Saline versus balanced solutions: Are clinical trials comparing two crystalloid solutions really needed?

Critical Care

Volumn 20, Issue 1, 2016, Pages

  Vincent, Jean Louis ^a   De Backer, Daniel ^b  

^a ERASME HOSPITAL   (Belgium)

^b UNIVERSITÉ LIBRE DE BRUXELLES   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

CHLORIDE; AMFOMYCIN; LIPOPEPTIDE; SODIUM CHLORIDE;

ARTICLE; BALANCED SOLUTION; CHEMICAL COMPOSITION; CLINICAL PRACTICE; CRYSTALLOID; HYPERCHLOREMIA; HYPERNATREMIA; HYPONATREMIA; METABOLIC ALKALOSIS; PRIORITY JOURNAL; SALINE SOLUTION; SOLUTION AND SOLUBILITY; CLINICAL TRIAL (TOPIC); FLUID THERAPY; HUMAN; PROCEDURES; STANDARDS;

CLINICAL TRIALS AS TOPIC; FLUID THERAPY; HUMANS; LIPOPEPTIDES; SODIUM CHLORIDE;

EID: 84981156446     PISSN: 13648535     EISSN: 1466609X     Source Type: Journal    
DOI: 10.1186/s13054-016-1435-x     Document Type: Article

References (4)

1. Orbegozo Cortes D, Rayo Bonor A, Vincent JL. Isotonic crystalloid solutions: a structured review of the literature. Br J Anaesth. 2014;112:968-81.
2. Wilcox CS. Regulation of renal blood flow by plasma chloride. J Clin Invest. 1983;71:726-35.
3. Kiraly LN, Differding JA, Enomoto TM, Sawai RS, Muller PJ, Diggs B, et al. Resuscitation with normal saline (NS) vs. lactated ringers (LR) modulates hypercoagulability and leads to increased blood loss in an uncontrolled hemorrhagic shock swine model. J Trauma. 2006;61:57-64.
4. Young P, Bailey M, Beasley R, Henderson S, Mackle D, McArthur C, et al. Effect of a buffered crystalloid solution vs saline on acute kidney injury among patients in the intensive care unit: the SPLIT randomized clinical trial. JAMA. 2015;314:1701-10.