The in vivo functions of desumoylating enzymes

Subcellular Biochemistry

Volumn 54, Issue , 2010, Pages 170-183

  Bawa Khalfe, Tasneem ^a   Yeh, Edward T H ^a  

^a UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ISOPROTEIN; PROTEINASE; SUMO 1 PROTEIN;

GENETICS; METABOLISM; PROTEIN TRANSPORT; SUMOYLATION;

ENDOPEPTIDASES; PROTEIN ISOFORMS; PROTEIN TRANSPORT; SUMO-1 PROTEIN; SUMOYLATION;

EID: 84979841907     PISSN: 03060225     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-1-4419-6676-6_14     Document Type: Article

References (61)

1. Li, S.J., Hochstrasser, M. (1999) A new protease required for cell-cycle progression in yeast. Nature 398: pp. 246-51
2. Li, S.J., Hochstrasser, M. (2000) The yeast ULP2 (SMT4) gene encodes a novel protease specific for the ubiquitin-like Smt3 protein. Mol Cell Biol 20: pp. 2367-77
3. Yeh, E.T., Gong, L., Kamitani, T. (2000) Ubiquitin-like proteins: new wines in new bottles. Gene 248: pp. 1-14
4. Gan-Erdene, T., Nagamalleswari, K., Yin, L. (2003) Identification and characterization of DE N1, a deneddylase of the ULP family. J Biol Chem 278: pp. 28892-900
5. Cheng, J., Bawa, T., Lee, P. (2006) Role of desumoylation in the development of prostate cancer. Neoplasia 8: pp. 667-76
6. Yeh, E.T. (2009) SUMOylation and De-SUMOylation: wrestling with life’s processes. J Biol Chem 284: pp. 8223-7
7. Hay, R.T. (2007) SUMO-specific proteases: a twist in the tail. Trends Cell Biol 17: pp. 370-6
8. Bohren, K.M., Nadkarni, V., Song, J.H. (2004) A M55V polymorphism in a novel SUMO gene (SUMO-4) differentially activates heat shock transcription factors and is associated with susceptibility to type I diabetes mellitus. J Biol Chem 279: pp. 27233-8
9. Owerbach, D., McKay, E.M., Yeh, E.T. (2005) A proline-90 residue unique to SUMO-4 prevents maturation and sumoylation. Biochem Biophys Res Commun 337: pp. 517-20
10. Murtas, G., Reeves, P.H., Fu, Y.F. (2003) A nuclear protease required for flowering-time regulation in Arabidopsis reduces the abundance of SMALL UBIQUITIN-RELATED MODIFIER conjugates. Plant Cell 15: pp. 2308-19
11. Colby, T., Matthai, A., Boeckelmann, A. (2006) SUMO-conjugating and SUMO-deconjugating enzymes from Arabidopsis. Plant Physiol 142: pp. 318-32
12. Chosed, R., Mukherjee, S., Lois, L.M. (2006) Evolution of a signalling system that incorporates both redundancy and diversity: Arabidopsis SUMOylation. Biochem J 398: pp. 521-9
13. Reverter, D., Lima, C.D. (2006) Structural basis for SENP2 protease interactions with SUMO precursors and conjugated substrates. Nat Struct Mol Biol 13: pp. 1060-8
14. Mikolajczyk, J., Drag, M., Bekes, M. (2007) Small ubiquitin-related modifier (SUMO)-specific proteases: profiling the specificities and activities of human SENPs. J Biol Chem 282: pp. 26217-24
15. Shen, L., Tatham, M.H., Dong, C. (2006) SUMO protease SENP1 induces isomerization of the scissile peptide bond. Nat Struct Mol Biol 13: pp. 1069-77
16. Cheng, J., Kang, X., Zhang, S. (2007) SUMO-specific protease 1 is essential for stabilization of HIF1alpha during hypoxia. Cell 131: pp. 584-95
17. Bacco, A., Ouyang, J., Lee, H.Y. (2006) The SUMO-specific protease SENP5 is required for cell division. Mol Cell Biol 26: pp. 4489-98
18. Lima, C.D., Reverter, D. (2008) Structure of the human SENP7 catalytic domain and poly-SUMO deconjugation activities for SENP6 and SENP7. J Biol Chem 283: pp. 32045-55
19. Li, S.J., Hochstrasser, M. (2003) The Ulp1 SUMO isopeptidase: distinct domains required for viability, nuclear envelope localization and substrate specificity. J Cell Biol 160: pp. 1069-81
20. Zhang, H., Saitoh, H., Matunis, M.J. (2002) Enzymes of the SUMO modification pathway localize to filaments of the nuclear pore complex. Mol Cell Biol 22: pp. 6498-508
21. Hang, J., Dasso, M. (2002) Association of the human SUMO-1 protease SENP2 with the nuclear pore. J Biol Chem 277: pp. 19961-6
22. Kim, Y.H., Sung, K.S., Lee, S.J. (2005) Desumoylation of homeodomain-interacting protein kinase 2 (HIPK2) through the cytoplasmic-nuclear shuttling of the SUMO-specific protease SENP1. FEBS Lett 579: pp. 6272-8
23. Itahana, Y., Yeh, E.T., Zhang, Y. (2006) Nucleocytoplasmic shuttling modulates activity and ubiquitination-dependent turnover of SUMO-specific protease 2. Mol Cell Biol 26: pp. 4675-89
24. Nishida, T., Tanaka, H., Yasuda, H. (2000) A novel mammalian Smt3-specific isopeptidase 1 (SMT3IP1) localized in the nucleolus at interphase. Eur J Biochem 267: pp. 6423-7
25. Yun, C., Wang, Y., Mukhopadhyay, D. (2008) Nucleolar protein B23/nucleophosmin regulates the vertebrate SUMO pathway through SENP3 and SENP5 proteases. J Cell Biol 183: pp. 589-95
26. Gong, L., Yeh, E.T. (2006) Characterization of a family of nucleolar SUMO-specific proteases with preference for SUMO-2 or SUMO-3. J Biol Chem 281: pp. 15869-77
27. Haindl, M., Harasim, T., Eick, D. (2008) The nucleolar SUMO-specific protease SENP3 reverses SUMO modification of nucleophosmin and is required for rRNA processing. EMBO Rep 9: pp. 273-9
28. Kim, K.I., Baek, S.H., Jeon, Y.J. (2000) A new SUMO-1-specific protease, SUSP1, that is highly expressed in reproductive organs. J Biol Chem 275: pp. 14102-6
29. Choi, S.J., Chung, S.S., Rho, E.J. (2006) Negative modulation of RXRalpha transcriptional activity by small ubiquitin-related modifier (SUMO) modification and its reversal by SUMO-specific protease SUSP1. J Biol Chem 281: pp. 30669-77
30. Mukhopadhyay, D., Ayaydin, F., Kolli, N. (2006) SUSP1 antagonizes formation of highly SUMO2/3-conjugated species. J Cell Biol 174: pp. 939-49
31. Shen, L.N., Geoffroy, M.C., Jaffray, E.G. (2009) Characterization of SENP7, a SUMO-2/3-specific isopeptidase. Biochem J 421: pp. 223-30
32. Bawa-Khalfe, T., Cheng, J., Wang, Z. (2007) Induction of the SUMO-specific protease 1 transcription by the androgen receptor in prostate cancer cells. J Biol Chem 282: pp. 37341-9
33. Ohbayashi, N., Kawakami, S., Muromoto, R. (2008) The IL-6 family of cytokines modulates STAT3 activation by desumoylation of PML through SENP1 induction. Biochem Biophys Res Commun 371: pp. 823-8
34. Kuo, M.L., Besten, W., Thomas, M.C. (2008) Arf-induced turnover of the nucleolar nucleophosmin-associated SUMO-2/3 protease Senp3. Cell Cycle 7: pp. 3378-87
35. Huang C, Han Y, Wang Y et al. SENP3 is responsible for HIF-1 transactivation under mild oxidative stress via p300 de-SUMOylation. EMBO J 2009.
36. Ross, S., Best, J.L., Zon, L.I. (2002) SUMO-1 modification represses Sp3 transcriptional activation and modulates its subnuclear localization. Mol Cell 10: pp. 831-42
37. Gregoire, S., Yang, X.J. (2005) Association with class IIa histone deacetylases upregulates the sumoylation of MEF2 transcription factors. Mol Cell Biol 25: pp. 2273-87
38. Cheng, J., Wang, D., Wang, Z. (2004) SENP1 enhances androgen receptor-dependent transcription through desumoylation of histone deacetylase 1. Mol Cell Biol 24: pp. 6021-8
39. Kaikkonen, S., Jaaskelainen, T., Karvonen, U. (2009) SUMO-specific protease 1 (SENP1) reverses the hormone-augmented SUMOylation of androgen receptor and modulates gene responses in prostate cancer cells. Mol Endocrinol 23: pp. 292-307
40. Cheng, J., Perkins, N.D., Yeh, E.T. (2005) Differential regulation of c-Jun-dependent transcription by SUMO-specific proteases. J Biol Chem 280: pp. 14492-8
41. Best, J.L., Ganiatsas, S., Agarwal, S. (2002) SUMO-1 protease-1 regulates gene transcription through PML. Mol Cell 10: pp. 843-55
42. Kadoya, T., Yamamoto, H., Suzuki, T. (2002) Desumoylation activity of Axam, a novel Axin-binding protein, is involved in downregulation of beta-catenin. Mol Cell Biol 22: pp. 3803-19
43. Yamamoto, H., Ihara, M., Matsuura, Y. (2003) Sumoylation is involved in beta-catenin-dependent activation of Tcf-4. EMBO J 22: pp. 2047-59
44. Shitashige, M., Satow, R., Honda, K. (2008) Regulation of Wnt signaling by the nuclear pore complex. Gastroenterology 134: pp. 1961-1971
45. Nishida, T., Kaneko, F., Kitagawa, M. (2001) Characterization of a novel mammalian SUMO-1/Smt3-specific isopeptidase, a homologue of rat axam, which is an axin-binding protein promoting beta-catenin degradation. J Biol Chem 276: pp. 39060-6
46. Vethantham, V., Rao, N., Manley, J.L. (2007) Sumoylation modulates the assembly and activity of the pre-mRNA 3’ processing complex. Mol Cell Biol 27: pp. 8848-58
47. Taylor, D.L., Ho, J.C., Oliver, A. (2002) Cell-cycle-dependent localisation of Ulp1, a Schizosaccharomyces pombe Pmt3 (SUMO)-specific protease. J Cell Sci 115: pp. 1113-22
48. Schwartz, D.C., Felberbaum, R., Hochstrasser, M. (2007) The Ulp2 SUMO protease is required for cell division following termination of the DNA damage checkpoint. Mol Cell Biol 27: pp. 6948-61
49. Yates, K.E., Korbel, G.A., Shtutman, M. (2008) Repression of the SUMO-specific protease Senp1 induces p53-dependent premature senescence in normal human fibroblasts. Aging Cell 7: pp. 609-21
50. Chiu, S.Y., Asai, N., Costantini, F. (2008) SUMO-specific protease 2 is essential for modulating p53-Mdm2 in development of trophoblast stem cell niches and lineages. PLoS Biol 6: pp. e310
51. Li, X., Zhang, R., Luo, D. (2005) Tumor necrosis factor alpha-induced desumoylation and cytoplasmic translocation of homeodomain-interacting protein kinase 1 are critical for apoptosis signal-regulating kinase 1-JNK/ p38 activation. J Biol Chem 280: pp. 15061-70
52. Li, X., Luo, Y., Yu, L. (2008) SENP1 mediates TNF-induced desumoylation and cytoplasmic translocation of HIPK1 to enhance ASK1-dependent apoptosis. Cell Death Differ 15: pp. 739-50
53. Yamaguchi, T., Sharma, P., Athanasiou, M. (2005) Mutation of SENP1/SuPr-2 reveals an essential role for desumoylation in mouse development. Mol Cell Biol 25: pp. 5171-82
54. McDoniels-Silvers, A.L., Nimri, C.F. (2002) Differential gene expression in human lung adenocarcinomas and squamous cell carcinomas. Clin Cancer Res 8: pp. 1127-38
55. Veltman, I.M., Vreede, L.A., Cheng, J. (2005) Fusion of the SUMO/Sentrin-specific protease 1 gene SENP1 and the embryonic polarity-related mesoderm development gene MESDC2 in a patient with an infantile teratoma and a constitutional t(12; 15)(q13; q25). Hum Mol Genet 14: pp. 1955-63
56. Tagawa, H., Miura, I., Suzuki, R. (2002) Molecular cytogenetic analysis of the breakpoint region at 6q21-22 in T-cell lymphoma/leukemia cell lines. Genes Chromosomes Cancer 34: pp. 175-85
57. Moschos, S.J., Smith, A.P., Mandic, M. (2007) SAGE and antibody array analysis of melanoma-infiltrated lymph nodes: identification of Ubc9 as an important molecule in advanced-stage melanomas. Oncogene 26: pp. 4216-25
58. Mo, Y.Y., Yu, Y., Theodosiou, E. (2005) A role for Ubc9 in tumorigenesis. Oncogene 24: pp. 2677-83
59. Jacques, C., Baris, O., Prunier-Mirebeau, D. (2005) Two-step differential expression analysis reveals a new set of genes involved in thyroid oncocytic tumors. J Clin Endocrinol Metab 90: pp. 2314-20
60. Dunnebier, T., Bermejo, J.L., Haas, S. (2009) Common variants in the UBC9 gene encoding the SUMO-conjugating enzyme are associated with breast tumor grade. Int J Cancer 125: pp. 596-602
61. Wang, L., Banerjee, S. (2004) Differential PIAS3 expression in human malignancy. Oncol Rep 11: pp. 1319-24