Comparison of Short-Wavelength Reduced-Illuminance and Conventional Autofluorescence Imaging in Stargardt Macular Dystrophy

American Journal of Ophthalmology

Volumn 168, Issue , 2016, Pages 269-278

  Strauss, Rupert W ^a,b,c   Muñoz, Beatriz ^a   Jha, Anamika ^d   Ho, Alexander ^d   Cideciyan, Artur V ^e   Kasilian, Melissa L ^b   Wolfson, Yulia ^a   Sadda, SriniVas ^d,f   West, Sheila ^d,f   Scholl, Hendrik P N ^a   Michaelides, Michel ^b,c  

^a JOHNS HOPKINS UNIVERSITY   (United States)

^b MOORFIELDS EYE HOSPITAL   (United Kingdom)

^c UNIVERSITY COLLEGE LONDON   (United Kingdom)

^d Doheny Image Reading Center   (United States)

^e UNIVERSITY OF PENNSYLVANIA   (United States)

^f UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PHENYLEPHRINE; TROPICAMIDE;

ADULT; ARTICLE; AUTOFLUORESCENCE; AUTOFLUORESCENCE IMAGING; CHILD; CLINICAL ARTICLE; CLINICAL ASSESSMENT; COHORT ANALYSIS; COMPARATIVE STUDY; COMPUTER PROGRAM; CONFIDENCE INTERVAL; CONFOCAL SCANNING LASER OPHTHALMOSCOPE; CORRELATION ANALYSIS; CORRELATION COEFFICIENT; ENGLAND; EYE FUNDUS; HUMAN; IMAGE ANALYSIS; IMAGE QUALITY; KAPPA STATISTICS; LASER; MULTICENTER STUDY; OPTICAL COHERENCE TOMOGRAPHY DEVICE; OUTCOME ASSESSMENT; PRIORITY JOURNAL; QUALITATIVE ANALYSIS; QUANTITATIVE ANALYSIS; RELIABILITY; SCANNING LASER OPHTHALMOSCOPY; SENSITIVITY ANALYSIS; SHORT WAVELENGTH REDUCED ILLUMINANCE AUTOFLUORESCENCE IMAGING; STARGARDT DISEASE; STATISTICAL ANALYSIS; FEMALE; FLUORESCENCE ANGIOGRAPHY; FLUORESCENCE IMAGING; MACULAR DEGENERATION; MALE; MIDDLE AGED; OPHTHALMOSCOPY; PATHOLOGY; PATHOPHYSIOLOGY; PROCEDURES; REPRODUCIBILITY; RETINA MACULA LUTEA;

ADULT; FEMALE; FLUORESCEIN ANGIOGRAPHY; FUNDUS OCULI; HUMANS; MACULA LUTEA; MACULAR DEGENERATION; MALE; MIDDLE AGED; OPHTHALMOSCOPY; OPTICAL IMAGING; REPRODUCIBILITY OF RESULTS;

EID: 84978998167     PISSN: 00029394     EISSN: 18791891     Source Type: Journal    
DOI: 10.1016/j.ajo.2016.06.003     Document Type: Article

References (18)

1. 1 Roosing, S., Thiadens, A.A., Hoyng, C.B., Klaver, C.C., den Hollander, A.I., Cremers, F.P., Causes and consequences of inherited cone disorders. Prog Retin Eye Res 42 (2014), 1–26.
2. 2 Allikmets, R., Singh, N., Sun, H., et al. A photoreceptor cell-specific ATP-binding transporter gene (ABCR) is mutated in recessive Stargardt macular dystrophy. Nat Genet 15 (1997), 236–246.
3. 3 Quazi, F., Lenevich, S., Molday, R.S., ABCA4 is an N-retinylidene-phosphatidylethanolamine and phosphatidylethanolamine importer. Nat Commun, 3, 2012, 925.
4. 4 Mata, N.L., Weng, J., Travis, G.H., Biosynthesis of a major lipofuscin fluorophore in mice and humans with ABCR-mediated retinal and macular degeneration. Proc Natl Acad Sci U S A 97:13 (2000), 7154–7159.
5. 5 Fujinami, K., Lois, N., Mukherjee, R., et al. A longitudinal study of Stargardt disease: quantitative assessment of fundus autofluorescence, progression, and genotype correlations. Invest Ophthalmol Vis Sci 54:13 (2013), 8181–8190.
6. 6 Choudhry, N., Giani, A., Miller, J.W., Fundus autofluorescence in geographic atrophy: a review. Semin Ophthalmol 25:5-6 (2010), 206–213.
7. 7 von Ruckmann, A., Fitzke, F.W., Bird, A.C., Distribution of fundus autofluorescence with a scanning laser ophthalmoscope. Br J Ophthalmol 79:5 (1995), 407–412.
8. 8 Delori, F.C., Dorey, C.K., Staurenghi, G., Arend, O., Goger, D.G., Weiter, J.J., In vivo fluorescence of the ocular fundus exhibits retinal pigment epithelium lipofuscin characteristics. Invest Ophthalmol Vis Sci 36:3 (1995), 718–729.
9. 9 Csaky, K.G., Richman, E.A., Ferris, F.L. 3rd, Report from the NEI/FDA Ophthalmic Clinical Trial Design and Endpoints Symposium. Invest Ophthalmol Vis Sci 49:2 (2008), 479–489.
10. 10 Strauss, R.W., Ho, A., Munoz, B., et al. The Natural History of the Progression of Atrophy Secondary to Stargardt Disease (ProgStar) Studies: Design and Baseline Characteristics: ProgStar Report No. 1. Ophthalmology 123:4 (2016), 817–828.
11. 11 Sparrow, J.R., Nakanishi, K., Parish, C.A., The lipofuscin fluorophore A2E mediates blue light-induced damage to retinal pigmented epithelial cells. Invest Ophthalmol Vis Sci 41:7 (2000), 1981–1989.
12. 12 Boulton, M., Dontsov, A., Jarvis-Evans, J., Ostrovsky, M., Svistunenko, D., Lipofuscin is a photoinducible free radical generator. J Photochem Photobiol B 19:3 (1993), 201–204.
13. 13 Cideciyan, A.V., Swider, M., Aleman, T.S., et al. Reduced-illuminance autofluorescence imaging in ABCA4-associated retinal degenerations. J Opt Soc Am A Opt Image Sci Vis 24:5 (2007), 1457–1467.
14. 14 Kuehlewein, L., Hariri, A.H., Ho, A., et al. Comparison of manual and semiautomated fundus autofluorescence analysis of macular atrophy in Stargardt disease phenotype. Retina 36:6 (2016), 1216–1221.
15. 15 Cideciyan, A.V., Jacobson, S.G., Aleman, T.S., et al. In vivo dynamics of retinal injury and repair in the rhodopsin mutant dog model of human retinitis pigmentosa. Proc Natl Acad Sci U S A 102:14 (2005), 5233–5238.
16. 16 Delori, F., Greenberg, J.P., Woods, R.L., et al. Quantitative measurements of autofluorescence with the scanning laser ophthalmoscope. Invest Ophthalmol Vis Sci 52:13 (2011), 9379–9390.
17. 17 Strauss, R.W., Munoz, B., Wolfson, Y., et al. Assessment of estimated retinal atrophy progression in Stargardt macular dystrophy using spectral-domain optical coherence tomography. Br J Ophthalmol, 2015, 10.1136/bjophthalmol-2015-307035 [Epub ahead of print].
18. 18 Gomes, N.L., Greenstein, V.C., Carlson, J.N., et al. A comparison of fundus autofluorescence and retinal structure in patients with Stargardt disease. Invest Ophthalmol Vis Sci 50:8 (2009), 3953–3959.