE; BODY COMPOSITION; COMPLICATION; DIABETES MELLITUS, TYPE 2; DRUG EFFECTS; FEMALE; GLUCOSE CLAMP TECHNIQUE; GLUCOSE INTOLERANCE; MALE; METABOLISM; MIDDLE AGED; MUSCLE; OBESITY; PATHOPHYSIOLOGY; PHYSIOLOGY; PROCEDURES;

ADIPOSE TISSUE; BODY COMPOSITION; DIABETES MELLITUS, TYPE 2; FEMALE; GLUCOSE CLAMP TECHNIQUE; GLUCOSE INTOLERANCE; HUMANS; INSULIN RESISTANCE; MALE; MIDDLE AGED; MUSCLES; OBESITY;

EID: 84981187938     PISSN: 01688227     EISSN: 18728227     Source Type: Journal    
DOI: 10.1016/j.diabres.2016.07.018     Document Type: Article

References (26)

1. Himsworth, H.P., Diabetes mellitus: its differentiation into insulin-sensitive and insulin-insensitive types. Diabet Med 28:12 (2011), 1440–1444, 10.1111/j.1464-5491.2011.3508.x.
2. World Fact Organization: Obesity and overweight: WHO Fact Sheet, No. 311, 2013.
3. Rabe, K., Lehrke, M., Parhofer, K.G., Broedl, C.U., Adipokines and insulin resistance. Mol Med 14:11–12 (2008), 741–751, 10.2119/2008-00058.Rabe Epub 2008 Sep 17.
4. Ford, E.S., Prevalence of the metabolic syndrome defined by the International Diabetes Federation among adults in the US. Diabetes Care 28:11 (2005), 2745–2749.
5. Galassi, A., Reynolds, K., He, J., Metabolic syndrome and risk of cardiovascular disease: a meta-analysis. Am J Med 119:10 (2006), 812–819.
6. Gami, A.S., Witt, B.J., Howard, D.E., Erwin, P.J., Gami, L.A., Somers, V.K., et al. Metabolic syndrome and risk of incident cardiovascular events and death: a systematic review and meta-analysis of longitudinal studies. J Am Coll Cardiol 49:4 (2007), 403–414.
7. DeFronzo, R.A., Tobin, J.D., Andres, R., Glucose clamp technique: a method for quantifying insulin secretion and resistance. Am J Physiol 273:3 (1979), E214–E223.
8. Matthews, D.R., Hosker, J.P., Rudenski, A.S., Naylor, B.A., Treacher, D.F., Turner, R.C., Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 28:7 (1985), 412–419.
9. Bergman, R.N., Ider, Y.Z., Bowden, C.R., Cobelli, C., Quantitative estimation of insulin sensitivity. Am J Physiol 236:6 (1979), E667–E677.
10. Bonora, E., Moghetti, P., Zancanaro, C., Cigolini, M., Querena, M., Cacciatori, V., et al. Estimates of in vivo insulin action in man: comparison of insulin tolerance tests with euglycemic and hyperglycemic glucose clamp studies. J Clin Endocrinol Metab 68:2 (1989), 374–378.
11. Greenfield, M.S., Doberne, L., Kraemer, F., Tobey, T., Reaven, G., Assessment of insulin resistance with the insulin suppression test and the euglycemic clamp. Diabetes 30:5 (1981), 387–392.
12. Bergman, R.N., Prager, R., Volund, A., Olefsky, J.M., Equivalence of the insulin sensitivity index in man derived by the minimal model method and the euglycemic glucose clamp. J Clin Invest 79:3 (1987), 790–800.
13. Jinnouchi, H., Sugiyama, S., Hieshima, K., Kurinami, N., Kajiwara, K., Jinnouchi, T., et al. Liraglutide, a glucagon-like peptide-1 analog, increased insulin sensitivity assessed by hyperinsulinemic-euglycemic clamp examination in patients with uncontrolled type 2 diabetes mellitus. J Diabetes Res, 2015, 2015, 706416, 10.1155/2015/706416 Epub 2015 Apr 2.
14. Yki-Järvinen, H., Koivisto, V.A., Insulin sensitivity in newly diagnosed type 1 diabetics after ketoacidosis and after three months of insulin therapy. J Clin Endocrinol Metab 59:3 (1984), 371–378.
15. Cha, K., Chertow, G.M., Gonzalez, J., Lazarus, J.M., Wilmore, D.W., Multifrequency bioelectrical impedance estimates the distribution of body water. J Appl Physiol 79:4 (1995), 1316–1319.
16. Cha, K., Shin, S., Shon, C., Choi, S., Wilmore, D.W., Evaluation of segmental bioelectrical impedance analysis (SIBA) for measuring muscle distribution. J ICHPER SD-ASIA, 1997, 11–14.
17. Cobb, J., Gall, W., Adam, K.P., Nakhle, P., Button, E., Hathorn, J., et al. A novel fasting blood test for insulin resistance and prediabetes. J Diabetes Sci Technol 7:1 (2013), 100–110.
18. Miyazaki, Y., Glass, L., Triplitt, C., Wajcberg, E., Mandarino, L.J., DeFronzo, R.A., Abdominal fat distribution and peripheral and hepatic insulin resistance in type 2 diabetes mellitus. Am J Physiol Endocrinol Metab 283:6 (2002), E1135–E1143.
19. Meigs, J.B., Wilson, P.W., Fox, C.S., Vasan, R.S., Nathan, D.M., Sullivan, L.M., et al. Body mass index, metabolic syndrome, and risk of type2 diabetes or cardiovascular disease. J Clin Endocrinol Metab 91:8 (2006), 2906–2912.
20. DeFronzo, R.A., Lilly lecture 1987. The triumvirate: beta-cell, muscle, liver. A collusion responsible for NIDDM. Diabetes 37:6 (1988), 667–687.
21. Shulman, G.I., Ectopic fat in insulin resistance, dyslipidemia, and cardiometabolic disease. N Engl J Med 371:12 (2014), 1131–1141.
22. Gastaldelli, A., Role of beta-cell dysfunction, ectopic fat accumulation and insulin resistance in the pathogenesis of type 2 diabetes mellitus. Diabetes Res Clin Pract 93:Suppl 1 (2011), S60–S65, 10.1016/S0168-8227(11)70015-8.
23. Yatsuya, H., Nihashi, T., Li, Y., Hotta, Y., Matsushita, K., Muramatsu, T., et al. Independent association of liver fat accumulation with insulin resistance. Obes Res Clin Pract 8:4 (2014), e350–e355.
24. Yki-Järvinen, H., Helve, E., Koivisto, V.A., Hyperglycemia decreases glucose uptake in type 1 diabetes. Diabetes 36:8 (1987), 892–896.
25. Matsuda, M., DeFronzo, R.A., Insulin sensitivity indices obtained from oral glucose tolerance testing: comparison with the euglycemic insulin clamp. Diabetes Care 22:9 (1999), 1462–1470.
26. DeFronzo, R.A., Pathogenesis of type 2 (non-insulin dependent) diabetes mellitus: a balanced overview. Diabetologia 35:4 (1992), 389–397.