Arterial stiffness is positively associated with 18F-fluorodeoxyglucose positron emission tomography-assessed subclinical vascular inflammation in people with early type 2 diabetes

Diabetes Care

Volumn 39, Issue 8, 2016, Pages 1440-1447

  De Boer, Stefanie A ^a   Hovinga De Boer, Marieke C ^b   Heerspink, Hiddo J L ^a   Lefrandt, Joop D ^a   Van Roon, Arie M ^a   Lutgers, Helen L ^a   Glaudemans, Andor W J M ^a   Kamphuisen, Pieter W ^a   Slart, Riemer H J A ^a,c   Mulder, Douwe J ^a  

^a UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

^b MEANDER MEDICAL CENTER   (Netherlands)

^c UNIVERSITY OF TWENTE   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

C REACTIVE PROTEIN; FLUORODEOXYGLUCOSE F 18; GLUCOSE; HEMOGLOBIN A1C; ANTIDIABETIC AGENT; CHOLESTEROL; GLUCOSE BLOOD LEVEL; GLYCOSYLATED HEMOGLOBIN;

ABDOMINAL AORTA; ADULT; AGE; AGED; AORTA ARCH; ARTERIAL STIFFNESS; ARTICLE; ASCENDING AORTA; ATHEROSCLEROSIS; AUGMENTATION INDEX; BODY MASS; CAROTID ARTERY; CLINICAL ARTICLE; COMPUTER ASSISTED EMISSION TOMOGRAPHY; DESCENDING AORTA; DISEASE ASSOCIATION; FEMALE; FEMORAL ARTERY; GENDER; GLUCOSE BLOOD LEVEL; HEMOGLOBIN BLOOD LEVEL; HUMAN; ILIAC ARTERY; INFERIOR CAVA VEIN; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; PROTEIN BLOOD LEVEL; PULSE WAVE; SYSTOLIC BLOOD PRESSURE; VASCULITIS; AORTA; BLOOD; BLOOD PRESSURE; COMPLICATION; CROSS-SECTIONAL STUDY; DIAGNOSTIC IMAGING; METABOLISM; MIDDLE AGED; PATHOLOGY; POSITRON EMISSION TOMOGRAPHY-COMPUTED TOMOGRAPHY; PROSPECTIVE STUDY; STATISTICAL MODEL; VASCULAR DISEASE;

AGED; AORTA; BLOOD GLUCOSE; BLOOD PRESSURE; C-REACTIVE PROTEIN; CAROTID ARTERIES; CHOLESTEROL; CROSS-SECTIONAL STUDIES; DIABETES MELLITUS, TYPE 2; FEMALE; FEMORAL ARTERY; FLUORODEOXYGLUCOSE F18; HEMOGLOBIN A, GLYCOSYLATED; HUMANS; HYPOGLYCEMIC AGENTS; LINEAR MODELS; MALE; MIDDLE AGED; POSITRON EMISSION TOMOGRAPHY COMPUTED TOMOGRAPHY; PROSPECTIVE STUDIES; PULSE WAVE ANALYSIS; VASCULAR DISEASES; VASCULAR STIFFNESS;

EID: 84980347628     PISSN: 01495992     EISSN: 19355548     Source Type: Journal    
DOI: 10.2337/dc16-0327     Document Type: Article

References (27)

1. Goodfellow J, Ramsey MW, Luddington LA, et al. Endothelium and inelastic arteries: an early marker of vascular dysfunction in noninsulin dependent diabetes. BMJ 1996; 312:744-745
2. Cruickshank K, Riste L, Anderson SG, Wright JS, Dunn G, Gosling RG. Aortic pulse-wave velocity and its relationship to mortality in diabetes and glucose intolerance: an integrated index of vascular function? Circulation 2002; 106:2085-2090
3. Libby P. Inflammation in atherosclerosis. Nature 2002; 420:868-874
4. 18F]-fluorodeoxyglucose positron emission tomography. Circulation 2002; 105:2708-2711
5. 18F-FDG PET scanning exploring plaque vulnerability. J Nucl Cardiol 2011; 18:1066-1075
6. Rudd JH, Myers KS, Bansilal S, et al. Relationships among regional arterial inflammation, calcification, risk factors, and biomarkers: a prospective fluorodeoxyglucose positronemission tomography/computed tomography imaging study. Circ Cardiovasc Imaging 2009; 2:107-115
7. 18F]-fluorodeoxyglucose positron emission tomography is associated with the metabolic syndrome. J Am Coll Cardiol 2007; 49:1533-1539
8. Moon SH, Cho YS, Noh TS, Choi JY, Kim BT, Lee KH. Carotid FDG uptake improves prediction of future cardiovascular events in asymptomatic individuals. JACC Cardiovasc Imaging 2015; 8:949-956
9. 18F-fluorodeoxyglucose positron emission tomography uptake. J Am Coll Cardiol 2012; 59:2080-2088
10. 18F-fluorodeoxyglucose positron emission tomography. Circ Cardiovasc Imaging 2010; 3:142-148
11. Mitchell GF, Hwang SJ, Vasan RS, et al. Arterial stiffness and cardiovascular events: the Framingham Heart Study. Circulation 2010; 121:505-511
12. Laurent S, Cockcroft J, Van Bortel L, et al.; European Network for Non-invasive Investigation of Large Arteries. Expert consensus document on arterial stiffness: methodological issues and clinical applications. Eur Heart J 2006; 27:2588-2605
13. Pauca AL, O'Rourke MF, Kon ND. Prospective evaluation of a method for estimating ascending aortic pressure from the radial artery pressure waveform. Hypertension 2001; 38: 932-937
14. Boellaard R, Delgado-Bolton R, Oyen WJ, et al.; European Association of Nuclear Medicine (EANM). FDG PET/CT: EANM procedure guidelines for tumour imaging: version 2.0. Eur J Nucl Med Mol Imaging 2015; 42:328-354
15. 18F-FDG PET/CT identifies patients at risk for future vascular events in an otherwise asymptomatic cohort with neoplastic disease. J Nucl Med 2009; 50:1611-1620
16. Bucerius J, Hyafil F, Verberne HJ, et al, Cardiovascular Committee of the European Association of Nuclear Medicine (EANM). Position paper of the cardiovascular committee of the European Association of Nuclear Medicine (EANM) on PET imaging of atherosclerosis. Eur J Nucl Med Mol Imaging 2016; 43: 780-792
17. Jain S, Khera R, Corrales-Medina VF, Townsend RR, Chirinos JA. "Inflammation and arterial stiffness in humans". Atherosclerosis 2014; 237:381-390
18. Xu J, Zou MH. Molecular insights and therapeutic targets for diabetic endothelial dysfunction. Circulation 2009; 120:1266-1286
19. Donath MY, Shoelson SE. Type 2 diabetes as an inflammatory disease. Nat Rev Immunol 2011; 11:98-107
20. Maki-Petaja KM, Hall FC, Booth AD, et al. Rheumatoid arthritis is associated with increased aortic pulse-wave velocity, which is reduced by anti-tumor necrosis factor-alpha therapy. Circulation 2006; 114:1185-1192
21. Sanz J, Fayad ZA. Imaging of atherosclerotic cardiovascular disease. Nature 2008; 451:953-957
22. 18F-FDG circulation time, injected dose, uptake parameters, and fasting blood glucose levels. Eur J Nucl Med Mol Imaging 2014; 41:369-383
23. Joly L, Djaballah W, Koehl G, et al. Aortic inflammation, as assessed by hybrid FDGPET/CT imaging, is associated with enhanced aortic stiffness in addition to concurrent calcification. Eur J Nucl Med Mol Imaging 2009; 36:979-985
24. Rogers IS, Nasir K, Figueroa AL, et al. Feasibility of FDG imaging of the coronary arteries: comparison between acute coronary syndrome and stable angina. JACC Cardiovasc Imaging 2010; 3:388-397
25. 18F-FDG uptake to macrophages in vitro. J Nucl Med 2012; 53:55-58
26. Tahara N, Kai H, Ishibashi M, et al. Simvastatin attenuates plaque inflammation: evaluation by fluorodeoxyglucose positron emission tomography. J Am Coll Cardiol 2006; 48:1825-1831
27. 18F-fluorodeoxyglucose PET/CTimaging improves quantitation of atherosclerotic plaque inflammation: results from the CAMONA study. J Nucl Cardiol 2014; 21:588-597