Characterization of gelatin/chitosan scaffold blended with aloe vera and snail mucus for biomedical purpose

International Journal of Biological Macromolecules

Volumn 92, Issue , 2016, Pages 645-653

  López Angulo, Daniel Enrique ^a   do Amaral Sobral, Paulo José ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Biocompatible scaffolds; Interconnected matrix; Tissue regeneration

Indexed keywords

CHITOSAN; GELATIN; MOLECULAR SCAFFOLD; NANOCOMPOSITE; AMINO ACID;

ALOE VERA; AMINO ACID COMPOSITION; ARTICLE; BINDING AFFINITY; BINDING SITE; BIODEGRADABILITY; BIODEGRADATION; BIOLOGICAL ACTIVITY; COMPRESSIVE STRENGTH; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; IN VITRO STUDY; INFRARED SPECTROSCOPY; MUCUS; NANOPORE; POROSITY; SCANNING ELECTRON MICROSCOPY; SENSITIVITY ANALYSIS; STRUCTURE ANALYSIS; TENSILE STRENGTH; TISSUE ENGINEERING; X RAY DIFFRACTION; ALOE; ANIMAL; CHEMISTRY; FREEZE DRYING; PIG; SNAIL; TISSUE SCAFFOLD;

ALOE; AMINO ACIDS; ANIMALS; CHITOSAN; FREEZE DRYING; GELATIN; MICROSCOPY, ELECTRON, SCANNING; MUCUS; SNAILS; SPECTROSCOPY, FOURIER TRANSFORM INFRARED; SUS SCROFA; TISSUE SCAFFOLDS; X-RAY DIFFRACTION;

EID: 84979586951     PISSN: 01418130     EISSN: 18790003     Source Type: Journal    
DOI: 10.1016/j.ijbiomac.2016.07.029     Document Type: Article

References (64)

1. [1] Shani, E., Ayalon, A., Hammad, I.A., Sikron, F., What picture is worth a thousand words? A comparative evaluation of a burn prevention programme by type of medium in Israel. Health Promot. Int. 18 (2003), 369–378 PMID: 14695367.
2. [2] Papini, R., Management of burn injuries of various depths, clinical Review ABC of burns. BMJ 329 (2004), 158–160, 10.1136/bmj.329.7458.158.
3. [3] Lari, A.R., Panjeshahin, M.R., Talei, A.R., Rossignol, A.M., Alaghehbandan, R., Epidemiology of childhood burn injuries in fars Province. Iran J. Burn Care Rehabil. 23 (2002), 39–45 PMID: 11803311.
4. [4] Murugan, R., Huang, Z.M., Yang, F., Ramakrishna, S., Nanofibrous scaffold engineering using electrospinning. J. Nanosci. Nanotechnol. 12 (2007), 4595–4603 PMID: 18283850.
5. [5] Kumbar, S.G., Nukavarapu, S.P., James, R., Nair, L.S., Laurencin, C.T., Electrospun poly(lactic acid-co-glycolic acid) scaffolds for skin tissue engineering. Biomaterials 29 (2008), 4100–4107, 10.1016/j.biomaterials.2008.06.028.
6. [6] Enrione, J., Osorio, F., López, D., Weinstein-Oppenheimer, C., Fuentes, M., Ceriani, R., Brown, D., Albornoz, F., Sánchez, E., Villalobos, P., Somoza, R., Young, M., Acevedo, C., Characterizatio n of a gelatin/chitosan/hyaluronan scaffold polymer. Electronic J. Biotech., 2010, 10.2225/vol13-issue5-fulltext-15 ISSN: 0717-3458.
7. [7] Dainiak, B., Allan, U., Savina, N., Cornelio, L., James, E., Stuart, L., Mikhalosvsky, V., Jungvid, H., Galaev, I., Gelatin-fibrinogen cryogel dermal matrices for wound repair: preparation, optimization an in vitro study. Biomaterials 31 (2010), 67–76 ISSN 0142-9612.
8. [8] Chen, G., Ushida, T., Tatehishi, T., Scaffold design for tissue engineering. Macromol. Biosci. 2 (2002), 67–77, 10.1002/1616-5195(20020201)2:2<67:AID-MABI67>3.0.CO;2-F.
9. [9] Liu, Y., Shu, X.Z., Prestwich, G.D., Osteochondral defect repair with autologous bone marrow-derived mesenchymal stem cells in an injectable, in situ crosslinked synthetic extracellular matrix. Tissue Eng. 12 (2006), 3405–3416, 10.1089/ten.2006.12.3405.
10. [10] Gomes, S.R., Rodrigues, G., Martins, G.G., Henriques, C.M.R., Silva, J.C., In vitro evaluation of crosslinked electrospun fish gelatin scaffolds. Mate. Sci. Eng. 33 (2013), 1219–1227, 10.1016/j.msec.2012.12.014.
11. [11] Chen, Y.L., Lee, H.P., Chan, H.Y., Sung, L.Y., Chen, H.C., Hu, Y.C., Composite chondroitin-6-sulfate/dermatan sulfate/chitosan scaffolds for cartilage tissue engineering. Biomaterials 28 (2007), 2294–2305, 10.1016/j.biomaterials.2007.01.027.
12. [12] Suh, J.K., Matthew, H.W., Application of chitosan-based polysaccharide biomaterials in cartilage tissue engineering: a review. Biomaterials 21 (2000), 2589–2598, 10.1016/S0142-9612(00)00126-5.
13. [13] Martino, A.D., Sittinger, M., Risbud, M.V., Chitosan: a versatile biopolymer for orthopaedic tissue-engineering. Biomaterials 26 (2005), 5983–5990, 10.1016/j.biomaterials.2005.03.016.
14. [14] Kumar, M.N., Muzzarelli, R.A., Muzzarelli, C., Sashiwa, H., Domb, A.J., Chitosan chemistry and pharmaceutical perspectives. Chem. Rev. 104 (2004), 6017–6084, 10.1021/cr030441b.
15. [15] Bonnemain, B., Helix and drugs: snails for western health care from antiquity to the present. Evid. Based Complement Alternat. Med. 1 (2005), 25–28, 10.1093/ecam/neh057.
16. [16] Iguchi, S.M., Aikawa, T., Matsumoto, J.J., Antibacterial activity of snail mucus mucin. Comp. Biochem. Physiol. 72 (1982), 571–574 PMID: 6126300.
17. [17] Fujiwara, S., Noguchi, T., Degradation of purines: only ureidoglycollate lyase out of four allantoin-degrading enzymes is present in mammals. Biochem. J. 312 (1995), 315–318, 10.1042/bj3120315.
18. [18] Thornfeldt, C., Cosmeceuticals containing herbs: fact, fiction, and future. Dermatol. Surg. 31 (2005), 873–880 PMID: 16029681.
19. [19] Spellman, M.C., Pincus, S.H., Efficacy and safety of azelaic acid and glycolic acid combination therapy compared with tretinoin therapy for acné. Clin. Ther. 20 (1998), 4711–4721, 10.1016/S0149-2918(98)80134-3.
20. [20] Femenia, A., Sánchez, E.S., Simal, S., Rosselló, C., Compositional features of polysaccharides from aloe vera (aloe barbadensis miller) plant tissues. Carbohydr. Polym. 39 (1999), 109–117 PII: S0144-8617(98)00163-5.
21. [21] Choi, S., Chung, M.A., Review on the relationship between aloe vera components and their biologic effects. Semin. Integr. Med. 5 (2003), 53–62 749-2081/03/101-0001$30.00/010.1016/S1543-1150(03)00005-X.
22. [22] Lee, C.K., Immunomodulatory activity. Park, Y.I., Lee, S.K., (eds.) New Perspectives on Aloe, 2006, Springer Science, NY, 155–167.
23. [23] Ro, J.Y., Anti-allergic responses. Park, Y.I., Lee, S.K., (eds.) New Perspectives on Aloe, 2006, Springer Science, NY, 95–126.
24. [24] Reynolds, T., Dweck, A.C., Aloe vera leaf gel: a review update. J. Ethnopharmacol. 68 (1999), 3–37 PMID: 10624859.
25. [25] Choi, S., Son, B.W., Son, Y.S., Park, Y.I., Lee, S.K., Chung, M.H., The wound-healing effect of a glycoprotein fraction isolated from aloe vera. Br. J. Derm. 145 (2001), 535–545, 10.1046/j.1365-2133.2001.04410.x.
26. [26] McHale, M.K., Bergmann, N.M., West, J.L., Histogenesis in three-dimensional scaffolds. Principles of Regenerative Medicine, second edition, 2011, Elsevier Inc., 675–691, 10.1016/B978-0-12-381422-7.10037-9.
27. [27] Zhang, Y.Z., Venugopal, J., Huang, Z.M., Lim, C.T., Ramakrishna, S., Crosslinking of the electrospun gelatin nanofibers. Polymer 47 (2006), 2911–2917.
28. [28] Díaz, P., López, D., Matiacevich, S., Osorio, F., Enrione, J., State diagram of salmon (Salmo salar) gelatin films. J. Sci. Food Agric. 91 (2011), 2558–2565, 10.1002/jsfa.4451.
29. [29] Tan, Q., Songgang, L., Ren, J., Chen, Ch., Fabrication of porous scaffolds with a controllable microstructure and mechanical properties by porogen fusion technique. Int. J. Mol. Sci. 12 (2011), 890–904, 10.3390/ijms12020890.
30. [30] Sarem, M., Moztarzadeh, F., Mozafari, M., Shastri, P., Optimization strategies on the structural modeling of gelatin/chitosan scaffolds to mimic human meniscus tissue. Mater. Sci. Eng. 33 (2013), 4777–4785, 10.1016/j.msec.2013.07.036.
31. [31] Frohm, M., Gunne, H., Bergman, A.C., Agerberth, B., Bergman, T., Boman, A., Lidén, S., Biochemical and antibacterial analysis of human wound and blister fluid. Eur. J. Biochem. 237 (1996), 86–92, 10.1111/j.1432-1033.1996.0086n.x.
32. [32] Raja, M.H., Yaakob, R.N., Amin, C.M., Noorfaizan, I.A., Chemical and functional properties of bovine and porcine skin gelatin. Int. Food Res. J. 18 (2011), 813–817.
33. [33] Joly-Duhamel, C., Hellio, D., Djabourov, M., All gelatin networks: 1. biodiversity and physical chemistry†. Langmuir 18 (2002), 7208–7217, 10.1021/la020189n.
34. [34] Chiou, B., Avena-Bustillos, R.J., Shey, J., Yee, E., Peter, J., Bechtel, H., Imam, G., Glenn, W., Rheological and mechanical properties of cross-linked fish gelatins. Polymer 47 (2006), 6379–6386, 10.1016/j.polymer.2006.07.004.
35. [35] Eastoe, J.E., Leach, A.A., Chemical constitution of gelatin. Ward, A.G., Courts, A., (eds.) The Science and Technology of Gelatin, 1977, Academic Press, New York, 73–107.
36. [36] Brauker, J.H., Carr-Brendel, V.E., Martinson, L.A., Crudele, J., Johnston, W.D., Johnson, R.C., Neovascularization of synthetic membranes directed by membrane micro architecture. J. Biomed. Mater. Res. 29 (1995), 1517–1524 PMID: 8600142.
37. [37] Klawitter, J.J., Hulbert, S.F., Application of porous ceramics for the attachment of load-bearing internal orthopedic applications. J. Biomed. Mater. Res. A Symp. 2 (1971), 161–168, 10.1002/jbm.820190308.
38. [38] Yang, S., Leong, K.F., Du, Z., Chua, C.K., The design of scaffolds for use in tissue engineering—part I: traditional factors. Tissue Eng. 7:6 (2001), 679–689, 10.1089/107632701753337645.
39. [39] Whang, K., Healy, K.E., Elenz, D.R., Engineering bone regeneration with bioabsorbable scaffolds with novel microarchitecture. Tissue Eng. 5 (1999), 35–51 PMID: 10207188.
40. [40] Yannas, I.V., Lee, E., Orgill, D.P., Skrabut, E.M., Murphy, G.F., Synthesis and characterization of a model extracellular matrix that induces partial regeneration of adult mammalian skin. Proc. Natl. Acad. Sci. U. S. A. 86 (1989), 933–937 PMCID: PMC286593 .
41. [41] Salgado, A.J., Coutinho, O.P., Reis, R.L., Bone tissue engineering: state of the art and future trends. Macromol. Biosci. 8 (2004), 743–765 PMID: 15468269.
42. [42] Loh, Q.L., Choong, B., Three-dimensional scaffolds for tissue engineering applications: role of porosity and pore size. Tissue Eng.: Part B, 19(6), 2013, 10.1089/ten.teb.2012.0437.
43. [43] Serra, I.R., Fradique, R., Vallejo, M.C.S., Correia, T.R., Miguel, S.P., Correia, I.J., Production and characterization of chitosan/gelatin/β-TCP scaffolds for improved bone tissue regeneration. Mater. Sci. Eng. 55 (2015), 592–604, 10.1016/j.msec.2015.05.072.
44. [44] He, J.K., Li, D.C., Liu, Y.X., Yao, B., Lu, B., Lian, Q., Fabrication and characterization of chitosan/gelatin porous scaffolds with predefined internal microstructures. Polymer 48 (2007), 4578–4588, 10.1016/j.polymer.2007.05.048.
45. [45] Nam, Y.S., Yoon, J.J., Park, T.G., A novel fabrication method of macroporous biodegradable polymer scaffolds using gas foaming salt as a porogen. J. Biomed. Mater. Res. 53 (2000), 1–7, 10.1002/(SICI)1097-4636(2000)53:1<1:AID-JBM1>3.0.CO;2-R.
46. [46] Li, J., Pan, J., Zhang, L., Culture of hepatocytes on frutose-modified chitosan scaffolds. Biomaterials 24 (2003), 2317–2322, 10.1016/S0142-9612(03)00048-6.
47. [47] Freyman, T., Yannas, I., Gibson, L., Cells materials as porous scaffold for tissue engineering. Prog. Mater. Sci. 46 (2001), 273–282, 10.1016/S0079-6425(00)00018-9.
48. [48] Mao, J.S., Zhao, L., Yin, Y.J., Yao, K., Structure and properties of bilayer chitosan-gelatin scaffolds. Biomaterials 24 (2003), 1067–1074, 10.1016/s0142-9612(02)00442-8.
49. [49] Kakkar, P., Verma, S., Manjubala, I., Madhan, B., Development of keratin-chitosan-gelatin composite scaffold for soft tissue engineering. Mater. Sci. Eng. 45 (2014), 343–347, 10.1016/j.msec.2014.09.021.
50. [50] Liu, Y., Lim, J., Teoh, S., Review: development of clinically relevant scaffolds for vascularised bone tissue engineering. Biotechnol. Adv. 31 (2013), 688–705, 10.1016/j.biotechadv.2012.10.003.
51. [51] Tseng, H.J., Tsou, T.L., Wang, H.J., Hsu, S.H., Characterization of chitosan–gelatin scaffolds for dermal tissue engineering. J. Tissue Eng. Regen. Med. 7 (2013), 20–31, 10.1002/term.492.
52. [52] Banerjee, I., Mishra, D., Maiti, T.K., PLGA microspheres incorporated gelatin scaffold: microspheres modulate scaffold properties. Int. J. Biomat. 20 (2009), 1–9, 10.1155/2009/143659.
53. [53] Alizadeh, M., Abbasi, F., Khoshfetrat, A.B., Ghaleh, H., Microstructure and characteristic properties of gelatin/chitosan scaffold prepared by a combined freeze-drying/leaching method. Mater. Sci. Eng. 33 (2013), 3958–3967, 10.1016/j.msec.2013.05.039.
54. [54] Thein-Han, W.W., Saikhun, J., Pholpramoo, C., Misra, R.D.K., Kitiyanant, Y., Chitosan–gelatin scaffolds for tissue engineering: physico-chemical properties and biological response of buffalo embryonic stem cells and transfectant of GFP–buffalo embryonic stem cells. Acta Biomater. 5 (2009), 3453–3466, 10.1016/j.actbio.2009.05.012.
55. [55] Wei, Z., Dejie, Jiao., Xu, Junxiao, Using fourier transform infrared spectroscopy to study effects of magnetic field treatment on wheat (Triticum aestivum L.) seedlings. J. Spectrosc., 2015, 1–7, 10.1155/2015/570190.
56. [56] Sisson, K., Zhang, C., Farach-Carson, M.C., Chase, D.B.R., John, F., In vitro evaluation of crosslinked electrospun fish gelatin scaffolds. Biomacromolecules 10 (2009), 1675–1680, 10.1016/j.msec.2012.12.014.
57. [57] De Wael, K., Verstraete, A., Van Vlierberghe, S., Dejonghe, W., Dubruel, P., Adriaens, A., The electrochemistry of a gelatin modified gold electrode. Int. J. Electrochem. Sci. 6 (2011), 1810–1819.
58. [58] Cheng, M., Deng, J., Yang, F., Gong, Y., Zhao, N., Zhang, X., Study on physical properties and nerve cell affinity of composite films from chitosan and gelatin solutions. Biomaterials 24 (2013), 2871–2880, 10.1016/S0142-9612(03)00117-0.
59. [59] Zhai, M., Zhao, L., Yoshii, F., Kume, T., Study on antibacterial starch/chitosan blend film formed under the action of irradiation. Carbohydr. Polym. 57 (2004), 83–88, 10.1016/j.carbpol.2004.04.003.
60. [60] Peng, Z., Peng, Z., Shen, Y., Fabrication and properties of gelatin/chitosan composite hydrogel. Polym. Plast. Technol. 50 (2011), 1160–1164, 10.1080/03602559.2011.574670.
61. [61] Kasahara, H., Tanaka, E., Fukuyama, N., Sato, E., Sakamoto, H., Tabata, Y., Kiyoshi, A., Harukazu, I., Shinozaki, Y., Kimura, K., Kuwabara, E., Koide, S., Nakazawa, H., Mori, H., Biodegradable gelatin hydrogel potentiates the angiogenic effect of fibroblast growth factor 4 plasmid in rabbit hindlimb ischemia. J. Am. Coll. Cardiol. 41 (2003), 1056–1062, 10.1016/S0735-1097(02)03007-3.
62. [62] Hjerde, R.J., Varum, K.M., Grasdalen, H., Tokura, S., Smidsrod, O., Chemical composition of O-(carboxymethyl)-chitins in relation to lysozyme degradation rates. Carbohydr. Polym. 34 (1997), 131–139, 10.1016/S0144-8617(97)00113-6.
63. [63] Dominguez-Fernandez, R.N., Arzate-Vazquez, I., Chanona-Perez, J.J., Welti-Chanes, J.S., Alvarado-Gonzalez, J.S., Calderon-Domınguez, G., Garibay-Febles, V., Gutierrez-Lopez, G.F., Aloe vera gel: structure, chemical composition, processing, biological activity and importance in pharmaceutical and food industry. Rev. Mex. Ing. Quím. 11 (2012), 23–43 ISSN 1665-2738 http://www.scielo.org.mx/scielo.php?script=sci_arttext&pid=S166527382012000100003&lng=es&nrm=iso.
64. [64] Iguchi, S.M., Aikawa, T., Matsumoto, J.J., Antibacterial activity of snail mucus mucin. Comp. Biochem. and Physiol. 72 (1982), 571–574, 10.1016/0300-9629(82)90123-2.