Fat grafting for alleviating persistent pain after breast cancer treatment: A randomized controlled trial

Journal of Plastic, Reconstructive and Aesthetic Surgery

Volumn 69, Issue 9, 2016, Pages 1192-1202

  Juhl, Alexander A ^a   Karlsson, Páll ^a   Damsgaard, Tine E ^a  

^a AARHUS UNIVERSITY HOSPITAL   (Denmark)

Author keywords

Breast cancer; Fat grafting; Neuropathic pain symptom inventory; Persistent pain; Randomized controlled trial

Indexed keywords

ADULT; AGED; ANALGESIC ACTIVITY; ARTICLE; BREAST CANCER; CANCER PAIN; CANCER SURGERY; CLINICAL ARTICLE; CLINICAL EVALUATION; CONTROLLED STUDY; FAT GRAFTING; FEMALE; FOLLOW UP; HUMAN; HUMAN TISSUE; MASTECTOMY; NEUROPATHIC PAIN; NEUROPATHIC PAIN SYMPTOM INVENTORY; OUTCOME ASSESSMENT; PAIN ASSESSMENT; PAIN RECEPTOR; PATIENT AND OBSERVER SCAR ASSESSMENT SCALE; POSTOPERATIVE PAIN; PRIORITY JOURNAL; QUALITY OF LIFE; RANDOMIZED CONTROLLED TRIAL; SKIN BIOPSY; SURGICAL TECHNIQUE; VISUAL ANALOG SCALE; ADIPOSE TISSUE; ADOLESCENT; ADVERSE EFFECTS; BREAST NEOPLASMS; BREAST RECONSTRUCTION; MIDDLE AGED; NEURALGIA; PAIN MEASUREMENT; PAIN, POSTOPERATIVE; PROCEDURES; REOPERATION; TRANSPLANTATION; TREATMENT OUTCOME; VERY ELDERLY; YOUNG ADULT;

ADIPOSE TISSUE; ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; BREAST NEOPLASMS; FEMALE; HUMANS; MAMMAPLASTY; MASTECTOMY; MIDDLE AGED; NEURALGIA; PAIN MEASUREMENT; PAIN, POSTOPERATIVE; QUALITY OF LIFE; REOPERATION; TREATMENT OUTCOME; YOUNG ADULT;

EID: 84979697537     PISSN: 17486815     EISSN: 18780539     Source Type: Journal    
DOI: 10.1016/j.bjps.2016.07.003     Document Type: Article

References (46)

1. 1 Peuckmann, V., Ekholm, O., Rasmussen, N.K., et al. Chronic pain and other sequelae in long-term breast cancer survivors: nationwide survey in Denmark. Eur J Pain 13:5 (2009), 478–485.
2. 2 Haroutiunian, S., Nikolajsen, L., Finnerup, N.B., Jensen, T.S., The neuropathic component in persistent postsurgical pain: a systematic literature review. Pain 154:1 (2013), 95–102.
3. 3 Lauria, G., Hsieh, S.T., Johansson, O., et al. European federation of neurological societies/peripheral nerve society guideline on the use of skin biopsy in the diagnosis of small fiber neuropathy. report of a joint task force of the european federation of neurological societies and the peripheral nerve society. Eur J Neurol 17:7 (2010), 903–912 e44-9.
4. 4 Gartner, R., Jensen, M.B., Nielsen, J., Ewertz, M., Kroman, N., Kehlet, H., Prevalence of and factors associated with persistent pain following breast cancer surgery. JAMA 302:18 (2009), 1985–1992.
5. 5 Carpenter, J.S., Andrykowski, M.A., Sloan, P., et al. Postmastectomy/postlumpectomy pain in breast cancer survivors. J Clin Epidemiol 51:12 (1998), 1285–1292.
6. 6 Caffo, O., Amichetti, M., Ferro, A., Lucenti, A., Valduga, F., Galligioni, E., Pain and quality of life after surgery for breast cancer. Breast Cancer Res Treat 80:1 (2003), 39–48, 10.1023/A:1024435101619.
7. 7 Kalso, E., Tasmuth, T., Neuvonen, P.J., Amitriptyline effectively relieves neuropathic pain following treatment of breast cancer. Pain 64:2 (1996), 293–302.
8. 8 Dini, D., Bertelli, G., Gozza, A., Forno, G.G., Treatment of the post-mastectomy pain syndrome with topical capsaicin. Pain 54:2 (1993), 223–226.
9. 9 Watson, C.P., Evans, R.J., The postmastectomy pain syndrome and topical capsaicin: a randomized trial. Pain 51:3 (1992), 375–379.
10. 10 Watson, C.P., Evans, R.J., Watt, V.R., The post-mastectomy pain syndrome and the effect of topical capsaicin. Pain 38:2 (1989), 177–186.
11. 11 Tasmuth, T., Hartel, B., Kalso, E., Venlafaxine in neuropathic pain following treatment of breast cancer. Eur J Pain 6:1 (2002), 17–24.
12. 12 Vilholm, O.J., Cold, S., Rasmussen, L., Sindrup, S.H., Effect of levetiracetam on the postmastectomy pain syndrome. Eur J Neurol 15:8 (2008), 851–857.
13. 13 Caviggioli, F., Maione, L., Forcellini, D., Klinger, F., Klinger, M., Autologous fat graft in postmastectomy pain syndrome. Plast Reconstr Surg 128:2 (2011), 349–352, 10.1097/PRS.0b013e31821e70e7.
14. 14 Maione, L., Vinci, V., Caviggioli, F., et al. Autologous fat graft in postmastectomy pain syndrome following breast conservative surgery and radiotherapy. Aesthet Plast Surg 38:3 (2014), 528–532.
15. 15 Doig, G.S., Simpson, F., Randomization and allocation concealment: a practical guide for researchers. J Crit Care 20:2 (2005), 187–191 discussion 191–3.
16. 16 Coleman, S.R., Structural fat grafting: more than a permanent filler. Plast Reconstr Surg 118:3 (2006), 108S–120S, 10.1097/01.prs.0000234610.81672.e7.
17. 17 Kristiansen, K., Lyngholm-Kjaerby, P., Moe, C., Introduction and validation of DoloTest((R)): a new health-related quality of life tool used in pain patients. Pain Pract 10:5 (2010), 396–403, 10.1111/j.1533-2500.2010.00366.x.
18. 18 Bouhassira, D., Attal, N., Fermanian, J., et al. Development and validation of the neuropathic pain symptom inventory. Pain 108:3 (2004), 248–257.
19. 19 van de Kar, A.L., Corion, L.U., Smeulders, M.J., Draaijers, L.J., van der Horst, C.M., van Zuijlen, P.P., Reliable and feasible evaluation of linear scars by the patient and observer scar assessment scale. Plast Reconstr Surg 116:2 (2005), 514–522.
20. 20 McCarthy, B.G., Hsieh, S.T., Stocks, A., et al. Cutaneous innervation in sensory neuropathies: evaluation by skin biopsy. Neurology 45:10 (1995), 1848–1855.
21. 21 Lauria, G., Cornblath, D.R., Johansson, O., et al. EFNS guidelines on the use of skin biopsy in the diagnosis of peripheral neuropathy. Eur J Neurol 12:10 (2005), 747–758.
22. 22 Farrar, J.T., Portenoy, R.K., Berlin, J.A., Kinman, J.L., Strom, B.L., Defining the clinically important difference in pain outcome measures. Pain 88:3 (2000), 287–294.
23. 23 Farrar, J.T., Young, J.P. Jr., LaMoreaux, L., Werth, J.L., Poole, R.M., Clinical importance of changes in chronic pain intensity measured on an 11-point numerical pain rating scale. Pain 94:2 (2001), 149–158.
24. 24 Huang, S.H., Wu, S.H., Chang, K.P., et al. Alleviation of neuropathic scar pain using autologous fat grafting. Ann Plast Surg 74:2 (2015), S99–S104.
25. 25 Vaienti, L., Gazzola, R., Villani, F., Parodi, P.C., Perineural fat grafting in the treatment of painful neuromas. Tech Hand Up Extrem Surg 16:1 (2012), 52–55, 10.1097/BTH.0b013e31823cd218.
26. 26 Wong, L., Intercostal neuromas: a treatable cause of postoperative breast surgery pain. Ann Plast Surg 46:5 (2001), 481–484.
27. 27 Maione, L., Memeo, A., Pedretti, L., et al. Autologous fat graft as treatment of post short stature surgical correction scars. Injury 45:6 (2014), S126–S132.
28. 28 Conde-Green, A., Marano, A.A., Lee, E.S., et al. Fat grafting and adipose-derived regenerative cells in burn wound healing and scarring: a systematic review of the literature. Plast Reconstr Surg 137:1 (2016), 302–312.
29. 29 Klinger, M., Marazzi, M., Vigo, D., Torre, M., Fat injection for cases of severe burn outcomes: a new perspective of scar remodeling and reduction. Aesthet Plast Surg 32:3 (2008), 465–469, 10.1007/s00266-008-9122-1.
30. 30 Bruno, A., Delli Santi, G., Fasciani, L., Cempanari, M., Palombo, M., Palombo, P., Burn scar lipofilling: immunohistochemical and clinical outcomes. J Craniofac Surg 24:5 (2013), 1806–1814.
31. 31 Rigotti, G., Marchi, A., Galie, M., et al. Clinical treatment of radiotherapy tissue damage by lipoaspirate transplant: a healing process mediated by adipose-derived adult stem cells. Plast Reconstr Surg 119:5 (2007), 1409–1422, 10.1097/01.prs.0000256047.47909.71 discussion 1423-4.
32. 32 Pallua, N., Baroncini, A., Alharbi, Z., Stromps, J.P., Improvement of facial scar appearance and microcirculation by autologous lipofilling. J Plast Reconstr Aesthet Surg 67:8 (2014), 1033–1037.
33. 33 Klinger, M., Caviggioli, F., Klinger, F.M., et al. Autologous fat graft in scar treatment. J Craniofac Surg 24:5 (2013), 1610–1615.
34. 34 Zuk, P.A., Zhu, M., Ashjian, P., et al. Human adipose tissue is a source of multipotent stem cells. Mol Biol Cell 13:12 (2002), 4279–4295.
35. 35 Thangarajah, H., Vial, I.N., Chang, E., et al. IFATS collection: adipose stromal cells adopt a proangiogenic phenotype under the influence of hypoxia. Stem Cells 27:1 (2009), 266–274.
36. 36 Huang, S.H., Wu, S.H., Lee, S.S., et al. Fat grafting in burn scar alleviates neuropathic pain via anti-inflammation effect in scar and spinal cord. PLoS One, 10(9), 2015, e0137563.
37. 37 Gonzalez-Rey, E., Gonzalez, M.A., Varela, N., et al. Human adipose-derived mesenchymal stem cells reduce inflammatory and T cell responses and induce regulatory T cells in vitro in rheumatoid arthritis. Ann Rheum Dis 69:1 (2010), 241–248.
38. 38 Gonzalez, M.A., Gonzalez-Rey, E., Rico, L., Buscher, D., Delgado, M., Adipose-derived mesenchymal stem cells alleviate experimental colitis by inhibiting inflammatory and autoimmune responses. Gastroenterology 136:3 (2009), 978–989.
39. 39 Huang, S.H., Wu, S.H., Chang, K.P., et al. Autologous fat grafting alleviates burn-induced neuropathic pain in rats. Plast Reconstr Surg 133:6 (2014), 1396–1405.
40. 40 Sultan, S.M., Stern, C.S., Allen, R.J. Jr., et al. Human fat grafting alleviates radiation skin damage in a murine model. Plast Reconstr Surg 128:2 (2011), 363–372, 10.1097/PRS.0b013e31821e6e90.
41. 41 Perez-Cano, R., Vranckx, J., Lasso, J., et al. Prospective trial of adipose-derived regenerative cell (ADRC)-enriched fat grafting for partial mastectomy defects: the RESTORE-2 trial. Eur J Surg Oncol 38:5 (2012), 382–389.
42. 42 Granel, B., Daumas, A., Jouve, E., et al. Safety, tolerability and potential efficacy of injection of autologous adipose-derived stromal vascular fraction in the fingers of patients with systemic sclerosis: an open-label phase I trial. Ann Rheum Dis 74:12 (2015), 2175–2182.
43. 43 Fodor, P.B., Paulseth, S.G., Adipose derived stromal cell (ADSC) injections for pain management of osteoarthritis in the human knee joint. Aesthet Surg J 36:2 (2016), 229–236.
44. 44 Zimmerlin, L., Donnenberg, V.S., Pfeifer, M.E., et al. Stromal vascular progenitors in adult human adipose tissue. Cytom Part A 77:1 (2010), 22–30.
45. 45 Devigili, G., Tugnoli, V., Penza, P., et al. The diagnostic criteria for small fibre neuropathy: from symptoms to neuropathology. Brain 131:Pt 7 (2008), 1912–1925.
46. 46 Dellon, A.L., Abnormal skin biopsy for intraepidermal nerve fibers: when “decreased small nerve fibers” is not “small fiber neuropathy”. Microsurgery 35:7 (2015), 505–506.