Structural basis of Zika virus helicase in recognizing its substrates

Protein and Cell

Volumn 7, Issue 8, 2016, Pages 562-570

  Tian, Hongliang ^a,b   Ji, Xiaoyun ^c   Yang, Xiaoyun ^a   Zhang, Zhongxin ^d   Lu, Zuokun ^e   Yang, Kailin ^f   Chen, Cheng ^a   Zhao, Qi ^g   Chi, Heng ^a   Mu, Zhongyu ^a   Xie, Wei ^a   Wang, Zefang ^a   Lou, Huiqiang ^d   Yang, Haitao ^a,b   Rao, Zihe ^e  

^a TIANJIN UNIVERSITY   (China)

^b Tianjin International Joint Academy of Biotechnology and Medicine   (China)

^c NANJING UNIVERSITY   (China)

^d CHINA AGRICULTURAL UNIVERSITY   (China)

^e NANKAI UNIVERSITY   (China)

^f CLEVELAND CLINIC LERNER COLLEGE OF MEDICINE   (United States)

^g YALE UNIVERSITY   (United States)

Author keywords

ATP; crystal structure; flavivirus; helicase; Zika virus

Indexed keywords

ADENOSINE TRIPHOSPHATE; HELICASE; MANGANESE; RNA HELICASE; VIRAL PROTEIN; VIRUS RNA;

ARTICLE; ATPASE ACTIVITY ASSAY; CLONING; CONTROLLED STUDY; CRYSTAL STRUCTURE; DENGUE VIRUS 4; ENZYME SPECIFICITY; ENZYME SUBSTRATE COMPLEX; GENE EXPRESSION; HYDROGEN BOND; HYDROLYSIS KINETICS; MOLECULAR RECOGNITION; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN INTERACTION; PROTEIN PURIFICATION; PROTEIN RNA BINDING; VIRUS REPLICATION; ZIKA FEVER; ZIKA VIRUS; CHEMISTRY; ENZYMOLOGY; PROTEIN DOMAIN; X RAY CRYSTALLOGRAPHY;

CRYSTALLOGRAPHY, X-RAY; PROTEIN DOMAINS; RNA HELICASES; RNA, VIRAL; VIRAL PROTEINS; ZIKA VIRUS;

EID: 84978765843     PISSN: 1674800X     EISSN: 16748018     Source Type: Journal    
DOI: 10.1007/s13238-016-0293-2     Document Type: Article

References (22)

1. Brasil P, Pereira JP Jr, Raja Gabaglia C, Damasceno L, Wakimoto M, Ribeiro Nogueira RM, Carvalho de Sequeira P, Machado Siqueira A, Abreu de Carvalho LM, Cotrim da Cunha D et al (2016) Zika virus infection in pregnant women in Rio de Janeiro—preliminary report. N Engl J Med. http://www.nejm.org/doi/10.1056/NEJMoa1602412
2. Cowtan K (2006) The Buccaneer software for automated model building. 1. Tracing protein chains. Acta Crystallogr D Biol Crystallogr 62:1002–1011
3. Dick GW, Kitchen SF, Haddow AJ (1952) Zika virus. I. Isolations and serological specificity. Trans R Soc Trop Med Hyg 46:509–520
4. Duffy MR, Chen TH, Hancock WT, Powers AM, Kool JL, Lanciotti RS, Pretrick M, Marfel M, Holzbauer S, Dubray C et al (2009) Zika virus outbreak on Yap Island, federated states of Micronesia. N Engl J Med 360:2536–2543
5. Emsley P, Cowtan K (2004) Coot: model-building tools for molecular graphics. Acta Crystallogr D Biol Crystallogr 60:2126–2132
6. Haddow AD, Schuh AJ, Yasuda CY, Kasper MR, Heang V, Huy R, Guzman H, Tesh RB, Weaver SC (2012) Genetic characterization of Zika virus strains: geographic expansion of the Asian lineage. PLoS Negl Trop Dis 6:e1477
7. Hennessey M, Fischer M, Staples JE (2016) Zika virus spreads to new areas—region of the Americas, May 2015–January 2016. MMWR Morb Mortal Wkly Rep 65:55–58
8. Ioos S, Mallet HP, Leparc Goffart I, Gauthier V, Cardoso T, Herida M (2014) Current Zika virus epidemiology and recent epidemics. Med Mal Infect 44:302–307
9. Lanzetta PA, Alvarez LJ, Reinach PS, Candia OA (1979) An improved assay for nanomole amounts of inorganic phosphate. Anal Biochem 100:95–97
10. Lazear HM, Diamond MS (2016) Zika virus: new clinical syndromes and its emergence in the Western Hemisphere. J Virol. doi:10.1128/JVI.00252-16
11. Lindenbach BD, Rice CM (2001) Fundamental virology. Lippincott-Raven, Philadelphia, PA
12. Luo D, Xu T, Watson RP, Scherer-Becker D, Sampath A, Jahnke W, Yeong SS, Wang CH, Lim SP, Strongin A et al (2008) Insights into RNA unwinding and ATP hydrolysis by the flavivirus NS3 protein. EMBO J 27:3209–3219
13. McCoy AJ, Grosse-Kunstleve RW, Adams PD, Winn MD, Storoni LC, Read RJ (2007) Phaser crystallographic software. J Appl Crystallogr 40:658–674
14. Minor W, Otwinowski Z (1997) Processing of X-ray diffraction data collected in oscillation mode. Methods in enzymology volume 276: macromolecular crystallography, part A. Academic Press, New York, pp 307–326
15. Mlakar J, Korva M, Tul N, Popovic M, Poljsak-Prijatelj M, Mraz J, Kolenc M, Resman Rus K, Vesnaver Vipotnik T, Fabjan Vodusek V et al (2016) Zika virus associated with microcephaly. N Engl J Med 374:951–958
16. Murshudov GN, Skubak P, Lebedev AA, Pannu NS, Steiner RA, Nicholls RA, Winn MD, Long F, Vagin AA (2011) REFMAC5 for the refinement of macromolecular crystal structures. Acta Crystallogr D Biol Crystallogr 67:355–367
17. Noble CG, Chen YL, Dong H, Gu F, Lim SP, Schul W, Wang QY, Shi PY (2010) Strategies for development of Dengue virus inhibitors. Antiviral Res 85:450–462
18. Pierson TC, Diamond MS (2013) Flaviviruses, vol 2, 6th edn. Wolter Kluwer, Philadelphia
19. Rodrigues LC (2016) Microcephaly and Zika virus infection. The Lancet. doi:10.1016/S0140-6736(16)00742-X
20. Tang H, Hammack C, Ogden SC, Wen Z, Qian X, Li Y, Yao B, Shin J, Zhang F, Lee EM et al (2016) Zika virus infects human cortical neural progenitors and attenuates their growth. Cell Stem Cell. doi:10.1016/j.stem.2016.02.016
21. Tian H, Ji X, Yang X, Xie W, Yang K, Chen C, Wu C, Chi H, Mu Z, Wang Z et al (2016) The crystal structure of Zika virus helicase: basis for antiviral drug design. Protein Cell 7:450–454
22. Wikan N, Smith DR (2016) Zika virus: history of a newly emerging arbovirus. Lancet Infect Dis 16:e119–e126