Efficacy and tolerability of antidepressants in people aged 65 years or older with major depressive disorder – A systematic review and a meta-analysis

Journal of Affective Disorders

Volumn 205, Issue , 2016, Pages 1-12

  Tham, Anne ^a   Jonsson, Ulf ^a,b   Andersson, Gerhard ^a,c   Söderlund, Anne ^d   Allard, Per ^e   Bertilsson, Göran ^e  

^a KAROLINSKA INSTITUTE   (Sweden)

^b UPPSALA UNIVERSITY   (Sweden)

^c LINKÖPING UNIVERSITY   (Sweden)

^d MÄLARDALEN UNIVERSITY   (Sweden)

^e Swedish Agency for Health Technology Assessment and Social Assessment   (Sweden)

Author keywords

Antidepressants; Elderly; MDD; Meta analysis; Systematic review

Indexed keywords

AGOMELATINE; AMFEBUTAMONE; ANTIDEPRESSANT AGENT; DULOXETINE; PLACEBO; SEROTONIN UPTAKE INHIBITOR; VENLAFAXINE; VORTIOXETINE;

AGED; CLINICAL EFFECTIVENESS; CONTROLLED CLINICAL TRIAL (TOPIC); DRUG TOLERABILITY; HUMAN; MAINTENANCE THERAPY; MAJOR DEPRESSION; META ANALYSIS; OUTCOME ASSESSMENT; PRIORITY JOURNAL; PSYCHOPHARMACOTHERAPY; RANDOMIZED CONTROLLED TRIAL (TOPIC); REMISSION; REVIEW; RISK ASSESSMENT; SYSTEMATIC REVIEW; TREATMENT RESPONSE; ODDS RATIO; TREATMENT OUTCOME;

AGED; ANTIDEPRESSIVE AGENTS; DEPRESSIVE DISORDER, MAJOR; DULOXETINE HYDROCHLORIDE; HUMANS; ODDS RATIO; SEROTONIN UPTAKE INHIBITORS; TREATMENT OUTCOME;

EID: 84979018733     PISSN: 01650327     EISSN: 15732517     Source Type: Journal    
DOI: 10.1016/j.jad.2016.06.013     Document Type: Review

References (55)

1. A.P.A, Diagnostic and Statistical Manual of Mental Disorders (DSM-IV), 4th ed., 1994, American Psychiatric Association, Washington D.C.
2. Balshem, H., Helfand, M., Schünemann, H.J., Oxman, A.D., Kunz, R., Brozek, J., Vist, G.E., Falck-Ytter, Y., Meerpohl, J., Norris, S., Guyatt, G.H., GRADE guidelines: 3. Rating the quality of evidence. J. Clin. Epidemiol. 64 (2011), 401–406.
3. Brody, B.L., Field, L.C., Roch-Levecq, A.C., Moutier, C.Y., Edland, S.D., Brown, S.I., Treatment of depression associated with age-related macular degeneration: a double-blind, randomized, controlled study. Ann. Clin. Psychiatry 23 (2011), 277–284.
4. Burrows, A.B., Salzman, C., Satlin, A., Noble, K., Pollock, B.G., Gersh, T., A randomized, placebo-controlled trial of paroxetine in nursing home residents with non-major depression. Depress. Anxiety 15 (2002), 102–110.
5. Castro-Costa, E., Dewey, M., Stewart, R., Banerjee, S., Huppert, F., Mendonca-Lima, C., Bula, C., Reisches, F., Wancata, J., Ritchie, K., Tsolaki, M., Mateos, R., Prince, M., Prevalence of depressive symptoms and syndromes in later life in ten European countries: the SHARE study. Br. J. Psychiatry 191 (2007), 393–401.
6. Chapman, D.P., Perry, G.S., Depression as a major component of public health for older adults. Prev. Chron. Dis., 5, 2008, A22.
7. Copeland, J.R.M., Beekman, A.T.F., Dewey, M.E., Hooijer, C., Jordan, A., Lawlor, B.A., Lobo, A., Magnusson, H., Mann, A.H., Meller, I., Prince, M.J., Reischies, F., Turrina, C., Devries, M.W., Wilson, K.C.M., Depression in Europe. Geographical distribution among older people. Br. J. Psychiatry 174 (1999), 312–321.
8. Coupland, C., Dhiman, P., Morriss, R., Arthur, A., Barton, G., Hippisley-Cox, J., Antidepressant use and risk of adverse outcomes in older people: population based cohort study. BMJ, 343, 2011.
9. Culang, M.E., Sneed, J.R., Keilp, J.G., Rutherford, B.R., Pelton, G.H., Devanand, D.P., Roose, S.P., Change in cognitive functioning following acute antidepressant treatment in late-life depression. Am. J. Geriatr. Psychiatry 17 (2009), 881–888.
10. Etkin, A., Patenaude, B., Song, Y.J.C., Usherwood, T., Rekshan, W., Schatzberg, A.F., Rush, A.J., Williams, L.M., A cognitive–emotional biomarker for predicting remission with antidepressant medications: a report from the iSPOT-D trial. Neuropsychopharmacology, 2014.
11. Evans, M., Hammond, M., Wilson, K., Lye, M., Copeland, J., Placebo-controlled treatment trial of depression in elderly physically ill patients. Int. J. Geriatr. Psychiatry 12 (1997), 817–824.
12. Evans, M., Hammond, M., Wilson, K., Lye, M., Copeland, J., Treatment of depression in the elderly: effect of physical illness on response. Int. J. Geriatr. Psychiatry 12 (1997), 1189–1194.
13. Folstein, M.F., Folstein, S.E., McHugh, P.R., 'Mini mental state’. A practical method for grading the cognitive state of patients for the clinician. J. Psychiatr. Res. 12 (1975), 189–198.
14. Gallo, J.J., Bogner, H.R., Morales, K.H., Post, E.P., Ten Have, T., Bruce, M.L., Depression, cardiovascular disease, diabetes, and two-year mortality among older, primary-care patients. Am. J. Geriatr. Psychiatry 13 (2005), 748–755.
15. Gebara, M.A., Lipsey, K.L., Karp, J.F., Nash, M.C., Iaboni, A., Lenze, E.J., Cause or effect? selective serotonin reuptake inhibitors and falls in older adults: a systematic review. Am. J. Geriatr. Psychiatry 23 (2015), 1016–1028.
16. Gorwood, P., Weiller, E., Lemming, O., Katona, C., Escitalopram prevents relapse in older patients with major depressive disorder. Am. J. Geriatr. Psychiatry 15 (2007), 581–593.
17. Gurland, B., The impact of depression on quality of life of the elderly. Clin. Geriatr. Med. 8 (1992), 377–386.
18. Hamilton, M., Rating depressive patients. J. Clin. Psychiatry 41 (1980), 21–24.
19. Heres, S., Davis, J., Maino, K., Jetzinger, E., Kissling, W., Leucht, S., Why olanzapine beats risperidone, risperidone beats quetiapine, and quetiapine beats olanzapine: An exploratory analysis of head-to-head comparison studies of second-generation antipsychotics. Am. J. Psychiatry 163 (2006), 185–194.
20. Heun, R., Ahokas, A., Boyer, P., Gimenez-Montesinos, N., Pontes-Soares, F., Olivier, V., The efficacy of agomelatine in elderly patients with recurrent major depressive disorder: a placebo-controlled study. J. Clin. Psychiatry 74 (2013), 587–594.
21. Hewett, K., Chrzanowski, W., Jokinen, R., Felgentreff, R., Shrivastava, R.K., Gee, M.D., Wightman, D.S., O'Leary, M.C., Millen, L.S., Leon, M.C., Briggs, M.A., Krishen, A., Modell, J.G., Double-blind, placebo-controlled evaluation of extended-release bupropion in elderly patients with major depressive disorder. J. Psychopharmacol. 24 (2010), 521–529.
22. Hybels, C.F., Blazer, D.G., Epidemiology of late-life mental disorders. Clin. Geriatr. Med. 19 (2003), 663–696.
23. Kasper, S., de Swart, H., Friis Andersen, H., Escitalopram in the treatment of depressed elderly patients. Am. J. Geriatr. Psychiatry 13 (2005), 884–891.
24. Katona, C., Hansen, T., Olsen, C.K., A randomized, double-blind, placebo-controlled, duloxetine-referenced, fixed-dose study comparing the efficacy and safety of Lu AA21004 in elderly patients with major depressive disorder. Int. Clin. Psychopharmacol. 27 (2012), 215–223.
25. Klysner, R., Bent-Hansen, J., Hansen, H.L., Lunde, M., Pleidrup, E., Poulsen, D.L., Andersen, M., Petersen, H.E., Efficacy of citalopram in the prevention of recurrent depression in elderly patients: placebo-controlled study of maintenance therapy. Br. J. Psychiatry 181 (2002), 29–35.
26. Kok, R.M., Nolen, W.A., Heeren, T.J., Efficacy of treatment in older depressed patients: a systematic review and meta-analysis of double-blind randomized controlled trials with antidepressants. J. Affect. Disord. 141 (2012), 103–115.
27. Lenze, E.J., Mulsant, B.H., Blumberger, D.M., Karp, J.F., Newcomer, J.W., Anderson, S.J., Dew, M.A., Butters, M.A., Stack, J.A., Begley, A.E., Reynolds, C.F., Efficacy, safety, and tolerability of augmentation pharmacotherapy with aripiprazole for treatment-resistant depression in late life: A randomised, double-blind, placebo-controlled trial. Lancet 386 (2015), 2404–2412.
28. Lohoff, F.W., Overview of the genetics of major depressive disorder. Curr. Psychiatry Rep. 12 (2010), 539–546.
29. Luppa, M., Sikorski, C., Luck, T., Ehreke, L., Konnopka, A., Wiese, B., Weyerer, S., Konig, H.H., Riedel-Heller, S.G., Age- and gender-specific prevalence of depression in latest-life – systematic review and meta-analysis. J. Affect. Disord. 136 (2012), 212–221.
30. Manning, K.J., Alexopoulos, G.S., Banerjee, S., Morimoto, S.S., Seirup, J.K., Klimstra, S.A., Yuen, G., Kanellopoulos, T., Gunning-Dixon, F., Executive functioning complaints and escitalopram treatment response in late-life depression. Am. J. Geriatr. Psychiatry 23 (2015), 440–445.
31. Montgomery, S.A., Asberg, M., A new depression scale designed to be sensitive to change. Br. J. Psychiatry 134 (1979), 382–389.
32. Mottram, P., Wilson, K., Strobl, J., Antidepressants for depressed elderly. Cochrane Database Syst. Rev., 2006, CD003491.
33. Nelson, J.C., Delucchi, K., Schneider, L.S., Efficacy of second generation antidepressants in late-life depression: a meta-analysis of the evidence. Am. J. Geriatr. Psychiatry 16 (2008), 558–567.
34. Nelson, J.C., Delucchi, K.L., Schneider, L.S., Moderators of outcome in late-life depression: a patient-level meta-analysis. Am. J. Psychiatry 170 (2013), 651–659.
35. Nyth, A.L., Gottfries, C.G., Lyby, K., Smedegaard-Andersen, L., Gylding-Sabroe, J., Kristensen, M., Refsum, H.E., Ofsti, E., Eriksson, S., Syversen, S., A controlled multicenter clinical study of citalopram and placebo in elderly depressed patients with and without concomitant dementia. Acta Psychiatr. Scand. 86 (1992), 138–145.
36. Raskin, J., Wiltse, C.G., Siegal, A., Sheikh, J., Xu, J., Dinkel, J.J., Rotz, B.T., Mohs, R.C., Efficacy of duloxetine on cognition, depression, and pain in elderly patients with major depressive disorder: an 8-week, double-blind, placebo-controlled trial. Am. J. Psychiatry 164 (2007), 900–909.
37. Reynolds, C.F. 3rd, Dew, M.A., Pollock, B.G., Mulsant, B.H., Frank, E., Miller, M.D., Houck, P.R., Mazumdar, S., Butters, M.A., Stack, J.A., Schlernitzauer, M.A., Whyte, E.M., Gildengers, A., Karp, J., Lenze, E., Szanto, K., Bensasi, S., Kupfer, D.J., Maintenance treatment of major depression in old age. N. Engl. J. Med. 354 (2006), 1130–1138.
38. Richardson, T.M., Friedman, B., Podgorski, C., Knox, K., Fisher, S., He, H., Conwell, Y., Depression and its correlates among older adults accessing aging services. Am. J. Geriatr. Psychiatry 20 (2012), 346–354.
39. Robinson, M., Oakes, T.M., Raskin, J., Liu, P., Shoemaker, S., Craig Nelson, J., Acute and long-term treatment of late-life major depressive disorder: duloxetine versus placebo. Am. J. Geriatr. Psychiatry 22 (2014), 34–45.
40. Rochon, P.A., Gurwitz, J.H., Simms, R.W., Fortin, P.R., Felson, D.T., Minaker, K.L., Chalmers, T.C., A study of manufacturer-supported trials of nonsteroidal anti-inflammatory drugs in the treatment of arthritis. Arch. Intern. Med. 154 (1994), 157–163.
41. Roose, S.P., Sackeim, H.A., Krishnan, K.R., Pollock, B.G., Alexopoulos, G., Lavretsky, H., Katz, I.R., Hakkarainen, H., Old-Old Depression Study, G., Antidepressant pharmacotherapy in the treatment of depression in the very old: a randomized, placebo-controlled trial. Am. J. Psychiatry 161 (2004), 2050–2059.
42. Rovner, B.W., German, P.S., Brant, L.J., Clark, R., Burton, L., Folstein, M.F., Depression and mortality in nursing homes. JAMA 265 (1991), 993–996.
43. Schatzberg, A., Roose, S., A double-blind, placebo-controlled study of venlafaxine and fluoxetine in geriatric outpatients with major depression. Am. J. Geriatr. Psychiatry 14 (2006), 361–370.
44. Sneed, J.R., Roose, S.P., Keilp, J.G., Krishnan, K.R.R., Alexopoulos, G.S., Sackeim, H.A., Response inhibition predicts poor antidepressant treatment response in very old depressed patients. Am. J. Geriatr. Psychiatry 15 (2007), 553–563.
45. Sonnenberg, C.M., Deeg, D.J.H., Comijs, H.C., van Tilburg, W., Beekman, A.T.F., Trends in antidepressant use in the older population: results from the LASA-study over a period of 10 years. J. Affect. Disord. 111 (2008), 299–305.
46. Stubbs, B., A meta-analysis investigating falls in older adults taking selective serotonin reuptake inhibitors confirms an association but by no means implies causation. Am. J. Geriatr. Psychiatry, 23, 2015, 1098.
47. Stubbs, B., Brefka, S., Dallmeier, D., Stubbs, J., Vancampfort, D., Denkinger, M.D., Depression and reduced bone mineral density at the Hip and Lumbar Spine: a comparative meta-analysis of studies in adults 60 years and older. Psychosom. Med. 78 (2016), 492–500.
48. Stubbs, B., Stubbs, J., Gnanaraj, S.D., Soundy, A., Falls in older adults with major depressive disorder (MDD): a systematic review and exploratory meta-analysis of prospective studies. Int. Psychogeriatr. 28 (2016), 23–29.
49. Tedeschini, E., Levkovitz, Y., Iovieno, N., Ameral, V.E., Nelson, J.C., Papakostas, G.I., Efficacy of antidepressants for late-life depression: a meta-analysis and meta-regression of placebo-controlled randomized trials. J. Clin. Psychiatry 72 (2011), 1660–1668.
50. Turner, E.H., Matthews, A.M., Linardatos, E., Tell, R.A., Rosenthal, R., Selective publication of antidepressant trials and its influence on apparent efficacy. N. Engl. J. Med. 358 (2008), 252–260.
51. W.H.O, International Statistical Classification of Diseases and Related Health Problems, 10th Revision (ICD-10), 1992, World Health Organisation, Geneva.
52. Wilson, K.C., Mottram, P.G., Ashworth, L., Abou-Saleh, M.T., Older community residents with depression: long-term treatment with sertraline. Randomised, double-blind, placebo-controlled study. Br. J. Psychiatry 182 (2003), 492–497.
53. Wilson, K.C.M., Copeland, J.R.M., Taylor, S., Donoghue, J., McCracken, C.F.M., Natural history of pharmacotherapy of older depressed community residents. The MRC-ALPHA Study. Br. J. Psychiatry 175 (1999), 439–443.
54. Wise, T.N., Wiltse, C.G., Iosifescu, D.V., Sheridan, M., Xu, J.Y., Raskin, J., The safety and tolerability of duloxetine in depressed elderly patients with and without medical comorbidity. Int. J. Clin. Pract. 61 (2007), 1283–1293.
55. Wohlreich, M.M., Sullivan, M.D., Mallinckrodt, C.H., Chappell, A.S., Oakes, T.M., Watkin, J.G., Raskin, J., Duloxetine for the treatment of recurrent major depressive disorder in elderly patients: treatment outcomes in patients with comorbid arthritis. Psychosomatics 50 (2009), 402–412.