Citric Acid

Biotechnology: Second, Completely Revised Edition

Volumn 6-12, Issue , 2008, Pages 307-345

  Roehr, Max ^a   Kubicek, Christian P ^a   Komínek, Jiří ^a  

^a VIENNA UNIVERSITY OF TECHNOLOGY   (Austria)

Author keywords

Accumulate; Contaminations; Contribute; Metabolism; Microbiological

Indexed keywords

EID: 84978736571     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1002/9783527620999.ch9f     Document Type: Chapter

References (309)

1. ABE, M., TABUCHI, T., TAHARA, Y. (1970), Studies on organic acid fermentation in yeasts, J. Agr. Chem. Soc. Jpn. 44, 493--198.
2. AKIYAMA, S., SUZUKI, T., SUMINO, Y., NAKAO, Y., FUKUDA, H. (1972), Production of citric acid from n-paraffins by fluoroacetate sensitive mutant strains of Candida lipolytica, Agr. Biol. Chem. 36, 339-341.
3. AKIYAMA, S., SUZUKI, T., SUMINO, Y., NAKAO, Y., FUKUDA, H. (1973a), Production of citric acid from n-paraffins by fluoroacetate-sensitive mutants. I. Induction and citric acid productivity of fluoroacetate-sensitive mutant strains of Candida lipolytica, Agr. Biol. Chem. 37, 879-884.
4. AKIYAMA, S., SUZUKI, T., SUMINO, Y., NAKAO, Y., FUKUDA, H. (1973b), Production of citric acid from n-paraffins by fluoroacetate-sensitive mutants. II. Relation between aconitate hydrat-ase activity and citric acid productivity in fluoroacetate-sensitive mutant strains of Candida lipolytica, Agr. Biol. Chem. 37, 885-888.
5. ALTER, J. E., BLUMBERG, R. (1981), U.S. Patent 4251671.
6. ANNE, J., PEBERDY, J. F. (1975), Conditions for induced fusion of fungal protoplasts in polyethyl-ene glycol solutions, Arch. Microbiol. 105, 201-205.
7. ANNE, J., PEBERDY, J. F. (1976), Induced fusion of fungal protoplasts following treatment with po-lyethyleneglycol, J. Gen. Microbiol. 92, 413-417.
8. ARTS, E., KUBICEK, C. P., ROEHR, M. (1987), Regulation of phosphofructokinase from Aspergillus niger: effect of fructose-2,6-bisphosphate on the action of citrate, amonium ions and AMP, J. Gen. Microbiol. 133, 1195-1199.
9. ATAKUZIEV, T. A., KHASANOV, R. S., MIRZAEV, F. M., RAZDORSKIKH, L. M. (1980), Citric acid production waste as the main component of sul-fomineral cement, Dokl. Akad. Nauk UzSSR (3), 48-50.
10. AVERS, R., Jr. (1957), U.S. Patent 2810755.
11. BANIEL, A. M. (1982), Eur. Patent 49429.
12. BANIEL, A. M., GONEN, D. (1991), U.S. Patent 4994609.
13. BANIEL, A. M., BLUMBERG, R., HAJDU, K. (1974), Ger. Patent 2329480.
14. BANUELOS, M., GANCEDO, C, GANCEDO, J. M. (1977), Activation by phosphate of yeast phosphofructokinase, J. Biol. Chem. 252, 6394-6398.
15. BARTH, G., KREBS, D. (1985), Ger. Patent (GDR) 227448.
16. BATTI, M. A. (1966), U.S. Patent 3290227.
17. BAUER, U., MARR, R., RUECKL, W., SIEBENHO-FER, M. (1988), Extraction of citric acid from aqueous solutions, Chem. Biochem. Eng. Q. 2, 230-232.
18. BAUER, U., MARR, R., RUECKL, W., SIEBENHO-FER, M. (1989), Reactive extraction of citric acid from an aqueous fermentation broth, Ber. Bun-sen-Ges. Phys. Chem. 93, 980-984.
19. BEHRENS, U., WEISSBRODT, E., LEHMANN, W. (1978), Zur Kinetik der Citronensäurebildung bei Candida lipolytica, Z. Allg. Mikrobiol. 18, 549-558.
20. BEMISH, T. A., CHIANG, J. P., PATWARDHAN, B. H., SOLOW, D. J. (1993), U.S. Patent 5237098.
21. BENNETT, J. W., KLICH, M. A. (Eds.) (1992), Aspergillus: Biology and Industrial Applications. Stoneham: Butterworth-Heinemann.
22. BENNETT, J. W., LASURE, L. L. (Eds.) (1985), Gene Manipulations in Fungi. Orlando, FA: Academic Press.
23. BENNETT, J. W., LASURE, L. L. (1991), More Gene Manipulations in Fungi. San Diego, CA: Academic Press.
24. BERCOVITZ, A., PELEG, Y., BATTAT, E., ROKEM, J. S., GOLDBERG, I. (1990), Localization of pyruvate carboxylase in organic acid producing Aspergillus strains, Appl. Environ. Microbiol. 56, 1594-1597.
25. BERNHAUER, K. (1928), Über die Charakterisierung der Stämme von Aspergillus niger aufgrund ihres biochemischen Verhaltens. 1. Vergleichende Untersuchungen über die Säurebildung durch verschiedene Pilzstämme, Biochem. Z. 197, 278-286.
26. BERNHAUER, K. (1929), Über die Charakterisierung der Stämme von Aspergillus niger aufgrund ihres biochemischen Verhaltens. 2. Die Bedeutung saurer Substrate für die Charakterisierung und Züchtung der Pilzstämme, Biochem. Z. 205, 240-244.
27. BERNHAUER, K. (1934), Die Citronensäuregärung, Ergebn. Enzymforsch. 3, 185-277.
28. BERNHAUER, K. (1940). Oxydative Gärungen, in: Handbuch der Enzymologie (NORD, F. F., WEIDENHAGEN, R., Eds.). Leipzig: Akademische Verlagsgesellschaft.
29. BIGELIS, R. (1985), Primary metabolism and industrial fermentations, in: Gene Manipulations in Fungi (BENNETT, J. W., LASURE, L. L., Eds.), pp. 357-101. Orlando, FA: Academic Press.
30. BIGELIS, R., ARORA, D. K. (1992), Organic acids of fungi, in: Handbook of Applied Mycology, Vol. 4. (ARORA, D. K., ELANDER, R. P., Mu-KERJI, K. G., Eds), pp. 357-376. New York: Marcel Dekker.
31. BlZEK, V., HORACEK, J., RERICHA, R., KOUSOVA, M. (1992), Amine extraction of hydroxycarbox-ylic acids. 1. Extraction of citric acid with 1-octa-nol/n-heptane solutions of trialkylamine, Ind. Eng. Chem. Res. 31, 1554-1562; 2632.
32. BONATELLI, R., Jr., AZEVEDO, J. L. (1982), Improved reproducibility of citric acid production in Aspergillus niger, Biotechnol. Lett. 4, 761-766.
33. BONATELLI, R., Jr., AZEVEDO, J. L., VALENT, G. U. (1983), Parasexuality in a citric acid producing strain of Aspergillus niger, Rev. Brasil. Genet. VI, (3), 399-405.
34. BORGLUM, G. B., MARSHALL, J. J. (1984), The potential of immobilized biocatalysts for production of industrial chemicals, Appl. Biochem. Biotechnol. 9, 117-130.
35. BOUCHARD, E. F., MERRITT, E. G. (1979), Citric acid, in: Kirk-Othmer's Encyclopedia of Chemical Technology, Vol. 6, (GRAYSON, M., ECK-ROTH, D., Eds.), 3rd Edn., pp. 150-179. New York: Wiley.
36. BRIFFAUD, J., ENGASSER, M. (1979), Citric acid production from glucose. I. Growth and excretion kinetics in a stirred fermentor, Biotechnol. Bioeng. 21, 2083-2092.
37. BROWN, D. E., VAS, R. C. (1973), Maturity and product formation in cultures of microorganisms, Biotechnol. Bioeng. 15, 321-330.
38. CADDICK, M. X. (1992), Characterization of a major Aspergillus regulatory gene are A, in: Molecular Biology of Filamentous Fungi (STAHL, U., TUDZYNSKI, P., Eds.), pp. 141-151. Weinheim: VCH.
39. CAHN, F. J. (1935), Citric acid fermentation on solid materials, Ind. Eng. Chem. 27, 201.
40. CHANG, L. T., TERRY, C. A. (1953), Intergenic complementation of glucoamylase and citric acid production in two species of Aspergillus, Appl. Microbiol. 25, 890-895.
41. CHAUDHARY, K., ETHIRAJ, S., LAKSHMINARAYA-NA, K., TAURO, P. (1978), Citric acid production from Indian cane molasses by Aspergillus niger under solid state fermentation conditions, J. Ferment. Technol. 56, 554-557.
42. Chemische Fabrik J. A. Benckiser (1932), Ger. Patent 555810.
43. CHMIEL, A. (1975a), Kinetic studies on citric acid production by Aspergillus niger. I. Phases of mycelium growth and product formation, Acta Microbiol. Pol. Ser. B 7, 185-193.
44. CHMIEL, A. (1975b), Kinetic studies on citric acid production by Aspergillus niger. II. The two-stage process, Acta Microbiol. Pol. Ser. B 7, 237-242.
45. CHUNG, B. H., CHANG, H. N. (1988), Aerobic fungal cell immobilization in a dual hollow-fiber bioreactor: continuous production of citric acid, Biotechnol. Bioeng. 32, 205-212.
46. CIEGLER, A., RAPER, K. B. (1957), Application of heterokaryons of Aspergillus to commercial type fermentations, Appl. Microbiol. 5, 106-110.
47. CLARK, D. S. (1964), U.S. Patent 3118821.
48. CLARK, D. S., ITO, K., HORITSU, H. (1966), Effect of manganese and other heavy metals on submerged citric acid fermentation of molasses, Biotechnol. Bioeng. 8, 465-471.
49. CLELAND, W. W., JOHNSON, M. J. (1954), Tracer experiments on the mechanism of citric acid formation by Aspergillus niger, J. Biol. Chem. 208, 679-692.
50. CLEMENT, M. T. (1952), Citric acid fermentation of beet molasses by Aspergillus niger in submerged culture, Can. J. Technol. 30, 82-88.
51. COLIN, P. (1960), French Patent 1211066.
52. COLIN, P. (1968), French Patent 1548328.
53. COLIN, P., MOUNDLIC, J. (1967), French Patent 1494958.
54. COOPER, J. I., FOSTER, D. E. (1990), Anaerobic digestion of 400000 gallons/day of fermentation wastes in fixed-bed, downflow digesters. Waste characterization studies to commercial operation, Energy Biomass Wastes 13, 1061-1077.
55. CURRIE, J. N. (1916), On the citric acid production of Aspergillus niger, Science 44, 215.
56. CURRIE, J. N. (1917), The citric acid fermentation of Aspergillus niger, J. Biol. Chem. 31, 15-37.
57. DAS, A., ROY, P. (1978), Improved production of citric acid by a diploid strain of Aspergillus niger. Can. J. Microbiol. 24, 622-625.
58. DAVIS, H. (1948), Detection and occurrence of acid-producing fungi, MSc Thesis, University of Texas, Austin, TX.
59. DAWSON, M. W., MADDOX, I. S., BROOKS, J. D. (1989), Evidence for nitrogen catabolite repression during citric acid production by Aspergillus niger under phosphate limited growth conditions, Biotechnol. Bioeng. 33, 1500-1504.
60. DERYCKE, D., PIPYN, P. (1990), Anaerobic digestion, ammonia stripping/recovery and (devitrification of a citric acid factory effluent, Meded. Fac. Landbouwwet. Rijksuniv. Gent 55, 1481-1483.
61. DOELGER, W. P., PRESCOTT, S. C (1934), Citric acid fermentation, Ind. Eng. Chem. 26, 1142-1149.
62. Donau Chemie AG (1993), Austrian Patent 396464 B.
63. DRURI, M. ZAKOWSKA, Z. (1986), Isolation from beet molasses of fractions toxic to Aspergillus niger by extraction with organic solvents, Przem. Ferment. Owocowo-Warzywny 30, 14-16.
64. DRURI, M., ZAKOWSKA, Z. (1987), Untersuchung von Bestandteilen der Zuckerrübenmelasse, die auf Aspergillus niger bei der Citronensäurepro-duktion toxisch wirken, Acta Biotechnol. 7, 275-278.
65. DUFLOT, P., LELEU, J. B. (1989), Eur. Patent 346196.
66. EDLAUER, R., KIRKOVITS, A. E., WESTERMAYER, R., STOJAN, O. (1990), Eur. Patent 377430.
67. EIKMEIER H., REHM, H. J. (1984), Production of citric acid with immobilized Aspergillus niger, 3rd, Eur. Congr. Biotechnol., Vol. 2, pp. 179-184. Weinheim: Verlag Chemie.
68. EIKMEIER H., REHM, H. J. (1987a), Semicontin-uous and continuous production of citric acid with immobilized cells of Aspergillus niger, Z. Naturforsch. C: Biosci. 42, 408-113.
69. EIKMEIER H., REHM, H. J. (1987b), Stability of calcium alginate during citric acid production of immobilized Aspergillus niger, Appl. Microbiol. Biotechnol. 26, 105-111.
70. EYAL, A. M., BRESSLER, E. (1993), Industrial separation of carboxylic and amino acids by liquid membranes: applicability, process considerations, and potential advantages, Biotechnol. Bioeng. 41, 287-295 (mini-review).
71. FEIR, H. A., SUZUKI, I. (1969), Pyruvate carboxylase from Aspergillus niger: kinetic study of a bio-tin-containing carboxylase, Can. J. Biochem. 47, 697-710.
72. FELMAN, S. W., PATEL, C, PATWARDHAN, B. H., SOLOW, D. J. (1994), U.S. Patent 5,352.825
73. FELMAN, S. W., PATEL, C, PATWARDHAN, B. H., SOLOW, D. J. (1995a), Eur. Pat. Appl. 633239.
74. FELMAN, S. W., PATEL, G, PATWARDHAN, B. H., SOLOW, D. J. (1995b), Eur. Pat. Appl. 633240.
75. FERENCZY, L. (1984), in: Cell Fusion: Gene Transfer and Transformation (BEERS, R. F., Jr., BAS-SETT, E. G., Eds.), pp. 145-169. New York: Raven Press.
76. FERENCZY, L., FARKAS, G. L. (Eds.) (1980), Advances in Protoplast Research, Budapest: Akad-emiai Kiado; Oxford: Pergamon Press.
77. FERENCZY, L., KEVEI, F., SZEGEDI, M. (1975a), High-frequency fusion of fungal protoplasts, Ex-perientia 31, 1028-1029.
78. FERENCZY, L., KEVEI, F., SZEGEDI, M. (1975b), Fusion of fungal protoplasts, in: Abstracts, 4th Int. Symp. Yeasts and Other Protoplasts, Nottingham, p. 29.
79. FERNBACH, A., YUILL, J. L., Rowntree & Co, Ltd. (1927), Brit. Patents 266414; 266415.
80. FERNBACH, A., YUILL, J. L., MCLELLAN, B. G., Rowntree & Co. (1932), Ger. Patent 461356.
81. FERRARA, L., DE CESARI, L., SALVINI, E. (1977), n-Paraffins: a new feedstock for the production of citric acid and its derivatives, Chim. Ind. 59, 202-206.
82. FIEDUREK, J., SZCZODRAK, J., ILCZUK, Z. (1988), Citric acid synthesis by Aspergillus niger mutants resistant to 2-desoxyglucose, Acta Microbiol. Pol. 36, 303-307.
83. FODOR, L. M., COBB, R. L. (1986), U.S. Patent 4601340.
84. FOERSTER, H. J., POTENCSIK, I. (1971), Ger. Patent Appl. 2013756.
85. Food and Drug Administration, Washington (1975), Food additives. Solvent extraction process for citric acid, Fed. Regist. 40, 49080-49 082.
86. FOSTER, J. W. (1949), Chemical Activities of Fungi. New York: Academic Press.
87. FOSTER, J. W., DAVIS, H. (1949), Bull. Torrey CI. 50, 511-516.
88. FUJII, N., YASUDA, K., SAKAKIBARA, M. (1994), Effect of volume ratio of cellulose carriers and time interval of repeated batch culture on citric acid productivity by immobilized Aspergillus niger, J. Ferment. Bioeng. 78, 389-393.
89. FUKUDA, H., SUZUKI, T., AKIYAMA, S., SUMINO, Y. (1982), Ger. Patent 2108094 02.
90. FUKUI, S., TANAKA, A. (1980), Production of useful compounds from alkane media in Japan, Adv. Biochem. Eng. 17, 1-35.
91. GADAU, M. E., LINGG, A. J. (1992), Protoplast fusion in fungi, in: Handbook of Applied Mycology, Vol. 4. (ARORA, D. K., ELANDER, R. P., MUKERJI, K. G., Eds.), pp. 101-128. New York: Marcel Dekker.
92. GADEN, E. L. (1955), Fermentation kinetics and productivity, Chem. Ind. (N.Y.) 12, 154-159.
93. GARDNER, W. H. (1966), Food acidulants, New York: Allied Chemical Corporation.
94. GARDNER, J. F., JAMES, L. V., RUBBO, S. D. (1956), Production of citric acid by mutants of Aspergillus niger, J. Gen. Microbiol. 14, 228-237.
95. GARG, K., SHARMA, C. B. (1992), Repeated batch production of citric acid from sugar cane molasses using recycled solid-state surface culture of Aspergillus niger, J. Gen. Appl. Microbiol. 38, 605-615.
96. GOLDBERG, I., PELEG, Y., ROKEM, J. S. (1991), Citric, fumaric, and malic acids, in: Biotechnology and Food Ingredients (GOLDBERG, I., WILLIAMS, R. A., Eds.), pp. 349-374. New York: Van Nostrand Reinhold.
97. HABISON, A., KUBICEK, C. P., ROEHR, M. (1979), Phosphofructokinase as a regulatory enzyme in citric acid producing Aspergillus niger, FEMS Microbiol. Lett. 5, 39-41.
98. HABISON, A., KUBICEK, C. P., ROEHR, M. (1983), Partial purification and regulatory properties of phosphofructokinase from Aspergillus niger, Biochem. J. 209, 669-676.
99. HANG, Y. D. (1988), U.S. Patent 4, 791.058 A.
100. HANG, Y. D., WOODAMS, E. E. (1987), Apple pomace: a potential substrate for citric acid production by Aspergills niger, Biotechnol. Lett. 9, 183-186.
101. HARMSEN, H. J. M., KUBICEK-PRANZ, E. M., ROEHR, M., VISSER, J., KUBICEK, C. P. (1992), Regulation of 6-phosphofructo-2-kinase from the citric acid accumulating fungus Aspergillus niger, Appl. Microbiol. Biotechnol. 37, 784-788.
102. HARTL, J., MARR, R. (1993), Extraction processes for bioproduct separation, Sep. Sei. Technol. 28, 805-819.
103. HEINISCH, J. (1986), Isolation and characterization of the two structural genes coding for phosphofructokinase in yeast, Mol. Gen. Genet. 202, 75-83.
104. HEINRICH, M., REHM, H. J. (1982), Formation of gluconic acid at low pH-values by free and immobilized Aspergillus niger cells during citric acid fermentation, Eur. J. Appl. Microbiol. Biotechnol. 15, 88-92.
105. HELLMIG, R., BEHRENS, U., BOEHM, R., GOEBEL, R., STRIEGLER, J., WEISSBRODT, E. (1983), Ger. Patent (GDR) 203533.
106. HIRASHIMA, T., IKUTA, N., KUROHARA, T. (1985), Jpn. Patent 60193942.
107. HOCKERTZ, S., SCHMID, J., AULING, G. (1988), A specific transport system for manganese in the filamentous fungus Aspergillus niger, J. Gen. Microbiol. 133, 2515-3519.
108. HOCKERTZ, S., PLÖNZIG, J., AULING, G. (1989), Impairment of DNA formation is an early event in Aspergillus niger under manganese starvation, Appl. Microbiol. Biotechnol. 25, 590-593.
109. HONECKER, S., BlSPING, B., YANG, Z., REHM, H. J. (1989), Influence of sucrose concentration and phosphate limitation on citric acid production by immobilized cells of Aspergillus niger, Appl. Microbiol. Biotechnol. 31, 17-24.
110. HORITSU, H., ADACHI, S., TAKAHASHI, Y., KA-WAI, K., KAWANO, Y. (1985), Production of citric acid by Aspergillus niger immobilized in Polyacrylamide gels, Appl. Microbiol. Biotechnol. 22, 8-12.
111. HOSSAIN, M., BROOKS, J. D., MADDOX, I. S. (1983), Production of citric acid from whey permeate by fermentation using Aspergillus niger, N. Z. J. Dairy Sei. Technol. 18, 161-168.
112. HOSSAIN, M., BROOKS, J. D., MADDOX, I. S. (1984), The effect of sugar source on citric acid production by Aspergillus niger, Appl. Microbiol. Biotechnol. 19, 383-391.
113. HUANG, Y., ZHAO, Y., SU, S., GAO, L., ZHANG, W. (1990), Comprehensive utilization of calcium sulfate waste residues from production of citric acid, Huaxue Shijie 31, 570-571.
114. HUSTEDE, H., RUDY, H. (1976), U.S. Patent 3941656.
115. IIZUKA, H., SHIMIZU, J., ISHII, K., NAKAJIMA, Y. (1969), Ger. Patent 1812710.
116. ILCZUK, Z. (1968), Genetics of citric acid producing strains of Aspergillus niger, I. Citric acid synthesis by morphological mutants induced with UV, Acta Microbiol. Pol. 17, 331-336.
117. ILCZUK, Z. (1970), Genetik der Citronensäure erzeugenden Stämme von Aspergillus niger. 2. Ci-tronensäuresynthese von mittels UV-Strahlen induzierten auxotrophen Mutanten von A. niger, Die Nahrung 14, 97-105.
118. ILCZUK, Z. (1971a), Genetik der Citronensäure erzeugenden Stämme von Aspergillus niger. 3. Ci-tronensäuresynthese durch erzwungene Hetero-karyen zwischen auxotrophen Mutanten von A. niger, Die Nahrung 15, 251-262.
119. ILCZUK, Z. (1971b), Genetik der Citronensäure erzeugenden Stämme von Aspergillus niger. 4. Ci-tronensäuresynthese durch heterozygotische Di-ploide von A. niger, Die Nahrung 15, 381-388.
120. IMI (TAMI) Inst. f. Research & Development, Haifa (1972), Isr. Patent 39710.
121. JAKLITSCH, W. M., KUBICEK, C. P., SCRUTTON, M. C. (1991), Intracellular location of enzymes involved in citrate accumulation in Aspergillus niger, Can. J. Microbiol. 37, 823-827.
122. JAMES, L. V., RUBBO, J. F., GARDNER, S. D. (1956), Isolation of high acid-yielding mutants of Aspergillus niger by a paper culture selection technique, J. Gen. Microbiol. 14, 223-227.
123. JIANG, Y. M., SU, Y. F. (1987), Study on synthetic methods of trialkylphosphine oxides and their extraction behavior toward some acids, Sep. Sci. Technol. 22, 315-323.
124. JIN, Q., LAN, Q., ZHU, B. (1993), The breeding of thermotolerant citric acid overproducing strains from Aspergillus niger, Weishengwu Xuebao 33, 204-209.
125. JOHNSON, M. J. (1954), in: Industrial Fermentations Vol. 1 (UNDERKOFLER, L. A., HICKEY, R. J., Eds.), pp. 42(M45. New York: Chem. Pubi. Co.
126. KACZMAROWICZ, G. (1987), Pol. Patent 136823 Bl.
127. KAISER, M., NOELTE, D., WEIZENBECK, E., MAY, U., KREIBICH, G., BEHRENS, U., STOTTMEI-STER, U., WEISSBRODT, E., SCHMIDT, J., et al. (1990), Ger. Patent (GDR) 275480.
128. KAROW, E. O., WAKSMAN, S. A. (1947), Production of citric acid in submerged culture, Ind. Eng. Chem. 39, 821-825.
129. KAWANO, T. (1987), Jpn. Patent 62062896.
130. KHAN, A. H., GHOSE, T. K. (1973), Kinetics of citric acid fermentation by Aspergillus niger, J. Ferment. Technol. 51, 734-741.
131. KINOSHITA S., TANAKA, K., AKITA, S. (1961a), U.S. Patent 2973303.
132. KINOSHITA, S., TERADA, O., OISHI, K. (1961b), U.S. Patent 2993838.
133. KIRIMURA, K., YAGUCHI, T., USAMI, S. (1986), In-traspecific protoplast fusion of citric acid-producing strains of Aspergillus niger, J. Ferment. Technol. 64, 473-479.
134. KIRIMURA, K., HIROWATARI, Y., USAMI, S. (1987), Alterations of respiratory systems in Aspergillus niger under the conditions of citric acid fermentation, Agric. Biol. Chem. 51, 1299-1303.
135. KIRIMURA, K., NAKAJIMA, I., LEE, S. P., KA-WABE, S., USAMI, S. (1988a), Citric acid production by the diploid strains of Aspergillus niger obtained by protoplast fusion, Appl. Microbiol. Biotechnol. 27, 504-506.
136. KIRIMURA, K., LEE, S. P., NAKAJIMA, I., KA-WABE, S., USAMI, S. (1988b), Improvement in citric acid production by haploidization of Aspergillus niger diploid strains, J. Ferment. Technol. 66, 375-382.
137. KIRIMURA, K., SARANGBIN, S., RUGSASEEL, S., USAMI, S. (1992), Citric acid production by 2-desoxyglucose resistant mutant strains of Aspergillus niger, Appl. Microbiol. Biotechnol. 36, 573-577.
138. KOEPP, H. J., SCHOBERTH, S. M., SAHM, H. (1985), Anaerobic treatment of wastewater from citric acid production, Conserv. Recycl. 8, 211-219.
139. KOEPP-BANK, H. J. (1986), Microbial anaerobic treatment of wastewater from citric acid production, Ber. Kernforschungsanlage Jülich, 153 p.
140. KRETZSCHMANN, G., HÜTT, G., SCHOLZ, D. (1975), Ger. Patent 2331670.
141. KRISTIANSEN, B., CHARLEY, R. (1981), Adv. Bio-technol. (Proc. 6th Int. Ferm. Symp.) Vol. 1, pp. 221-227 (MOO-YOUNG, M., ROBINSON, C. W., VEZINA, C, Eds.). Toronto: Pergamon.
142. KRISTIANSEN, B., SINCLAIR, C. G. (1979), Production of citric acid continuous culture, Biotechnol. Bioeng. 21, 297-315.
143. KROISS, H. (1987), Aerobic and anaerobic treatment of industrial wastewater, Chem.-Tech. 16, 98, 100.
144. KUBICEK, C. P. (1988a), Regulatory aspects of the tricarboxylic acid cycle in filamentous fungi-a review, Trans. Br. Mycol. Soc. 90, 339-349.
145. KUBICEK, C. P. (1988b), The role of the citric acid cycle in fungal organic acid fermentations, Bio-chem. Soc. Symp. 54, 113-126.
146. KUBICEK, C. P., ROEHR, M. (1985), Aconitase and citric acid fermentation by Aspergillus niger, Appl. Environ. Microbiol. 50, 1336-1338.
147. KUBICEK, C. P., ROEHR, M. (1986), Citric Acid Fermentation, CRC Crit. Rev. Biotechnol. 3, 331-373.
148. KUBICEK, C. P., HAMPEL, W. A., ROEHR, M. (1979a), Manganese deficiency leads to elevated amino acid pools in citric acid producing Aspergillus niger, Arch. Microbiol. 123, 73-79.
149. KUBICEK, C. P., ZEHENTGRUBER, O., ROEHR, M. (1979b), An indirect method for studying the fine control of citric acid formation by Aspergillus niger, Biotechnol. Lett. 1, 57-62.
150. KUBICEK, C. P., ZEHENTGRUBER, O., EL-KALAK, H., ROEHR, M. (1980), Regulation of citric acid production by oxygen: effect of dissolved oxygen tension on adenylate levels and respiration in Aspergillus niger, Eur. J. Appl. Microbiol. Biotechnol. 9, 101-116.
151. KUBICEK, C. P., SCHREFERL-KUNAR, G., WOEH-RER, W., ROEHR, M. (1988), Evidence for a cytoplasmic pathway of oxalate biosynthesis in Aspergillus niger, Appl. Environ. Microbiol. 54, 633-637.
152. KUBICEK, C. P., WITTEVEEN, C. F. B., VISSER, J. (1994), Regulation of organic acid production by Aspergilli. In: The Genus Aspergillus. From Taxonomy and Genetics to Industrial Application (POWELL, K. A., RENWICK, A., PEBERDY, J. F., Eds.), pp 135-144. New York, London: Plenum Press.
153. KUBICEK-PRANZ, E. M., MOZELT, M., ROEHR, M., KUBICEK, C. P. (1990), Changes in the concentration of fructose-2,6-bisphosphate in Aspergillus niger during stimulation of acidogenesis by elevated sucrose concentrations, Biochim. Bio-phys. Acta 1033, 250-255.
154. KULPRATHIPANJA, S. (1988), U.S. Patent 4720579.
155. KULPRATHIPANJA, S. (1989), Eur. Patent 324210.
156. KULPRATHIPANJA, S., OROSKAR, A. R. (1991), U.S. Patent 5068419.
157. KULPRATHIPANJA, S., STRONG, S. A. (1990), U.S. Patent 4924027.
158. KULPRATHIPANJA, S., OROSKAR, A. R., PRIEG-NITZ, J. W. (1989), U.S. Patent 4851573.
159. LAKSHMINARAYANA, K., CHAUDHARY, K., ETHI-RAJ, S., TAURO, P. (1975), Solid state fermentation method for citric acid production using sugar cane bagasse, Biotechnol. Bioeng. 17, 291-293.
160. LAWRENCE, A. A. (1974), Food Acid Manufacture. Recent Developments. Park Ridge, NJ: Noyes Data Corporation.
161. LEE, Y. H., LEE, C. W., CHANG, H. N. (1989), Citric acid production by Aspergillus niger immobilized on polyurethane foam, Appl. Microbiol. Biotechnol. 30, 141-143.
162. LEGISA, M., BENCINA, M. (1994), Evidence for the activation of 6-phosphofructo-l-kinase by cAMP-dependent protein kinase in Aspergillus niger, FEMS Microbiol. Lett. 118, 327-334.
163. LEGISA, M. KIDRIC, J. (1989), Initiation of citric acid accumulation in the early stages of Aspergillus niger growth, Appl. Microbiol. Biotechnol. 31, 453-157.
164. LEGISA, M. MATTEY, M. (1986), Glycerol as an initiator of citric acid accumulation in Aspergillus niger, Enzyme Microb. Technol. 8, 607-609.
165. LEHNHARDT, W. F., SCHANEFELT, R. V., NAPIER, L. L. (1995), World Patent 9503268.
166. LEOPOLD, H. (1958), Versuche zur Erhöhung der Citronensäureproduktion eines aktiven Stammes von Aspergillus niger, Die Nahrung 2, HOISS.
167. LEOPOLD, H., VALTR, Z. (1964), Zur Wirkung des Kaliumferrocyanids bei der Herstellung von Melasselösungen für die Citronensäuregärung, Die Nahrung 8, 37-48.
168. LEOPOLD, H., VALTR, Z. (1970), Zur Frage der Qualitätsverbesserung der Konidien von Aspergillus w'ger-Stämmen bei der Citronensäuregärung, Z. Allg. Mikrobiol. 10, 121-127.
169. LOBO, Z., MAITRA, P. K. (1977), Genetics of yeast hexokinase, Genetics 86, 727-744.
170. LOCKWOOD, L. B. (1979), Citric acid, in: Microbial Technology, Vol. 1 (PEPPLER, H. J., Ed.), 2nd Edn., pp. 356-387. New York: Academic Press.
171. LuEDEKiNG, R., PIRET, E. L. (1959), A kinetic study of the lactic acid fermentation. Batch process at controlled pH, J. Biochem. Microbiol. Technol. Eng. 1, 393-412.
172. MA, H., KUBICEK, C. P., ROEHR, M. (1985), Metabolic effects of manganese deficiency in Aspergillus niger: evidence for increased protein degradation, Arch. Microbiol. 141, 266-268.
173. MADDOX, I. S., ARCHER, R. H. (1984), Food Technol. N. Z. 19, 24-26.
174. MARCHAL, R., CHAUDE, O., METCHE, M. (1977a), Production of citric acid from n-paraffins by Sac-charomycopsis lipolytics, kinetics and balance of the fermentation, Eur. J. Appl. Microbiol. 4, 111-123.
175. MARCHAL, R., VANDECASTEELE, J. P., METCHE, M. (1977b), Regulation of the central metabolism in relation to citric acid production in Sac-charomycopsis lipolytica, Arch. Microbiol. 113, 99-104.
176. MARIER, J. R., CLARK, D. S. (1960), An improved colorimetrie method for determining ferrocya-nide ion, and its application to molasses, Analyst 85, 574-578.
177. MARTIN, S. M. (1955), Effect of ferrocyanide on growth and acid production of Aspergillus niger, Can. J. Microbiol. 1, 644-652.
178. MARTIN, S. M. WATERS, W. R. (1952), Production of citric acid by submerged fermentation, Ind. Eng. Chem. 44, 2229-2239.
179. MARTINELLI, S. D., KINGHORN, J. R. (Eds.) (1994), Aspergillus: 50 Years on. Amsterdam, London, New York, Tokyo: Elsevier.
180. MARTINKOVÂ, L., MUSILKOVÂ, M., UJCOVÄ, E., MACHEK, F., SEICHERT, L. (1990), Protoplast fusion in Aspergillus niger strains accumulating citric acid, Folia Microbiol. (Prague) 35, 143-148.
181. MATSUDA, K., YOSHIDA, J. (1991), Jpn. Patent 03183487.
182. MATSUMOTO, T., ICHIKAWA, Y. (1986), Jpn. Patent 61219391.
183. MATSUMOTO, T., FUJIMAKI, A., NAGATA, T. (1983), U.S. Patent 4411998.
184. MATTEY, M. (1977), Citrate regulation of citric acid production in Aspergillus niger, FEMS Microbiol. Lett. 2, 71-74.
185. MATTEY, M., LEGISA, M., LOWE, S. (1988), Effect of lectins and inhibitors on membrane transport in Aspergillus niger, Biochem. Soc. Trans. 16, 969-970.
186. MCQUIGG, D., MARSTON, C. K., FITZPATRICK, G., CROWE, E., VORHIES, S. (1992), World Patent 9216490.
187. MEIXNER-MONORI, B., KUBICEK, C P., HABISON, A., KUBICEK-PRANZ, E. M., ROEHR, M. (1985), Presence and regulation of α-ketoglutarate dehydrogenase multienzyme complex in the filamentous fungus Aspergillus niger, J. Bacteriol. 161, 265-271.
188. MESSING, T., SCHMITZ, R. (1976), Citronensäure aus Saccharose-ein technisch genutzter mikro-bieller Prozeß auf der Basis von Melasse, Chem. Exp. Didakt. 2, 309-316.
189. MESSING, T., WAMSER, K. (1975), Ger. Patent Appl. 2543307.
190. MEZZADROLI, G. (1938), French Patent 833631.
191. MIALL, L. M., PARKER, G. F. (1975), Ger. Patent 2429224.
192. Miles Laboratories, Inc. (1961), Brit. Patent 905817.
193. MILSOM, P. E. (1987), Organic acids by fermentation, especially citric acid, in: Food Biotechnology, Vol. 1 (KING, R. D., CHEETHAM, P. S. J., Eds.), pp. 273-307. London: Elsevier.
194. MILSOM, P. E., MEERS, J. L. (1985), Citric acid, in: Comprehensive Biotechnology, Vol. 3 (BLANCH, H. W., DREW, S., WANG, D. I. C, Eds.), pp. 665-680. Oxford: Pergamon Press.
195. Montan-und Industrialwerke (vorm. J. D. Starck) (1924), Ger. Patent 461356.
196. Montan-und Industrialwerke (vorm. J. D. Starck) (1933), Ger. Patent 578820.
197. MORESI, M., CIMARELLI, D., GASPARRINI, G., LIUZZO, G., MARINELLI, R. (1980), Kinetics of citric acid fermentation from n-paraffins by yeasts, J. Chem. Tech. Biotechnol. 30, 266-277.
198. MOYER, A. J. (1953a), Effect of alcohols on the mycological production of citric acid in surface and submerged culture. 1. Nature of the alcohol effect, Appl. Microbiol. 1, 1-7.
199. MOYER, A. J. (1953b), Effect of alcohols on the mycological production of citric acid in surface and submerged culture. 2. Fermentation of crude carbohydrates, Appl. Microbiol. 1, 8-13.
200. NEVALEINEN, H., PENTTILÄ, M., (Eds.) (1989), Molecular Biology of Filamentous Fungi, Foundation for Biotechnical and Industrial Fermentation Research, Vol. 6. Helsinki: Foundation for Biotechnical and Industrial Fermentation Research.
201. NOYES, R. (1969), Citric Acid Production Processes. Park Ridge, NJ: Noyes Development Corporation.
202. OGAWA, K, TSUCHIMOCHI, M., TANIGUCHI, K, NAKATSU, S. (1989), Interspecific hybridization of Aspergillus usamii mut. shirousamii and Aspergillus niger by protoplast fusion, Agric. Biol. Chem. 53, 2873-2880.
203. OSMANI, S. A., SCRUTTON, M. C. (1983), The subcellular location of pyruvatecarboxylase and some other enzymes in Aspergillus nidulans, Eur. J. Biochem. 133, 551-560.
204. PEBERDY, J. F. (1987), Developments in protoplast fusion in fungi, Microbiol. Sci. 4, 108-114.
205. PEBERDY, J. F., FERENCZY, L. (Eds.) (1985), Fungal Protoplasts: Applications in Biochemistry and Genetics. New York: Marcel Dekker.
206. PELECHOVA, J., PETROVA, L., UJCOVA, E., MAR-TINKOVA, L. (1990), Selection of a hyperproduc-ing strain of Aspergillus niger for biosynthesis of citric acid on unusual carbon substrates, Folia Microbiol. (Prague) 35, 138-142.
207. PERLMAN, D. (1949), Mycological production of citric acid-the submerged culture method, Econ. Bot. 3, 360-374.
208. PERLMAN, D., SIH, C. J. (1960), Fungal synthesis of citric, fumaric, and itaconic acid, Progr. Ind. Microbiol. 2, 167-194.
209. PERLMAN, D., KITA, D. A., PETERSON, W. H. (1945), Production of citric acid from cane molasses, Arch. Biochem. Biophys. 11, 123-129.
210. PERQUIN, L. H. C. (1938), Bijdrage tot de kennis der oxydatieve dissimilatie van Aspergillus niger van tieghem, Dissertation, Technical University, Delft.
211. POELLMANN, H., MICHAUX, M., NELSON, E. B. (1990), Study on the influence of citric acid on retardation and formation of new hydrates in cement, Proc. 12th Int. Conf. Cem. Microsc, pp. 303-322.
212. PONTECORVO, G., ROPER, J. A., FORBES, E. (1953), Genetic recombination without sexual reproduction in Aspergillus niger, J. Gen. Microbiol. 8, 198-210.
213. POWELL, C. (1973), Citric acid process is safeguarded by complex control system, Proc Eng., January, 87-89.
214. POWELL, K. A., RENWICK, A., PEBERDY, J. (Eds.) (1994), The Genus Aspergillus from Taxonomy and Genetics to Industrial Application. FEMS Symposium No. 69. New York: Plenum Publishing Corp.
215. PRESCOTT, S. C, DUNN, C. G. (1959), Industrial Microbiology, 3rd Edn., pp. 533-618; 642-646. New York: McGraw Hill.
216. PRIOR, C, MAMESSIER, P., FUKUHARA, H., CHEN, X. J., WESOLOWSKI-LOUVEL, M. (1993), The hexokinase gene is required for transcriptional regulation of the glucose transporter gene RAGI in Kluyveromyces lactis, Mol. Cell. Biol. 13, 3882-3889.
217. PROCHAZKA, J., HEYBERGER, A., BIZEK, V., KOUSOVA, M., VOLAUFOVA, E. (1994), Amine extraction of hydroxycarboxylic acids. 2. Comparison of equilibria for lactic, malic, and citric acids, Ind. Eng. Chem. Res. 33, 1565-1573.
218. PUROHIT, H. J., RATLEDGE, C (1988), Mitochondrial location of pyruvate carboxylase in Aspergillus niger, FEMS Microbiol. Lett. 55, 129-132.
219. QUILICO, A., PANIZZI, L., VISCONTI, N. (1949), R. C. Accad. Lincei 50, 511-516.
220. RAPER, K. B., THOM, C. (1949), A Manual of the Penicillia. Baltimore, MD: Williams and Wil-kins.
221. RIEGER, M., KIOUSTELIDIS, J. (1975), Ger. Patent 2355059.
222. RIPPEL-BALDES, A. (1940), Über die Verbreitung von Aspergillus niger, insbesondere in Deutschland, Arch. Mikrobiol. 11, 1-32.
223. ROEHR, M., KUBICEK, C. P. (1981), Regulatory aspects of citric acid fermentation by Aspergillus niger, Proc. Biochem. 16, 34-38.
224. ROEHR, M., STADLER, P. J., SALZBRUNN, W., KUBICEK, C. P. (1979), An improved method for characterization of citrate production by Aspergillus niger, Biotechnol. Lett. 1, 281-286.
225. ROEHR, M., ZEHENTGRUBER, O., KUBICEK, C. P. (1981), Kinetics of biomass formation and citric acid production by Aspergillus niger on pilot plant scale, Biotechnol. Bioeng. 23, 2433-2445.
226. ROEHR, M., KUBICEK, C. P., KOMINEK, J. (1983), Citric acid, in: Biotechnlogy, 1st Edn., Vol. 3 (REHM, H.-J., REED, G., Eds.), pp. 419-154. Weinheim: Verlag Chemie.
227. ROEHR, M., KUBICEK, C. P., KOMINEK, J. (1992), Industrial acids and other small molecules, in: Aspergillus: Biology and Industrial Applications (BENNETT, J. W., KLICH, M. A., Eds.), pp. 91-131. Stoneham: Butterworth-Heinemann.
228. ROSENBAUM, J. B., MCKINNEY, W. A., BEARD, H. R., CROCKER, L., NISSEN, W. I. (1973), Sulfur dioxide emission control by hydrogen sulfide reaction in aqueous solution. Report of Investigations 7774, U.S. Department of the Interior, Bureau of Mines, Washington, DC: U.S. Government Printing Office.
229. RUDY, H. (1967), Fruchtsäuren. Heidelberg: Hü-thig-Verlag.
230. RUGSASEEL, S., KIRIMURA, K., USAMI, S. (1993), Selection of mutants of Aspergillus niger showing enhanced productivity of citric acid from starch in shaking culture, J. Ferment. Bioeng. 75, 226-228.
231. SALZBRUNN, W., KOMINEK, J., ROEHR, M. (1989), Eur. Patent 221880 Bl.
232. SALZBRUNN, W., KOMINEK, J., ROEHR, M. (1991), Eur. Patent 221- Bl.
233. SAMSON, R. A. (1992), Current taxonomic schemes of the genus Aspergillus and its teleomorphs, in: Aspergillus: Biology and Industrial Applications (BENNETT, J. W., KLICH, M. A., Eds.), pp. 355-390. Stoneham: Butterworth-Heinemann.
234. SATAVA, V., VEPREK, O., SKVARA, F. (1977), Possibilities of utilizing waste gypsum from the chemical industry, Sb. Vys. Sk. Chem. Technol. Praze, Chem. Technol. Silik. L7, 101-148.
235. SCHELLENBERGER, A., DOEPFER, K. P., FOER-STER, M., HOFFMANN, T., STEINMETZER, K., SCHAAF, R., MUELLER, U., KLUGE, H. (1991), Ger. Patent (GDR) 285792.
236. SCHMIDT, M., WALLRATH, J., DÖRNER, A., WEISS, H. (1992), Disturbed assembly of the respiratory chain NADH:ubiquinone reductase (complex I), in citric acid accumulating Aspergillus niger strain B60, Appl. Microbiol. Biotechnol. 36, 667-672.
237. SCHMITZ, R. (1976), Modifiziertes Kammersystem für die Fermentation kohlenhydrathaltiger Lösungen zu Citronensäure nach dem Oberflächenverfahren, Chem.-Tech. 5, 271-272.
238. SCHMITZ, R. (1977), Problemlösungen bei der Aufarbeitung von Fermentationslösungen zu reiner Citronensäure, Chem.-Tech. 6, 255-259.
239. SCHMITZ, R., WÖHLK, W. (1980), Die Fällungskristallisation am Beispiel der Tricalciumcitrat-Fäl-lung im Aufbereitungsprozeß der Citronensäu-reherstellung, Chemie-Technik 9, 345-348.
240. SCHREFERL, G., KUBICEK, C. P., ROEHR, M. (1986), Inhibition of citric acid accumulation by manganese ions in Aspergillus niger mutants with reduced citrate control of phosphofructo-kinase, J. Bacteriol. 165, 1019-1022.
241. SCHREFERL-KUNAR, G., GROTZ, M., ROEHR, M., KUBICEK, C. P. (1989), Increased citric acid production by mutants of Aspergillus niger with increased glycolytic capacity, FEMS Microbiol. Lett. 59, 297-300.
242. SCHULZ, G. (1959), Ger. Patent 1055483.
243. SCHULZ, G. (1963), U.S. Patent 3086928.
244. SCHULZ, G., RAUCH, J. (1975), Citronensäure, in: Ulimanns Encyklopädie der technischen Chemie, 4th Edn., Vol. 9 (BARTHOLOME, E., BIEKERT, E., HELLMANN, H., LEY, H., WEIGERT, M., Eds.), pp. 624-636. Weinheim: Verlag Chemie.
245. SCHWEIGER, L. B. (1959), Swiss Patent 342191.
246. SCHWEIGER, L. B. (1961), U.S. Patent 2970084.
247. SCHWEIGER, L. B. (1965), Ger. Paient 1198311.
248. SCHWEIGER, L. B., SNELL, R. L. (1949), U.S. Patent 2476159.
249. SEEHAUS, C, PILZ, F., AULING, G. (1990), High affinity manganese transport system by filamentous fungi-e.g. Aspergillus nidulans, Aspergillus niger; potential application to e.g. citric acid production, Zbl. Bakt. 272, 357-358 (abstract).
250. SHANKARANAND, V. S., LONSANE, B. K. (1994), Idiosyncrasies of solid-state fermentation systems in the biosynthesis of metabolites by some bacterial and fungal cultures, Proc. Biochem. 29, 29-37.
251. SHIMIZU, J., ISHII, K., NAKAJIMA, Y., IIZUKA, H. (1970), Jpn. Patent 45039035.
252. SHISHIKURA, A. (1944), Jpn. Patent 06048979.
253. SHU, P. (1947), Ph. D. Thesis, University of Wisconsin, Madison.
254. SHU, P., JOHNSON, M. J. (1947), Effect of the composition of the sporulation medium on citric acid production by Aspergillus niger in submerged culture, J. Bacteriol. 54, 161-167.
255. SHU, P., JOHNSON, M. J. (1948a), Citric acid production by submerged fermentation with Aspergillus niger, Ind. Eng. Chem. 40, 1202-1205.
256. SHU, P., JOHNSON, M. J. (1948b), The interdependence of medium constituents in citric acid production by submerged fermentation, J. Bacteriol. 56, 577-585.
257. SIEBERT, D., HUSTEDE, H. (1982), Citronensäure-Fermentation-biotechnologische Probleme und Möglichkeiten der Rechnersteuerung, Chem.-Ing.-Tech. 54, 659-669.
258. SIMONYAN, M. G., RESHETNIKOVA, I. A., GOR-LENKO, M. V. (1988), Metabolite synthesis by Aspergillus niger v. Tiegh. after its storage in different conditions during growth on polymers, Mikol. Fitopatol. 22, 240-243 (from CA 109:146227).
259. SMITH, J. E. (Ed.) (1994), Aspergillus. Biotechnology Handbooks, Vol. 7. New York: Plenum Publishing Corporation.
260. SMITH, J. E., No, W. S. (1972), Fluorometric determination of glycolytic intermediates and adenylates during sequential changes in replacement culture of Aspergillus niger, Can. J. Microbiol. 18, 1657-1664.
261. SNELL, R. L., SCHWEIGER, L. B. (1949), U.S. Patent 2492667.
262. SOMKUTI, G. A., BENCIVENGO, M. M. (1981), Citric acid fermentation in whey permeate, Dev. Ind. Microbiol. 22, 557-563.
263. STEEL, R., LENTZ, C. P., MARTIN, S. M. (1955), Submerged citric acid fermentation of sugar beet molasses: increase in scale, Can. J. Microbiol. 1, 299-311.
264. STEINBOCK, F., CHOOJUN, S., HELD, I., ROEHR, M., KUBICEK, C. P. (1993), Characterization and regulatory properties of a single hexokinase from the citric acid accumulating fungus Aspergillus niger, Biochim. Biophys. Acta 1200, 215-223.
265. STOTTMEISTER, U., BEHRENS, U., WEISSBRODT, E., BARTH, G., FRANKE-RINKER, D., SCHULZE, E. (1982), Use of paraffins and other noncarbo-hydrate carbon sources for microbial citric acid synthesis, Z. Allg. Mikrobiol. 22, 399-424.
266. STOTTMEISTER, U., BEHRENS, U., WEISSBRODT, E., WEIZENBECK, E., DUERESCH, R., KAISER, M., NOELTE, D., RlCHTER, H. P., SCHMIDT, J., et al. (1986), Ger. Patent (GDR) 239610.
267. SVARDAL, K., GOETZENDORFER, K., NOWAK, O., KROISS, H. (1993), Treatment of citric acid wastewater for high quality effluent on the anaerobic-aerobic route, Water Sci. Technol. 28, 177-186.
268. SWARTHOUT, E. J. (1966), U.S. Patent 3285831. SzUcs, J. (1925), Austrian Patent 101009. SzUcs, J. (1944), U.S. Patent 2353771.
269. TABUCHI, T., ABE, M. (1968), Jpn. Patent 43020707.
270. TABUCHI, T., HARA, S. (1973), Organic acid fermentation by yeasts. VII. Conversion of citrate fermentation to polyol fermentation in Candida lipolytica, J. Agr. Chem. Soc. Jpn. 47, 485-490.
271. TABUCHI, T., TANAKA, M., ABE, M. (1969), Production of citric acid by Candida lipolytica No. 228, J. Agr. Chem. Soc. Jpn. 43, 154-158.
272. TABUCHI, T., TAHARA, Y., TANAKA, M., YANAG-IUCHI, S. (1973), Organic acid fermentation by yeasts. IX. Preliminary experiments on the mechanism of citrate fermentation in yeasts. / Agr. Chem. Soc. Jpn. 47, 617-622.
273. TANAKA, K., KIMURA, K, YAMAGUCHI, K. (1968), Jpn. Patent 43013677'.
274. THOM, C, CURRIE, J. N. (1916), Aspergillus niger group, J. Agric. Res. VII, 1-15.
275. TORRES, N. V. (1994a), Modelling approach to control carbohydrate metabolism during citric acid accumulation by Aspergillus niger: I: Model definition and stability of the steady state, Bio-technol. Bioeng., 44, 104-111.
276. TORRES, N. V. (1994b), Modelling approach to control carbohydrate metabolism during citric acid accumulation by Aspergillus niger: II. Sensitivity analysis, Biotechnol. Bioeng. 44, 112-118.
277. TRONDHEIM, O. E. (1975), U.S. Patent 3886069.
278. TSUDA, M., FUJIWARA, Y., SHIRAISHI, T. (1975), U.S. Patent 3904684.
279. TVEIT, M. T. (1963), U.S. Patent 3105015.
280. UCHIO, R., KIYOMI, N., TAKINAMI, K. (1979), Jpn. Patent 54023193.
281. UNROD, V. I., DEJKALO, A. A., LYZHENKOVA, I. I., FEDORYAK, V. N. (1992), from: Izobreteniya 1992, (13), 86-87, S.U. Patent 1724618 Al.
282. USAMI, S. FUKUTOMI, N. (1977), Citric acid production by a solid fermentation method using sugar cane bagasse and concentrated liquor of pineapple waste, Hakko Kogaku Kaishi 55, 44-50.
283. VAIJA, J., LINKO, P. (1986), Continuous citric acid production by immobilized Aspergillus niger. Reactor performance and fermentation kinetics, / Mol. Catal. 38, 237-253.
284. VAIJA, J., LINKO, Y. Y., LINKO, P. (1982), Citric acid production with alginate bead entrapped Aspergillus niger ATCC 9142, Appl. Microbiol. Biotechnol. 7, 51-54.
285. VERHOFF, F. H. (1986), Citric acid, in: Ullmann's Encyclopedia of Industrial Chemistry, 5th Edn., Vol. A7 (GERHARTZ, W., Ed.), pp. 103-108. Weinheim: VCH.
286. WAKSMAN, S. A., KAROW, E. O. (1946), U.S. Patent 2394031.
287. WALLRATH, J., SCHMIDT, M., WEISS, H. (1991), Concomitant loss of respiratory chain NADH:ubiquinone reductase (complex I), and citric acid accumulation by Aspergillus niger, Appl. Microbiol. Biotechnol. 36, 76-81.
288. WEGNER, H., KELLERWESSEL, H. (1977), Ger. Patent 2618608.
289. WEHMER, C. (1896), in: Technische Mykologie (LAFAR, F., Ed.). Jena: Fischer. (Technical Mycology, translation by SALTER. C. T. C, 1898-1910. London: C. Griffith.)
290. WEHMER, C. (1903), Beiträge zur Kenntnis einheimischer Pilze. I. Zwei neue Schimmelpilze als Erreger einer Citronensäure-Gärung. Hannover/ Leipzig: Halm.
291. WEHMER, C. (1907), in: Handbuch der Technischen Mykologie, Vol. 4 (LAFAR, F., Ed.), pp. 192-238, 239-270. Jena: Fischer.
292. WEISSBRODT, E., BEHRENS, U., STOTTMEISTER, U., DUERESCH, R., RICHTER, H. P., SCHMIDT, J. (1987a), Ger. Patent (GDR) 248376.
293. WEISSBRODT, E., BEHRENS, U., STOTTMEISTER, U., DUERESCH, R., RICHTER, H. P., SCHMIDT, J. (1987b), Ger. Patent (GDR) 248377.
294. WELLER, G. (1981), Problems with determination of [wastewater discharge] minimum requirements in the molasses-utilizing industry, Münch. Beitr. Abwasser-, Fisch-. Flussbiol. 33 (Allg. Anerkannte Regeln Techn. Mindestanforderungen Gewässerschutz), 141-154.
295. WENDEL, K. (1957), Zur Frage der Stoffwechselsteigerung und Säuerung bei Aspergillus niger in Abhängigkeit von Züchtungs-und Substratbedingungen. I. Verfahren zur Erhaltung und Steigerung der Gärleistung säurebildender Pilze, insbesondere der Citronensäuregärstämme, Zentralbl. Bakt. 2 Abt. 110, 312-318.
296. WENDLER, L. (1988), Unused possibilities in the manufacture of high-quality plaster of Paris, Sklar Keram. 38, 35-36.
297. WOODWARD, J. C, SNELL, R. L., NICHOLLS, R. S. (1949), U.S. Patent 2492673.
298. Xu, W. Q., HANG, Y. D. (1988), Roller culture technique for citric acid production by Aspergillus niger, Proc. Biochem. 23, 117-118.
299. Xu, D. B., MADRID, C. P., ROEHR, M., KUBICEK, C. P. (1989a), The influence of type and concentration of the carbon source on production of citric acid by Aspergillus niger, Appl. Microbiol. Biotechnol. 30, 553-558.
300. Xu, D. B., ROEHR, M, KUBICEK, C. P. (1989b), Aspergillus niger cyclic AMP levels are not influenced by manganese deficiency and do not correlate with citric acid accumulation, Appl. Microbiol. Biotechnol. 32, 124-128.
301. YAMADA, K. (1965), "Science in Japan", 401, cited by LOCKWOOD, L. B. (1979).
302. YAMADA, K. (1977), Recent advances in industrial fermentation in Japan, Biotechnol. Bioeng. 19, 1563-1622.
303. Yi, M., PEN, Q., CHEN, D., PEN, L., ZHANG, M., WEN, R., MOU, X., WANG, W. (1987), Extraction of citric acid by N,N-disubstituted alkyl amides from fermentation aqueous solution, Beijing Daxue Xuebao, Ziran Kexueban 4, 30-37. (from CA 108:110761).
304. Yo, K. (1975), Jpn. Patent 50154488.
305. ZAHORSKY, B. (1913), U.S. Patent 1065358.
306. ZAKOWSKA, Z., GABARA, B. (1991), Changes in development and ultrastructure of Aspergillus niger mycelium in the presence of toxic substances from molasses in citric acid fermentation medium, Acta Microbiol. Pol. 40, 243-254.
307. ZAKOWSKA, Z., JALOCHA, A. (1984), Fraktionierung von Inhaltsstoffen der Zuckerrübenmelasse, die toxisch für die Citronensäureproduk-tion mit Aspergillus niger sind, Acta Biotechnol. 4, 171-178.
308. ZEHENTGRUBER, O., KUBICEK, C. P., ROEHR, M. (1980), Alternative respiration of Aspergillus niger, FEMS Microbiol. Lett. 8, 71-74.
309. ZHANG, Y., CHENG, Z. (1987), Teratogenic effect of citric acid in rats, Shanghai Yike Daxue Xuebao 14, 195-198 (from CA 107:216314).