Nasal potential difference outcomes support diagnostic decisions in cystic fibrosis

Journal of Cystic Fibrosis

Volumn 15, Issue 5, 2016, Pages 579-582

  Tridello, Gloria ^a   Menin, Laura ^a   Pintani, Emily ^a   Bergamini, Gabriella ^a,b   Assael, Baroukh Maurice ^a   Melotti, Paola ^a  

^a UNIVERSITY HOSPITAL OF VERONA   (Italy)

^b UNIVERSITY OF VERONA   (Italy)

Author keywords

CFTR genetic test; CFTR related disorders; Cystic fibrosis; Cystic fibrosis transmembrane conductance regulator; Diagnosis; Nasal potential difference measurements; Sweat test

Indexed keywords

ADENOSINE TRIPHOSPHATE; AMILORIDE; CHLORIDE; CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR; ISOPRENALINE; BETA ADRENERGIC RECEPTOR STIMULATING AGENT; EPITHELIAL SODIUM CHANNEL BLOCKING AGENT;

ADOLESCENT; ADULT; AGED; ARTICLE; CHILD; CLINICAL ASSESSMENT TOOL; CLINICAL DECISION MAKING; CONTROLLED STUDY; CYSTIC FIBROSIS; FEMALE; HUMAN; INTERMETHOD COMPARISON; MAJOR CLINICAL STUDY; MALE; NASAL POTENTIAL DIFFERENCE; OUTCOME ASSESSMENT; POTENTIAL DIFFERENCE; SENSITIVITY AND SPECIFICITY; SERMET SCORE; WILSCHANSKI INDEX; CHEMISTRY; DIFFERENTIAL DIAGNOSIS; DISCRIMINANT ANALYSIS; DRUG EFFECTS; ELECTRIC CONDUCTIVITY; GENETIC SCREENING; GENETICS; MEMBRANE POTENTIAL; METABOLISM; MUCUS; NOSE MUCOSA; PROCEDURES; RECEIVER OPERATING CHARACTERISTIC; SWEAT;

ADRENERGIC BETA-AGONISTS; ADULT; AMILORIDE; CYSTIC FIBROSIS; CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR; DIAGNOSIS, DIFFERENTIAL; DISCRIMINANT ANALYSIS; ELECTRIC CONDUCTIVITY; EPITHELIAL SODIUM CHANNEL BLOCKERS; FEMALE; GENETIC TESTING; HUMANS; ISOPROTERENOL; MALE; MEMBRANE POTENTIALS; MUCUS; NASAL MUCOSA; ROC CURVE; SENSITIVITY AND SPECIFICITY; SWEAT;

EID: 84978882328     PISSN: 15691993     EISSN: 18735010     Source Type: Journal    
DOI: 10.1016/j.jcf.2016.06.009     Document Type: Article

References (9)

1. [1] Bombieri, C., Claustres, M., De Boeck, K., Derichs, N., Dodge, J., Girodon, E., et al. Recommendations for the classification of diseases as CFTR-related disorders. J Cyst Fibros 10:Suppl. 2 (2011), S86–102.
2. [2] Knowles, M., Gatzy, J., Boucher, R., Increased bioelectric potential difference across respiratory epithelia in cystic fibrosis. N Engl J Med 305 (1981), 1489–1495.
3. [3] Derichs, N., Sanz, J., Von Kanel, T., Stolpe, C., Zapf, A., Tümmler, B., et al. Intestinal current measurement for diagnostic classification of patients with questionable cystic fibrosis: validation and reference data. Thorax 65 (2010), 594–599.
4. [4] De Boeck, K., Derichs, N., Fajac, I., de Jonge, H.R., Bronsveld, I., Sermet, I., et al. ECFS diagnostic network working group; EuroCareCF WP3 group on CF diagnosis. New clinical diagnostic procedures for cystic fibrosis in Europe. J Cyst Fibros 10 (2011), S53–S66.
5. [5] Standaert, T.A., Boitano, L., Emerson, J., Milgram, L.J., Konstan, M.W., Hunter, J., et al. Standardized procedure for measurement of nasal potential difference: An outcome measure in multicenter cystic fibrosis clinical trials. Pediatr Pulmonol 37 (2004), 385–392.
6. [6] Boyle, M.P., Diener-West, M., Milgram, L., Knowles, M., Foy, C., Zeitlin, P., et al. Cystic fibrosis therapeutics development network nasal PD study group. A multicenter study of the effect of solution temperature on nasal potential difference measurements. Chest 124 (2003), 482–489.
7. [7] Wilschanski, M., Famini, H., Strauss-Liviatan, N., Rivlin, J., Blau, H., Bibi, H., et al. Nasal potential difference measurements in patients with atypical cystic fibrosis. Eur Respir J 17 (2001), 1208–1215.
8. [8] Sermet-Gaudelus, I., Girodon, E., Sands, D., Stremmler, N., Vavrova, V., Deneuville, E., et al. Clinical phenotype and genotype of children with borderline sweat test and abnormal nasal epithelial chloride transport. Am J Respir Crit Care Med 182 (2010), 929–936.
9. [9] Farrell, P.M., Rosenstein, B.J., White, T.B., Accurso, F.J., Castellani, C., Cutting, G.R., et al. Guidelines for diagnosis of cystic fibrosis in newborns through older adults: Cystic Fibrosis Foundation consensus report. J Pediatr 153 (2008), s4–S14.