Treponema pallidum strain types and association with macrolide resistance in Sydney, Australia: New TP0548 gene types identified

Journal of Clinical Microbiology

Volumn 54, Issue 8, 2016, Pages 2172-2174

  Read, Phillip ^a,b   Tagg, Kaitlin A ^c   Jeoffreys, Neisha ^c   Guy, Rebecca J ^b   Gilbert, Gwendolyn L ^c   Donovan, Basil ^b,d  

^a SOUTH EASTERN SYDNEY LOCAL HEALTH DISTRICT   (Australia)

^b UNIVERSITY OF NEW SOUTH WALES   (Australia)

^c UNIVERSITY OF SYDNEY   (Australia)

^d SYDNEY EYE HOSPITAL   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

MACROLIDE; ANTIINFECTIVE AGENT;

ADULT; ANTIBIOTIC RESISTANCE; ARP GENE; ARTICLE; AUSTRALIA; BACTERIAL GENE; BACTERIAL STRAIN; BACTERIAL TRANSMISSION; DISEASE ASSOCIATION; FEMALE; GENE IDENTIFICATION; GENE MUTATION; GENE SEQUENCE; HEADACHE; HUMAN; MAJOR CLINICAL STUDY; MALE; MEN WHO HAVE SEX WITH MEN; NEUROSYPHILIS; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; SYPHILIS; TPR GENE; TREPONEMA PALLIDUM; VENEREAL DISEASE REACTION TEST; CLASSIFICATION; DRUG EFFECTS; GENOTYPE; ISOLATION AND PURIFICATION; MICROBIOLOGY; MIDDLE AGED; MOLECULAR TYPING; YOUNG ADULT;

ADULT; ANTI-BACTERIAL AGENTS; AUSTRALIA; DRUG RESISTANCE, BACTERIAL; FEMALE; GENOTYPE; HUMANS; MACROLIDES; MALE; MIDDLE AGED; MOLECULAR TYPING; SYPHILIS; TREPONEMA PALLIDUM; YOUNG ADULT;

EID: 84979619086     PISSN: 00951137     EISSN: 1098660X     Source Type: Journal    
DOI: 10.1128/JCM.00959-16     Document Type: Article

References (12)

1. The Kirby Institute. 2015. HIV, viral hepatitis and sexually transmissible infections in Australia: annual surveillance report 2015. The Kirby Institute, UNSW Australia, Sydney, Australia.
2. Read P, Jeoffreys N, Tagg K, Guy R, Gilbert G, Donovan B. 2014. Azithromycin-resistant syphilis-causing strains in Sydney: prevalence and risk factors. J Clin Microbiol 52:2776-2781. http://dx. doi. org/10. 1128 /JCM. 00301-14.
3. Marra C, Sahi S, Tantalo L, Godornes C, Reid T, Behets F, Rompalo A, Klausner JD, Yin Y, Mulcahy F, Golden MR, Centurion-Lara A, Lukehart SA. 2010. Enhanced molecular typing of Treponema pallidum: geographical distribution of strain types and association with neurosyphilis. J Infect Dis 202:1380-1388. http://dx. doi. org/10. 1086/656533.
4. Pillay A, Liu H, Chen C, Holloway B, Sturm W, Steiner B, Morse SA. 1998. Molecular subtyping of Treponema pallidum subspecies pallidum. Sex Transm Dis 25:408-414. http://dx. doi. org/10. 1097/00007435-199809000-00004.
5. Sena A, Pillay A, Cox DL, Radolf JD. 2015. Treponema and Brachyspira, human host-associated spirochetes, p 1055-1081. In Jorgensen JH, Pfaller MA, Carroll KC, Funke G, Landry ML, Richter SS, Warnock DW (ed), Manual of clinical microbiology, 11th ed, vol 1. ASM Press, Washington, D.C.
6. Grange P, Allix-Beguec C, Chanal J, Benhaddou N, Gerhardt P, Morini JP, Deleuze J, Lassau F, Janier M, Dupin N. 2013. Molecular subtyping of Treponema pallidum in Paris, France. Sex Transm Dis 40:641-644. http: //dx. doi. org/10. 1097/OLQ. 0000000000000006.
7. Grillova L, Strouhal M, Mikalova L, Smajs D. 2015. The 2 simultaneously published k sequence variants of tp0548 locus of Treponema pallidum ssp. pallidum isolates differ: the one published later has to be renamed as l. Sex Transm Dis 42:53. http://dx. doi. org/10. 1097/OLQ . 0000000000000220.
8. Tipple C, McClure M, Taylor GP. 2011. High prevalence of macrolide resistant Treponema pallidum strains in a London centre. Sex Transm Infect 87:486-488. http://dx. doi. org/10. 1136/sextrans-2011-050082.
9. Salado-Rasmussen K, Cowan S, Gerstoft J, Larsen HK, Hoffmann S, Knudsen TB, Katzenstein TL, Jensen JS. 2016. Molecular typing of Treponema pallidum in Denmark: a nationwide study of syphilis. Acta Derm Venereol 96:202-206. http://dx. doi. org/10. 2340/00015555-2190.
10. Grimes M, Sahi SK, Godornes BC, Tantalo LC, Roberts N, Bostick D, Marra CM, Lukehart SA. 2012. Two mutations associated with macrolide resistance in Treponema pallidum: increasing prevalence and correlation with molecular strain type in Seattle, Washington. Sex Transm Dis 39: 954-958. http://dx. doi. org/10. 1097/OLQ. 0b013e31826ae7a8.
11. Pillay A, Chen C, Morshed M, Philip S, Ballard R. 2011. P4-S3. 02: subtyping of Treponema pallidum strains by sequence analysis of tp0279 and tp0548. Sex Transm Infect 87(Suppl 1):A312. http://dx. doi. org/10 . 1136/sextrans-2011-050108. 517.
12. Azzato F, Ryan N, Fyfe J, Leslie D. 2012. Molecular subtyping of Treponema pallidum during a local syphilis epidemic in men who have sex with men in Melbourne, Australia. J Clin Microbiol 50:1895-1899. http://dx . doi. org/10. 1128/JCM. 00083-12.