Microbial Production of Acetone/Butanol/Isopropanol

Biotechnology: Second, Completely Revised Edition

Volumn 6-12, Issue , 2008, Pages 229-268

  Dürre, Peter ^a   Bahl, Hubert ^a,b  

^a UNIVERSITY OF GÖTTINGEN   (Germany)

^b UNIVERSITY OF ROSTOCK   (Germany)

Author keywords

Biochemistry; Fermentation; Organism; Pioneering; Sporulating

Indexed keywords

EID: 84978731101     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1002/9783527620999.ch6f     Document Type: Chapter

References (301)

1. AFSCHAR, A. S., BIEBL, H., SCHALLER, K., SCHÜ-GERL, K. (1985), Production of acetone and bu-tanol by Clostridium acetobutylicum in continuous culture with cell recycle, Appi. Microbiol. Biotechnol. 22, 394-398.
2. ALLCOCK, E. R., WOODS, D. R. (1981), Carboxy-methyl cellulase and cellobiase production by Clostridium acetobutylicum in an industrial fermentation medium, Appi Environ. Microbiol. 41, 539-541.
3. ANDERSCH, W., BAHL, H., GOTTSCHALK, G. (1982), Acetone-butanol production by Clostridium acetobutylicum in an ammonium-limited chemostat at low pH values, Biotechnol. Lett. 4, 29-32.
4. ANDERSCH, W., BAHL, H., GOTTSCHALK, G. (1983), Level of enzymes involved in acetate, bu-tyrate, acetone and butanol formation by Clostridium acetobutylicum, Appi. Microbiol. Biotechnol. 18, 327-332.
5. ANDREESEN, J. R., GOTTSCHALK, G. (1969), The occurrence of a modified Entner-Doudoroff pathway in Clostridium aceticum, Arch. Microbiol. 69, 160-170.
6. ANNOUS, B. A., BLASCHEK, H. P. (1991), Isolation and characterization of Clostridium acetobutylicum mutants with enhanced amylolytic activity, Appi. Environ. Microbiol. 57, 2544-2548.
7. ARROYO, R. (1938), Art of producing butanol and acetone by fermentation of molasses, U. S. Patent 2113471.
8. ARZBERGER, C. F. (1936), Process for the production of butyl alcohol by fermentation, U. S. Patent 2050219.
9. ARZBERGER, C. F. (1938), Process for the production of butyl alcohol by fermentation, U. S. Patent 2139108.
10. AWANG, G. M., JONES, G. A., INGLEDEW, W. M. (1988), The acetone-butanol ethanol fermentation, CRC Crit. Rev. Microbiol. 15 (Suppl. 1), S33-S67.
11. AZEDDOUG, H., HUBERT, J., REYSSET, G. (1992), Stable inheritance of shuttle vectors based on plasmid pIM13 in a mutant strain of Clostridium acetobutylicum, J. Gen. Microbiol. 138, 1371-1378.
12. BAHL, H. (1993), Heat shock response and onset of solvent formation in Clostridium acetobutylicum, in: The Clostridia and Biotechnology (WOODS, D. R., Ed.), pp. 247-259, Stoneham: Butterworth-Heinemann.
13. BAHL, H., DÜRRE, P. (1993), Clostridia, in: Biotechnology, 2nd Edn., Vol. 1 (REHM, H.-J., REED, G., Eds.), pp. 285-323, Weinheim: VCH.
14. BAHL, H., GOTTSCHALK, G. (1984), Parameters affecting solvent production by Clostridium acetobutylicum in continuous culture, Biotechnol. Bioeng. Symp. 14, 215-223.
15. BAHL, H., GOTTSCHALK, G. (1988), Microbial production of butanol/acetone, in: Biotechnology 1st Edn., Vol. 6b (REHM, H.-J., REED, G., Eds.), pp. 1-30, Weinheim: VCH.
16. BAHL, H., ANDERSCH, W., BRAUN, K., GOTTSCHALK, G. (1982a), Effect of pH and butyrate concentration on the production of acetone and butanol by Clostridium acetobutylicum grown in continuous culture, Eur. J. Appl. Microbiol. Biotechnol. 14, 17-20.
17. BAHL, H., ANDERSCH, W., GOTTSCHALK, G. (1982b), Continuous production of acetone and butanol by Clostridium acetobutylicum in a two-stage phosphate limited chemostat, Eur. J. Appl. Microbiol. Biotechnol. 15, 201-205.
18. BAHL, H., GOTTWALD, M., KUHN, A., RALE, V., ANDERSCH, W., GOTTSCHALK, G. (1986), Nutritional factors affecting the ratio of solvents produced by Clostridium acetobutylicum, Appl. Environ. Microbiol. 52, 169-172.
19. BALLONGUE, J., AMINE, J., MASION, E., PETITDE-MANGE, H., GAY, R. (1985), Induction of ace-toacetate decarboxylase in Clostridium acetobutylicum, FEMS Microbiol. Lett. 29, 273-277.
20. BALLONGUE, J., AMINE, J., MASION, E., PETITDE-MANGE, H., GAY, R. (1986), Rôle de l'acétate et du butyrate dans l'induction de la NADH:rubré-doxine oxydoréductase chez Clostridium acetobutylicum, Biochimie 68, 575-580.
21. BEESCH, S. C. (1948), Process for fermenting carbohydrates to butanol and acetone, U. S. Patent 2439791.
22. BEESCH, S. C. (1952), Acetone-butanol fermentation of sugars, Eng. Proc. Dev. 44, 1677-1682.
23. BEHRENS, S., NARBERHAUS, F., BAHL, H. (1993), Cloning, nucleotide sequence and structural analysis of the Clostridium acetobutylicum dnaJ gene, FEMS Microbiol. Lett. 114, 53-60.
24. BEIJERINCK, M. W. (1893), Ueber die Butylalko-holgährung und das Butylferment, Verhand. Kon. Akad. Wetenschappen Amsterdam 2. Sect., Teil 1, Nr. 10, 1-51.
25. BERNDT, H., SCHLEGEL, H. G. (1975), Kinetics and properties of β-ketothiolase from Clostridium pasteurianum, Arch. Microbiol. 103, 21-30.
26. BERTRAM, J., DÜRRE, P. (1989), Conjugal transfer and expression of streptococcal transposons in Clostridium acetobutylicum, Arch. Microbiol. 151, 551-557.
27. BERTRAM, J., KUHN, A., DÜRRE, P. (1990), Tn9/6-induced mutants of Clostridium acetobutylicum defective in regulation of solvent formation, Arch. Microbiol. 153, 373-377.
28. BOTKIN, S. (1892), Ueber einen Bacillus butyricus, Z. Hyg. Infektionskrankh. 11, 421-434.
29. BOWLES, L. K., ELLEFSON, W. L. (1985), Effects of butanol on Clostridium acetobutylicum, Appl. Environ. Microbiol. 50, 1165-1170.
30. BREDEMANN, G. (1909), Bacillus amylobacter A.M. et Bredemann in morphologischer, physiologischer und systematischer Beziehung. Mit besonderer Berücksichtigung des Stickstoffbindungsvermögens dieser Spezies, Cbl. Bakteriol. Parasitenkd. Infektionskrankh., II. Abt. 23, 385-568.
31. BREZNAK, J. A., COSTILOW, R. N. (1994), Physico-chemical factors in growth, in: Methods for General and Molecular Bacteriology (GERHARDT, P., MURRAY, R. G. E., WOOD, W. A., KRIEG, N. R., Eds.), pp. 137-154, Washington: Am. Soc. Microbiol.
32. BUCHNER, E., MEISENHEIMER, J. (1908), Über Buttersäuregärung, Ber. Dtsch. Chem. Ges. 41, 1410-1419.
33. BURCHHARDT, G., DÜRRE, P. (1990), Isolation and characterization of DNase-deficient mutants of Clostridium acetobutylicum, Curr. Microbiol. 21, 307-311.
34. CALAM, C. T. (1979), Isolation of Clostridium acetobutylicum strains producing butanol and acetone, in: Proc. 4th Symp. "Technische Mikrobiologie" (DELLWEG, H., Ed.), pp. 233-242, Berlin: Verlag Versuchs-und Lehranstalt für Spiritusfabrikation und Fermentationstechnologie im Institut für Gärungsgewerbe und Biotechnologie.
35. CARNARIUS, E. H., MCCUTCHAN, W. N. (1938), Process for the production of butyl alcohol by fermentation, U. S. Patent 2139111.
36. CARY, J. W., PETERSEN, D. J., PAPOUTSAKIS, E. T., BENNETT, G. N. (1988), Cloning and expression of Clostridium acetobutylicum phospho-transbutyrylase and butyrate kinase genes in Escherichia coli, J. Bacteriol. 170, 4613-1618.
37. CARY, J. W., PETERSEN, D. J., PAPOUTSAKIS, E. T., BENNETT, G. N. (1990), Cloning and expression of Clostridium acetobutylicum ATCC 824 acetoacetyl-coenzyme A:acetate/butyrate:coen-zyme A-transferase in Escherichia coli, Appl. Environ. Microbiol. 56, 1576-1583.
38. CATO, E. P., GEORGE, W. L., FINEGOLD, S. M. (1986), Genus Clostridium Prazmowski 1880, 23AL, in: Bergey's Manual of Systematic Bacteriology (SNEATH, P. H. A., MAIR, N. S., SHARPE, M. E., HOLT, J. G., Eds.), Vol. II, pp. 1141-1200, Baltimore: Williams & Wilkins.
39. CHEN, J.-S. (1993), Properties of acid-and solvent-forming enzymes of Clostridia, in: The Clostridia and Biotechnology (WOODS, D. R., Ed.), pp. 51-76, Stoneham: Butterworth-Heinemann.
40. CHEN, J.-S., HIU, S. F. (1986), Acetone-butanol-isopropanol production by Clostridium beijer-inckii (synonym, Clostridium butylicum), Biotechnol. Lett. 8, 371-376.
41. CHOJECKI, A., BLASCHEK, H. P. (1986), Effect of carbohydrate source on a-amylase and gluco-amylase formation by Clostridium acetobutylicum SA1, J. Ind. Microbiol. 1, 63-67.
42. COLBY, G. D., CHEN, J.-S. (1992), Purification and properties of 3-hydroxybutyryl-coenzyme A dehydrogenase from Clostridium beijerinckii ("Clostridium butylicum") NRRL B593, Appl. Environ. Microbiol. 58, 3297-3302.
43. CONTAG, P. R., WILLIAMS, M. G., ROGERS, P. (1990), Cloning of a lactate dehydrogenase gene from Clostridium acetobutylicum B643 and expression in Escherichia coli, Appl. Environ. Microbiol. 56, 3760-3765.
44. CYNKIN, M. A., DELWICHE, E. A. (1958), Metabolism of pentoses by Clostridia. I. Enzymes of ri-bose dissimilation in extracts of Clostridium per-fringens, J. Bacteriol. 75, 331-334.
45. CYNKIN, M. A., GIBBS, M. (1958), Metabolism of pentoses by Clostridia. II. The fermentation of C'4-labeled pentoses by Clostridium perfringens, Clostridium beijerinckii, and Clostridium butylicum, J. Bacteriol. 75, 335-338.
46. DABROCK, B., BAHL, H., GOTTSCHALK, G. (1992), Parameters affecting solvent production by Clostridium pasteurianum, Appl. Environ. Microbiol. 58, 1233-1239.
47. DADGAR, A. M., FOUTCH, G. L. (1985), Evaluation of solvents for the recovery of Clostridium fermentation products by liquid-liquid extraction, Biotechnol. Bioeng. Symp. 15, 611-620.
48. DAVIES, R., STEPHENSON, M. (1941), Studies on the acetone-butyl alcohol fermentation. I. Nutritional and other factors involved in the preparation of active suspensions of CI. acetobutylicum (Weizmann), Biochem. J. 35, 1320-1331.
49. DIEZ-GONZALEZ, F., HUNTER, J. B., RUSSELL, J. B. (1994), The "acetilactic" fermentation of Clostridium acetobutylicum P262, Abstr. Gen. Meet. Am. Soc. Microbiol., Las Vegas, May 23-27, 0-52.
50. DOMBECK, K. M., INGRAM, L. O. (1984), Effects of ethanol on the Escherichia coli plasma membrane, J. Bacteriol. 157, 233-239.
51. DUCLAUX, E. (1895), Sur la nutrition intra-cellu-laire, Ann. Inst. Pasteur 9, 811-839.
52. DÜRRE, P. (1993), Transposons in Clostridia, in: The Clostridia and Biotechnology (WOODS, D. R., Ed.), pp. 227-246, Stoneham: ButterworthHeinemann.
53. DÜRRE, P., KUHN, A., GOTTWALD, M., GOTTSCHALK, G. (1987), Enzymatic investigations on butanol dehydrogenase in extracts of Clostridium acetobutylicum, Appl. Microbiol. Biotechnol. 26, 268-272.
54. DÜRRE, P., BAHL, H., GOTTSCHALK, G. (1992), Die Aceton-Butanol-Gärung: Grundlage für einen modernen biotechnologischen Prozeß? Chem. Ing. Tech. 64, 491-498.
55. DYR, J., PROTIVA, J., PRAUS, R. (1958), Formation of neutral solvents in continuous fermentation by means of Clostridium acetobutylicum, in: Continuous Cultivation of Microorganisms. A Symposium (MALEK, I., Ed.), pp. 210-226, Prague: Cechoslovakian Academy of Sciences.
56. EMMERLING, O. (1897), Butylalkoholische Gäh-rung, Ber. Dtsch. Chem. Ges. 30, 451-153.
57. ENNIS, B. M., MADDOX, I. S. (1985), Use of Clostridium acetobutylicum P 262 for production of solvents from whey permeate, Biotechnol. Lett. 7, 503-508.
58. ENNIS, B. M., GUTIERREZ, N. A., MADDOX, I. S. (1986a), The acetone-butanol-ethanol fermentation: A current assessment, Process Biochem. 21, 131-147.
59. ENNIS, B. M., MARSHALL, C. T., MADDOX, I. S., PATERSON, A. H. J. (1986b), Continuous product recovery by in situ gas stripping/condensation during solvent production from whey permeate using Clostridium acetobutylicum, Biotechnol. Lett. 8, 725-730.
60. ENSLEY, B., MCHUGH, J. J., BARTON, L. L. (1975), Effect of carbon sources on formation of a-amylase and glucoamylase by Clostridium acetobutylicum, J. Gen. Appl. Microbiol. 21, 51-59.
61. FERNBACH, A., STRANGE, E. H. (1911), Improvements in the manufacture of higher alcohols, British Patent 15204.
62. FERNBACH, A., STRANGE, E. H. (1912), Improvements connected with fermentation processes for the production of acetone, and higher alcohols, from starch, sugars, and other carbohydrate materials, British Patent 21073.
63. FICK, M., PIERROT, P., ENGASSER, J. M. (1985), Optimal conditions for long-term stability of acetone-butanol production by continuous cultures of Clostridium acetobutylicum, Biotechnol. Lett. 7, 503-508.
64. FINN, R. K, NOWREY, J. E. (1959), A note on the stability of Clostridia when held in continuous culture, Appl. Microbiol. 7, 29-32.
65. FISCHER, R. J., HELMS, J., DÜRRE, P. (1993), Cloning, sequencing, and molecular analysis of the sol operon of Clostridium acetobutylicum, a chromosomal locus involved in solventogenesis, J. Bacteriol. 175, 6959-6969.
66. FITZ, A. (1876), Ueber die Gährung des Glycerins, Ber. Dtsch. Chem. Ges. 9, 1348-1352.
67. FITZ, A. (1877), Ueber Schizomyceten-Gährungen II [Glycerin, Mannit, Stärke, Dextrin], Ber. Dtsch. Chem. Ges. 10, 276-283.
68. FITZ, A. (1878), Ueber Schizomyceten-Gährungen III, Ber. Dtsch. Chem. Ges. 11, 42-55.
69. FITZ, A. (1882), Ueber Spaltpilzgährungen. VII. Mittheilung, Ber. Dtsch. Chem. Ges. 15, 867-880.
70. FOND, O., PETITDEMANGE, E., PETITDEMANGE, H., ENGASSER, J. M. (1983), Cellulose fermentation by a coculture of a mesophilic Clostridium and Clostridium acetobutylicum, Biotechnol. Bioeng. Symp. 13, 217-224.
71. FÖRBERG, C, HÄGGSTRÖM, L. (1985), Control of cell adhesion and activity during continuous production of acetone and butanol with adsorbed cells, Enzyme Microb. Technol. 7, 230-234.
72. FÖRBERG, C, ENFORS, S. O., HÄGGSTRÖM, L. (1983), Control of immobilized, non-growing cells for continuous production of metabolites, Eur. J. Appl. Microbiol. Biotechnol. 17, 143-147.
73. FREIBERG, G. W. (1925), Process for producing acetone and butyl alcohol, U. S. Patent 1537597.
74. FREIER, D., GOTTSCHALK, G. (1987), L(+)-lactate dehydrogenase of Clostridium acetobutylicum is activated by fructose-l, 6-bisphosphate, FEMS Microbiol. Lett. 43, 229-233.
75. FREIER-SCHRÖDER, D., WIEGEL, J., GOTTSCHALK, G. (1989), Butanol formation by Clostridium thermosaccharolyticum at neutral pH, Biotechnol. Lett. 11, 831-836.
76. FRENCH, D., KNAPP, D. W. (1950), The maltase of Clostridium acetobutylicum. Its specificity range and mode of action, J. Biol. Chem. 187, 463-467.
77. FRICK, C, SCHÜGERL, K. (1986), Continuous acetone-butanol production with free and immobilized Clostridium acetobutylicum, Appl. Microbiol. Biotechnol. 25, 186-193.
78. FRIDOVICH, I. (1972), Acetoacetate decarboxylase, in: The Enzymes (BOYER, P. D., Ed.), Vol. VI, pp. 255-270, New York: Academic Press.
79. FRIEDL, A., QURESHI, N., MADDOX, I. S. (1991), Continuous acetone-butanol-ethanol (ABE) fermentation using immobilized cells of Clostridium acetobutylicum in a packed bed reactor and integration with product removal by pervapora-tion, Biotechnol. Bioeng. 38, 518-527.
80. FUNK, F. J. (1925), Butyl alcohol and acetone fermentation process, U. S. Patent 1538516.
81. GABRIEL, C. L. (1928), Butanol fermentation process, Ind. Eng. Chem. 28, 1063-1067.
82. GARCIA III, A., IANNOTTI, E. L., FISHER, J. R. (1984), Reverse osmosis application for acetone-butanol fermentation, Biotechnol. Bioeng. Symp. 14, 543-552.
83. GARCIA III, A., IANNOTTI, E. L., FISHER, J. R. (1986), Butanol fermentation liquor production and separation by reverse osmosis, Biotechnol. Bioeng. 28, 785-791.
84. GAVARD, R., HAUTECOEUR, B., DESCOURTIEUX, H. (1957), Phosphotransbutyrylase de Clostridium acetobutylilcum, C. R. Acad. Sei. 244, 2323-2326.
85. GEORGE, H. A., JOHNSON, J. L, MOORE, W. E. C, HOLDEMAN, L. V., CHEN, J. S. (1983), Acetone, isopropanol, and butanol production by Clostridium bejierinckii (syn. Clostridium butylicum) and Clostridium aurantibutyricum, Appl. Environ. Microbiol. 45, 1160-1163.
86. GERISCHER, U., DÜRRE, P. (1990), Cloning, sequencing, and molecular analysis of the aceto-acetate decarboxylase gene region from Clostridium acetobutylicum, J. Bacteriol. 172, 6907-6918.
87. GERISCHER, U., DÜRRE, P. (1992), mRNA analysis of the adc gene region of Clostridium acetobutylicum during the shift to solventogenesis, J. Bacteriol. 174, 426-433.
88. GOODLOVE, P. E., CUNNINGHAM, P. R., PARKER, J., CLARK, D. P. (1989), Cloning and sequence analysis of the fermentative alcohol-dehydro-genase-encoding gene of Escherichia coli, Gene 85, 209-214.
89. GOTTSCHAL, J. C, MORRIS, J. G. (1981a), The induction of acetone and butanol production in cultures of Clostridium acetobutylicum by elevated concentrations of acetate and butyrate, FEMS Microbiol. Lett. 12, 385-389.
90. GOTTSCHAL, J. C, MORRIS, J. G. (1981b), Nonproduction of acetone and butanol by Clostridium acetobutylicum during glucose-and ammonium-limitation in continuous culture, Biotechnol. Lett. 3, 525-530.
91. GOTTSCHAL, J. C, MORRIS, J. G. (1982), Continuous production of acetone and butanol by Clostridium acetobutylicum growing in turbidostat culture, Biotechnol. Lett. 4, 477-482.
92. GOTTSCHALK, G. (1986), Bacterial Metabolism, 2nd Edn., New York: Springer-Verlag.
93. GOTTWALD, M., GOTTSCHALK, G. (1985), The internal pH of Clostridium acetobutylicum and its effect on the shift from acid to solvent formation, Arch. Microbiol. 143, 42-46.
94. GOTTWALD, M., HIPPE, H., GOTTSCHALK, G. (1984), Formation of «-butanol from D-glucose by strains of the "Clostridium tetanomorphum" group, Appl. Environ. Microbiol. 48, 573-576.
95. GRETHLEIN, A. J., WORDEN, R. M., JAIN, M. K., DATTA, R. (1991), Evidence for production of n-butanol from carbon monoxide by Butyribac-terium methylotrophicum, J. Ferment. Bioeng. 72, 58-60.
96. GRIMBERT, L. (1893), Fermentation anaerobie produite par le Bacillus orthobutylicus. Ses variations sous certaines influences biologiques, Ann. Inst. Pasteur 7, 353-402.
97. GROOT, W. J., SCHOUTENS, G. H., VAN BEELEN, P. N., VAN DEN OEVER, C. E., KOSSEN, N. W. F. (1984a), Increase of substrate conversion by per-vaporation in the continuous butanol fermentation, Biotechnol. Lett. 6, 789-792.
98. GROOT, W. J., VAN DEN OEVER, C. E., KOSSEN, N. W. F. (1984b), Pervaporation for simultaneous product recovery in the butanol/isopropanol batch fermentation, Biotechnol. Lett. 6, 709-714.
99. GROOT, W. J., VAN DER LANS, R. G. J. M., LUYB-EN, CH. A. M. (1992), Technologies for butanol recovery integrated with fermentations, Process Biochem. 27, 61-75.
100. GRUBER, M. (1887), Eine Methode der Cultur anaerobischer Bacterien nebst Bemerkungen zur Morphologie der Buttersäuregährung, Cbl. Bacteriol. Parasitenkd. 1, 367-372.
101. GRUPE, H., GOTTSCHALK, G. (1992), Physiological events in Clostridium acetobutylicum during the shift from acidogenesis to solventogenesis in continuous culture and presentation of a model for shift induction, Appl. Environ. Microbiol. 58, 3896-3902.
102. HÄGGSTRÖM, L., ENFORS, S. O. (1982), Continuous production of butanol with immobilized cells of Clostridium acetobutylicum, Appl. Biochem. Biotechnol. 7, 35-37.
103. HANCOCK, K. R., ROCKMAN, E., YOUNG, C. A., PEARCE, L., MADDOX, I. S., SCOTT, D. B. (1991), Expression and nucleotide sequence of the Clostridium acetobutylicum /S-galactosidase gene cloned in Escherichia coli, J. Bacteriol. 173, 3084-3095.
104. HANSON, A. M., RODGERS, N. E. (1946), Influence of iron concentration and attenuation on the metabolism of Clostridium acetobutylicum, J. Bacteriol. 51, 568-569.
105. HARRIS, J., MULDER, R., KELL, D. B., WALTER, R. P., MORRIS, J. G. (1986), Solvent production by Clostridium pasteurianum in media of high sugar content, Biotechnol. Lett. 8, 889-892.
106. HARTMANIS, M. G. N. (1987), Butyrate kinase from Clostridium acetobutylicum, J. Biol. Chem. 262, 617-621.
107. HARTMANIS, M. G. N., GATENBECK, S. (1984), Intermediary metabolism in Clostridium acetobutylicum: Levels of enzymes involved in the formation of acetate and butyrate, Appl. Environ. Microbiol. 47, 1277-1283.
108. HARTMANIS, M. G. N., KLASON, T., GATENBECK, S. (1984), Uptake and activation of acetate and butyrate in Clostridium acetobutylicum, Appl. Microbiol. Biotechnol. 20, 66-71.
109. HASTINGS, J. J. H. (1978), Acetone-butyl alcohol fermentation, in: Economic Microbiology, Vol. 2. Primary Products of Metabolism (ROSE, A. H., Ed.), pp. 31-45, New York: Academic Press.
110. HERMANN, M., FAYOLLE, F., MARCHAL, R., POD-VIN, L., SEBALD, M., VANDECASTEELE, J.-P. (1985), Isolation and characterization of buta-nol-resistant mutants of Clostridium acetobutylicum, Appl. Environ. Microbiol. 50, 1238-1243.
111. HERRERO, A. A. (1983), End-product inhibition in anaerobic fermentations, Trends Biotechnol. 1, 49-53.
112. HIGGINS, C. F. (1992), ABC transporters from microorganisms to man, Annu. Rev. Cell Biol. 8, 67-113.
113. HIPPE, H., ANDREESEN, J. R., GOTTSCHALK, G. (1992), The genus Clostridium-nonmedical, in: The Prokaryotes, 2nd Edn. (BALOWS, A., TRÜ-PER, H. G., DWORKIN, M., HARDER, W., SCHLEIFER, K.-H., Eds.), Vol. II, pp. 1800-1866, New York: Springer-Verlag.
114. Hiu, S. F., ZHU, C.-Z., YAN, R.-T., CHEN, J.-S. (1987), Butanol-ethanol dehydrogenase and bu-tanol-ethanol-isopropanol dehydrogenase: Different alcohol dehydrogenases in two strains of Clostridium beijerinckii (Clostridium butylicum), Appl. Environ. Microbiol. 53, 697-703.
115. HOCKENHULL, D. J., HERBERT, D. (1945), The amylase and maltase of Clostridium acetobutylicum, Biochem. J. 39, 102-106.
116. HOLT, R. A., STEPHENS, G. M., MORRIS, J. G. (1984), Production of solvents by Clostridium acetobutylicum cultures maintained at neutral pH, Appl. Environ. Microbiol. 48, 1166-1170.
117. HOLT, R. A., CAIRNS, A. J., MORRIS, J. G. (1988), Production of butanol by Clostridium puniceum in batch and continuous culture, Appl. Microbiol, Biotechnol. 27, 319-324.
118. HÜSEMANN, M. H. W., PAPOUTSAKIS, E. T. (1989), Comparison between in vivo and in vitro enzyme activities in continuous and batch fermentations of Clostridium acetobutylicum, Appl. Microbiol. Biotechnol. 30, 585-595.
119. HUTKINS, R. W., KASHKET, E. R. (1986), Phosphotransferase activity in Clostridium acetobutylicum from acidogenic to solventogenic phases of growth, Appl. Environ. Microbiol. 51, 1121-1123.
120. INGRAM, L. O. (1986), Microbial tolerance to alcohols: Role of the cell membrane, Trends Biotechnol. 4, 40-44.
121. IZSAK, A., FUNK, F. J. (1933), Process of producing butyl alcohol, U. S. Patent 1908361.
122. JANATI-IDRISSI, R., JUNELLES, A. M., EL KANOU-NI, A., PETITDEMANGE, H., GAY, R. (1987), Sélection de mutants de Clostridium acetobutylicum défectifs dans la production d'acétone, Ann. Inst. Pasteur/Microbiol. 138, 313-323.
123. JÖBSES, I. M. L., ROELS, J. A. (1983), Experience with solvent production by Clostridium beijerinckii in continuous culture, Biotechnol. Bioeng. 25, 1187-1194.
124. JONES, D. T., WOODS, D. R. (1986), Acetone-butanol fermentation revisited, Microbiol. Rev. 50, 484-524.
125. JUNGERMANN, K., THAUER, R. K., LEIMENSTOLL, G., DECKER, K. (1973), Function of reduced pyridine nucleotide-ferredoxin oxidoreductases in saccharolytic Clostridia, Biochim. Biophys. Acta 305, 268-280.
126. KASHKET, E. R., CAO, Z.-Y. (1993), Isolation of a degeneration-resistant mutant of Clostridium acetobutylicum NCIMB 8052, Appl. Environ. Microbiol. 59, 4198-1202.
127. KATAGIRI, H., IMAI, K., SUGIMARI, T. (1960), On the metabolism of organic acids by Clostridium acetobutylicum. Part I. Formation of lactic acid and racemase, Bull. Agr. Chem. Soc. Jpn. 24, 163-172.
128. KEIS, S., BENNETT, C, JONES, D. T. (1994), Differentiation of solvent producing clostridial strains by restriction analysis typing, ribotyping and phage typing, Abstr. 7th Int. Symp. Genet. Ind. Microorg., Montreal, June 26-July 1, p. 201.
129. KEMPNER, W., KUBOWITZ, F. (1933), Wirkung des Lichtes auf die Kohlenoxydhemmung der Buttersäuregärung, Biochem. Z. 265, 245-252.
130. KIM, A. Y., BLASCHEK, H. P. (1991), Isolation and characterization of a filamentous viruslike particle from Clostridium acetobutylicum NCIB 6444, J. Bacteriol. 173, 530-535.
131. KIM, A. Y., BLASCHEK, H. P. (1993), Construction and characterization of a phage-plasmid hybrid (phagemid), pCAKl, containing the replicative form of viruslike particle CAK1 isolated from Clostridium acetobutylicum NCIB 6444, J. Bacteriol. 175, 3838-3843.
132. KIM, B. H., ZEIKUS, J. G. (1985), Importance of hydrogen metabolism in regulation of solventogenesis by Clostridium acetobutylicum, Dev. Ind. Microbiol. 26, 549-556.
133. KIM, A. Y., ATTWOOD, G. T., HOLT, S. M., WHITE, B. A., BLASCHEK, H. P. (1994), Heterologous expression of endo-β-l, 4-D-glucanase from Clostridium cellulovorans in Clostridium acetobutylicum ATCC 824 following transformation of the engB gene, Appl. Environ. Microbiol. 60, 337-340.
134. KUBOWITZ, F. (1934), Über die Hemmung der Buttersäuregärung durch Kohlenoxyd, Biochem. Z. 274, 285-298.
135. KUTZENOK, A., ASCHNER, M. (1952), Degenerative processes in a strain of Clostridium butylicum, J. Bacteriol. 64, 829-836.
136. LAPAGE, S. P., SHELTON, J. E., MITCHELL, T. G., MACKENZIE, A. R. (1970), Culture collections and the preservation of bacteria, in: Methods in Microbiology (NORRIS, J. R., RIBBONS, D. W., Eds.), Vol. 3A, pp. 125-228, London: Academic Press.
137. LARGIER, S. T., LONG, S., SANTANGELO, J. D., JONES, D. T., WOODS, D. R. (1985), Immobilized Clostridium acetobutylicum P 262 mutants for solvent production, Appl. Environ. Microbiol. 50, 477-481.
138. LEE, S. F., FORSBERG, C. W., GIBBINS, L. N. (1985a), Xylanolytic activity of Clostridium acetobutylicum, Appl. Environ. Microbiol. 50, 1068-1076.
139. LEE, S. F., FORSBERG, C. W., GIBBINS, L. N. (1985b), Cellulytic activity of Clostridium acetobutylicum, Appl. Environ. Microbiol. 50, 220-228.
140. LEE, S. F., FORSBERG, C. W., RATTRAY, J. B. (1987), Purification and characterization of two endoxylanases from Clostridium acetobutylicum ATCC 824, Appl. Environ. Microbiol. 53, 664-650.
141. LEE, S. Y., BENNETT, G. N., PAPOUTSAKIS, E. T. (1992), Construction of Escherichia coli-Clos-tridium acetobutylicum shuttle vectors and transformation of Clostridium acetobutylicum strains, Biotechnol. Lett. 14, 427-432.
142. LEGG, D. A., STILES, H. R. (1937), Process of producing butyl alcohol, U. S. Patent 2089562.
143. LEMMEL, S. A. (1985), Mutagenesis in Clostridium acetobutylicum, Biotechnol. Lett. 7, 711-716.
144. LEMMEL, S. A., DATTA, R., FRANKIEWICZ, J. R. (1986), Fermentation of xylan by Clostridium acetobutylicum, Enzyme Microb. Technol. 8, 217-221.
145. LENZ, T. G., MOREIRA, A. R. (1980), Economic evaluation of the acetone-butanol fermentation, Ind. Eng. Chem. Prod. Res. Dev. 19, 478-483.
146. ESKIW, B. K., BIBB, M. J., CHATER, K. F. (1991), The use of a rare codon specifically during development? Mol. Microbiol. 5, 2861-2867.
147. EUNG, J. C. Y., WANG, D. I. C. (1981), Production of acetone and butanol by Clostridium acetobutylicum in continuous culture using free and immobilized cells, Proc. 2nd World Congr. Chem. Eng. 1, 348-352.
148. LIN, Y.-L., BLASCHEK, H. P. (1983), Butanol production by a butanol-tolerant strain of Clostridium acetobutylicum in extruded corn broth, Appl. Environ. Microbiol. 45, 966-973.
149. LIN, Y.-L., BLASCHEK, H. P. (1984), Transformation of heat-treated Clostridium acetobutylicum protoplasts with pUBHO plasmid DNA, Appl. Environ. Microbiol. 48, 737-742.
150. LINDEN, J. C, MOREIRA, A. R., LENZ, T. G. (1986), Acetone and butanol, in: Comprehensive Biotechnology. The Principles of Biotechnology; Engineering Consideration (COONEY, C. L., HUMPHREY, A. E., Eds.), pp. 915-931, Oxford: Pergamon Press.
151. LONG, S., JONES, D. T., WOODS, D. R. (1984a), The relationship between sporulation and solvent production in Clostridium acetobutylicum P262, Biotechnol. Lett. 6, 529-534.
152. LONG, S., JONES, D. T., WOODS, D. R. (1984b), Initiation of solvent production, clostridial stage and endospore formation in Clostridium acetobutylicum P262, Appl. Microbiol. Biotechnol. 20, 256-261.
153. LOUGHLIN, J. F. (1935), Production of butyl alcohol and acetone by fermentation, U. S. Patent 1992921.
154. MADDOX, I. S. (1980), Production of «-butanol from whey filtrate using Clostridium acetobutylicum NCIB 2951, Biotechnol. Lett. 2, 493-498.
155. MADDOX, I. S. (1983), Use of silicalite for the adsorption of «-butanol from fermentation liquors, Biotechnol. Lett. 5, 89-94.
156. MADDOX, I. S., MURRAY, A. E. (1983), Production of «-butanol by fermentation of wood hydroly-sate, Biotechnol. Lett. 5, 175-178.
157. MADDOX, I. S., QURESHI, N., GUTIERREZ, N. A. (1994), Utilization of whey by Clostridia and process technology, in: The Clostridia and Biotechnology (WOODS, D. R., Ed.), pp. 343-369, Stoneham: Butterworth-Heinemann.
158. MARCHAL, R., BLANCHET, D., VANDECASTEELE, J. P. (1985), Industrial optimization of acetone-butanol fermentation: A study of the utilization of Jerusalem artichokes, Appl. Microbiol. Biotechnol. 23, 92-98.
159. MARCZAK, R., PETITDEMANGE, H., ALIMI, F., BALLONGUE, R., GAY, R. (1983), Influence de la phase de croissance et de la composition du milieu sur le taux de biosynthese de la NADH:rubredoxine oxydoreductase chez Clostridium acetolbutylicum, C. R. Acad. Sei, Ser. 3 296, 469-474.
160. MARCZAK, R., BALLONGUE, R., PETITDEMANGE, H., GAY, R. (1984), Regulation of the biosynthesis of NADH-rubredoxin oxidoreductase in Clostridium acetobutylicum, Curr. Microbiol. 10, 165-168.
161. MARCZAK, R., BALLONGUE, J., PETITDEMANGE, H., GAY, R. (1985), Differential levels of ferre-doxin and rubredoxin in Clostridium acetobutylicum, Biochimie 67, 241-248.
162. MCCLUNG, L. S., MCCOY, E. (1935), Studies on anaerobic bacteria. VII. The serological relations of Clostridium acetobutylicum, CI. felsi-neum and CI. roseum, Arch. Mikrobiol. 6, 239-249.
163. MCCOY, E. F. (1946), Production of butyl alcohol and acetone by fermentation, U. S. Patent 2398837.
164. MCCOY, E., MCCLUNG, L. S. (1935), Studies on anaerobic bacteria. VI. The nature and systematic position of a new chromogenic Clostridium, Arch. Mikrobiol. 6, 230-238.
165. MCCOY, E., FRED, E. B., PETERSON, W. H., HASTINGS, E. G. (1926), A cultural study of the acetone butyl alcohol organism, J. Infect. Dis. 39, 457-183.
166. MCNEIL, B., KRISTIANSEN, B. (1986), The acetone butanol fermentation, Adv. Appl. Microbiol. 31, 61-92.
167. MEINECKE, B., BAHL, H., GOTTSCHALK, G. (1984), Selection of an asporogenous strain of Clostridium acetobutylicum in continuous culture under phosphate limitation, Appl. Environ. Microbiol. 48, 1064-1065.
168. MEINECKE, B., BERTRAM, J., GOTTSCHALK, G. (1989), Purification and characterization of the pyruvate-ferredoxin oxidoreductase from Clostridium acetobutylicum, Arch. Microbiol. 152, 244-250.
169. MERMELSTEIN, L. D., PAPOUTSAKIS, E. T. (1993), In vivo methylation in Escherichia coli by the Bacillus subtilis phage <(>3T I methyltransferase to protect plasmids from restriction upon transformation of Clostridium acetobutylicum ATCC 824, Appl. Environ. Microbiol. 59, 1077-1081.
170. MERMELSTEIN, L. D., WELKER, N. E., BENNETT, G. N., PAPOUTSAKIS, E. T. (1992), Expression of cloned homologous fermentative genes in Clostridium acetobutylicum ATCC 824, Bio/Technology 10, 190-195.
171. MERMELSTEIN, L. D., PAPOUTSAKIS, E. T., PETERSEN, D. J., BENNETT, G. N. (1993), Metabolic engineering of Clostridium acetobutylicum ATCC 824 for increased solvent production by enhancement of acetone formation enzyme activities using a synthetic acetone Operon, Biotechnol. Bioeng. 42, 1053-1060.
172. MICHELS, J. (1990), Reinigung der NADP▪'▪-abhängigen Butanol-Dehydrogenase aus Clostridium acetobutylicum über Triazinyl-Farbstoffe, Thesis, University of Göttingen.
173. MINTON, N. P., BREHM, J. K., SWINFIELD, T.-J., WHELAN, S. M., MAUCHLINE, M. L., BODS-WORTH, N., OULTRAM, J. D. (1993), Clostridial cloning vectors, in: The Clostridia and Biotechnology (WOODS, D. R., Ed.), pp. 119-150, Stoneham: Butterworth-'Heinemann.
174. MITCHELL, W. J. (1992), Carbohydrate assimilation by saccharolytic Clostridia, Res. Microbiol. 143, 245-250.
175. MITCHELL, W. J., SHAW, J. E., ANDREWS, L. (1991), Properties of the glucose phosphotransferase system of Clostridium acetobutylicum NCIB 8052, Appl. Environ. Microbiol. 57, 2534-2539.
176. MONOT, F., ENGASSER, J. M. (1983), Production of acetone and butanol by batch and continuous culture of Clostridium acetobutylicum under nitrogen limitation, Biotechnol. Lett. 5, 213-218.
177. MONOT, F., MARTIN, J. R., PETITDEMANGE, H., GAY, R. (1982), Acetone and butanol production by Clostridium acetobutylicum in a synthetic medium, Appl. Environ. Microbiol. 44, 1318-1324.
178. MONOT, F., ENGASSER, J. M., PETITDEMANGE, H. (1983), Regulation of acetone butanol production in batch and continuous cultures of Clostridium acetobutylicum, Biotechnol. Bioeng. Symp. 13, 207-216.
179. MOREIRA, A. R. (1983), Acetone-butanol fermentation, in: Organic Chemicals from Biomass (WISE, D. L., Ed.), pp. 385-406, Menlo Park: Benjamin/Cummins Publ. Co., Inc.
180. MOREIRA, A. R., ULMER, D. C, LINDEN, J. C. (1981), Butanol toxicity in the butylic fermentation, Biotechnol. Bioeng. Symp. 11, 567-579.
181. MÜLLER, J. (1938a), Production of neutral solvents by fermentation, U. S. Patent 2132039.
182. MÜLLER, J. (1938b), Fermentation mash, U. S. Patent 2123078.
183. NAIR, R. V., BENNETT, G. N., PAPOUTSAKIS, E. T. (1994), Molecular characterization of an aldehyde/alcohol dehydrogenase gene from Clostridium acetobutylicum ATCC 824, J. Bacteriol. 176, 871-885.
184. NAKAMURA, S., OKADO, I., ABE, T., NISHIDA, S. (1979), Taxonomy of Clostridium tetani and related species, J. Gen. Microbiol. 113, 29-35.
185. NAKAMURA, T., IGARASHI, Y., KODAMA, T. (1990), Acetoacetyl-CoA transferase and thiolase reactions are catalyzed by a single enzyme in Clostridium acetobutylicum ATCC824, Agr. Biol. Chem. 54, 276-268.
186. NARBERHAUS, F., BAHL, H. (1992), Cloning, sequencing, and molecular analysis of the groESL operon of Clostridium acetobutylicum, J. Bacteriol. 174, 3282-3289.
187. NARBERHAUS, F., GIEBELER, K., BAHL, H. (1992), Molecular characterization of the dnaK gene region of Clostridium acetobutylicum, including grpE, dnaJ, and a new heat shock gene, J. Bacteriol. 174, 3290-3299.
188. NELSON, D. L., WEBB, B. P. (1978), Acetone, in: Kirk-Othmer Encyclopedia of Chemical Technology, 3rd Edn. (MARK, H. F., OTHMER, D. F., OVERBERGER, C. G., SEABORG, G. T., GRAYSON, M., ECKROTH, D., Eds.), Vol. 1, pp. 179-192, New York: John Wiley & Sons.
189. OGATA, S., HONGO, M. (1979), Bacteriophages of the genus Clostridium, Adv. Appl. Microbiol. 25, 241-273.
190. OSBURN, O. L., WERKMAN, C. H. (1935), Utilization of agricultural wastes. II. Influence of nitrogenous substrate on production of butyl and iso-propyl alcohols by Clostridium butylicum, Ind. Eng. Chem. 27, 416-419.
191. OULTRAM, J. D., YOUNG, M. (1985), Conjugal transfer of plasmid pAMbl from Streptococcus lactis and Bacillus subtilis to Clostridium acetobutylicum, FEMS Microbiol. Lett. 27, 129-134.
192. OULTRAM, J. D., DAVIES, A., YOUNG, M. (1987), Conjugal transfer of a small plasmid from Bacillus subtilis to Clostridium acetobutylicum by cointegrate formation with plasmid pAMßl, FEMS Microbiol. Lett. 42, 113-119.
193. OULTRAM, J. D., LOUGHLIN, M., SWINFIELD, T.-J., BREHM, J. K., THOMPSON, D. E., MINTON, N. P. (1988a), Introduction of plasmids into whole cells of Clostridium acetobutylicum by electropo-ration, FEMS Microbiol. Lett. 56, 83-88.
194. OULTRAM, J. D., PECK, H., BREHM, J. K., THOMPSON, D. E., SWINFIELD, T. J., MINTON, N. P. (1988b), Introduction of genes for leucine biosynthesis from Clostridium pasteurianum into C. acetobutylicum by cointegrate conjugal transfer, Mol. Gen. Genet. 214, 177-179.
195. OULTRAM, J. D., SCHIMMING, S., WALMSLEY, R., LOUGHLIN, M., SCHWARTZ, W., STAUDENBAUER, W. L., MINTON, N. P. (1990), Introduction of cellulase (eel) genes from Clostridium thermocellum into Clostridium acetobutylicum, Abstr. 6th Int. Symp. Genet. Ind. Microorg., Strasbourg, August 12-18, C 54.
196. OULTRAM, J. D., BURR, I. A., ELMORE, M. J., MINTON, N. P. (1993), Cloning and sequence analysis of the genes encoding phosphotransbu-tyrylase and butyrate kinase from Clostridium acetobutylicum NCIMB 8052, Gene 131, 107-112.
197. OXFORD, A. E., LAMPEN, J. O., PETERSON, W. H. (1940), 190. Growth factor and other nutritional requirements of the acetone butanol organism, CI. acetobutylicum, Biochem. J. 34, 1588-1597.
198. PALOSAARI, N. R, ROGERS, P. (1988), Purification and properties of the inducible coenzyme A-linked butyraldehyde dehydrogenase from Clostridium acetobutylicum, J. Bacteriol. 170, 2971-2976.
199. PAPA, A. J. (1982), Isopropyl alcohol, in: Kirk-Othmer Encyclopedia of Chemical Technology, 3rd Edn. (MARK, H. F., OTHMER, D. F., OVERBERGER, C. G., SEABORG, G. T., GRAYSON, M., ECKROTH, D., Eds.), Vol. 19, pp. 198-220, New York: John Wiley & Sons.
200. PAQUET, V., CROUX, C, GOMA, G., SOUCAILLE, P. (1991), Purification and characterization of the extracellular a-amylase from Clostridium acetobutylicum, Appl. Environ. Microbiol. 57, 212-218.
201. PASTEUR, L. (1861), Animacules infusoires vivant sans gaz oxygène libre et déterminant des fermentations, C. R. Hebd. Séances Acad. Sei. 52, 344-347.
202. PASTEUR, L. (1861b), Expériences et vues nouvelles sur la nature des fermentations, C. R. Hebd. Séances Acad. Sei. 52, 1260-1264.
203. PASTEUR, L. (1862), Quelques résultats nouveaux relatifs aux fermentations acétique et butyrique, Bull. Soc. Chim. Paris Mai 1862, 52-53.
204. PASTEUR, L. (1863), Recherches sur le putréfaction, C. R. Hebd. Séances Acad. Sei. 56, 1189-1194.
205. PERDRIX, L. (1891), Sur les fermentations produites par un microbe anaérobie de l'eau, Ann. Inst. Pasteur 5, 287-311.
206. PETERSEN, M. (1991), Untersuchungen zur Lipase-Sekretion von Clostridium tetanomorphum und Reinigung des lipolytisch aktiven Enzyme, Thesis, University of Göttingen.
207. PETERSEN, D. J., BENNETT, G. N. (1990), Purification of acetoacetate decarboxylase from Clostridium acetobutylicum ATCC 824 and cloning of the acetoacetate decarboxylase gene in Escherichia coli, Appl. Environ. Microbiol. 56, 3491-3498.
208. PETERSEN, D. J., BENNETT, G. N. (1991), Cloning of the Clostridium acetobutylicum ATCC 824 acetyl coenzyme A acetyltransferase (thiolase; EC 2.3.1.9) gene, Appl. Environ. Microbiol. 57, 2735-2741.
209. PETERSEN, D. J., WELCH, R. W., RUDOLPH, F. B., BENNETT, G. N. (1991), Molecular cloning of an alcohol (butanol) dehydrogenase gene cluster from Clostridium acetobutylicum ATCC 824, J. Bacteriol. 173, 1831-1834.
210. PETERSEN, D. J., CARY, J. W., VANDERLEYDEN, J., BENNETT, G. N. (1993), Sequence and arrangement of genes encoding enzymes of the acetone-production pathway of Clostridium acetobutylicum ATCC 824, Gene 123, 93-97.
211. PETITDEMANGE, H., CHERRIER, C, RAVAL, G., GAY, R. (1976), Regulation of the NADH and NADPH-ferredoxin oxidoreductases in Clostridia of the butyric group, Biochim. Biophys. Acta 421, 334-347.
212. PETITDEMANGE, H., CHERRIER, C, BENGONE, J. M., GAY, R. (1977), Etude des activités NADH et NADPH-ferrédoxine oxydoréductasiques chez Clostridium acetobutylicum, Can. J. Microbiol. 23, 152-160.
213. PETITDEMANGE, H., MARCZAK, R, BLUSSON, H., GAY, R. (1979), Isolation and properties of reduced nicotinamide adenine dinucleotide-rubre-doxin oxidoreductase of Clostridium acetobutylicum, Biochem. Biophys. Res. Commun. 4, 1258-1265.
214. PICH, A., BAHL, H. (1991), Purification and characterization of the DNA-dependent RNA polymerase from Clostridium acetobutylicum, J. Bacteriol. 173, 2120-2124.
215. PICH, A., NARBERHAUS, F., BAHL, H. (1990), Induction of heat shock proteins during initiation of solvent formation in Clostridium acetobutylicum, Appl. Microbiol. Biotechnol. 33, 697-704.
216. PIERROT, P., FICK, M., ENGASSER, J. M. (1986), Continuous acetone-butanol fermentation with high productivity by cell ultrafiltration and cell recycling, Biotechnol. Lett. 8, 253-256.
217. PRESCOTT, S. G., DUNN, C. G. (1959), Industrial Microbiology, 3rd Edn., New York: McGraw-Hill Book Co.
218. PRINGSHEIM, H. H. (1906a), Ueber den Ursprung des Fuselöls und eine Alkohole bildende Bakterienform, Cbl. Bakteriol. Parasitenkd. Infek-tionskrankh., II. Abt. 15, 300-321.
219. PRINGSHEIM, H. (1906b), Ueber ein Stickstoff assimilierendes Clostridium, Cbl. Bakteriol. Parasitenkd. Infektionskrankh., II. Abt. 15, 795-800.
220. QURESHI, N., MADDOX, I. S. (1987), Continuous solvent production from whey permeate using cells of Clostridium acetobutylicum immobilized by adsorption onto bonechar, Enzyme Microb. Technol. 9, 668-671.
221. REID, S. J., ALLCOCK, E. R., JONES, D. T., WOODS, D. R. (1983), Transformation of Clostridium acetobutylicum protoplasts with bacteriophage DNA, Appl. Environ. Microbiol. 45, 305-307.
222. REYSSET, G., SEBALD, M. (1985), Conjugal transfer of plasmid-mediated antibiotic resistance from streptococci to Clostridium acetobutylicum, Ann. Inst. Pasteur/Microbiol. 136B, 275-282.
223. REYSSET, G., SEBALD, M. (1993), Transformation/electrotransformation of Clostridia, in: The Clostridia and Biotechnology (WOODS, D. R., Ed.), pp. 151-156, Stoneham: Butterworth-Heinemann.
224. REYSSET, G., HUBERT, J., PODVIN, L., SEBALD, M. (1988), Transfection and transformation of Clostridium acetobutylicum strain NI-4081 protoplasts, Biotechnol. Techniques 2, 199-204.
225. ROGERS, P. (1986), Genetics and biochemistry of Clostridium relevant to development of fermentation processes, Adv. Appl. Microbiol. 31, 1-60.
226. ROGERS, P., GOTTSCHALK, G. (1993), Biochemistry and regulation of acid and solvent production in Clostridia, in: The Clostridia and Biotechnology (WOODS, D. R., Ed.), pp. 25-50, Stone-ham: Butterworth-Heinemann.
227. ROGERS, P., PALOSAARI, N. (1987), Clostridium acetobutylicum mutants that produce butyralde-hyde and altered quantities of solvents, Appl. Environ. Microbiol. 53, 2761-2766.
228. Roos, J. W., MCLAUGHLIN, J., PAPOUTSAKIS, E. T. (1984), The effect of pH on nitrogen supply, cell lysis, and solvent production in fermentations of Clostridium acetobutylicum, Biotechnol. Bioeng. 27, 681-694.
229. Ross, D. (1961), The acetone-butanol fermentation, Prog. Ind. Microbiol. 3, 73-85.
230. RUBBO, S. D., MAXWELL, M., FAIRBRIDGE, R. A., GILLESPIE, J. M. (1941), The bacteriology, growth factor requirements and fermentation reactions of Clostridium acetobutylicum (Weiz-mann), Aust. J. Exp. Biol. Med. 19, 185-197.
231. SANTANGELO, J. D., JONES, D. T., WOODS, D. R. (1991), Metronidazole activation and isolation of Clostridium acetobutylicum electron transport genes, J. Bacteriol. 173, 1088-1095.
232. SANTANGELO, J. D., DÜRRE, P., WOODS, D. R. (1994), Characterization and expression of the hydrogenase I gene from Clostridium acetobutylicum P262, Abstr. 7th Int. Symp. Genet. Ind. Mi-croorg., Montreal, June 26-July 1, p. 96.
233. SASS, C, WALTER, J., BENNETT, G. N. (1993), Isolation of mutants of Clostridium acetobutylicum ATCC 824 deficient in protease activity, Curr. Microbiol. 26, 151-154.
234. SAUER, U., DÜRRE, P. (1992), Possible function of tRNAAco in regulation of solvent formation in Clostridium acetobutylicum, FEMS Microbiol. Lett. 100, 147-154.
235. SAUER, U., DÜRRE, P. (1993), Sequence and molecular characterization of a DNA region encoding a small heat shock protein of Clostridium acetobutylicum, J. Bacteriol. 175, 3394-3400.
236. SAUER, U., TREUNER, A., SANTANGELO, J. D., BUCHHOLZ, M., DÜRRE, P. (1994), Sporulation and primary er factor homologous genes in Clostridium acetobutylicum, Abstr. 7th Int. Symp. Genet. Ind. Microorg., Montreal, June 26-July 1, p. 249.
237. SCHARDINGER, F. (1905), Bacillus macerans, ein Aceton bildender Rottebacillus, Cbl. Bakteriol. Parasitenkd. Infektionskrankh., II. Abt. 14, 772-781.
238. SCHARDINGER, F. (1907), Verhalten von Weizen-und Roggenmehl zu Methylenblau und zu Stärkekleister, nebst einem Anhange über die Bildung höherer Alkohole durch hitzebeständige Mikroorganismen aus Weizenmehl, Cbl. Bakteriol. Parasitenkd. Infektionskrankh., II. Abt. 18, 748-767.
239. SCHATTENFROH, A., GRASSBERGER, R. (1899), Weitere Mitteilungen über Buttersäuregärung, Cbl. Bakteriol. Parasitenkd. Infektionskrankh., II. Abt. 5, 697-702.
240. SCHATTENFROH, A., GRASSBERGER, R. (1900), Ueber Buttersäuregährung. I. Abhandlung, Arch. Hyg. 37, 54-103.
241. SCHLOTE, D., GOTTSCHALK, G. (1986), Effect of cell recycle on continuous butanol-acetone fermentation with Clostridium acetobutylicum under phosphate limitation, Appl. Microbiol. Biotechnol. 24, 1-6.
242. SCOTT, D., HEDRICK, L. R. (1952), The amylase of Clostridium acetobutylicum, J. Bacteriol. 63, 795-803.
243. SHERMAN, P. D. (1978), Butyl alcohols, in: Kirk-Othmer Encyclopedia of Chemical Technology, 3rd Edn. (MARK, H. F., OTHMER, D. F., OVER-BERGER, C. G., SEABORG, G. T., GRAYSON, M., ECKROTH, D. Eds.), Vol. 4, pp. 338-345, New York: John Wiley & Sons.
244. SPIVEY, M. J. (1978), The acetone/butanol/ethanol fermentation, Process Biochem. 13, 2-5.
245. STEPHENS, G. M., HOLT, R. A., GOTTSCHAL, J. C, MORRIS, J. G. (1985), Studies on the stability of solvent production by Clostridium acetobutylicum in continuous culture, J. Appl. Bacteriol. 59, 597-605.
246. STRÄTZ, M., SAUER, U., KUHN, A., DÜRRE, P. (1994), Plasmid transfer into the homoacetogen Acetobacterium woodii by electroporation and conjugation, Appl. Environ. Microbiol. 60, 1033-1037.
247. TAGAKI, W., WESTHEIMER, F. H. (1968), Acetoacetate decarboxylase. The molecular weight of the enzyme and subunits, Biochemistry 7, 895-900.
248. TAYA, M., ISHII, S., KOBAYASHI, T. (1985), Monitoring and control for extractive fermentation of Clostridium acetobutylicum, J. Ferment. Technol. 63, 181-187.
249. THAUER, R. K., JUNGERMANN, K., DECKER, K. (1977), Energy conservation in chemotrophic anaerobic bacteria, Bacteriol. Rev. 41, 100-180.
250. THOMPSON, D. K., CHEN, J.-S. (1990), Purification and properties of an acetoacetyl coenzyme A-reacting phosphotransbutyrylase from Clostridium beijerinckii ("Clostridium butylicum") NRRL B593, Appl. Environ. Microbiol. 56, 607-613.
251. TRUFFAUT, N., SEBALD, M. (1988), Study of Plasmids isolated from saccharolytic Clostridia: Construction of hybrid plasmids and transfer to Escherichia coli and Bacillus subtilis, Biotechnol. Lett. 10, 1-6.
252. TRUFFAUT, N., HUBERT, J., REYSSET, G. (1989), Construction of shuttle vectors useful for transforming Clostridium acetobutylicum, FEMS Microbiol. Lett. 58, 15-20.
253. TWAROG, R., WOLFE, R. S. (1962), Enzymatic phosphorylation of butyrate, J. Biol. Chem. 237, 2474-2477.
254. ULLMANN, S., DÜRRE, P. (1994), Cloning and sequencing of the DNA gyrase genes of Clostridium acetobutylicum DSM 792, Abstr. 7th Int. Symp. Genet. Ind. Microorg., Montreal, June 26-July 1, p. 23.
255. VALENTINE, R. C, WOLFE, R. S. (1960), Purification and role of phosphotransbutyrylase, J. Biol. Chem. 235, 1948-1952.
256. VELDKAMP, H. (1965), Enrichment cultures of pro-karyotic organisms, in: Methods in Microbiology (NORRIS, J. R., RIBBONS, D. W., Eds.), Vol. 3A, pp. 305-361, London: Academic Press.
257. VERHASSELT, P., PONCELET, F., VITS, K., VAN GOOL, A., VANDERLEYDEN, J. (1989), Cloning and expression of a Clostridium acetobutylicum a-amylase gene in Escherichia coli, FEMS Microbiol. Lett. 59, 135-140.
258. VOGET, C. E., MIGNONE, C. F., ERTOLA, R. J. (1985), Butanol production from apple pomace, Biotechnol. Lett. 7, 43-16.
259. VOLESKY, B., SZCZESNY, T. (1983), Bacterial conversion of pentose sugars to acetone and butanol, Adv. Biochem. Eng. Biotechnol. 27, 101-117.
260. VOLLHERBST-SCHNECK, K., SANDS, J. A., MON-TENECOURT, B. S. (1984), Effect of butanol on lipid composition and fluidity of Clostridium acetobutylicum ATCC 824, Appl. Environ. Microbiol. 47, 193-194.
261. VON HUGO, H., GOTTSCHALK, G. (1974), Distribution of 1-phosphofructokinase and PEP:fructose phosphotransferase activity in Clostridia, FEBS Lett. 46, 106-108.
262. WALTER, K. A., BENNETT, G. N., PAPOUTSAKIS, E. T. (1992), Molecular characterization of two Clostridium acetobutylicum ATCC 824 butanol dehydrogenase isozyme genes, J. Bacteriol. 174, 7149-7158.
263. WALTER, K. A., NAIR, R. V., CARY, J. W., BENNETT, G. N., PAPOUTSAKIS, E. T. (1993), Sequence and arrangement of two genes of the bu-tyrate-synthesis pathway of Clostridium acetobutylicum ATCC 824, Gene 134, 107-111.
264. WALTON, M. T. (1945), Process for the production of riboflavin by butyl alcohol producing bacteria, U. S. Patent 2368074.
265. WANG, D. I. C, COONEY, C. L., DEMAIN. A. L., DUNHILL, P. (1979), Fermentation and Enzyme Technology, New York: John Wiley & Sons.
266. WARREN, S., ZERNER, B., WESTHEIMER, F. H. (1966), Acetoacetate decarboxylase. Identification of lysine at the active site, Biochemistry 5, 817-823.
267. WATERSON, R. M., CASTELLINO, F. J., HASS, G. M., HILL, R. L. (1972), Purification and characterization of crotonase from Clostridium acetobutylicum, J. Biol. Chem. 247, 5266-5271.
268. WEIZMANN, C. (1915), Improvements in the bacterial fermentation of carbohydrates and in bacterial cultures for the same, British Patent 4845.
269. WEIZMANN, C. (1919), Production of acetone and alcohol by bacteriological processes, U. S. Patent 1315585.
270. WELCH, R. W., RUDOLPH, F. B., PAPOUTSAKIS, E. T. (1989), Purification and characterization of the NADH-dependent butanol dehydrogenase from Clostridium acetobutylicum (ATCC 824), Arch. Biochem. Biophys. 273, 309-318.
271. WELCH, R. W., CLARK, S. W., BENNETT, G. N., RUDOLPH, F. B. (1992), Effects of rifampicin and chloramphenicol on product and enzyme levels of the acid-and solvent-producing pathways of Clostridium acetobutylicum (ATCC 824), Enzyme Microb. Technol. 14, 277-283.
272. WELSH, F. W., VELIKY, I. A. (1984), The production of acetone-butanol from acid whey, Biotechnol. Lett. 6, 61-64.
273. WESTHEIMER, F. H. (1969), Acetoacetate decarboxylase from Clostridium acetobutylicum, Methods Enzymol. 14, 231-241.
274. WIESENBORN, D. P., RUDOLPH, F. B., PAPOUTSAKIS, E. T. (1988), Thiolase from Clostridium ace-▪ tobutylicum ATCC 824 and its role in the synthesis of acids and solvents, Appl. Environ. Microbiol. 54, 2717-2722.
275. WIESENBORN, D. P., RUDOLPH, F. B., PAPOUTSAKIS, E. T. (1989a), Phosphotransbutyrylase from Clostridium acetobutylicum ATCC 824 and its role in acidogenesis, Appl. Environ. Microbiol. 55, 317-322.
276. WIESENBORN, D. P., RUDOLPH, F. B., PAPOUTSAKIS, E. T. (1989b), Coenzyme A transferase from Clostridium acetobutylicum ATCC 824 and its role in the uptake of acids, Appl. Environ. Microbiol. 55, 323-329.
277. WILDE, E., HIPPE, H., TOSUNOGLU, N., SCHALLEHN, G., HERWIG, K., GOTTSCHALK, G. (1989), Clostridium tetanomorphum sp. nov., nom. rev., Int. J. Syst. Bacteriol. 39, 127-134.
278. WILKINSON, S. R., YOUNG, M. (1994), Targeted integration of genes into the Clostridium acetobutylicum chromosome, Microbiology 140, 89-95.
279. WILLIAMS, D. R., YOUNG, D. I., YOUNG, M. (1990), Conjugative plasmid transfer from Escherichia coli to Clostridium acetobutylicum, J. Gen. Microbiol. 136, 819-826.
280. WINOGRADSKY, S. (1902), Clostridium pastorian-um, seine Morphologie und, seine Eigenschaften als Buttersäureferment, Cbl. Bakteriol. Parasitenkd. Infektionskrankh., II. Abt. 9, 43-54, 107-112.
281. WONG, J., BENNETT, G. N. (1994), Studies of DNA supercoiling in Clostridium acetobutylicum ATCC824, Abstr. Gen. Meet. Am. Soc. Microbiol., Las Vegas, May 23-27, O-40.
282. WOODRUFF, J. C, STILES, H. R., LEGG, D. A. (1937), Process of producing butyl alcohol, U. S. Patent 2089522.
283. WOOLLEY, R. C, MORRIS, J. G. (1990), Stability of solvent production by Clostridium acetobutylicum in continuous culture: strain differences, J. Appl. Bacteriol. 69, 718-728.
284. WOOLLEY, R. C, PENNOCK, A., ASHTON, R. J., DAVIES, A., YOUNG, M. (1989), Transfer of Tn/545 and Tn9/6 to Clostridium acetobutylicum, Plasmid 22, 169-174.
285. YAN, R.-T., CHEN, J.-S. (1990), Coenzyme A-acy-lating aldehyde dehydrogenase from Clostridium beijerinckii NRRL B592, Appl. Environ. Microbiol. 56, 2591-2599.
286. YAN, R.-T., ZHU, C.-X., GOLEMBOSKI, C, CHEN, J.-S. (1988), Expression of solvent-forming enzymes and onset of solvent production in batch cultures of Clostridium beijerinckii ("Clostridium butylicum"), Appl. Environ. Microbiol. 54, 642-648.
287. YAROVENKO, V. L. (1964), Principles of the continuous alcohol and butanol-acetone fermentation processes, in: Continuous Cultivation of Microorganisms, 2nd Symp. (MALEK, I., Ed.), pp. 205-217, Prague: Cechoslovakian Academy of Sciences.
288. YOON, K.-H., LEE, J.-K., KIM, B. H. (1991), Construction of a Clostridium acetobutylicum-Esch-erichia coli shuttle vector, Biotechnol. Lett. 13, 1-6.
289. YOSHINO, S., YOSHINO, T., HARA, S., OGATA, S., HAYASHIDA, S. (1990), Construction of shuttle vector plasmid between Clostridium acetobutylicum and Escherichia coli, Agr. Biol. Chem. 54, 437-441.
290. YOUNG, M. (1993), Development and exploitation of conjugative gene transfer in Clostridia, in: The Clostridia and Biotechnology (WOODS, D. R., Ed.), pp. 99-117, Stoneham: Butterworth-Heinemann.
291. YOUNG, M, MINTON, N. P., STAUDENBAUER, W. L. (1989), Recent advances in the genetics of the Clostridia, FEMS Microbiol. Rev. 63, 301-326.
292. YOUNGLESON, J. S., SANTANGELO, J. D., JONES, D. T., WOODS, D. R. (1988), Cloning and expression of a Clostridium acetobutylicum alcohol dehydrogenase gene in Escherichia coli, Appl. Environ. Microbiol. 54, 676-682.
293. YOUNGLESON, J. S., JONES, W. A., JONES, D. T., WOODS, D. R. (1989a), Molecular analysis and nucleotide sequence of the adhl gene encoding an NADPH-dependent butanol dehydrogenase in the Gram-positive anaerobe Clostridium acetobutylicum, Gene 78, 355-364.
294. YOUNGLESON, J. S., JONES, D. T., WOODS, D. R. (1989b), Homology between hydroxybutyryl and hydroxyacyl coenzyme A dehydrogenase enzymes from Clostridium acetobutylicum fermentation and vertebrate fatty acid /J-oxidation pathways, J. Bacteriol. 171, 6800-6807.
295. Yu, P.-L., PEARCE, L. E. (1986), Conjugal transfer of streptococcal antibiotic resistance plasmids into Clostridium acetobutylicum, Biotechnol. Lett. 8, 469-474.
296. Yu, E. K. C, SADDLER, J. N. (1983), Enhanced acetone-butanol fermentation by Clostridium, acetobutylicum grown on D-xylose in the presence of acetic or butyric acid, FEMS Microbiol. Lett. 18, 103-107.
297. Yu, E. K. C, CHAN, M. K.-H., SADDLER, J. N. (1985), Butanol production from cellulosic substrates by sequential co-culture of Clostridium thermocellum and C. acetobutylicum, Biotechnol. Lett. 7, 509-514.
298. Yu, P. L., SMART, J. B., ENNIS, B. M. (1987), Differential induction of β-galactosidase activities in the fermentation of whey permeate by Clostridium acetobutylicum, Appl. Microbiol. Biotechnol. 26, 254-257.
299. ZILLIG, W., HOLZ, I., WUNDERL, S. (1991), Hyper-thermus butylicus gen. nov., sp. nov., a hyper-thermophilic, anaerobic, peptide-fermenting, facultatively H2S-generating archaebacterium, Int. J. Syst. Bacteriol. 41, 169-170.
300. ZOUTBERG, G. R., WILLEMSBERG, R., SMIT, G., TEIXEIRA DE MATTOS, M. J., NEIJSSEL, O. M. (1989a), Aggregate-formation by Clostridium butyricum, Appl. Microbiol. Biotechnol. 32, 17-21.
301. ZOUTBERG, G. R., WILLEMSBERG, R., SMIT, G., TEIXEIRA DE MATTOS, M. J., NEIJSSEL, O. M. (1989b), Solvent production by an aggregate-forming variant of Clostridium butyricum, Appl. Microbiol. Biotechnol. 32, 22-26.