Altered default mode network (DMN) resting state functional connectivity following a mindfulness-based exposure therapy for posttraumatic stress disorder (PTSD) in combat veterans of Afghanistan and Iraq

Depression and Anxiety

Volumn 33, Issue 4, 2016, Pages 289-299

  King, Anthony P ^a,b   Block, Stefanie R ^a,b,c   Sripada, Rebecca K ^b,d   Rauch, Sheila ^e   Giardino, Nicholas ^b   Favorite, Todd ^a,b   Angstadt, Michael ^b   Kessler, Daniel ^b   Welsh, Robert ^a,f   Liberzon, Israel ^a,b,c  

^a VA ANN ARBOR HEALTHCARE SYSTEM   (United States)

^b UNIVERSITY OF MICHIGAN HEALTH SYSTEM   (United States)

^c UNIVERSITY OF MICHIGAN   (United States)

^d VA National Serious Mental Illness Treatment Resource and Evaluation Center   (United States)

^e EMORY UNIVERSITY   (United States)

^f UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

Brain imaging neuroimaging; Functional MRI; Mindfulness meditation; PTSD posttraumatic stress disorder; Treatment

Indexed keywords

ADULT; AFGHANISTAN; AMYGDALA; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DEFAULT MODE NETWORK; DORSAL ANTERIOR CINGULATE CORTEX; DORSOLATERAL PREFRONTAL CORTEX; EXECUTIVE FUNCTION; EXPOSURE THERAPY; FUNCTIONAL CONNECTIVITY; FUNCTIONAL MAGNETIC RESONANCE IMAGING; FUNCTIONAL NEUROIMAGING; GROUP THERAPY; HUMAN; IRAQ; LONGITUDINAL STUDY; MALE; MINDFULNESS; PILOT STUDY; POSTERIOR CINGULATE; POSTTRAUMATIC STRESS DISORDER; PRIORITY JOURNAL; RESTING STATE FUNCTIONAL CONNECTIVITY; RESTING STATE NETWORK; SALIENCE NETWORK; VENTROMEDIAL PREFRONTAL CORTEX; VETERAN; BRAIN; IMPLOSIVE THERAPY; NUCLEAR MAGNETIC RESONANCE IMAGING; PATHOPHYSIOLOGY; PROCEDURES; PSYCHOLOGY; REST; STATISTICS AND NUMERICAL DATA; STRESS DISORDERS, POST-TRAUMATIC;

ADULT; AFGHANISTAN; BRAIN; HUMANS; IMPLOSIVE THERAPY; IRAQ; MAGNETIC RESONANCE IMAGING; MALE; MINDFULNESS; PSYCHOTHERAPY, GROUP; REST; STRESS DISORDERS, POST-TRAUMATIC; VETERANS;

EID: 84978276980     PISSN: 10914269     EISSN: 15206394     Source Type: Journal    
DOI: 10.1002/da.22481     Document Type: Article

References (59)

1. Fulton JJ, Calhoun PS, Wagner HR, et al. The prevalence of posttraumatic stress disorder in operation enduring free-dom/operation iraqi freedom (OEF/OIF) veterans: a meta-analysis. J Anxiety Disord 2015;31:98–107.
2. Bradley R, Greene J, Russ E, Dutra L, Westen D. A multidimensional meta-analysis of psychotherapy for PTSD. Am J Psychiatry 2005;162:214–227.
3. Steenkamp MM, Litz BT, Hoge CW, Marmar CR. Psychotherapy for military-related PTSD: a review of randomized clinical trials. J Am Med Assoc 2015;314:489–500.
4. Institute of Medicine. Treatment of Posttraumatic Stress Disorder: An Assessment of the Evidence. Washington, DC: National Academy of Sciences; 2008.
5. Forbes D, Lloyd D, Nixon RD, et al. A multisite randomized controlled effectiveness trial of cognitive processing therapy for military-related posttraumatic stress disorder. J Anxiety Disord 2012;26:442–452.
6. Schnurr PP, Friedman MJ, Engel CC, et al. Cognitive behavioral therapy for posttraumatic stress disorder in women: a randomized controlled trial. J Am Med Assoc 2007;297:820–830.
7. Suris A, Link-Malcolm J, Chard K, Ahn C, North C. A randomized clinical trial of cognitive processing therapy for veterans with PTSD related to military sexual trauma. J Trauma Stress 2013;26:28–37.
8. Jeffreys MD, Reinfeld C, Nair PV, Garcia HA, Mata-Galan E, Rentz TO. Evaluating treatment of posttraumatic stress disorder with cognitive processing therapy and prolonged exposure therapy in a VHA specialty clinic. J Anxiety Disord 2014;28:108–114.
9. Tuerk PW, Yoder M, Grubaugh A, Myrick H, Hamner M, Acierno R. Prolonged exposure therapy for combat-related posttraumatic stress disorder: an examination of treatment effectiveness for veterans of the wars in Afghanistan and Iraq. J Anxiety Disord 2011;25:397–403.
10. Kehle-Forbes SM, Meis LA, Spoont MR, Polusny MA. Treatment initiation and dropout from prolonged exposure and cognitive processing therapy in a VA outpatient clinic. Psychol Trauma Theory, Research, Practice, and Policy 2016;8(1):107–114.
11. Ma SH, Teasdale JD. Mindfulness-based cognitive therapy for depression: replication and exploration of differential relapse prevention effects. J Consult Clin Psychol 2004;72:31–40.
12. Segal ZV, Williams JMG, Teasdale JD. Mindfulness-Based Cognitive Therapy for Depression: A New Approach to Preventing Relapse. New York, NY: Guilford Press; 2002.
13. Segal ZV, Bieling P, Young T, et al. Antidepressant monotherapy vs sequential pharmacotherapy and mindfulness-based cognitive therapy, or placebo, for relapse prophylaxis in recurrent depression. Arch Gen Psychiatry 2010;67:1256–1264.
14. Eisendrath SJ, Gillung E, Delucchi K, et al. A preliminary study: efficacy of mindfulness-based cognitive therapy versus sertraline as first-line treatments for major depressive disorder. Mindfulness 2015;6:475–482.
15. Eisendrath SJ, Gillung EP, Delucchi KL, et al. Mindfulness-based cognitive therapy (MBCT) versus the health-enhancement program (HEP) for adults with treatment-resistant depression: a randomized control trial study protocol. BMC Complement Altern Med 2014;14:95.
16. Hoge EA, Bui E, Marques L, et al. Randomized controlled trial of mindfulness meditation for generalized anxiety disorder: effects on anxiety and stress reactivity. J Clin Psychiatry 2013;74:786–792.
17. Kimbrough E, Magyari T, Langenberg P, Chesney M, Berman B. Mindfulness intervention for child abuse survivors. J Clin Psychol 2010;66:17–33.
18. Earley MD, Chesney MA, Frye J, Greene PA, Berman B, Kimbrough E. Mindfulness intervention for child abuse survivors: a 2.5-year follow-up. J Clin Psychol 2014;70:933–941.
19. Kearney DJ, McDermott K, Malte C, Martinez M, Simpson TL. Association of participation in a mindfulness program with measures of PTSD, depression and quality of life in a veteran sample. J Clin Psychol 2012;68:101–116.
20. Kearney DJ, McDermott K, Malte C, Martinez M, Simpson TL. Effects of participation in a mindfulness program for veterans with posttraumatic stress disorder: a randomized controlled pilot study. J Clin Psychol 2013;69:14–27.
21. King AP, Erickson TM, Giardino ND, et al. A pilot study of group mindfulness-based cognitive therapy (MBCT) for combat veterans with posttraumatic stress disorder (PTSD). Depress Anxiety 2013;30:638–645.
22. Polusny MA, Erbes CR, Thuras P, et al. Mindfulness-based stress reduction for posttraumatic stress disorder among veterans: a randomized clinical trial. J Am Med Assoc 2015;314:456–465.
23. Holzel BK, Lazar SW, Gard T, Schuman-Olivier Z, Vago DR, Ott U. How does mindfulness meditation work? Proposing mechanisms of action from a conceptual and neural perspective. Perspect Psychol Sci 2011;6:537–559.
24. Vago DR, Silbersweig DA. Self-awareness, self-regulation, and self-transcendence (S-ART): a framework for understanding the neurobiological mechanisms of mindfulness. Front Hum Neurosci 2012;6.
25. Fox KC, Spreng RN, Ellamil M, Andrews-Hanna JR, Christoff K. The wandering brain: meta-analysis of functional neuroimaging studies of mind-wandering and related spontaneous thought processes. Neuroimage 2015;111:611–621.
26. Mittner M, Boekel W, Tucker AM, Turner BM, Heathcote A, Forstmann BU. When the brain takes a break: a model-based analysis of mind wandering. J. Neurosci. 2014;34:16286–16295.
27. Brewer JA, Worhunsky PD, Gray JR, Tang YY, Weber J, Kober H. Meditation experience is associated with differences in default mode network activity and connectivity. Proc. Natl. Acad. Sci. U S A 2011;108:20254–20259.
28. Doll A, Holzel BK, Boucard CC, Wohlschlager AM, Sorg C. Mindfulness is associated with intrinsic functional connectivity between default mode and salience networks. Front Hum Neurosci 2015;9:461.
29. Froeliger B, Garland EL, Kozink RV, et al. Meditation-state functional connectivity (msFC): strengthening of the dorsal attention network and beyond. Evid Based Complement Alternat Med 2012;2012:680407.
30. Garrison KA, Zeffiro TA, Scheinost D, Constable RT, Brewer JA. Meditation leads to reduced default mode network activity beyond an active task. Cogn Affect Behav Neurosci 2015;15:712–720.
31. Hasenkamp W, Barsalou LW. Effects of meditation experience on functional connectivity of distributed brain networks. Front Human Neurosci 2012;6:38.
32. Kong F, Wang X, Song Y, Liu J. Brain regions involved in dispositional mindfulness during resting state and their relation with well-being. Soc Neurosci 2015;1–13.
33. Wells RE, Yeh GY, Kerr CE, et al. Meditation’s impact on default mode network and hippocampus in mild cognitive impairment: a pilot study. Neurosci Lett 2013;556:15–19.
34. Daniels JK, McFarlane AC, Bluhm RL, et al. Switching between executive and default mode networks in posttraumatic stress disorder: alterations in functional connectivity. J Psychiatry Neurosci 2010;35:258–266.
35. Lanius RA, Bluhm RL, Coupland NJ, et al. Default mode network connectivity as a predictor of post-traumatic stress disorder symptom severity in acutely traumatized subjects. Acta Psychiatr Scand 2010;121:33–40.
36. Lei D, Li K, Li L, et al. Disrupted functional brain connectome in patients with posttraumatic stress disorder. Radiology 2015;276:818–827.
37. Rabinak CA, Angstadt M, Welsh RC, et al. Altered amygdala resting-state functional connectivity in post-traumatic stress disorder. Front Psychiatry 2011;2:62.
38. Sripada RK, King AP, Garfinkel SN, et al. Altered resting-state amygdala functional connectivity in men with posttraumatic stress disorder. J Psychiatry Neurosci 2012;37:241–249.
39. Sripada RK, King AP, Welsh RC, et al. Neural dysregulation in posttraumatic stress disorder: evidence for disrupted equilibrium between salience and default mode brain networks. Psychosom Med 2012;74:904–911.
40. Tursich M, Ros T, Frewen PA, Kluetsch RC, Calhoun VD, Lanius RA. Distinct intrinsic network connectivity patterns of posttraumatic stress disorder symptom clusters. Acta Psychiatr Scand 2015;132:29–38.
41. Ashburner J. A fast diffeomorphic image registration algorithm. Neuroimage 2007;38:95–113.
42. Power JD, Barnes KA, Snyder AZ, Schlaggar BL, Petersen SE. Spurious but systematic correlations in functional connectivity MRI networks arise from subject motion. Neuroimage 2012;59:2142–2154.
43. Maldjian JA, Laurienti PJ, Kraft RA, Burdette JH. An automated method for neuroanatomic and cytoarchitectonic atlas-based interrogation of fMRI data sets. Neuroimage 2003;19:1233–1239.
44. Friston KJ, Holmes AP, Price CJ, Buchel C, Worsley KJ. Multisubject fMRI studies and conjunction analyses. Neuroimage 1999;10:385–396.
45. Kilpatrick LA, Suyenobu BY, Smith SR, et al. Impact of Mindfulness-based stress reduction training on intrinsic brain connectivity. Neuroimage 2011;56:290–298.
46. Creswell JD TA, Lindsay EK, Greco CM, et al. Alterations in resting state functional connectivity link mindfulness meditation with reduced interleukin-6. Biol Psychiatry 2016 (in press).
47. Roland LT, Lenze EJ, Hardin FM, et al. Effects of mindfulness based stress reduction therapy on subjective bother and neural connectivity in chronic tinnitus. Otolaryngol Head Neck Surg 2015;152:919–926.
48. Haase L, May AC, Falahpour M, et al. A pilot study investigating changes in neural processing after mindfulness training in elite athletes. Front Behav Neurosci 2015;9:229.
49. Taren AA, Gianaros PJ, Greco CM, et al. Mindfulness meditation training alters stress-related amygdala resting state functional connectivity: a randomized controlled trial. Soc Cogn Affec Neurosci 2015;10(12):1758–1768.
50. Bluhm R, Williamson P, Lanius R, et al. Resting state default-mode network connectivity in early depression using a seed region-of-interest analysis: decreased connectivity with caudate nucleus. Psychiatry Clin Neurosci 2009;63:754– 761.
51. Petersen SE, Posner MI. The attention system of the human brain: 20 years after. Annu Rev Neurosci 2012;35:73–89.
52. Posner MI, Petersen SE. The attention system of the human brain. Annu Rev Neurosci 1990;13:25–42.
53. Miller EK, Cohen JD. An integrative theory of prefrontal cortex function. Annu Rev Neurosci 2001;24:167–202.
54. Fan J, McCandliss BD, Fossella J, Flombaum JI, Posner MI. The activation of attentional networks. Neuroimage 2005;26:471–479.
55. Botvinick MM, Braver TS, Barch DM, Carter CS, Cohen JD. Conflict monitoring and cognitive control. Psychol Rev 2001;108:624–652.
56. Carter CS, van Veen V. Anterior cingulate cortex and conflict detection: an update of theory and data. Cogn Affect Behav Neurosci 2007;7:367–379.
57. Koenigsberg HW, Fan J, Ochsner KN, et al. Neural correlates of using distancing to regulate emotional responses to social situations. Neuropsychologia 2010;48:1813–1822.
58. Ochsner KN, Bunge SA, Gross JJ, Gabrieli JD. Rethinking feelings: an fMRI study of the cognitive regulation of emotion. J Cogn Neurosci 2002;14:1215–1229.
59. Fernandez-Duque D, Baird JA, Posner MI. Executive attention and metacognitive regulation. Conscious Cogn 2000;9:288–307.