Association Between Heart Rate at Rest and Incident Atrial Fibrillation (from the Copenhagen Electrocardiographic Study)

American Journal of Cardiology

Volumn 118, Issue 5, 2016, Pages 708-713

  Skov, Morten W ^a   Bachmann, Troels N ^a   Rasmussen, Peter V ^a   Olesen, Morten S ^a   Pietersen, Adrian ^b   Graff, Claus ^c   Lind, Bent ^b   Struijk, Johannes J ^c   Køber, Lars ^d   Haunsø, Stig ^a,d   Svendsen, Jesper H ^a,d   Gerds, Thomas A ^a   Holst, Anders G ^a   Nielsen, Jonas B ^a,e  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b Laboratory of Copenhagen General Practitioners   (Denmark)

^c AALBORG UNIVERSITY   (Denmark)

^d UNIVERSITY OF COPENHAGEN   (Denmark)

^e UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; AGED; ARTICLE; ATRIAL FIBRILLATION; CLINICAL OUTCOME; CLINICAL STUDY; COMORBIDITY; CONFIDENCE INTERVAL; CONTROLLED STUDY; CORRELATION ANALYSIS; DRUG USE; ELECTROCARDIOGRAM; FEMALE; FOLLOW UP; HAZARD RATIO; HEART RATE; HUMAN; MAJOR CLINICAL STUDY; MALE; MORTALITY; OUTCOME ASSESSMENT; PACEMAKER IMPLANTATION; PRIMARY MEDICAL CARE; PRIORITY JOURNAL; REST; ARTIFICIAL HEART PACEMAKER; COMPLICATION; DENMARK; ELECTROCARDIOGRAPHY; MIDDLE AGED; PROCEDURES; REGISTER; RISK FACTOR; SURVIVAL ANALYSIS; TIME FACTOR;

ADULT; AGED; ATRIAL FIBRILLATION; DENMARK; ELECTROCARDIOGRAPHY; FEMALE; FOLLOW-UP STUDIES; HEART RATE; HUMANS; MALE; MIDDLE AGED; PACEMAKER, ARTIFICIAL; REGISTRIES; REST; RISK FACTORS; SURVIVAL ANALYSIS; TIME FACTORS;

EID: 84979669608     PISSN: 00029149     EISSN: 18791913     Source Type: Journal    
DOI: 10.1016/j.amjcard.2016.06.013     Document Type: Article

References (26)

1. 1 Go, A.S., Hylek, E.M., Phillips, K.A., Chang, Y., Henault, L.E., Selby, J.V., Singer, D.E., Prevalence of diagnosed atrial fibrillation in adults: national implications for rhythm management and stroke prevention: the Anticoagulation and Risk Factors in Atrial Fibrillation (ATRIA) study. JAMA 285 (2001), 2370–2375.
2. 2 Lloyd-Jones, D., Adams, R.J., Brown, T.M., Carnethon, M., Dai, S., De Simone, G., Ferguson, T.B., Ford, E., Furie, K., Gillespie, C., Go, A., Greenlund, K., Haase, N., Hailpern, S., Ho, P.M., Howard, V., Kissela, B., Kittner, S., Lackland, D., Lisabeth, L., Marelli, A., McDermott, M.M., Meigs, J., Mozaffarian, D., Mussolino, M., Nichol, G., Roger, V.L., Rosamond, W., Sacco, R., Sorlie, P., Stafford, R., Thom, T., Wasserthiel-Smoller, S., Wong, N.D., Wylie-Rosett, J., Executive summary: heart disease and stroke statistics–2010 update: a report from the American Heart Association. Circulation 121 (2010), 948–954.
3. 3 Dyer, A.R., Persky, V., Stamler, J., Paul, O., Shekelle, R.B., Berkson, D.M., Lepper, M., Schoenberger, J.A., Lindberg, H.A., Heart rate as a prognostic factor for coronary heart disease and mortality: findings in three Chicago epidemiologic studies. Am J Epidemiol 112 (1980), 736–749.
4. 4 Kannel, W.B., Kannel, C., Paffenbarger, R.S. Jr., Cupples, L.A., Heart rate and cardiovascular mortality: the Framingham Study. Am Heart J 113 (1987), 1489–1494.
5. 5 Mensink, G.B., Hoffmeister, H., The relationship between resting heart rate and all-cause, cardiovascular and cancer mortality. Eur Heart J 18 (1997), 1404–1410.
6. 6 Tverdal, A., Hjellvik, V., Selmer, R., Heart rate and mortality from cardiovascular causes: a 12 year follow-up study of 379 843 men and women aged 40–45 years. Eur Heart J 29 (2008), 2772–2781.
7. 7 Opdahl, A., Ambale Venkatesh, B., Fernandes, V.R., Wu, C.O., Nasir, K., Choi, E.Y., Almeida, A.L., Rosen, B., Carvalho, B., Edvardsen, T., Bluemke, D.A., Lima, J.A., Resting heart rate as predictor for left ventricular dysfunction and heart failure: MESA (Multi-Ethnic Study of Atherosclerosis). J Am Coll Cardiol 63 (2014), 1182–1189.
8. 8 Ho, J.E., Larson, M.G., Ghorbani, A., Cheng, S., Coglianese, E.E., Vasan, R.S., Wang, T.J., Long-term cardiovascular risks associated with an elevated heart rate: the Framingham Heart Study. J Am Heart Assoc, 3, 2014, e000668.
9. 9 Thelle, D.S., Selmer, R., Gjesdal, K., Sakshaug, S., Jugessur, A., Graff-Iversen, S., Tverdal, A., Nystad, W., Resting heart rate and physical activity as risk factors for lone atrial fibrillation: a prospective study of 309,540 men and women. Heart 99 (2013), 1755–1760.
10. 10 Böhm, M., Schumacher, H., Linz, D., Reil, J.C., Ukena, C., Lonn, E., Teo, K., Sliwa, K., Schmieder, R.E., Sleight, P., Yusuf, S., Low resting heart rates are associated with new-onset atrial fibrillation in patients with vascular disease: results of the ONTARGET/TRANSCEND studies. J Intern Med 278 (2015), 303–312.
11. 11 O'Neal, W.T., Almahmoud, M.F., Soliman, E.Z., Resting heart rate and incident atrial fibrillation in the elderly. Pacing Clin Electrophysiol 38 (2015), 591–597.
12. 12 Okin, P.M., Wachtell, K., Kjeldsen, S.E., Julius, S., Lindholm, L.H., Dahlöf, B., Hille, D.A., Nieminen, M.S., Edelman, J.M., Devereux, R.B., Incidence of atrial fibrillation in relation to changing heart rate over time in hypertensive patients: the LIFE study. Circ Arrhythm Electrophysiol 1 (2008), 337–343.
13. 13 Nielsen, J.B., Graff, C., Pietersen, A., Lind, B., Struijk, J.J., Olesen, M.S., Haunsø, S., Gerds, T.A., Svendsen, J.H., Køber, L., Holst, A.G., J-shaped association between QTc interval duration and the risk of atrial fibrillation: results from the Copenhagen ECG study. J Am Coll Cardiol 61 (2013), 2557–2564.
14. 14 Olesen, J.B., Lip, G.Y., Hansen, M.L., Hansen, P.R., Tolstrup, J.S., Lindhardsen, J., Selmer, C., Ahlehoff, O., Olsen, A.M., Gislason, G.H., Torp-Pedersen, C., Validation of risk stratification schemes for predicting stroke and thromboembolism in patients with atrial fibrillation: nationwide cohort study. BMJ, 342, 2011, d124.
15. 15 Madsen, M., Davidsen, M., Rasmussen, S., Abildstrom, S.Z., Osler, M., The validity of the diagnosis of acute myocardial infarction in routine statistics: a comparison of mortality and hospital discharge data with the Danish MONICA registry. J Clin Epidemiol 56 (2003), 124–130.
16. 16 Nielsen, J.B., Graff, C., Rasmussen, P.V., Pietersen, A., Lind, B., Olesen, M.S., Struijk, J.J., Haunsø, S., Svendsen, J.H., Køber, L., Gerds, T.A., Holst, A.G., Risk prediction of cardiovascular death based on the QTc interval: evaluating age and gender differences in a large primary care population. Eur Heart J 35 (2014), 1335–1344.
17. 17 Schemper, M., Smith, T.L., A note on quantifying follow-up in studies of failure time. Control Clin Trials 17 (1996), 343–346.
18. 18 van Houwelingen, H.C., From model building to validation and back: a plea for robustness. Stat Med 33 (2014), 5223–5238.
19. 19 R Core Team (2015). R: A Language and Environment for Statistical Computing. R Foundation for Statistical Computing, Vienna, Austria. URL http://www.R-project.org/. Accessed on May 26, 2016.
20. 20 Russell, M.W., Law, I., Sholinsky, P., Fabsitz, R.R., Heritability of ECG measurements in adult male twins. J Electrocardiol 30:Suppl (1998), 64–68.
21. 21 Dalageorgou, C., Ge, D., Jamshidi, Y., Nolte, I.M., Riese, H., Savelieva, I., Carter, N.D., Spector, T.D., Snieder, H., Heritability of QT interval: how much is explained by genes for resting heart rate?. J Cardiovasc Electrophysiol 19 (2008), 386–391.
22. 22 den Hoed, M., Eijgelsheim, M., Esko, T., Brundel, B.J., Peal, D.S., Evans, D.M., Nolte, I.M., Segrè, A.V., Holm, H., Handsaker, R.E., Westra, H.J., Johnson, T., Isaacs, A., Yang, J., Lundby, A., Zhao, J.H., Kim, Y.J., Go, M.J., Almgren, P., Bochud, M., Boucher, G., Cornelis, M.C., Gudbjartsson, D., Hadley, D., Harst van der, P., Hayward, C., Heijer den, M., Igl, W., Jackson, A.U., Kutalik, Z., Luan, J., Kemp, J.P., Kristiansson, K., Ladenvall, C., Lorentzon, M., Montasser, M.E., Njajou, O.T., O'Reilly, P.F., Padmanabhan, S., St Pourcain, B., Rankinen, T., Salo, P., Tanaka, T., Timpson, N.J., Vitart, V., Waite, L., Wheeler, W., Zhang, W., Draisma, H.H., Feitosa, M.F., Kerr, K.F., Lind, P.A., Mihailov, E., Onland-Moret, N.C., Song, C., Weedon, M.N., Xie, W., Yengo, L., Absher, D., Albert, C.M., Alonso, A., Arking, D.E., de Bakker, P.I., Balkau, B., Barlassina, C., Benaglio, P., Bis, J.C., Bouatia-Naji, N., Brage, S., Chanock, S.J., Chines, P.S., Chung, M., Darbar, D., Dina, C., Dörr, M., Elliott, P., Felix, S.B., Fischer, K., Fuchsberger, C., de Geus, E.J., Goyette, P., Gudnason, V., Harris, T.B., Hartikainen, A.L., Havulinna, A.S., Heckbert, S.R., Hicks, A.A., Hofman, A., Holewijn, S., Hoogstra-Berends, F., Hottenga, J.J., Jensen, M.K., Johansson, A., Junttila, J., Kääb, S., Kanon, B., Ketkar, S., Khaw, K.T., Knowles, J.W., Kooner, A.S., Kors, J.A., Kumari, M., Milani, L., Laiho, P., Lakatta, E.G., Langenberg, C., Leusink, M., Liu, Y., Luben, R.N., Lunetta, K.L., Lynch, S.N., Markus, M.R., Marques-Vidal, P., Mateo Leach, I., McArdle, W.L., McCarroll, S.A., Medland, S.E., Miller, K.A., Montgomery, G.W., Morrison, A.C., Müller-Nurasyid, M., Navarro, P., Nelis, M., O'Connell, J.R., O'Donnell, C.J., Ong, K.K., Newman, A.B., Peters, A., Polasek, O., Pouta, A., Pramstaller, P.P., Psaty, B.M., Rao, D.C., Ring, S.M., Rossin, E.J., Rudan, D., Sanna, S., Scott, R.A., Sehmi, J.S., Sharp, S., Shin, J.T., Singleton, A.B., Smith, A.V., Soranzo, N., Spector, T.D., Stewart, C., Stringham, H.M., Tarasov, K.V., Uitterlinden, A.G., Vandenput, L., Hwang, S.J., Whitfield, J.B., Wijmenga, C., Wild, S.H., Willemsen, G., Wilson, J.F., Witteman, J.C., Wong, A., Wong, Q., Jamshidi, Y., Zitting, P., Boer, J.M., Boomsma, D.I., Borecki, I.B., van Duijn, C.M., Ekelund, U., Forouhi, N.G., Froguel, P., Hingorani, A., Ingelsson, E., Kivimaki, M., Kronmal, R.A., Kuh, D., Lind, L., Martin, N.G., Oostra, B.A., Pedersen, N.L., Quertermous, T., Rotter, J.I., van der Schouw, Y.T., Verschuren, W.M., Walker, M., Albanes, D., Arnar, D.O., Assimes, T.L., Bandinelli, S., Boehnke, M., de Boer, R.A., Bouchard, C., Caulfield, W.L., Chambers, J.C., Curhan, G., Cusi, D., Eriksson, J., Ferrucci, L., van Gilst, W.H., Glorioso, N., de Graaf, J., Groop, L., Gyllensten, U., Hsueh, W.C., Hu, F.B., Huikuri, H.V., Hunter, D.J., Iribarren, C., Isomaa, B., Jarvelin, M.R., Jula, A., Kähönen, M., Kiemeney, L.A., van der Klauw, M.M., Kooner, J.S., Kraft, P., Iacoviello, L., Lehtimäki, T., Lokki, M.L., Mitchell, B.D., Navis, G., Nieminen, M.S., Ohlsson, C., Poulter, N.R., Qi, L., Raitakari, O.T., Rimm, E.B., Rioux, J.D., Rizzi, F., Rudan, I., Salomaa, V., Sever, P.S., Shields, D.C., Shuldiner, A.R., Sinisalo, J., Stanton, A.V., Stolk, R.P., Strachan, D.P., Tardif, J.C., Thorsteinsdottir, U., Tuomilehto, J., van Veldhuisen, D.J., Virtamo, J., Viikari, J., Vollenweider, P., Waeber, G., Widen, E., Cho, Y.S., Olsen, J.V., Visscher, P.M., Willer, C., Franke, L. Global BPgen Consortium; CARDIoGRAM Consortium, Erdmann, J., Thompson, J.R. PR GWAS Consortium, Pfeufer, A. QRS GWAS Consortium, Sotoodehnia, N. QT-IGC Consortium, Newton-Cheh, C., CHARGE-AF Consortium, Ellinor, P.T., Stricker, B.H., Metspalu, A., Perola, M., Beckmann, J.S., Smith, G.D., Stefansson, K., Wareham, N.J., Munroe, P.B., Sibon, O.C., Milan, D.J., Snieder, H., Samani, N.J., Loos, R.J., Identification of heart rate-associated loci and their effects on cardiac conduction and rhythm disorders. Nat Genet 45 (2013), 621–631.
23. 23 Arora, R., Recent insights into the role of the autonomic nervous system in the creation of substrate for atrial fibrillation: implications for therapies targeting the atrial autonomic nervous system. Circ Arrhythm Electrophysiol 5 (2012), 850–859.
24. 24 Kwok, C.S., Anderson, S.G., Myint, P.K., Mamas, M.A., Loke, Y.K., Physical activity and incidence of atrial fibrillation: a systematic review and meta-analysis. Int J Cardiol 177 (2014), 467–476.
25. 25 Goldberger, J.J., Johnson, N.P., Gidea, C., Significance of asymptomatic bradycardia for subsequent pacemaker implantation and mortality in patients >60 years of age. Am J Cardiol 108 (2011), 857–861.
26. 26 Rix, T.A., Riahi, S., Overvad, K., Lundbye-Christensen, S., Schmidt, E.B., Joensen, A.M., Validity of the diagnoses atrial fibrillation and atrial flutter in a Danish patient registry. Scand Cardiovasc J 46 (2012), 149–153.