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Volumn 1, Issue 2, 2015, Pages 1-11

Chemical diversity investigation of hepatotoxic pyrrolizidine alkaloids in Qianliguang (Senecio scandens) and related species by UHPLC-QTOF-MS1

Author keywords

Pyrrolizidine alkaloids; Qianliguang (Senecio scandens); Qualitation; Quantification; UHPLC QTOF MS

Indexed keywords


EID: 84979730905     PISSN: 23118571     EISSN: 25892894     Source Type: Journal    
DOI: 10.15806/j.issn.2311-8571.2014.0010     Document Type: Article
Times cited : (5)

References (43)
  • 2
    • 40749124888 scopus 로고    scopus 로고
    • Detection, hepatotoxicity, and tumorigenicity of pyrrolizidine alkaloids in Chinese herbal plants and herbal dietary supplements
    • Fu PP, Xia QS, Chou MW, Lin G. Detection, hepatotoxicity, and tumorigenicity of pyrrolizidine alkaloids in Chinese herbal plants and herbal dietary supplements. J. Food Drug Anal 2007, 15: 400-415.
    • (2007) J. Food Drug Anal , vol.15 , pp. 400-415
    • Fu, PP1    Xia, QS2    Chou, MW3    Lin, G.4
  • 3
    • 1642323484 scopus 로고    scopus 로고
    • Pyrrolizidine alkaloids-genotoxicity, metabolism enzymes, metabolic activation, and mechanisms
    • Fu PP, Xia Q, Lin G, Chou MW. Pyrrolizidine alkaloids-genotoxicity, metabolism enzymes, metabolic activation, and mechanisms. Drug Metab. Rev 2004, 36: 1-55.
    • (2004) Drug Metab. Rev , vol.36 , pp. 1-55
    • Fu, PP1    Xia, Q2    Lin, G3    Chou, MW.4
  • 4
    • 0037636041 scopus 로고    scopus 로고
    • Gender differences in microsomal metabolic activation of hepatotoxic clivorine in rat
    • Lin G, Cui YY, Liu XQ. Gender differences in microsomal metabolic activation of hepatotoxic clivorine in rat. Chem Res Toxicity 2003, 16: 768-774.
    • (2003) Chem Res Toxicity , vol.16 , pp. 768-774
    • Lin, G1    Cui, YY2    Liu, XQ.3
  • 5
    • 2442694125 scopus 로고    scopus 로고
    • Metabolic formation of DHP-derived DNA adducts from a representative otonecine type pyrrolizidine alkaloid clivorine and the extract of Ligularia hodgsonnii hook
    • Xia Q, Chou MW, Lin G, Fu PP. Metabolic formation of DHP-derived DNA adducts from a representative otonecine type pyrrolizidine alkaloid clivorine and the extract of Ligularia hodgsonnii hook. Chem Res Toxicity 2004, 17: 702-708.
    • (2004) Chem Res Toxicity , vol.17 , pp. 702-708
    • Xia, Q1    Chou, MW2    Lin, G3    Fu, PP.4
  • 6
    • 84892867576 scopus 로고    scopus 로고
    • Lack of metabolic activation and predominant formation of an excreted metabolite of nontoxic platynecine-type pyrrolizidine alkaloids
    • Ruan J, Liao C, Ye Y, Lin G. Lack of metabolic activation and predominant formation of an excreted metabolite of nontoxic platynecine-type pyrrolizidine alkaloids. Chem Res Toxicol 2014, 27: 7-16.
    • (2014) Chem Res Toxicol , vol.27 , pp. 7-16
    • Ruan, J1    Liao, C2    Ye, Y3    Lin, G.4
  • 7
    • 84861872055 scopus 로고    scopus 로고
    • Importance of metabolic activation study to the safe use of Chinese herbal medicines
    • Ma B, Li N, Lin G. Importance of metabolic activation study to the safe use of Chinese herbal medicines. Cur. Drug Metab 2012, 13: 652-658.
    • (2012) Cur. Drug Metab , vol.13 , pp. 652-658
    • Ma, B1    Li, N2    Lin, G.3
  • 8
    • 85095765691 scopus 로고    scopus 로고
    • Medicinal Plant Images Database. School of Chinese Medicine, Hong Kong Baptist University
    • Medicinal Plant Images Database. School of Chinese Medicine, Hong Kong Baptist University. http://libproject.hkbu.edu.hk/was40/detail? channelid=1288&lang=cn&record=1&searchword=(((alphabet=A)% 20And%20family_latin=('Asteraceae'))%20And%20parentJatin= 'Senecio')%20And%20family_latin=('Asteraceae')&sortfield=%20 name_formal_latin_sort
  • 9
    • 77956262888 scopus 로고    scopus 로고
    • The Committee of Pharmacopeia of the People's Republic of China. Beijing: Chemical Industry Press
    • The Committee of Pharmacopeia of the People's Republic of China. Pharmacopeia of the People's Republic of China. Beijing: Chemical Industry Press, 2010.
    • (2010) Pharmacopeia of the People's Republic of China
  • 10
    • 0003915773 scopus 로고
    • College JNM. Shanghai: Shanghai Science and Technology Press
    • College JNM. The dictionary of Chinese medicines. Shanghai: Shanghai Science and Technology Press, 1977.
    • (1977) The dictionary of Chinese medicines
  • 11
    • 0033788020 scopus 로고    scopus 로고
    • Medicinal plants in China containing pyrrolizidine alkaloids
    • Roeder E. Medicinal plants in China containing pyrrolizidine alkaloids. Pharmazie 2000, 55: 711-726.
    • (2000) Pharmazie , vol.55 , pp. 711-726
    • Roeder, E.1
  • 12
    • 84882253698 scopus 로고    scopus 로고
    • Senecio scandens Buch.-Ham.: a review on its ethnopharmacology, phytochemistry, pharmacology, and toxicity
    • Wang D, Huang L, Chen S. Senecio scandens Buch.-Ham.: a review on its ethnopharmacology, phytochemistry, pharmacology, and toxicity. J. Ethnopharmacol 2013, 149: 1-23.
    • (2013) J. Ethnopharmacol , vol.149 , pp. 1-23
    • Wang, D1    Huang, L2    Chen, S.3
  • 13
    • 33751276612 scopus 로고    scopus 로고
    • General situation of the toxicity researches on Senecio
    • Liang AH, Ye ZG. General situation of the toxicity researches on Senecio. China J. Chin. Mater. Med 2006, 31: 93-97.
    • (2006) China J. Chin. Mater. Med , vol.31 , pp. 93-97
    • Liang, AH1    Ye, ZG.2
  • 14
    • 84882286385 scopus 로고    scopus 로고
    • Medicines and Healthcare Products Regulatory Agency. MLX 296: proposals to prohibit the sale, supply or importation of unlicensed herbal medicinal products for internal use which contain Senecio species, Accessed May 1, 2014
    • Medicines and Healthcare Products Regulatory Agency. MLX 296: proposals to prohibit the sale, supply or importation of unlicensed herbal medicinal products for internal use which contain Senecio species. Monograph on the Internet. Available at: http://www.mhra.gov.uk/Publications/Consultations/Medicinesconsultations/MLXs/CON 1004416. Accessed May 1, 2014.
    • Monograph on the Internet
  • 15
    • 0031664299 scopus 로고    scopus 로고
    • Chemical diversity and variation of pyrrolizidine alkaloids of the senecionine type: biological need or coincidence
    • Harmann T, Dierich B. Chemical diversity and variation of pyrrolizidine alkaloids of the senecionine type: biological need or coincidence. Planta 1998, 206: 443-451.
    • (1998) Planta , vol.206 , pp. 443-451
    • Harmann, T1    Dierich, B.2
  • 16
    • 79960039689 scopus 로고    scopus 로고
    • Authentication of Senecio scandens and S. vulgaris based on the comprehensive secondary metabolic patterns gained by UPLC-DAD/ESI-MS
    • Yang X, Yang L, Xiong A, Li D, Wang Z. Authentication of Senecio scandens and S. vulgaris based on the comprehensive secondary metabolic patterns gained by UPLC-DAD/ESI-MS. J. Pharm. Biomed. Anal 2011, 56: 165-72.
    • (2011) J. Pharm. Biomed. Anal , vol.56 , pp. 165-172
    • Yang, X1    Yang, L2    Xiong, A3    Li, D4    Wang, Z.5
  • 17
    • 0007705359 scopus 로고
    • Alkaloidal constituents of Senecio scandens
    • Batra V, Rajagopalan TR. Alkaloidal constituents of Senecio scandens. Curr. Sci 1977, 46: 141.
    • (1977) Curr. Sci , vol.46 , pp. 141
    • Batra, V1    Rajagopalan, TR.2
  • 18
    • 70350748757 scopus 로고    scopus 로고
    • Preliminary phytochemical test of Senecio scandens Buch.-Ham. and examination on chemical composition of its antimicrobial part
    • Xu XB, Lin HY, Feng YS, Chen JJ. Preliminary phytochemical test of Senecio scandens Buch.-Ham. and examination on chemical composition of its antimicrobial part. J. Tradit. Chin. Vet. Med 2006, 25: 10-13.
    • (2006) J. Tradit. Chin. Vet. Med , vol.25 , pp. 10-13
    • Xu, XB1    Lin, HY2    Feng, YS3    Chen, JJ.4
  • 19
    • 27244455745 scopus 로고    scopus 로고
    • Separation and determination of toxic pyrrolizidine alkaloids in traditional Chinese medicines by micellar electrokinetic chromatography with organic modifier
    • Yu L, Xu Y, Feng H, Li SF. Separation and determination of toxic pyrrolizidine alkaloids in traditional Chinese medicines by micellar electrokinetic chromatography with organic modifier. Electrophoresis 2005, 26: 3397-3404.
    • (2005) Electrophoresis , vol.26 , pp. 3397-3404
    • Yu, L1    Xu, Y2    Feng, H3    Li, SF.4
  • 21
    • 39749202897 scopus 로고    scopus 로고
    • Identification of five hepatotoxic pyrrolizidine alkaloids in a commonly used traditional Chinese medicinal herb, Herba Senecionis scandentis (Qianliguang)
    • Li SL, Lin G, Fu PP, Chan CL, Li M, Jiang ZH, Zhao ZZ. Identification of five hepatotoxic pyrrolizidine alkaloids in a commonly used traditional Chinese medicinal herb, Herba Senecionis scandentis (Qianliguang). Rapid Commun. Mass Spectrom 2008, 22: 591-602.
    • (2008) Rapid Commun. Mass Spectrom , vol.22 , pp. 591-602
    • Li, SL1    Lin, G2    Fu, PP3    Chan, CL4    Li, M5    Jiang, ZH6    Zhao, ZZ.7
  • 22
    • 84855395622 scopus 로고    scopus 로고
    • Studies on the alkaloids of Senecio scandens growing in Guangdong
    • Guo XF, Liu MH, Peng W, Wang YG, Yang CP, Su WW. Studies on the alkaloids of Senecio scandens growing in Guangdong. Zhong Yao Cai 2011, 34: 724-726.
    • (2011) Zhong Yao Cai , vol.34 , pp. 724-726
    • Guo, XF1    Liu, MH2    Peng, W3    Wang, YG4    Yang, CP5    Su, WW.6
  • 24
    • 39049114506 scopus 로고    scopus 로고
    • Quantitative analysis by HPLC-MS2 of the pyrrolizidine alkaloid adonifoline in Senecio scandens
    • Zhang F, Wang CH, Wang W, Chen LX, Ma HY, Zhang CF, Zhang M, Bligh SW, Wang ZT. Quantitative analysis by HPLC-MS2 of the pyrrolizidine alkaloid adonifoline in Senecio scandens. Phytochem Anal 2008, 19: 25-31.
    • (2008) Phytochem Anal , vol.19 , pp. 25-31
    • Zhang, F1    Wang, CH2    Wang, W3    Chen, LX4    Ma, HY5    Zhang, CF6    Zhang, M7    Bligh, SW8    Wang, ZT.9
  • 25
    • 36148968062 scopus 로고    scopus 로고
    • Quantitative analysis of total retronecine esters-type pyrrolizidine alkaloids in plant by high performance liquid chromatography
    • Zhang F, Wang CH, Xiong AZ, Wang W, Yang L, Branford-White CJ, Wang ZT, Bligh SW. Quantitative analysis of total retronecine esters-type pyrrolizidine alkaloids in plant by high performance liquid chromatography. Anal. Chim. Acta 2007, 605: 94-101.
    • (2007) Anal. Chim. Acta , vol.605 , pp. 94-101
    • Zhang, F1    Wang, CH2    Xiong, AZ3    Wang, W4    Yang, L5    Branford-White, CJ6    Wang, ZT7    Bligh, SW.8
  • 26
    • 0031764999 scopus 로고    scopus 로고
    • Determination of hepatotoxic pyrrolizidine alkaloids by on-line high performance liquid chromatography mass spectrometry with an electrospray interface
    • Lin G, Zhou KY, Zhao XG, Wang ZT, But PP. Determination of hepatotoxic pyrrolizidine alkaloids by on-line high performance liquid chromatography mass spectrometry with an electrospray interface. Rapid Commun. Mass Spectrom 1998, 12: 1445-1456.
    • (1998) Rapid Commun. Mass Spectrom , vol.12 , pp. 1445-1456
    • Lin, G1    Zhou, KY2    Zhao, XG3    Wang, ZT4    But, PP.5
  • 27
    • 84859099087 scopus 로고    scopus 로고
    • Characteristic ion clusters as determinants for the identification of pyrrolizidine alkaloid N-oxides in pyrrolizidine alkaloid-containing natural products using HPLC-MS analysis
    • Ruan JQ, Li N, Xia QS, Fu PP, Peng SY, Ye Y, Lin G. Characteristic ion clusters as determinants for the identification of pyrrolizidine alkaloid N-oxides in pyrrolizidine alkaloid-containing natural products using HPLC-MS analysis. J. Mass Spectrom 2012, 47: 331-337.
    • (2012) J. Mass Spectrom , vol.47 , pp. 331-337
    • Ruan, JQ1    Li, N2    Xia, QS3    Fu, PP4    Peng, SY5    Ye, Y6    Lin, G.7
  • 28
    • 78049280983 scopus 로고    scopus 로고
    • A new approach for simultaneous screening and quantification of toxic pyrrolizidine alkaloids in some potential pyrrolizidine alkaloid-containing plants by using ultra performance liquid chromatography-tandem quadrupole mass spectrometry
    • Zhou Y, Li N, Choi FF, Qiao CF, Song JZ, Li SL, Liu X, Cai ZW, Fu PP, Lin G, Xu HX. A new approach for simultaneous screening and quantification of toxic pyrrolizidine alkaloids in some potential pyrrolizidine alkaloid-containing plants by using ultra performance liquid chromatography-tandem quadrupole mass spectrometry. Anal. Chim. Acta 2010, 681: 33-40.
    • (2010) Anal. Chim. Acta , vol.681 , pp. 33-40
    • Zhou, Y1    Li, N2    Choi, FF3    Qiao, CF4    Song, JZ5    Li, SL6    Liu, X7    Cai, ZW8    Fu, PP9    Lin, G10    Xu, HX.11
  • 29
    • 70349998709 scopus 로고    scopus 로고
    • Determination of pyrrolizidine alkaloids in comfrey by liquid chromatography-electro-spray ionization mass spectrometry
    • Liu F, Wan SY, Jiang Z, Li SF, Ong ES, Osorio JC. Determination of pyrrolizidine alkaloids in comfrey by liquid chromatography-electro-spray ionization mass spectrometry. Talanta 2009, 80: 916-923.
    • (2009) Talanta , vol.80 , pp. 916-923
    • Liu, F1    Wan, SY2    Jiang, Z3    Li, SF4    Ong, ES5    Osorio, JC.6
  • 30
    • 60149112789 scopus 로고    scopus 로고
    • Simultaneous characterization of pyrrolizidine alkaloids and N-oxides in Gynura segetum by liquid chromatography/ion trap mass spectrometry
    • Qi X, Wu B, Cheng Y, Qu H. Simultaneous characterization of pyrrolizidine alkaloids and N-oxides in Gynura segetum by liquid chromatography/ion trap mass spectrometry. Rapid Commun. Mass Spectrom 2009, 23: 291-302.
    • (2009) Rapid Commun. Mass Spectrom , vol.23 , pp. 291-302
    • Qi, X1    Wu, B2    Cheng, Y3    Qu, H.4
  • 31
    • 16644372170 scopus 로고    scopus 로고
    • Investigation of pyrrolizidine alkaloids and their N-oxides in commercial comfrey-containing products and botanical materials by liquid chromatography electrospray ionization mass spectrometry
    • Altamirano JC, Gratz SR, Wolnik KA. Investigation of pyrrolizidine alkaloids and their N-oxides in commercial comfrey-containing products and botanical materials by liquid chromatography electrospray ionization mass spectrometry. J AOAC Int 2005, 88: 406-412.
    • (2005) J AOAC Int , vol.88 , pp. 406-412
    • Altamirano, JC1    Gratz, SR2    Wolnik, KA.3
  • 32
    • 9944262888 scopus 로고    scopus 로고
    • Screening for pyrrolizidine alkaloids in plant materials by electron ionization RP-HPLC-MS with thermabeam interface
    • Mroczek T, Baj S, Chrobok A, Glowniak K. Screening for pyrrolizidine alkaloids in plant materials by electron ionization RP-HPLC-MS with thermabeam interface. Biomed. Chromatogr 2004, 18: 745-751.
    • (2004) Biomed. Chromatogr , vol.18 , pp. 745-751
    • Mroczek, T1    Baj, S2    Chrobok, A3    Glowniak, K.4
  • 33
    • 0033938762 scopus 로고    scopus 로고
    • Characterization of two structural forms of otonecine-type pyrrolizidine alkaloids from Ligularia hodgsonii by NMR spectroscopy
    • Lin G, Rose P, Chatson KB, Hawes EM, Zhao XG, Wang ZT. Characterization of two structural forms of otonecine-type pyrrolizidine alkaloids from Ligularia hodgsonii by NMR spectroscopy. J. Nat. Prod 2000, 63: 857-860.
    • (2000) J. Nat. Prod , vol.63 , pp. 857-860
    • Lin, G1    Rose, P2    Chatson, KB3    Hawes, EM4    Zhao, XG5    Wang, ZT.6
  • 34
    • 0036851873 scopus 로고    scopus 로고
    • Species differences in the in vitro metabolic activation of the hepatotoxic pyrrolizidine alkaloid clivorine
    • Lin G, Cui YY, Liu XQ, Wang ZT. Species differences in the in vitro metabolic activation of the hepatotoxic pyrrolizidine alkaloid clivorine. Chem Res Toxicity 2002, 15: 1421-1428.
    • (2002) Chem Res Toxicity , vol.15 , pp. 1421-1428
    • Lin, G1    Cui, YY2    Liu, XQ3    Wang, ZT.4
  • 35
    • 0000724877 scopus 로고
    • Chemistry. biology and chemoecology of the pyrrolizidine alkaloids
    • Pelletier SW (Ed). Oxford: Pergamon Press
    • Hartmann T, Witte L. Chemistry. biology and chemoecology of the pyrrolizidine alkaloids. In Alkaloids-Chemical and Biological Perspectives, vol. 9: Pelletier SW (Ed). Oxford: Pergamon Press, 1995: 155.
    • (1995) Alkaloids-Chemical and Biological Perspectives , vol.9 , pp. 155
    • Hartmann, T1    Witte, L.2
  • 37
    • 33947446227 scopus 로고
    • The Structure of Riddelliine, the Alkaloid in Senecio Riddellii. I
    • Adams R, Hamlin Jr. KE, Jelinek CF, Phillips RF. The Structure of Riddelliine, the Alkaloid in Senecio Riddellii. I. J. Am. Chem. Soc 1942, 64: 2760-2763.
    • (1942) J. Am. Chem. Soc , vol.64 , pp. 2760-2763
    • Adams, R1    Hamlin, KE2    Jelinek, CF3    Phillips, RF.4
  • 38
    • 0021714919 scopus 로고
    • Epoxidation of pyrrolizidine alkaloids. (1). Chemical conversion of seneciphylline and jacozine to senecicannabine
    • Yoshihisa A, Tsutomu F. Epoxidation of pyrrolizidine alkaloids. (1). Chemical conversion of seneciphylline and jacozine to senecicannabine. Chem. Pharm. Bull 1984, 32: 4616-4619.
    • (1984) Chem. Pharm. Bull , vol.32 , pp. 4616-4619
    • Yoshihisa, A1    Tsutomu, F.2
  • 39
    • 80255136014 scopus 로고    scopus 로고
    • Pyrrolizidine alkaloid variation in shoots and roots of segregating hybrids between Jacobaea vulgaris and Jacobaea aquatica
    • Cheng D, Kirk H, Mulder PP, Vrieling K, Klinkhamer PG. Pyrrolizidine alkaloid variation in shoots and roots of segregating hybrids between Jacobaea vulgaris and Jacobaea aquatica. New Phytol 2011, 192: 1010-23.
    • (2011) New Phytol , vol.192 , pp. 1010-1023
    • Cheng, D1    Kirk, H2    Mulder, PP3    Vrieling, K4    Klinkhamer, PG.5
  • 40
    • 0016011143 scopus 로고
    • The senecio alkaloids. Structure and absolute configuration of swazine
    • Gordon-Gray CG, Wells RB. The senecio alkaloids. Structure and absolute configuration of swazine. J. Chem. Soc. Perkin 1 1974, 13: 1556-1561.
    • (1974) J. Chem. Soc. Perkin 1 , vol.13 , pp. 1556-1561
    • Gordon-Gray, CG1    Wells, RB.2
  • 41
    • 0036982014 scopus 로고    scopus 로고
    • Pyrrolizidine Alkaloids-Tumorigenic Components in Chinese Herbal Medicines and Dietary Supplements
    • Fu PP, Yang YC, Xia QS, Chou MW, Cui YY, Lin G. Pyrrolizidine Alkaloids-Tumorigenic Components in Chinese Herbal Medicines and Dietary Supplements. J. Food Drug Anal 2002, 10: 198-211.
    • (2002) J. Food Drug Anal , vol.10 , pp. 198-211
    • Fu, PP1    Yang, YC2    Xia, QS3    Chou, MW4    Cui, YY5    Lin, G.6
  • 43
    • 70350783909 scopus 로고    scopus 로고
    • Qianliguang (Senecio scandens) safety dilemma: dose is the key?
    • Lin G, Li SL, Li M, Li N, Sun-Kin Chan S, Chan WY, Zhao ZZ. Qianliguang (Senecio scandens) safety dilemma: dose is the key? Planta Med 2009, 75: 1 107-1111.
    • (2009) Planta Med , vol.75 , Issue.1 , pp. 107-1111
    • Lin, G1    Li, SL2    Li, M3    Li, N4    Sun-Kin Chan, S5    Chan, WY6    Zhao, ZZ.7


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