Fetal sex dependency of maternal vascular adaptation to pregnancy: a prospective population-based cohort study

BJOG: An International Journal of Obstetrics and Gynaecology

Volumn 123, Issue 7, 2016, Pages 1087-1095

  Broere Brown, Z A ^a   Schalekamp Timmermans, S ^a   Hofman, A ^a   Jaddoe, V W V ^a   Steegers, E A P ^a  

^a ERASMUS MEDICAL CENTER   (Netherlands)

Author keywords

Blood pressure; fetal growth restriction; fetal sex; notching; pre eclampsia; pulsatility index; spontaneous preterm birth

Indexed keywords

ADAPTATION; ADULT; ARTICLE; BIRTH WEIGHT; BLOOD PRESSURE; COHORT ANALYSIS; EMBRYONIC AND PLACENTAL STRUCTURES; FEMALE; FETAL SEX; FETUS; FIRST TRIMESTER PREGNANCY; GESTATIONAL AGE; HUMAN; LIVE BIRTH; MAJOR CLINICAL STUDY; MALE; MATERNAL VASCULAR ADAPTATION; MEASUREMENT; NETHERLANDS; PARAMETERS CONCERNING THE FETUS, NEWBORN AND PREGNANCY; PLACENTA FUNCTION; POPULATION BASED COHORT STUDY; PREECLAMPSIA; PREGNANCY; PREMATURE LABOR; PRIORITY JOURNAL; PROSPECTIVE STUDY; PULSATILITY INDEX OF THE UTERINE ARTERY; SECOND TRIMESTER PREGNANCY; SEX DIFFERENCE; SEXUAL DEVELOPMENT; THIRD TRIMESTER PREGNANCY; UTERINE ARTERY; UTERINE ARTERY DOPPLER MEASUREMENT; UTERINE ARTERY NOTCHING;

EID: 84978402774     PISSN: 14700328     EISSN: 14710528     Source Type: Journal    
DOI: 10.1111/1471-0528.13519     Document Type: Article

References (34)

1. Carbillon L, Uzan M, Uzan S. Pregnancy, vascular tone, and maternal hemodynamics: a crucial adaptation. Obstet Gynecol Surv 2000;55:574–81.
2. Burton GJ. Oxygen, the Janus gas; its effects on human placental development and function. J Anat 2009;215:27–35.
3. Burton GJ, Yung HW, Cindrova-Davies T, Charnock-Jones DS. Placental endoplasmic reticulum stress and oxidative stress in the pathophysiology of unexplained intrauterine growth restriction and early onset preeclampsia. Placenta 2009;30(Suppl A):S43–8.
4. Steegers EA, von Dadelszen P, Duvekot JJ, Pijnenborg R. Pre-eclampsia. Lancet 2010;376:631–44.
5. Brosens I, Pijnenborg R, Vercruysse L, Romero R. The, “Great Obstetrical Syndromes” are associated with disorders of deep placentation. Am J Obstet Gynecol 2011;204:193–201.
6. Molvarec A, Szarka A, Walentin S, Szucs E, Nagy B, Rigo J Jr. Circulating angiogenic factors determined by electrochemiluminescence immunoassay in relation to the clinical features and laboratory parameters in women with pre-eclampsia. Hypertens Res 2010;33:892–8.
7. Noori M, Donald AE, Angelakopoulou A, Hingorani AD, Williams DJ. Prospective study of placental angiogenic factors and maternal vascular function before and after preeclampsia and gestational hypertension. Circulation 2010;122:478–87.
8. Madazli R, Aydin S, Uludag S, Vildan O, Tolun N. Maternal plasma levels of cytokines in normal and preeclamptic pregnancies and their relationship with diastolic blood pressure and fibronectin levels. Acta Obstet Gynecol Scand 2003;82:797–802.
9. Brown ZA, Schalekamp-Timmermans S, Tiemeier HW, Hofman A, Jaddoe VW, Steegers EA. Fetal sex specific differences in human placentation: a prospective cohort study. Placenta 2014;35:359–64.
10. Jaddoe VW, van Duijn CM, Franco OH, van der Heijden AJ, van Iizendoorn MH, de Jongste JC, et al. The Generation R Study: design and cohort update 2012. Eur J Epidemiol 2012;27:739–56.
11. Verburg BO, Jaddoe VW, Wladimiroff JW, Hofman A, Witteman JC, Steegers EA. Fetal hemodynamic adaptive changes related to intrauterine growth: the Generation R Study. Circulation 2008;117:649–59.
12. Baschat AA, Hecher K. Fetal growth restriction due to placental disease. Semin Perinatol 2004;28:67–80.
13. Coolman M, de Groot CJ, Jaddoe VW, Hofman A, Raat H, Steegers EA. Medical record validation of maternally reported history of preeclampsia. J Clin Epidemiol 2010;63:932–7.
14. Brown MA, Lindheimer MD, De Swiet M, Van Assche A, Moutquin JM. The classification and diagnosis of the hypertensive disorders of pregnancy: statement from the International Society for the Study of Hypertension in Pregnancy (ISSHP). Hypertens Pregnancy 2001;20:IX–XIV.
15. Verburg BO, Steegers EA, De Ridder M, Snijders RJ, Smith E, Hofman A, et al. New charts for ultrasound dating of pregnancy and assessment of fetal growth: longitudinal data from a population-based cohort study. Ultrasound Obstet Gynecol 2008;31:388–96.
16. Royston P, Ambler G, Sauerbrei W. The use of fractional polynomials to model continuous risk variables in epidemiology. Int J Epidemiol 1999;28:964–74.
17. Cerin E, Mackinnon DP. A commentary on current practice in mediating variable analyses in behavioural nutrition and physical activity. Public Health Nutr 2009;12:1182–8.
18. Mackinnon DP, Fairchild AJ. Current directions in mediation analysis. Curr Dir Psychol Sci 2009;18:16.
19. Gaillard R, Arends LR, Steegers EA, Hofman A, Jaddoe VW. Second- and third-trimester placental hemodynamics and the risks of pregnancy complications: the Generation R Study. Am J Epidemiol 2013;177:743–54.
20. Stark MJ, Dierkx L, Clifton VL, Wright IM. Alterations in the maternal peripheral microvascular response in pregnancies complicated by preeclampsia and the impact of fetal sex. J Soc Gynecol Investig 2006;13:573–8.
21. Vatten LJ, Skjaerven R. Offspring sex and pregnancy outcome by length of gestation. Early Hum Dev 2004;76:47–54.
22. Byrne J, Warburton D. Male excess among anatomically normal fetuses in spontaneous abortions. Am J Med Genet 1987;26:605–11.
23. Orzack SH, Stubblefield JW, Akmaev VR, Colls P, Munne S, Scholl T, et al. The human sex ratio from conception to birth. Proc Natl Acad Sci USA 2015;112:E2102–11.
24. Strott CA, Yoshimi T, Ross GT, Lipsett MB. Ovarian physiology: relationship between plasma LH and steroidogenesis by the follicle and corpus luteum; effect of HCG. J Clin Endocrinol Metab 1969;29:1157–67.
25. Cole LA. Biological functions of hCG and hCG-related molecules. Reprod Biol Endocrinol 2010;8:102.
26. Illescas T, Fernandez C, Ortega D, de la Puente M, Coronado P, Montalvo J. Influence of gravidity and foetal gender on the value of screening variables in the first trimester of pregnancy. Eur J Obstet Gynecol Reprod Biol 2013;167:14–7.
27. Spencer K. The influence of fetal sex in screening for Down syndrome in the second trimester using AFP and free β-hCG. Prenat Diagn 2000;20:648–51.
28. Larsen SO, Wojdemann KR, Shalmi AC, Sundberg K, Christiansen M, Tabor A. Gender impact on first trimester markers in Down syndrome screening. Prenat Diagn 2002;22:1207–8.
29. Yaron Y, Wolman I, Kupferminc MJ, Ochshorn Y, Many A, Orr-Urtreger A. Effect of fetal gender on first trimester markers and on Down syndrome screening. Prenat Diagn 2001;21:1027–30.
30. Spencer K, Ong CY, Liao AW, Papademetriou D, Nicolaides KH. The influence of fetal sex in screening for trisomy 21 by fetal nuchal translucency, maternal serum free β-hCG and PAPP-A at 10-14 weeks of gestation. Prenat Diagn 2000;20:673–5.
31. Cowans NJ, Stamatopoulou A, Maiz N, Spencer K, Nicolaides KH. The impact of fetal gender on first trimester nuchal translucency and maternal serum free β-hCG and PAPP-A MoM in normal and trisomy 21 pregnancies. Prenat Diagn 2009;29:578–81.
32. Ghidini A, Salafia CM. Histologic placental lesions in women with recurrent preterm delivery. Acta Obstet Gynecol Scand 2005;84:547–50.
33. Challis J, Newnham J, Petraglia F, Yeganegi M, Bocking A. Fetal sex and preterm birth. Placenta 2013;34:95–9.
34. Magdoud K, Hellal R, Zemni R, Touraine R, Mahjoub T, Almawi WY. Association of the IL-10 receptor A536G (S138G) loss-of-function variant with recurrent miscarriage. Am J Reprod Immunol 2014;72:1–4.