Chorioallantoic membrane microtumor model to study the mechanisms of tumor angiogenesis, vascular permeability, and tumor cell intravasation

Methods in Molecular Biology

Volumn 1430, Issue , 2016, Pages 283-298

  Deryugina, Elena I ^a  

^a NONE

Author keywords

Animal models of cancer dissemination; Cancer metastasis; Chick embryo; Chorioallantoic membrane; Epidermal growth factor receptor; Matrix metalloproteinase 1; Tumor angiogenesis; Tumor cell intravasation; Tumor invasion; Vascular permeability

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR; INTERSTITIAL COLLAGENASE; SMALL INTERFERING RNA;

ANGIOGENESIS; ANIMAL CELL; ANIMAL EXPERIMENT; BLOOD VESSEL PERMEABILITY; CANCER CELL; CANCER GROWTH; CHICK EMBRYO; CHORIOALLANTOIS; CONTROLLED STUDY; DOWN REGULATION; EMBRYO CULTURE; EPIFLUORESCENCE MICROSCOPY; HUMAN; HUMAN CELL; NONHUMAN; SQUAMOUS CELL CARCINOMA; TUMOR CELL; TUMOR CELL INTRAVASATION; TUMOR GROWTH; TUMOR INVASION; UMBILICAL VEIN; ANIMAL; CANCER TRANSPLANTATION; CAPILLARY PERMEABILITY; METABOLISM; NEOVASCULARIZATION (PATHOLOGY); PATHOLOGY; TUMOR CELL LINE; VASCULARIZATION;

ANIMALS; CAPILLARY PERMEABILITY; CELL LINE, TUMOR; CHICK EMBRYO; CHORIOALLANTOIC MEMBRANE; HUMANS; MATRIX METALLOPROTEINASE 1; NEOPLASM INVASIVENESS; NEOPLASM TRANSPLANTATION; NEOVASCULARIZATION, PATHOLOGIC; RECEPTOR, EPIDERMAL GROWTH FACTOR;

EID: 84979226384     PISSN: 10643745     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-1-4939-3628-1_19     Document Type: Chapter

References (14)

1. Valastyan S, Weinberg RA (2011) Tumor metastasis: molecular insights and evolving paradigms. Cell 147:275-292
2. Mina LA, Sledge GW Jr (2011) Rethinking the metastatic cascade as a therapeutic target. Nat Rev Clin Oncol 8:325-332
3. Francia G, Cruz-Munoz W, Man S, Xu P, Kerbel RS (2011) Mouse models of advanced spontaneous metastasis for experimental therapeutics. Nat Rev Cancer 11:135-141
4. Deryugina EI, Quigley JP (2008) Chick embryo chorioallantoic membrane model systems to study and visualize human tumor cell metastasis. Histochem Cell Biol 130:1119-1130
5. Romanoff AL (1960) The avian embryo. The Macmillan Co, New York
6. Weis SM, Cheresh DA (2011) Tumor angiogenesis: molecular pathways and therapeutic targets. Nat Med 17:1359-1370
7. Raza A, Franklin MJ, Dudek AZ (2010) Pericytes and vessel maturation during tumor angiogenesis and metastasis. Am J Hematol 85:593-598
8. Dudley AC (2012) Tumor endothelial cells. Cold Spring Harb Perspect Med 2:a006536
9. Chantrain CF, Henriet P, Jodele S et al (2006) Mechanisms of pericyte recruitment in tumour angiogenesis: a new role for metalloproteinases. Eur J Cancer 42:310-318
10. Carmeliet P, Jain RK (2011) Principles and mechanisms of vessel normalization for cancer and other angiogenic diseases. Nat Rev Drug Discov 10:417-427
11. Ebos JM, Lee CR, Cruz-Munoz W et al (2009) Accelerated metastasis after short-term treatment with a potent inhibitor of tumor angiogenesis. Cancer Cell 15:232-239
12. Conn EM, Botkjaer KA, Kupriyanova TA et al (2009) Comparative analysis of metastasis variants derived from human prostate carcinoma cells: roles in intravasation of VEGF-mediated angiogenesis and uPA-mediated invasion. Am J Pathol 175:1638-1652
13. Bekes EM, Schweighofer B, Kupriyanova TA et al (2011) Tumor-recruited neutrophils and neutrophil TIMP-free MMP-9 regulate coordinately the levels of tumor angiogenesis and efficiency of malignant cell intravasation. Am J Pathol 179:1455-1470
14. Juncker-Jensen A, Deryugina EI, Rimann I et al (2013) Tumor MMP-1 activates endothelial PAR1 to facilitate vascular intravasation and metastatic dissemination. Cancer Res 73:4196-4211