Labour pain with remifentanil patient-controlled analgesia versus epidural analgesia: a randomised equivalence trial

BJOG: An International Journal of Obstetrics and Gynaecology

Volumn 124, Issue 4, 2017, Pages 652-660

  Logtenberg, S L M ^a   Oude Rengerink, K ^a   Verhoeven, C J ^b,c   Freeman, L M ^d   van den Akker, E S A ^e   Godfried, M B ^e   van Beek, E ^f   Borchert, O W H M ^f   Schuitemaker, N ^g   van Woerkens, E C S M ^g   Hostijn, I ^h   Middeldorp, J M ^d   van der Post, J A ^a   Mol, B W ⁱ  

^a ACADEMIC MEDICAL CENTER   (Netherlands)

^b VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^c MÁXIMA MEDICAL CENTER   (Netherlands)

^d LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^e ONZE LIEVE VROUWE GASTHUIS   (Netherlands)

^f ST ANTONIUS HOSPITAL   (Netherlands)

^g DEPARTMENT OF SURGERY   (Netherlands)

^h Midwifery Practice Alnatal   (Netherlands)

ⁱ UNIVERSITY OF ADELAIDE   (Australia)

Author keywords

Epidural analgesia; labour pain; pain intensity score; pain satisfaction score; remifentanil patient controlled analgesia; satisfaction with pain relief

Indexed keywords

REMIFENTANIL; ROPIVACAINE; SUFENTANIL; NARCOTIC ANALGESIC AGENT;

ADULT; ARTICLE; BODY TEMPERATURE; CONTINUOUS INFUSION; CONTROLLED STUDY; DUTCHMAN; EPIDURAL ANALGESIA; FEMALE; HUMAN; LABOR PAIN; LOADING DRUG DOSE; MULTICENTER STUDY; MULTIPARA; NULLIPARA; OPEN STUDY; OXYGEN DESATURATION; PAIN INTENSITY; PATIENT CONTROLLED ANALGESIA; PATIENT PREFERENCE; PREGNANT WOMAN; RANDOMIZED CONTROLLED TRIAL; RESPIRATION DEPRESSION; SATISFACTION; SIDE EFFECT; VISUAL ANALOG SCALE; ANALGESIA; AREA UNDER THE CURVE; LABOR; NETHERLANDS; OBSTETRIC ANALGESIA; PAIN MEASUREMENT; PATIENT SATISFACTION; PREGNANCY; PROCEDURES; STATISTICS AND NUMERICAL DATA;

ADULT; ANALGESIA, EPIDURAL; ANALGESIA, OBSTETRICAL; ANALGESIA, PATIENT-CONTROLLED; ANALGESICS, OPIOID; AREA UNDER CURVE; FEMALE; HUMANS; LABOR PAIN; LABOR, OBSTETRIC; NETHERLANDS; PAIN MANAGEMENT; PAIN MEASUREMENT; PATIENT SATISFACTION; PREGNANCY; REMIFENTANIL;

EID: 84978872928     PISSN: 14700328     EISSN: 14710528     Source Type: Journal    
DOI: 10.1111/1471-0528.14181     Document Type: Article

References (19)

1. American College of Obstetricians and Gynecologists Committee Opinion #295: pain relief during labor. Obstet Gynecol 2004;104:213.
2. NVOG (Dutch Society of Obstetrics and Gynecology). Guideline Medicamenteuze Pijnbehandeling Tijdens de Bevalling (Pain Relief During Labor). Amsterdam: NVOG, 2008.
3. Jones L, Othman M, Dowswell T, Alfirevic Z, Gates S, Newburn M, et al. Pain management for women in labour: an overview of systematic reviews. Cochrane Database 2012;3:CD009234.
4. Kan RE, Hughes SC, Rosen MA, Kessin C, Preston PG, Lobo EP. Intravenous remifentanil. Anaesthesiology 1998;88:1467–749.
5. Egan TD. Pharmakinetics and pharmacodynamics of remifentanil; an update in the year 2000. Curr Opin Anaesthesiol 2000;13:449–55.
6. Hodnett ED. Pain and women's satisfaction with the experience of childbirth: a systematic review. Am J Obstet Gynecol 2002;186:160–72.
7. Rijnders M, Baston H, Schönbeck Y, van der Pal K, Prins M, Green J, et al. Perinatal factors related to negative or positive recall of birth experience in women 3 years postpartum in the Netherlands. Birth 2008;35:107–16.
8. Schnabel A, Hahn N, Broscheit J, Muellenbach RM, Rieger L, Roewer N, et al. Remifentanil for labour analgesia: a meta analysis of randomised controlled trials. Eur J Anaesthesiol 2012;29:177–85.
9. Stocki D, Matot I, Einav S, Eventov-Friedman S, Ginosar Y, Weiniger CF. A randomized controlled trial of the efficacy and respiratory effects of patient-controlled intravenous remifentanil analgesia and patient-controlled epidural analgesia in laboring women. Anesth Analg 2014;118:589–97.
10. Volmanen P, Sarvela J, Akural EI, Raudaskoski T, Korttila K, Alahuhta S. Intravenous remifentanil vs. epidural levobupivacaine with fentanyl for pain relief in early labor: a randomised, controlled, double-blinded study. Acta Anaesthesiol Scand 2008;52:249–55.
11. Douma MR, Middeldorp JM, Verwey RA, Dahan A, Stienstra R. A randomised comparison of intravenous remifentanil patient-controlled analgesia with epidural ropivacaine/sufentanil during labour. Int J Obstet Anesth 2011;20:118–23.
12. Ismail MT, Hassanin MZ. Neuraxial analgesia versus intravenous remifentanil for pain relief in early labor in nulliparous women. Arch Gynecol Obstet 2012;286:1375–81.
13. Tveit TO, Seiler S, Halvorsen A, Rosland JH. Labour analgesia: a randomised, controlled trial comparing intravenous remifentanil and epidural analgesia with ropivacaine and fentanyl. Eur J Anaesthesiol 2012;29:129–36.
14. Stourac P, Suchmelova H, Stodulkova M, Huser M, Krikava I, Janku P, et al. Comparison of parturient-controlled remifentanil with epidural bupivacaine and sufentanil for labour analgesia: Randomised controlled trial. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 2014;158:227–32.
15. Ullman R, Smith LA, Burns E, Mori R, Dowswell T. Parenteral opioids for maternal pain management in labour. Cochrane Database Syst Rev 2011;10:CD007396.
16. Freeman L, Bloemenkamp K, Franssen M, Papatsonis D, Hajenius P, Hollmann M. Remifentanil patient controlled analgesia versus epidural analgesia in labour; a randomised multicentre equivalence trial. BMJ 2015;350:h846.
17. Cappelleri JC, Bushmakin AG, Zlateva G, Sadosky A. Pain responder analysis: use of area under the curve to enhance interpretation of clinical trial results. Pain Practice 2009;9:348–53.
18. Donders AR, van der Heijden GJ, Stijnen T, Moons KG. Review: a gentle introduction to imputation of missing values. J Clinical Epidemiol 2006;59:1087–91.
19. Van der Heijden GJ, Donders AR, Stijnen T, Moons KG. Imputation of missing values is superior to complete case analysis and the missing -indicator method in multivariable diagnostic research: a clinical example. J Clin Epidemiol 2006;59:110.