Redox-Triggered Release of Moxifloxacin from Mesoporous Silica Nanoparticles Functionalized with Disulfide Snap-Tops Enhances Efficacy Against Pneumonic Tularemia in Mice

Small (Weinheim an der Bergstrasse, Germany)

Volumn 12, Issue 27, 2016, Pages 3690-3702

  Lee, Bai Yu ^a   Li, Zilu ^a   Clemens, Daniel L ^a   Dillon, Barbara Jane ^a   Hwang, Angela A ^a   Zink, Jeffrey I ^a   Horwitz, Marcus A ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

disulfide snap top; francisella tularensis; intracellular delivery; mesoporous silica nanoparticle; redox potential

Indexed keywords

CONTROLLED DRUG DELIVERY; MACROPHAGES; MAMMALS; MESOPOROUS MATERIALS; PATHOGENS; REDOX REACTIONS; SULFUR COMPOUNDS; TARGETED DRUG DELIVERY;

DISULFIDE SNAP-TOP; FRANCISELLA TULARENSIS; INTRACELLULAR DELIVERY; MESOPOROUS SILICA NANOPARTICLES; REDOX POTENTIALS;

SILICA NANOPARTICLES;

MOXIFLOXACIN; NANOPARTICLE; QUINOLONE DERIVATIVE; SILICON DIOXIDE;

ANIMAL; BAGG ALBINO MOUSE; CHEMISTRY; DRUG DELIVERY SYSTEM; FEMALE; MOUSE; PROCEDURES; TULAREMIA;

ANIMALS; DRUG DELIVERY SYSTEMS; FEMALE; FLUOROQUINOLONES; MICE; MICE, INBRED BALB C; NANOPARTICLES; SILICON DIOXIDE; TULAREMIA;

EID: 84978414606     PISSN: None     EISSN: 16136829     Source Type: Journal    
DOI: 10.1002/smll.201600892     Document Type: Article

References (64)