Periodontal and peri-implant diseases: identical or fraternal infections?

Molecular Oral Microbiology

Volumn 31, Issue 4, 2016, Pages 285-301

  Robitaille, N ^a   Reed, D N ^b   Walters, J D ^a   Kumar, P S ^a  

^a OHIO STATE UNIVERSITY   (United States)

^b Division of General Practice and Material Sciences   (United States)

Author keywords

16S; bacteria; dental implant; peri implantitis; peri mucositis; periodontitis

Indexed keywords

BACTERIAL COLONIZATION; HISTOPATHOLOGY; HUMAN; MICROBIAL ACTIVITY; MICROBIOME; MICROENVIRONMENT; MOUTH FLORA; NONHUMAN; PERIIMPLANT MUCOSITIS; PERIIMPLANTITIS; PERIODONTAL DISEASE; PERIODONTITIS; REVIEW; RISK FACTOR;

EID: 84979021668     PISSN: 20411006     EISSN: 20411014     Source Type: Journal    
DOI: 10.1111/omi.12124     Document Type: Review

References (108)

1. Aas, J.A., Paster, B.J., Stokes, L.N., Olsen, I. and Dewhirst, F.E. (2005) Defining the normal bacterial flora of the oral cavity. J Clin Microbiol 43: 5721–5732.
2. Achermann, G. and Day, C.C.M. (2012) How Will Dentistry Look in 2020? Amsterdam: Straumann.
3. Almaguer-Flores, A., Olivares-Navarrete, R., Wieland, M., Ximenez-Fyvie, L.A., Schwartz, Z. and Boyan, B.D. (2012) Influence of topography and hydrophilicity on initial oral biofilm formation on microstructured titanium surfaces invitro. Clin Oral Implants Res 23: 301–307.
4. Al-Radha, A.S., Dymock, D., Younes, C. and O’Sullivan, D. (2012) Surface properties of titanium and zirconia dental implant materials and their effect on bacterial adhesion. J Dent 40: 146–153.
5. Amoroso, P.F., Adams, R.J., Waters, M.G. and Williams, D.W. (2006) Titanium surface modification and its effect on the adherence of Porphyromonas gingivalis: an invitro study. Clin Oral Implants Res 17: 633–637.
6. Apse, P., Ellen, R.P., Overall, C.M. and Zarb, G.A. (1989) Microbiota and crevicular fluid collagenase activity in the osseointegrated dental implant sulcus: a comparison of sites in edentulous and partially edentulous patients. J Periodontal Res 24: 96–105.
7. Badihi Hauslich, L., Sela, M.N., Steinberg, D., Rosen, G. and Kohavi, D. (2013) The adhesion of oral bacteria to modified titanium surfaces: role of plasma proteins and electrostatic forces. Clin Oral Implants Res 24(Suppl A100): 49–56.
8. Bassetti, M., Schar, D., Wicki, B. etal. (2014) Anti-infective therapy of peri-implantitis with adjunctive local drug delivery or photodynamic therapy: 12-month outcomes of a randomized controlled clinical trial. Clin Oral Implants Res 25: 279–287.
9. Becker, W., Becker, B.E., Newman, M.G. and Nyman, S. (1990) Clinical and microbiologic findings that may contribute to dental implant failure. Int J Oral Maxillofac Implants 5: 31–38.
10. Becker, S.T., Beck-Broichsitter, B.E., Graetz, C., Dorfer, C.E., Wiltfang, J. and Hasler, R. (2014) Peri-implantitis versus periodontitis: functional differences indicated by transcriptome profiling. Clin Implant Dent Relat Res 16: 401–411.
11. Berglundh, T., Lindhe, J., Ericsson, I., Marinello, C.P., Liljenberg, B. and Thomsen, P. (1991) The soft tissue barrier at implants and teeth. Clin Oral Implants Res 2: 81–90.
12. Berglundh, T., Zitzmann, N.U. and Donati, M. (2011) Are peri-implantitis lesions different from periodontitis lesions? J Clin Periodontol 38(Suppl 11): 188–202.
13. Bollen, C.M., Papaioanno, W., Van Eldere, J., Schepers, E., Quirynen, M. and van Steenberghe, D. (1996) The influence of abutment surface roughness on plaque accumulation and peri-implant mucositis. Clin Oral Implants Res 7: 201–211.
14. Branemark, P.I. (1983) Osseointegration and its experimental background. J Prosthet Dent 50: 399–410.
15. Bremer, F., Grade, S., Kohorst, P. and Stiesch, M. (2011) In vivo biofilm formation on different dental ceramics. Quintessence Int 42: 565–574.
16. Burgers, R., Hahnel, S., Reichert, T.E. etal. (2010) Adhesion of Candida albicans to various dental implant surfaces and the influence of salivary pellicle proteins. Acta Biomater 6: 2307–2313.
17. Busenlechner, D., Furhauser, R., Haas, R., Watzek, G., Mailath, G. and Pommer, B. (2014) Long-term implant success at the Academy for Oral Implantology: 8-year follow-up and risk factor analysis. J Periodontal Implant Sci 44: 102–108.
18. Busscher, H.J., de Jong, H.P., van Pelt, A.W. and Arends, J. (1984) The surface free energy of human dental enamel. Biomater Med Devices Artif Organs 12: 37–49.
19. Callan, D.P., Cobb, C.M. and Williams, K.B. (2005) DNA probe identification of bacteria colonizing internal surfaces of the implant-abutment interface: a preliminary study. J Periodontol 76: 115–120.
20. Carcuac, O. and Berglundh, T. (2014) Composition of human peri-implantitis and periodontitis lesions. J Dent Res 93: 1083–1088.
21. Charalampakis, G. and Belibasakis, G.N. (2015) Microbiome of peri-implant infections: lessons from conventional, molecular and metagenomic analyses. Virulence 6: 183–187.
22. Costa, F.O., Takenaka-Martinez, S., Cota, L.O., Ferreira, S.D., Silva, G.L. and Costa, J.E. (2012) Peri-implant disease in subjects with and without preventive maintenance: a 5-year follow-up. J Clin Periodontol 39: 173–181.
23. Dabdoub, S.M., Tsigarida, A.A. and Kumar, P.S. (2013) Patient-specific analysis of periodontal and peri-implant microbiomes. J Dent Res 92: 168S–175S.
24. Danser, M.M., van Winkelhoff, A.J., de Graaff, J., Loos, B.G. and van der Velden, U. (1994) Short-term effect of full-mouth extraction on periodontal pathogens colonizing the oral mucous membranes. J Clin Periodontol 21: 484–489.
25. Danser, M.M., van Winkelhoff, A.J. and van der Velden, U. (1997) Periodontal bacteria colonizing oral mucous membranes in edentulous patients wearing dental implants. J Periodontol 68: 209–216.
26. De Boever, A.L. and De Boever, J.A. (2006) Early colonization of non-submerged dental implants in patients with a history of advanced aggressive periodontitis. Clin Oral Implants Res 17: 8–17.
27. Derks, J., Hakansson, J., Wennstrom, J.L., Klinge, B. and Berglundh, T. (2014) Patient-reported outcomes of dental implant therapy in a large randomly selected sample. Clin Oral Implants Res. 26(5): 586–591, May 2015, Epub:2014.
28. Dhert, W.J., Klein, C.P., Wolke, J.G., van der Velde, E.A., de Groot, K. and Rozing, P.M. (1991) A mechanical investigation of fluorapatite, magnesiumwhitlockite, and hydroxylapatite plasma-sprayed coatings in goats. J Biomed Mater Res 25: 1183–1200.
29. Dierens, M., Vandeweghe, S., Kisch, J., Persson, G.R., Cosyn, J. and De Bruyn, H. (2013) Long-term follow-up of turned single implants placed in periodontally healthy patients after 16 to 22 years: microbiological outcome. J Periodontol. 84(7): 880–894. doi: 10.1902/jop.2012.120187. Epub 2012 Aug 30.
30. Emecen-Huja, P., Eubank, T.D., Shapiro, V., Yildiz, V., Tatakis, D.N. and Leblebicioglu, B. (2013) Peri-implant versus periodontal wound healing. J Clin Periodontol 40: 816–824.
31. Ericsson, I., Berglundh, T., Marinello, C., Liljenberg, B. and Lindhe, J. (1992) Long-standing plaque and gingivitis at implants and teeth in the dog. Clin Oral Implants Res 3: 99–103.
32. Esposito, M., Grusovin, M.G. and Worthington, H.V. (2012a) Interventions for replacing missing teeth: treatment of peri-implantitis. Cochrane Database Syst Rev 1: CD004970.
33. Esposito, M., Grusovin, M.G. and Worthington, H.V. (2012b) Treatment of peri-implantitis: what interventions are effective? A Cochrane systematic review. Eur J Oral Implantol 5(Suppl): S21–S41.
34. Evian, C.I., Emling, R., Rosenberg, E.S. etal. (2004) Retrospective analysis of implant survival and the influence of periodontal disease and immediate placement on long-term results. Int J Oral Maxillofac Implants 19: 393–398.
35. 2+ modification of titanium surfaces on early microbial biofilm formation. BMC Oral Health 11: 8.
36. Grossner-Schreiber, B., Griepentrog, M., Haustein, I. etal. (2001) Plaque formation on surface modified dental implants. An invitro study. Clin Oral Implants Res 12: 543–551.
37. Grossner-Schreiber, B., Teichmann, J., Hannig, M., Dorfer, C., Wenderoth, D.F. and Ott, S.J. (2009) Modified implant surfaces show different biofilm compositions under invivo conditions. Clin Oral Implants Res 20: 817–826.
38. Hanisch, O., Cortella, C.A., Boskovic, M.M., James, R.A., Slots, J. and Wikesjo, U.M. (1997) Experimental peri-implant tissue breakdown around hydroxyapatite-coated implants. J Periodontol 68: 59–66.
39. Heitz-Mayfield, L.J., Salvi, G.E., Mombelli, A., Faddy, M., Lang, N.P. and Implant Complication Research, G. (2012) Anti-infective surgical therapy of peri-implantitis. A 12-month prospective clinical study. Clin Oral Implants Res 23: 205–210.
40. Heuer, W., Kettenring, A., Stumpp, S.N. etal. (2012) Metagenomic analysis of the peri-implant and periodontal microflora in patients with clinical signs of gingivitis or mucositis. Clin Oral Investig 16: 843–850.
41. Hultin, M., Gustafsson, A., Hallstrom, H., Johansson, L.A., Ekfeldt, A. and Klinge, B. (2002) Microbiological findings and host response in patients with peri-implantitis. Clin Oral Implants Res 13: 349–358.
42. Judgar, R., Giro, G., Zenobio, E. etal. (2014) Biological width around one- and two-piece implants retrieved from human jaws. Biomed Res Int 2014: 850120.
43. Karoussis, I.K., Salvi, G.E., Heitz-Mayfield, L.J., Bragger, U., Hammerle, C.H. and Lang, N.P. (2003) Long-term implant prognosis in patients with and without a history of chronic periodontitis: a 10-year prospective cohort study of the ITI Dental Implant System. Clin Oral Implants Res 14: 329–339.
44. Kim, M.L., Jeong, C.M., Jeon, Y.C., Byon, E., Jeong, Y. and Cho, L.R. (2012) The effects of Mg-ion implantation and sandblasting on Porphyromonas gingivalis attachment. Clin Oral Implants Res 23: 245–252.
45. Klinge, B., Meyle, J. and Working, G. (2012) Peri-implant tissue destruction. The Third EAO Consensus Conference 2012. Clin Oral Implants Res 23(Suppl 6): 108–110.
46. Klokkevold, P.R. and Han, T.J. (2007) How do smoking, diabetes, and periodontitis affect outcomes of implant treatment? Int J Oral Maxillofac Implants 22(Suppl): 173–202.
47. Koyanagi, T., Sakamoto, M., Takeuchi, Y., Maruyama, N., Ohkuma, M. and Izumi, Y. (2013) Comprehensive microbiological findings in peri-implantitis and periodontitis. J Clin Periodontol 40: 218–226.
48. Kumar, P.S., Mason, M.R., Brooker, M.R. and O’Brien, K. (2012) Pyrosequencing reveals unique microbial signatures associated with healthy and failing dental implants. J Clin Periodontol 39: 425–433.
49. Lang, N.P., Berglundh, T. and Working Group 4 of Seventh European Workshop on Periodontology (2011) Periimplant diseases: where are we now?–Consensus of the Seventh European Workshop on Periodontology. J Clin Periodontol 38(Suppl 11): 178–181.
50. Lang, N.P., Bragger, U., Walther, D., Beamer, B. and Kornman, K.S. (1993) Ligature-induced peri-implant infection in cynomolgus monkeys. I. Clinical and radiographic findings. Clin Oral Implants Res 4: 2–11.
51. Lee, K.H., Maiden, M.F., Tanner, A.C. and Weber, H.P. (1999) Microbiota of successful osseointegrated dental implants. J Periodontol 70: 131–138.
52. Leknes, K.N., Lie, T., Wikesjo, U.M., Bogle, G.C. and Selvig, K.A. (1994) Influence of tooth instrumentation roughness on subgingival microbial colonization. J Periodontol 65: 303–308.
53. Leonhardt, A., Renvert, S. and Dahlen, G. (1999) Microbial findings at failing implants. Clin Oral Implants Res 10: 339–345.
54. Lindhe, J. and Meyle, J. (2008) Peri-implant diseases: Consensus Report of the Sixth European Workshop on Periodontology. J Clin Periodontol 35: 282–285.
55. Lindhe, J., Berglundh, T., Ericsson, I., Liljenberg, B. and Marinello, C. (1992) Experimental breakdown of peri-implant and periodontal tissues. A study in the beagle dog. Clin Oral Implants Res 3: 9–16.
56. Malmstrom, HS1., Fritz, ME., Timmis, DP. and Van Dyke, TE. (1990) Osseo-integrated implant treatment of a patient with rapidly progressive periodontitis. A case report. J Periodontol 61(5): 300–304.
57. Maruyama, N., Maruyama, F., Takeuchi, Y., Aikawa, C., Izumi, Y. and Nakagawa, I. (2014) Intraindividual variation in core microbiota in peri-implantitis and periodontitis. Sci Rep 13(4): 6602. doi: 10.1038/srep06602.
58. Meyer, K. and Lie, T. (1977) Root surface roughness in response to periodontal instrumentation studied by combined use of microroughness measurements and scanning electron microscopy. J Clin Periodontol 4: 77–91.
59. Mombelli, A. and Lang, N.P. (1992) Antimicrobial treatment of peri-implant infections. Clin Oral Implants Res 3: 162–168.
60. Mombelli, A. and Lang, N.P. (1994) Microbial aspects of implant dentistry. Periodontol 2000 4: 74–80.
61. Mombelli, A. and Mericske-Stern, R. (1990) Microbiological features of stable osseointegrated implants used as abutments for overdentures. Clin Oral Implants Res 1: 1–7.
62. Mombelli, A., van Oosten, M.A., Schurch, E. Jr and Land, N.P. (1987) The microbiota associated with successful or failing osseointegrated titanium implants. Oral Microbiol Immunol 2: 145–151.
63. Mombelli, A., Buser, D. and Lang, N.P. (1988) Colonization of osseointegrated titanium implants in edentulous patients. Early results. Oral Microbiol Immunol 3: 113–120.
64. Mombelli, A., Muhle, T., Bragger, U., Lang, N.P. and Burgin, W.B. (1997) Comparison of periodontal and peri-implant probing by depth-force pattern analysis. Clin Oral Implants Res 8: 448–454.
65. Mombelli, A., Feloutzis, A., Bragger, U. and Lang, N.P. (2001) Treatment of peri-implantitis by local delivery of tetracycline. Clinical, microbiological and radiological results. Clin Oral Implants Res 12: 287–294.
66. Mombelli, A., Muller, N. and Cionca, N. (2012) The epidemiology of peri-implantitis. Clin Oral Implants Res 23(Suppl 6): 67–76.
67. Nakou, M., Mikx, F.H., Oosterwaal, P.J. and Kruijsen, J.C. (1987) Early microbial colonization of permucosal implants in edentulous patients. J Dent Res 66: 1654–1657.
68. Nevins, M. and Langer, B. (1995) The successful use of osseointegrated implants for the treatment of the recalcitrant periodontal patient. J Periodontol 66: 150–157.
69. NIDCR (2014) Tooth Loss Among Adults 20–64. Bethesda, MD: NIDCR.
70. Papaioannou, W., Quirynen, M., Nys, M. and van Steenberghe, D. (1995) The effect of periodontal parameters on the subgingival microbiota around implants. Clin Oral Implants Res 6: 197–204.
71. Perera-Costa, D., Bruque, J.M., González-Martín, M.L., Gómez-García, A.C. and Vadillo-Rodríguez, V. (2014) Studying the influence of surface topography on bacterial adhesion using spatially organized microtopographic surface patterns. Langmuir 30: 4633–4641.
72. Persson, L.G., Lekholm, U., Leonhardt, A., Dahlen, G. and Lindhe, J. (1996) Bacterial colonization on internal surfaces of Branemark system implant components. Clin Oral Implants Res 7: 90–95.
73. Ponsonnet, L., Reybier, K., Jaffrezic, N. etal. (2003) Relationship between surface properties (roughness, wettability) of titanium and titanium alloys and cell behaviour. Mater Sci Eng C 23: 551–560.
74. Quirynen, M. (1994) The clinical meaning of the surface roughness and the surface free energy of intra-oral hard substrata on the microbiology of the supra- and subgingival plaque: results of invitro and invivo experiments. J Dent 22(Suppl 1): S13–S16.
75. Quirynen, M. and Van Assche, N. (2012) RCT comparing minimally with moderately rough implants. Part 2: microbial observations. Clin Oral Implants Res 23: 625–634.
76. Quirynen, M., van der Mei, H.C., Bollen, C.M. etal. (1993) An invivo study of the influence of the surface roughness of implants on the microbiology of supra- and subgingival plaque. J Dent Res 72: 1304–1309.
77. Quirynen, M., Vogels, R., Peeters, W., van Steenberghe, D., Naert, I. and Haffajee, A. (2006) Dynamics of initial subgingival colonization of ‘pristine’ peri-implant pockets. Clin Oral Implants Res 17: 25–37.
78. Quirynen, M., Abarca, M., Van Assche, N., Nevins, M. and Van Steenberghe, D. (2007) Impact of supportive periodontal therapy and implant surface roughness on implant outcome in patients with a history of periodontitis. J Clin Periodontol 34: 805–815.
79. Rams, T.E. and Link, C.C. Jr (1983) Microbiology of failing dental implants in humans: electron microscopic observations. J Oral Implantol 11: 93–100.
80. Rams, T.E., Roberts, T.W., Tatum, H. Jr and Keyes, P.H. (1984) The subgingival microbial flora associated with human dental implants. J Prosthet Dent 51: 529–534.
81. Ribeiro, F.V., Casarin, R.C., Nociti Junior, F.H., Sallum, E.A., Sallum, A.W. and Casati, M.Z. (2006) Comparative invitro study of root roughness after instrumentation with ultrasonic and diamond tip sonic scaler. J Appl Oral Sci 14: 124–129.
82. Rimondini, L., Cerroni, L., Carrassi, A. and Torricelli, P. (2002) Bacterial colonization of zirconia ceramic surfaces: an invitro and invivo study. Int J Oral Maxillofac Implants 17: 793–798.
83. Roos-Jansaker, A.M., Lindahl, C., Renvert, H. and Renvert, S. (2006a) Nine- to fourteen-year follow-up of implant treatment. Part II: presence of peri-implant lesions. J Clin Periodontol 33: 290–295.
84. Roos-Jansaker, A.M., Renvert, H., Lindahl, C. and Renvert, S. (2006b) Nine- to fourteen-year follow-up of implant treatment. Part III: factors associated with peri-implant lesions. J Clin Periodontol 33: 296–301.
85. Rosenberg, E.S., Torosian, J.P. and Slots, J. (1991) Microbial differences in 2 clinically distinct types of failures of osseointegrated implants. Clin Oral Implant Res 2: 135–144.
86. Rosenberg, E.S., Cho, S.C., Elian, N., Jalbout, Z.N., Froum, S. and Evian, C.I. (2004) A comparison of characteristics of implant failure and survival in periodontally compromised and periodontally healthy patients: a clinical report. Int J Oral Maxillofac Implants 19: 873–879.
87. Salvi, G.E., Furst, M.M., Lang, N.P. and Persson, G.R. (2008) One-year bacterial colonization patterns of Staphylococcus aureus and other bacteria at implants and adjacent teeth. Clin Oral Implants Res 19: 242–248.
88. Salvi, G.E., Aglietta, M., Eick, S., Sculean, A., Lang, N.P. and Ramseier, C.A. (2012) Reversibility of experimental peri-implant mucositis compared with experimental gingivitis in humans. Clin Oral Implants Res 23: 182–190.
89. Sanz, M., Newman, M.G., Nachnani, S., Holt, R., Stewart, R. and Flemmig, T. (1990) Characterization of the subgingival microbial flora around endosteal sapphire dental implants in partially edentulous patients. Int J Oral Maxillofac Implants 5: 247–253.
90. Sardin, S., Morrier, J.J., Benay, G. and Barsotti, O. (2004) In vitro streptococcal adherence on prosthetic and implant materials. Interactions with physicochemical surface properties. J Oral Rehabil 31: 140–148.
91. Sbordone, L., Barone, A., Ciaglia, R.N., Ramaglia, L. and Iacono, V.J. (1999) Longitudinal study of dental implants in a periodontally compromised population. J Periodontol 70: 1322–1329.
92. Scarano, A., Piattelli, M., Caputi, S., Favero, G.A. and Piattelli, A. (2004) Bacterial adhesion on commercially pure titanium and zirconium oxide disks: an invivo human study. J Periodontol 75: 292–296.
93. Schou, S. (2008) Implant treatment in periodontitis-susceptible patients: a systematic review. J Oral Rehabil 35: 9–22.
94. Schwarz, F., John, G., Mainusch, S., Sahm, N. and Becker, J. (2012) Combined surgical therapy of peri-implantitis evaluating two methods of surface debridement and decontamination. A two-year clinical follow up report. J Clin Periodontol 39: 789–797.
95. Sculean, A., Gruber, R. and Bosshardt, D.D. (2014) Soft tissue wound healing around teeth and dental implants. J Clin Periodontol 41(Suppl 15): S6–S22.
96. Socransky, S.S. and Manganiello, S.D. (1971) The oral microbiota of man from birth to senility. J Periodontol 42: 485–496.
97. Socransky, S.S., Haffajee, A.D., Cugini, M.A., Smith, C. and Kent, R.L. Jr (1998) Microbial complexes in subgingival plaque. J Clin Periodontol 25: 134–144.
98. Sreenivasan, P.K., DeVizio, W., Prasad, K.V. etal. (2010) Regional differences within the dentition for plaque, gingivitis, and anaerobic bacteria. J Clin Dent 21: 13–19.
99. Sumida, S., Ishihara, K., Kishi, M. and Okuda, K. (2002) Transmission of periodontal disease-associated bacteria from teeth to osseointegrated implant regions. Int J Oral Maxillofac Implants 17: 696–702.
100. Swelem, A.A., Gurevich, K.G., Fabrikant, E.G., Hassan, M.H. and Aqou, S. (2014) Oral health-related quality of life in partially edentulous patients treated with removable, fixed, fixed-removable, and implant-supported prostheses. Int J Prosthodont 27: 338–347.
101. Tamura, N., Ochi, M., Miyakawa, H. and Nakazawa, F. (2013) Analysis of bacterial flora associated with peri-implantitis using obligate anaerobic culture technique and 16S rDNA gene sequence. Int J Oral Maxillofac Implants 28: 1521–1529.
102. Thoma, D.S., Muhlemann, S. and Jung, R.E. (2014) Critical soft-tissue dimensions with dental implants and treatment concepts. Periodontol 2000 66: 106–118.
103. Weerkamp, A.H., Uyen, H.M. and Busscher, H.J. (1988) Effect of zeta potential and surface energy on bacterial adhesion to uncoated and saliva-coated human enamel and dentin. J Dent Res 67: 1483–1487.
104. van Winkelhoff, A.J., Goene, R.J., Benschop, C. and Folmer, T. (2000) Early colonization of dental implants by putative periodontal pathogens in partially edentulous patients. Clin Oral Implants Res 11: 511–520.
105. de Wit, R. and Bouvier, T. (2006) ‘Everything is everywhere, but, the environment selects’; what did Baas Becking and Beijerinck really say? Environ Microbiol 8: 755–758.
106. Wu, B., Liang, J., Plassman, B.L., Remle, C. and Luo, X. (2012) Edentulism trends among middle-aged and older adults in the United States: comparison of five racial/ethnic groups. Community Dent Oral Epidemiol 40: 145–153.
107. Zhuang, L.F., Watt, R.M., Mattheos, N., Si, M.S., Lai, H.C. and Lang, N.P. (2014) Periodontal and peri-implant microbiota in patients with healthy and inflamed periodontal and peri-implant tissues. Clin Oral Implants Res. Nov 14. doi: 10.1111/clr.12508. [Epub ahead of print].
108. Zitzmann, N.U. and Berglundh, T. (2008) Definition and prevalence of peri-implant diseases. J Clin Periodontol 35: 286–291.