Isovaleric acid in stool correlates with human depression

Nutritional Neuroscience

Volumn 19, Issue 7, 2016, Pages 279-283

  Szczesniak, Olga ^a   Hestad, Knut A ^b,c,d   Hanssen, Jon Fredrik ^a   Rudi, Knut ^a  

^a NORWEGIAN UNIVERSITY OF LIFE SCIENCES   (Norway)

^b INNLANDET HOSPITAL TRUST   (Norway)

^c INLAND NORWAY UNIVERSITY OF APPLIED SCIENCES   (Norway)

^d NORWEGIAN UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Norway)

Author keywords

Cortisol; Depression; Isovaleric acid; Microbiota; VFA

Indexed keywords

HYDROCORTISONE; ISOBUTYRIC ACID; ISOVALERIC ACID; PROPIONIC ACID; ANTIDEPRESSANT AGENT; BIOLOGICAL MARKER; VALERIC ACID DERIVATIVE;

ARTICLE; CHEMILUMINESCENCE IMMUNOASSAY; CONTROLLED STUDY; DEPRESSION; FECES ANALYSIS; FECES MICROFLORA; GAS CHROMATOGRAPHY; HUMAN; INTESTINE FLORA; MAJOR CLINICAL STUDY; NEUROTRANSMITTER RELEASE; PRIORITY JOURNAL; SALIVA ANALYSIS; SENSITIVITY AND SPECIFICITY; ADULT; CHEMISTRY; CLASSIFICATION; CLOSTRIDIALES; COHORT ANALYSIS; DRUG EFFECTS; DYSBIOSIS; EPIDEMIOLOGY; FECES; FLAME IONIZATION DETECTION; ISOLATION AND PURIFICATION; METABOLISM; MICROBIOLOGY; MOLECULAR TYPING; NORWAY; PATHOPHYSIOLOGY; PSYCHOLOGY; REGRESSION ANALYSIS; REPRODUCIBILITY; SALIVA;

ADULT; ANTIDEPRESSIVE AGENTS; BIOMARKERS; CLOSTRIDIALES; COHORT STUDIES; CONFOUNDING FACTORS (EPIDEMIOLOGY); DEPRESSION; DYSBIOSIS; FECES; FLAME IONIZATION; GASTROINTESTINAL MICROBIOME; HUMANS; HYDROCORTISONE; MOLECULAR TYPING; NORWAY; PENTANOIC ACIDS; REGRESSION ANALYSIS; REPRODUCIBILITY OF RESULTS; SALIVA;

EID: 84978517816     PISSN: 1028415X     EISSN: 14768305     Source Type: Journal    
DOI: 10.1179/1476830515Y.0000000007     Document Type: Article

References (17)

1. WHO. Depression 2012 [cited 2014 20.05.2014]. http://www.who.int/mediacentre/factsheets/fs369/en/.
2. R.C.Kessler, C.B.Nelson, K.A.McGonagle, J.Liu, M.Swartz, D.G.Blazer. Comorbidity of DSM-III-R major depressive disorder in the general population:results from the US National Comorbidity Survey. Br J Psychiatry Suppl 1996; 30:17–30.
3. J.A.Foster, K.A.McVey Neufeld. Gut-brain axis:how the microbiome influences anxiety and depression. Trends Neurosci 2013;36(5):305–12. doi:10.1016/j.tins.2013.01.005
4. G.Frost, M.L.Sleeth, M.Sahuri-Arisoylu, B.Lizarbe, S.Cerdan, L.Brody, The short-chain fatty acid acetate reduces appetite via a central homeostatic mechanism. Nat Commun 2014;5. doi:10.1038/ncomms4611
5. A.Naseribafrouei, K.Hestad, E.Avershina, M.Sekelja, A.Linlokken, R.Wilson, Correlation between the human fecal microbiota and depression. Neurogastroenterol Motil 2014;26(8):1155–62. doi:10.1111/nmo.12378
6. S.K.Lacher, R.Mayer, K.Sichardt, K.Nieber, C.E.Muller. Interaction of valerian extracts of different polarity with adenosine receptors:identification of isovaltrate as an inverse agonist at A1 receptors. Biochem Pharmacol 2007;73(2):248–58. doi:10.1016/j.bcp.2006.09.029
7. E.A.Beaton, L.A.Schmidt, A.R.Ashbaugh, D.L.Santesso, M.M.Antony, R.E.McCabe, Low salivary cortisol levels among socially anxious young adults:preliminary evidence from a selected and a non-selected sample. Personal Individ Differ 2006;41(7):1217–28. doi:10.1016/j.paid.2006.02.020
8. H.A.Barker. Amino acid degradation by anaerobic bacteria. Annu Rev Biochem 1981;50:23–40. doi:10.1146/annurev.bi.50.070181.000323
9. + -ATPase inhibition induced by intracerebroventricular administration of isovaleric acid in cerebral cortex of young rats. Brain Res 2009;1262:81–8. doi:10.1016/j.brainres.2009.01.005
10. I.K.Lyoo, S.Yoon, T.S.Kim, J.Hwang, J.E.Kim, W.Won, A randomized, double-blind placebo-controlled trial of oral creatine monohydrate augmentation for enhanced response to a selective serotonin reuptake inhibitor in women with major depressive disorder. Am J Psychiatry. 2012;169(9):937–45. doi:10.1176/appi.ajp.2012.12010009
11. M.Owens, J.Herbert, P.B.Jones, B.J.Sahakian, P.O.Wilkinson, V.J.Dunn, Elevated morning cortisol is a stratified population-level biomarker for major depression in boys only with high depressive symptoms. Proc Natl Acad Sci USA 2014;111(9):3638–43. doi:10.1073/pnas.1318786111
12. A.A.Badawy, S.L.Lake, D.M.Dougherty. Mechanisms of the pellagragenic effect of leucine:stimulation of hepatic tryptophan oxidation by administration of branched-chain amino acids to healthy human volunteers and the role of plasma free tryptophan and total kynurenines. Int J Tryp Res 2014;7:23–32. doi:10.4137/IJTR.S18231
13. M.L.Britz, R.G.Wilkinson. Leucine dissimilation to isovaleric and isocaproic acids by cell suspensions of amino acid fermenting anaerobes:the Stickland reaction revisited. Can J Microbiol 1982;28(3):291–300. doi:10.1139/m82-043
14. Y.W.Lee, D.H.Lee, J.Vockley, N.D.Kim, Y.K.Lee, C.S.Ki. Different spectrum of mutations of isovaleryl-CoA dehydrogenase (IVD) gene in Korean patients with isovaleric acidemia. Mol Genet Metabol 2007;92(1–2):71–7. doi:10.1016/j.ymgme.2007.05.003
15. K.A.Hestad, S.Tonseth, C.D.Stoen, T.Ueland, P.Aukrust. Raised plasma levels of tumor necrosis factor alpha in patients with depression:normalization during electroconvulsive therapy. J ECT 2003;19(4):183–8. doi:10.1097/00124509-200312000-00002
16. Y.Furusawa, Y.Obata, S.Fukuda, T.A.Endo, G.Nakato, D.Takahashi, Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells. Nature 2013;504(7480):446–50. doi:10.1038/nature12721
17. N.P.Hyland, J.F.Cryan. A gut feeling about GABA:focus on GABAB receptors. Front Pharmacol 2010;1. doi:10.3389/fphar.2010.00124