Association of a promoter polymorphism in FSHR with ovarian reserve and response to ovarian stimulation in women undergoing assisted reproductive treatment

Reproductive BioMedicine Online

Volumn 33, Issue 3, 2016, Pages 391-397

  Tohlob, Dalia ^a,b   Abo Hashem, Ekbal ^b   Ghareeb, Nawal ^b   Ghanem, Mohammed ^b   Elfarahaty, Reham ^b   Byers, Helen ^a   Pemberton, Philip ^c   Roberts, Stephen A ^d   Newman, William G ^a   Mohiyiddeen, Lamiya ^e  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

^b MANSOURA UNIVERSITY   (Egypt)

^c MANCHESTER ROYAL INFIRMARY   (United Kingdom)

^d UNIVERSITY OF MANCHESTER   (United Kingdom)

^e MANCHESTER UNIVERSITY NHS FOUNDATION TRUST   (United Kingdom)

Author keywords

FSHR; hyperstimulation; IVF; ovarian response; polymorphism

Indexed keywords

BUSERELIN ACETATE; FOLLITROPIN; GANIRELIX; HUMAN MENOPAUSAL GONADOTROPIN; MUELLERIAN INHIBITING FACTOR; RECOMBINANT FOLLITROPIN; FOLLITROPIN RECEPTOR;

ADULT; ALLELE; ARTICLE; BIRTH RATE; CONTROLLED OVARIAN HYPERSTIMULATION; FEMALE; FOLLITROPIN BLOOD LEVEL; FSHR GENE; GENE; GENE FREQUENCY; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENOTYPE; HUMAN; INFERTILITY THERAPY; INTRACYTOPLASMIC SPERM INJECTION; LIVE BIRTH; MAJOR CLINICAL STUDY; OOCYTE; OUTCOME ASSESSMENT; OVARIAN RESERVE; OVARY FOLLICLE CELL; OVARY HYPERSTIMULATION; PROMOTER REGION; TREATMENT RESPONSE; CHEMISTRY; GENETICS; HAPLOTYPE; ODDS RATIO; OVULATION INDUCTION; REGRESSION ANALYSIS;

ADULT; FEMALE; GENOTYPE; HAPLOTYPES; HUMANS; ODDS RATIO; OVARIAN RESERVE; OVULATION INDUCTION; POLYMORPHISM, GENETIC; PROMOTER REGIONS, GENETIC; RECEPTORS, FSH; REGRESSION ANALYSIS; REPRODUCTIVE TECHNIQUES, ASSISTED;

EID: 84979574347     PISSN: 14726483     EISSN: 14726491     Source Type: Journal    
DOI: 10.1016/j.rbmo.2016.06.001     Document Type: Article

References (18)

1. Achrekar, S.K., Modi, D.N., Desai, S.K., Mangoli, V.S., Mangoli, R.V., Mahale, S.D., Poor ovarian response to gonadotrophin stimulation is associated with FSH receptor polymorphism. Reprod. Biomed. Online 18 (2009), 509–515.
2. Altmae, S., Hovatta, O., Stavreus-Evers, A., Salumets, A., Genetic predictors of controlled ovarian hyperstimulation: where do we stand today?. Hum. Reprod. Update 17 (2011), 813–828.
3. Binder, H., Strick, R., Zaherdoust, O., Dittrich, R., Hamori, M., Beckmann, M.W., Oppelt, P.G., Assessment of FSHR variants and antimullerian hormone in infertility patients with a reduced ovarian response to gonadotropin stimulation. Fertil. Steril 97 (2012), 1169–1175.
4. Boudjenah, R., Molina-Gomes, D., Torre, A., Bergere, M., Bailly, M., Boitrelle, F., Taieb, S., Wainer, R., Benahmed, M., de Mazancourt, P., Selva, J., Vialard, F., Genetic polymorphisms influence the ovarian response to rFSH stimulation in patients undergoing in vitro fertilization programs with ICSI. PLoS ONE, 7, 2012, e38700.
5. Cerra, C., Oliver, J., Roberts, S.A., Horne, G., Newman, W.G., Mohiyiddeen, L., A single nucleotide polymorphism of bone morphogenic protein-15 is not associated with ovarian reserve or response to ovarian stimulation. Hum. Reprod 29 (2014), 2832–2837.
6. Desai, S.S., Achrekar, S.K., Pathak, B.R., Desai, S.K., Mangoli, V.S., Mangoli, R.V., Mahale, S.D., Follicle-stimulating hormone receptor polymorphism (G-29A) is associated with altered level of receptor expression in Granulosa cells. J. Clin. Endocrinol. Metab 96 (2011), 2805–2812.
7. Desai, S.S., Achrekar, S.K., Paranjape, S.R., Desai, S.K., Mangoli, V.S., Mahale, S.D., Association of allelic combinations of FSHR gene polymorphisms with ovarian response. Reprod. Biomed. Online 27 (2013), 400–406.
8. Ferraretti, A.P., La Marca, A., Fauser, B.C., Tarlatzis, B., Nargund, G., Gianaroli, L., ESHRE working group on Poor Ovarian Response. ESHRE consensus on the definition of “poor response” to ovarian stimulation for in vitro fertilization: the Bologna criteria. Hum. Reprod 26 (2011), 1616–1624.
9. Grady, R., Alavi, N., Vale, R., Khandwala, M., McDonald, S.D., Elective single embryo transfer and perinatal outcomes: a systematic review and meta-analysis. Fertil. Steril 97 (2012), 324–331.
10. Humaidan, P., Quartarolo, J., Papanikolaou, E.G., Preventing ovarian hyperstimulation syndrome: guidance for the clinician. Fertil. Steril 94 (2010), 389–400.
11. Ilgaz, N.S., Aydos, O.S., Karadag, A., Taspinar, M., Eryilmaz, O.G., Sunguroglu, A., Impact of follicle-stimulating hormone receptor variants in female infertility. J. Assist. Reprod. Genet 32 (2015), 1659–1668.
12. Lake, S., Lyon, H., Silverman, E., Weiss, S., Laird, N., Schaid, D., Estimation and tests of haplotype-environment interaction when linkage phase is ambiguous. Hum. Hered 55 (2002), 56–65.
13. Mohiyiddeen, L., Newman, W.G., McBurney, H., Mulugeta, B., Roberts, S.A., Nardo, L.G., Follicle-stimulating hormone receptor gene polymorphisms are not associated with ovarian reserve markers. Fertil. Steril 97 (2012), 677–681.
14. Mohiyiddeen, L., Newman, W.G., Cerra, C., McBurney, H., Mulugeta, B., Roberts, S.A., Nardo, L.G., A common Asn680Ser polymorphism in the follicle-stimulating hormone receptor gene is not associated with ovarian response to gonadotropin stimulation in patients undergoing in vitro fertilization. Fertil. Steril 99 (2013), 149–155.
15. Nakayama, T., Kuroi, N., Sano, M., Tabara, Y., Katsuya, T., Ogihara, T., Makita, Y., Hata, A., Yamada, M., Takahashi, N., Hirawa, N., Umemura, S., Miki, T., Soma, M., Mutation of the follicle-stimulating hormone receptor gene 5′-untranslated region associated with female hypertension. Hypertension 48 (2006), 512–518.
16. Simoni, M., Nieschlag, E., Gromoll, J., Isoforms and single nucleotide polymorphisms of the FSH receptor gene: implications for human reproduction. Hum. Reprod. Update 8 (2002), 413–421.
17. Trevisan, C.M., Peluso, C., Cordts, E.B., de Oliveira, R., Christofolini, D.M., Barbosa, C.P., Bianco, B., Ala307Thr and Asn680Ser Polymorphisms of FSHR Gene in Human Reproduction Outcomes. Cell. Physiol. Biochem 34 (2014), 1527–1535.
18. Wunsch, A., Ahda, Y., Banaz-Yasar, F., Sonntag, B., Nieschlag, E., Simoni, M., Gromoll, J., Single-nucleotide polymorphisms in the promoter region influence the expression of the human follicle-stimulating hormone receptor. Fertil. Steril 84 (2005), 446–453.